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| | GU3_00040 | DNA topoisomerase I-related protein; COG0551 Zn-finger domain associated with topoisomerase type I. (180 aa) |
| | GU3_00625 | Hypothetical protein. (329 aa) |
| | rep | ATP-dependent DNA helicase Rep; Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction. (671 aa) |
| | GU3_00705 | COG2166 SufE protein probably involved in Fe-S center assembly. (139 aa) |
| | nfuA | Fe/S biogenesis protein NfuA; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. (192 aa) |
| | secB | Preprotein translocase subunit SecB; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. (161 aa) |
| | ftsZ | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (355 aa) |
| | gyrB | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (805 aa) |
| | GU3_01975 | Hypothetical protein; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. (81 aa) |
| | GU3_02155 | General secretion pathway protein L; COG3166 Tfp pilus assembly protein PilN. (353 aa) |
| | glmU | Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (452 aa) |
| | GU3_02355 | Putative Mg chelatase; COG0606 Predicted ATPase with chaperone activity. (503 aa) |
| | cyaY | Protein CyaY; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. (103 aa) |
| | GU3_02455 | DNA helicase II; COG0210 Superfamily I DNA and RNA helicases. (722 aa) |
| | GU3_02470 | COG0514 Superfamily II DNA helicase. (608 aa) |
| | engB | GTP-binding protein YsxC; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. (211 aa) |
| | GU3_02695 | BipA protein; COG1217 Predicted membrane GTPase involved in stress response. (611 aa) |
| | recG | ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (690 aa) |
| | GU3_03325 | COG3175 Cytochrome oxidase assembly factor. (175 aa) |
| | GU3_03345 | Hypothetical protein. (143 aa) |
| | zapB | Transcriptional regulator; Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA. (69 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (736 aa) |
| | murI | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (266 aa) |
| | GU3_03480 | Undecaprenyl pyrophosphate phosphatase; COG0671 Membrane-associated phospholipid phosphatase. (231 aa) |
| | topB | DNA topoisomerase III; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA su [...] (638 aa) |
| | murB | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (342 aa) |
| | mpl | UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. (452 aa) |
| | GU3_03845 | Penicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). (776 aa) |
| | erpA | Iron-sulfur cluster insertion protein erpA; Required for insertion of 4Fe-4S clusters for at least IspG. (114 aa) |
| | GU3_03985 | PA-phosphatase-like phosphoesterase; COG0671 Membrane-associated phospholipid phosphatase. (233 aa) |
| | GU3_04010 | Serine-type D-Ala-D-Ala carboxypeptidase; COG1686 D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. (407 aa) |
| | GU3_04035 | ABC transporter-like protein; COG1127 ABC-type transport system involved in resistance to organic solvents, ATPase component. (259 aa) |
| | lptA | Lipopolysaccharide transport periplasmic protein LptA; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm. (173 aa) |
| | lptC | Hypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. (182 aa) |
| | GU3_04190 | ABC-type transporter, ATP-binding protein; COG1127 ABC-type transport system involved in resistance to organic solvents, ATPase component. (266 aa) |
| | GU3_04205 | Toluene tolerance protein Ttg2D; COG2854 ABC-type transport system involved in resistance to organic solvents, auxiliary component. (205 aa) |
| | GU3_04210 | Anti-anti-sigma factor family protein; COG3113 Predicted NTP binding protein (contains STAS domain). (94 aa) |
| | GU3_04215 | BolA-like protein; COG5007 Predicted transcriptional regulator, BolA superfamily; Belongs to the BolA/IbaG family. (56 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (418 aa) |
| | ftsI | Peptidoglycan glycosyltransferase; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. (582 aa) |
| | murE | UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (494 aa) |
| | murF | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanineligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (446 aa) |
| | mraY | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (360 aa) |
| | murD | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (414 aa) |
| | ftsW | Cell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. (391 aa) |
| | murG | Undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (355 aa) |
| | murC | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (485 aa) |
| | ddl | D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (305 aa) |
