STRINGSTRING
ALO38136.1 ALO38136.1 thyA thyA trmB trmB ALO38291.1 ALO38291.1 ALO38308.1 ALO38308.1 metW metW ALO38369.1 ALO38369.1 ALO38525.1 ALO38525.1 ALO38567.1 ALO38567.1 rsmG rsmG cobA-2 cobA-2 ALO38829.1 ALO38829.1 ALO38899.1 ALO38899.1 ALO39041.1 ALO39041.1 ALO40402.1 ALO40402.1 prmC prmC ALO40410.1 ALO40410.1 trmL trmL rsmI rsmI ubiE ubiE ALO39147.1 ALO39147.1 ALO39162.1 ALO39162.1 prmA prmA ALO39306.1 ALO39306.1 ALO39364.1 ALO39364.1 rsmD rsmD ALO39533.1 ALO39533.1 ALO39693.1 ALO39693.1 rlmF rlmF ALO40470.1 ALO40470.1 prmB prmB metE-2 metE-2 cobA cobA ALO37061.1 ALO37061.1 rlmB rlmB ALO37080.1 ALO37080.1 ALO37107.1 ALO37107.1 rlmN rlmN ALO39844.1 ALO39844.1 ALO39887.1 ALO39887.1 ALO40494.1 ALO40494.1 trmD trmD ubiG ubiG ALO37241.1 ALO37241.1 rlmH rlmH metE metE ALO37392.1 ALO37392.1 trmJ trmJ ALO37825.1 ALO37825.1 rlmE rlmE ALO37029.1 ALO37029.1 rsmA rsmA mnmC mnmC rsmH rsmH ALO38023.1 ALO38023.1 ALO38103.1 ALO38103.1 ALO40314.1 ALO40314.1 ALO36795.1 ALO36795.1 ALO36840.1 ALO36840.1 rlmJ rlmJ rlmD rlmD pcm pcm ALO37005.1 ALO37005.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ALO38136.1ATP phosphoribosyltransferase regulatory subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (1453 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (266 aa)
trmBtRNA (guanine-N7)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (255 aa)
ALO38291.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (391 aa)
ALO38308.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (404 aa)
metWMethionine biosynthesis protein MetW; Derived by automated computational analysis using gene prediction method: Protein Homology. (209 aa)
ALO38369.1Cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (185 aa)
ALO38525.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (147 aa)
ALO38567.1SET domain-containing protein-lysine N-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (259 aa)
rsmG16S rRNA (guanine(527)-N(7))-methyltransferase RsmG; Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. (223 aa)
cobA-2Sirohydrochlorin ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. (484 aa)
ALO38829.1(2Fe-2S)-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (347 aa)
ALO38899.1rRNA (guanine-N1)-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (282 aa)
ALO39041.1Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (254 aa)
ALO40402.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (247 aa)
prmCprotein-(glutamine-N5) methyltransferase, release factor-specific; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. (288 aa)
ALO40410.1Methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. (434 aa)
trmLrRNA methylase; Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide. (156 aa)
rsmITetrapyrrole methylase; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (312 aa)
ubiEUbiquinone biosynthesis methyltransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (256 aa)
ALO39147.1protein-L-isoaspartate O-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (226 aa)
ALO39162.1Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1257 aa)
prmARibosomal protein L11 methyltransferase; Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family. (306 aa)
ALO39306.1Type I restriction endonuclease subunit M; Derived by automated computational analysis using gene prediction method: Protein Homology. (535 aa)
ALO39364.1Methyltransferase type 11; Derived by automated computational analysis using gene prediction method: Protein Homology. (253 aa)
rsmD16S rRNA (guanine(966)-N(2))-methyltransferase RsmD; Derived by automated computational analysis using gene prediction method: Protein Homology. (209 aa)
ALO39533.1Chemotaxis protein CheR; Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP. (276 aa)
ALO39693.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (139 aa)
rlmF23S rRNA methyltransferase; Specifically methylates the adenine in position 1618 of 23S rRNA. (331 aa)
ALO40470.1rRNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (421 aa)
prmBprotein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue; Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily. (307 aa)
metE-25-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (763 aa)
cobAuroporphyrin-III C-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (260 aa)
ALO37061.1Siroheme synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (326 aa)
rlmB23S rRNA methyltransferase; Specifically methylates the ribose of guanosine 2251 in 23S rRNA. (248 aa)
ALO37080.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase A24 family. (225 aa)
ALO37107.1Heavy metal resistance protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (433 aa)
rlmN23S rRNA (adenine(2503)-C2)-methyltransferase; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. (382 aa)
ALO39844.15-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the formation of tetrahydropteroyl-L-glutamate and methionine from L-homocysteine and 5-methyltetrahydropteroyltri-L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology. (342 aa)
ALO39887.1O-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (344 aa)
ALO40494.1Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (138 aa)
trmDHypothetical protein; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. (252 aa)
ubiGBifunctional 3-demethylubiquinone 3-O-methyltransferase/2-octaprenyl-6-hydroxy phenol methylase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. (240 aa)
ALO37241.1Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (231 aa)
rlmH50S rRNA methyltransferase; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. (156 aa)
metE5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (764 aa)
ALO37392.1SAM-dependent methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (240 aa)
trmJRNA methyltransferase; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. (263 aa)
ALO37825.1Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (202 aa)
rlmErRNA methyltransferase; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. (212 aa)
ALO37029.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (178 aa)
rsmA16S rRNA methyltransferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (263 aa)
mnmCHypothetical protein; Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34; In the C-terminal section; belongs to the DAO family. (621 aa)
rsmHRibosomal RNA small subunit methyltransferase H; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (356 aa)
ALO38023.116S rRNA methyltransferase; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. (242 aa)
ALO38103.16-O-methylguanine DNA methyltransferase; Regulates genes involved in the repair of alkylated DNA; repairs DNA containing 6-O-methylguanine; Derived by automated computational analysis using gene prediction method: Protein Homology. (354 aa)
ALO40314.1Modification methylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (360 aa)
ALO36795.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (371 aa)
ALO36840.1RNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (260 aa)
rlmJCompetence protein ComJ; Specifically methylates the adenine in position 2030 of 23S rRNA. (284 aa)
rlmD23S rRNA methyltransferase; Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily. (479 aa)
pcmprotein-L-isoaspartate O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. (274 aa)
ALO37005.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (453 aa)
Your Current Organism:
Alcaligenes faecalis
NCBI taxonomy Id: 511
Other names: A. faecalis, ATCC 8750, Achromobacter sp. ATCC8750, Alcaligenes sp. BP11, CIP 55.84, CIP 60.80, DSM 30030, IAM 12369, IFO 13111, JCM 20522, JCM 20663, NBRC 13111, NCAIM B.01104, NCIMB 8156, NCTC 11953
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