27 items (Aspergillus oryzae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AO090038000436	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (237 aa)
	AO090005000623	TPR_REGION domain-containing protein. (660 aa)
	AO090005000666	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (332 aa)
	AO090001000378	Uncharacterized protein. (153 aa)
	atg12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with atg5 through a ubiquitin-like conjugating system involving also atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-atg5 conjugate functions as an E3-like enzyme which is required for lipidation of atg8 and atg8 association to the vesicle membranes (By similarity). (176 aa)
	AO090003000679	Ubiquitin-like domain-containing protein. (154 aa)
	AO090003000728	Ubiquitin carboxyl-terminal hydrolase. (610 aa)
	AO090003000999	UBIQUITIN_CONJUGAT_2 domain-containing protein. (139 aa)
	AO090003001106	Uncharacterized protein. (249 aa)
	mdm34	Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. Mdm34 is required for the interaction of the ER-resident membrane protein mmm1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10. (566 aa)
	AO090003001362	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (274 aa)
	AO090003001363	Fungal_trans domain-containing protein. (386 aa)
	AO090023000476	Uncharacterized protein. (170 aa)
	AO090023000600	DUF4139 domain-containing protein. (317 aa)
	atg1	Serine/threonine-protein kinase atg1; Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing [...] (934 aa)
	AO090023000971	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (354 aa)
	AO090020000050	Uncharacterized protein. (811 aa)
	AO090023000972	BZIP domain-containing protein. (290 aa)
	atg5	Autophagy protein 5; Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with atg12, through a ubiquitin-like conjugating system involving atg7 as an E1- like activating enzyme and atg10 as an E2- [...] (322 aa)
	atg8	Autophagy-related protein 8; Ubiquitin-like modifier involved in autophagosomes formation. With atg4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved [...] (118 aa)
	AO090701000026	Uncharacterized protein. (355 aa)
	AO090701000781	Uncharacterized protein. (632 aa)
	AO090120000129	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (149 aa)
	AO090120000201	Uncharacterized protein. (523 aa)
	tel1	Serine/threonine-protein kinase tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity). (2925 aa)
	AO090120000484	Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (932 aa)
	AO090113000003	USP domain-containing protein; Belongs to the peptidase C19 family. (661 aa)

Your Current Organism:

Aspergillus oryzae

NCBI taxonomy Id: 510516
Other names: A. oryzae RIB40, Aspergillus oryzae RIB40

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AO090001000378	AO090023000476	Q2UNG3	Q2UHE8	Uncharacterized protein.	Uncharacterized protein.	0.982
AO090001000378	AO090701000026	Q2UNG3	Q2U9H8	Uncharacterized protein.	Uncharacterized protein.	0.998
AO090001000378	AO090701000781	Q2UNG3	Q2U7M4	Uncharacterized protein.	Uncharacterized protein.	0.968
AO090003000679	AO090003000728	Q2UKT8	Q2UKP2	Ubiquitin-like domain-containing protein.	Ubiquitin carboxyl-terminal hydrolase.	0.811
AO090003000679	AO090003000999	Q2UKT8	Q2UK07	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.922
AO090003000679	AO090003001106	Q2UKT8	Q2UJR5	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.465
AO090003000679	AO090005000623	Q2UKT8	Q2US00	Ubiquitin-like domain-containing protein.	TPR_REGION domain-containing protein.	0.617
AO090003000679	AO090020000050	Q2UKT8	Q2U568	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.999
AO090003000679	AO090113000003	Q2UKT8	Q2U5U4	Ubiquitin-like domain-containing protein.	USP domain-containing protein; Belongs to the peptidase C19 family.	0.811
AO090003000679	AO090120000129	Q2UKT8	Q2U6R2	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.934
AO090003000679	AO090120000484	Q2UKT8	Q2U5W4	Ubiquitin-like domain-containing protein.	Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.496
AO090003000679	atg8	Q2UKT8	Q2UBH5	Ubiquitin-like domain-containing protein.	Autophagy-related protein 8; Ubiquitin-like modifier involved in autophagosomes formation. With atg4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved [...]	0.609
AO090003000679	tel1	Q2UKT8	Q2U639	Ubiquitin-like domain-containing protein.	Serine/threonine-protein kinase tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity).	0.552
AO090003000728	AO090003000679	Q2UKP2	Q2UKT8	Ubiquitin carboxyl-terminal hydrolase.	Ubiquitin-like domain-containing protein.	0.811
AO090003000728	AO090005000623	Q2UKP2	Q2US00	Ubiquitin carboxyl-terminal hydrolase.	TPR_REGION domain-containing protein.	0.629
AO090003000728	AO090023000476	Q2UKP2	Q2UHE8	Ubiquitin carboxyl-terminal hydrolase.	Uncharacterized protein.	0.721
AO090003000728	AO090023000972	Q2UKP2	Q2UG54	Ubiquitin carboxyl-terminal hydrolase.	BZIP domain-containing protein.	0.811
AO090003000728	AO090701000781	Q2UKP2	Q2U7M4	Ubiquitin carboxyl-terminal hydrolase.	Uncharacterized protein.	0.637
AO090003000999	AO090003000679	Q2UK07	Q2UKT8	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin-like domain-containing protein.	0.922
AO090003000999	AO090003001106	Q2UK07	Q2UJR5	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Uncharacterized protein.	0.673