| | ftsQ | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. (254 aa) |
| | ftsZ-2 | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (379 aa) |
| | GU3_04685 | ABC transporter permease; COG4137 ABC-type uncharacterized transport system, permease component. (255 aa) |
| | murJ | Hypothetical protein; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (520 aa) |
| | GU3_04795 | Type IV pilin; COG4968 Tfp pilus assembly protein PilE. (128 aa) |
| | GU3_04805 | Type IV pilin. (223 aa) |
| | GU3_04810 | COG2001 Uncharacterized protein conserved in bacteria. (379 aa) |
| | bamD | ComL family lipoprotein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (248 aa) |
| | prfC | Peptide chain release factor 3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily. (529 aa) |
| | GU3_05275 | Cytochrome c biogenesis protein transmembrane region; COG4232 Thiol:disulfide interchange protein. (143 aa) |
| | surA | Peptidylprolyl cis-trans isomerase SurA; Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. (431 aa) |
| | lptD | Organic solvent tolerance protein; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. (793 aa) |
| | rapA | ATP-dependent helicase HepA; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily. (957 aa) |
| | ddpX | D-ala-D-ala dipeptidase; Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide. (250 aa) |
| | GU3_05740 | Chaperone protein TorD; COG3381 Uncharacterized component of anaerobic dehydrogenases. (205 aa) |
| | GU3_06060 | Putative suppressor for copper-sensitivity B precursor; COG4233 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis. (686 aa) |
| | GU3_06115 | Penicillin-binding protein; COG1686 D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. (390 aa) |
| | rlpA | Rare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (274 aa) |
| | mrdB | Rod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (366 aa) |
| | mrdA | Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. (628 aa) |
| | rsfS | Iojap superfamily protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. (114 aa) |
| | lptE | Rare lipoprotein B; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane. (161 aa) |
| | prfA | Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (361 aa) |
| | iscS | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. (404 aa) |
| | GU3_06540 | Scaffold protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. (128 aa) |
| | GU3_06545 | HesB family protein; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. (107 aa) |
| | hscB | Co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. (172 aa) |
| | hscA | Chaperone protein HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. (614 aa) |
| | GU3_06565 | COG2975 Uncharacterized protein conserved in bacteria. (66 aa) |
| | GU3_06590 | Type IV pilus biogenesis/stability protein PilW; COG3063 Tfp pilus assembly protein PilF. (248 aa) |
| | bamB | WD40 domain-containing protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (390 aa) |
| | mltF | Membrane-bound lytic transglycosylase F; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. (468 aa) |
| | GU3_06910 | Hypothetical protein. (204 aa) |
| | GU3_06920 | Hypothetical protein; COG3571 Predicted hydrolase of the alpha/beta-hydrolase fold. (203 aa) |
| | bamE | Small protein A; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (112 aa) |
| | GU3_07245 | COG1534 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein. (98 aa) |
| | GU3_07430 | Hypothetical protein; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division. (73 aa) |
| | GU3_08030 | Asp/Glu racemase; COG3473 Maleate cis-trans isomerase. (265 aa) |
| | GU3_08375 | Asp/Glu/hydantoin racemase; COG3473 Maleate cis-trans isomerase. (243 aa) |
| | bamC | Lipoprotein-34 NlpB; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (322 aa) |
| | GU3_08525 | Histone-like DNA-binding protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (90 aa) |
| | torD | Chaperone protein TorD; COG3381 Uncharacterized component of anaerobic dehydrogenases. (223 aa) |
| | ureE | Bifunctional uroporphyrin-III C-methyltransferase/siroheme synthase; Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly. Belongs to the UreE family. (150 aa) |
| | GU3_08955 | ATPase AAA; COG0606 Predicted ATPase with chaperone activity. (411 aa) |
| | rlpA-2 | rplA family protein; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (101 aa) |
| | nagZ | Glycoside hydrolase family 3; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. (336 aa) |
| | mfd | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1145 aa) |
| | GU3_09275 | COG0071 Molecular chaperone (small heat shock protein); Belongs to the small heat shock protein (HSP20) family. (170 aa) |
| | GU3_09370 | Replication protein A. (126 aa) |
| | GU3_09385 | Conjugal transfer relaxase TraI; COG3843 Type IV secretory pathway, VirD2 components (relaxase). (592 aa) |
| | GU3_09495 | Hypothetical protein. (141 aa) |
| | mtgA | Monofunctional biosynthetic peptidoglycan transglycosylase; Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors; Belongs to the glycosyltransferase 51 family. (224 aa) |
| | GU3_09630 | Fimbrial assembly family protein. (192 aa) |
| | GU3_09780 | Mrp protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (357 aa) |
| | mltG | Hypothetical protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (334 aa) |
| | GU3_10055 | Septum site-determining protein MinD; COG2894 Septum formation inhibitor-activating ATPase. (270 aa) |
| | minC | Septum site-determining protein MinC; Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization; Belongs to the MinC family. (225 aa) |
| | rplT | 50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (118 aa) |
| | zapC | Hypothetical protein; Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ. (178 aa) |
| | GU3_10450 | COG3008 Paraquat-inducible protein B. (545 aa) |
| | mukB | Cell division protein MukB; COG3096 Uncharacterized protein involved in chromosome partitioning. (1471 aa) |
| | GU3_10555 | Condesin subunit E; COG3095 Uncharacterized protein involved in chromosome partitioning. (228 aa) |
| | GU3_10560 | Condesin subunit F; Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity. (467 aa) |
| | topA | DNA topoisomerase I subunit omega; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus rem [...] (875 aa) |
| | GU3_11225 | Murein lipoprotein. (80 aa) |
| | gyrA | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (871 aa) |
| | recD | Exodeoxyribonuclease V, alpha subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and r [...] (664 aa) |
| | recB | Exodeoxyribonuclease V, beta subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and re [...] (1201 aa) |
| | recC | Exodeoxyribonuclease V, gamma subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and r [...] (1137 aa) |
| | GU3_11475 | Hypothetical protein; COG0457 FOG: TPR repeat. (290 aa) |
| | GU3_11480 | COG3085 Uncharacterized protein conserved in bacteria. (112 aa) |
| | GU3_11595 | Cell division inhibitor. (130 aa) |
| | GU3_11910 | COG0783 DNA-binding ferritin-like protein (oxidative damage protectant); Belongs to the Dps family. (149 aa) |
| | GU3_12110 | COG3263 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain. (573 aa) |
| | GU3_12245 | Hypothetical protein. (258 aa) |
| | cpoB | Hypothetical protein; Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division; Belongs to the CpoB family. (257 aa) |
| | ruvB | Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (335 aa) |
| | ruvA | Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (200 aa) |
| | GU3_12945 | COG2825 Outer membrane protein; Belongs to the skp family. (166 aa) |
| | bamA | Surface antigen; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (779 aa) |
| | uppS | Undecaprenyl pyrophosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. (253 aa) |
| | frr | Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. (185 aa) |
| | GU3_13185 | COG2853 Surface lipoprotein. (264 aa) |
| | GU3_13190 | COG4235 Cytochrome c biogenesis factor. (404 aa) |
| | GU3_13195 | Cytochrome c heme lyase subunit CcmL; Possible subunit of a heme lyase. (157 aa) |
| | GU3_13200 | Thiol:disulfide interchange protein DsbE; COG0526 Thiol-disulfide isomerase and thioredoxins. (177 aa) |
| | GU3_13205 | Cytochrome c-type biogenesis protein CcmF; COG1138 Cytochrome c biogenesis factor. (652 aa) |
| | ccmE | Cytochrome c-type biogenesis protein CcmE; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family. (164 aa) |
| | GU3_13215 | Hypothetical protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmD/CycX/HelD family. (68 aa) |
| | ccmC | Cytochrome c biogenesis ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family. (248 aa) |
| | GU3_13225 | Putative heme exporter protein B; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmB/CycW/HelB family. (222 aa) |
| | ccmA | ATP binding protein of heme exporter A; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. (210 aa) |
| | GU3_13295 | COG1419 Flagellar GTP-binding protein. (453 aa) |
| | flhA | Flagellar biosynthesis protein FlhA; Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. (699 aa) |
| | fliR | Flagellar biosynthesis protein FliR; Role in flagellar biosynthesis. Belongs to the FliR/MopE/SpaR family. (262 aa) |
| | fliQ | Flagellar biosynthetic protein FliQ; Role in flagellar biosynthesis. Belongs to the FliQ/MopD/SpaQ family. (89 aa) |
| | fliP | Flagellar biosynthesis protein FliP; Plays a role in the flagellum-specific transport system. Belongs to the FliP/MopC/SpaP family. (249 aa) |
| | GU3_13325 | COG3190 Flagellar biogenesis protein. (100 aa) |
| | GU3_13345 | COG3144 Flagellar hook-length control protein. (653 aa) |
| | GU3_13350 | Flagellar protein FliJ. (145 aa) |
| | GU3_13360 | Flagellar assembly protein FliH; COG1317 Flagellar biosynthesis/type III secretory pathway protein. (263 aa) |
| | fliS | Flagellar protein FliS; COG1516 Flagellin-specific chaperone FliS. (128 aa) |
| | zipA | Cell division protein ZipA; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. (340 aa) |
| | GU3_13530 | COG1256 Flagellar hook-associated protein; Belongs to the flagella basal body rod proteins family. (649 aa) |
| | GU3_13535 | Flagellar rod assembly protein/muramidase FlgJ; COG3951 Rod binding protein. (323 aa) |
| | GU3_13565 | Flagellar hook capping protein; Required for flagellar hook formation. May act as a scaffolding protein. (232 aa) |
| | GU3_13590 | Flagellar basal body P-ring biosynthesis protein FlgA; Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P- ring assembly; Belongs to the FlgA family. (239 aa) |
| | GU3_13595 | COG2747 Negative regulator of flagellin synthesis (anti-sigma28 factor). (107 aa) |
| | GU3_13600 | Flagellar biosynthetic protein FlgN. (137 aa) |
| | GU3_13950 | LafE; COG3144 Flagellar hook-length control protein. (381 aa) |
| | GU3_13960 | LafC; COG1516 Flagellin-specific chaperone FliS. (131 aa) |
| | flgK | COG1256 Flagellar hook-associated protein. (440 aa) |
| | GU3_13990 | Peptidoglycan hydrolase; COG3951 Rod binding protein. (128 aa) |
| | GU3_14020 | Flagellar hook capping protein; Required for flagellar hook formation. May act as a scaffolding protein. (218 aa) |
| | GU3_14035 | Lateral flagellar basal body P-ring biosynthesis protein, LfgA; Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P- ring assembly; Belongs to the FlgA family. (221 aa) |
| | GU3_14040 | Lateral flagella anti-sigma-28 factor, LfgM; COG2747 Negative regulator of flagellin synthesis (anti-sigma28 factor). (92 aa) |
| | GU3_14045 | Hypothetical protein. (136 aa) |
| | GU3_14060 | Lateral flagellar assembly protein FliH; COG1317 Flagellar biosynthesis/type III secretory pathway protein. (233 aa) |
| | flhA-2 | Lateral flagellar biosynthesis protein; Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. (680 aa) |
| | GU3_14100 | Lateral flagellar biosynthetic protein LfiR; Role in flagellar biosynthesis. Belongs to the FliR/MopE/SpaR family. (259 aa) |
| | GU3_14105 | COG1987 Flagellar biosynthesis pathway, component FliQ. (88 aa) |
| | fliP-2 | Flagellar biosynthesis protein FliP; Plays a role in the flagellum-specific transport system. Belongs to the FliP/MopC/SpaP family. (244 aa) |
| | GU3_14215 | DNA-binding protein HU alpha; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (90 aa) |
| | GU3_14610 | DNA helicase IV; COG0210 Superfamily I DNA and RNA helicases. (670 aa) |
| | GU3_14720 | Chromosome segregation ATPase-like protein. (649 aa) |
| | GU3_14725 | Hypothetical protein. (452 aa) |
| | GU3_14850 | Hypothetical protein; COG0433 Predicted ATPase. (481 aa) |
| | GU3_14950 | Type IV pilus biogenesis protein TapP; COG3168 Tfp pilus assembly protein PilP. (170 aa) |
| | GU3_14955 | COG3167 Tfp pilus assembly protein PilO. (194 aa) |
| | GU3_14960 | COG3166 Tfp pilus assembly protein PilN. (184 aa) |
| | GU3_14965 | COG4972 Tfp pilus assembly protein, ATPase PilM. (340 aa) |
| | GU3_15035 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (464 aa) |
| | argR | Arginine repressor; Regulates arginine biosynthesis genes. (166 aa) |
| | GU3_15290 | peptidyl-tRNA hydrolase domain-containing protein; COG1186 Protein chain release factor B. (138 aa) |
| | GU3_15405 | Peptide chain release factor 2; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. (248 aa) |
| | GU3_15475 | Twitching mobility protein; COG2805 Tfp pilus assembly protein, pilus retraction ATPase PilT. (344 aa) |
| | zapD | Hypothetical protein; Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity. (244 aa) |
| | parC | DNA topoisomerase IV subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. (750 aa) |
| | parE | DNA topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. (631 aa) |
| | cpdA | Icc protein; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. (276 aa) |
| | uppP | Undecaprenyl pyrophosphate phosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (266 aa) |
| | GU3_15755 | Signal transduction histidine kinase LytS; COG3275 Putative regulator of cell autolysis. (558 aa) |
