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wzzB wzzB ugd ugd wbbK wbbK wbbJ wbbJ wbbI wbbI wbbH wbbH glf glf wzxB wzxB rfbC rfbC rfbA rfbA rfbD rfbD rfbB rfbB wcaN wcaN wcaM wcaM wcaL wcaL wcaK wcaK wzxC wzxC wcaJ wcaJ cpsG cpsG cpsB cpsB wcaI wcaI wcaH wcaH wcaG wcaG gmd gmd wcaF wcaF wcaE wcaE wcaD wcaD wcaC wcaC wcaB wcaB wcaA wcaA wzc wzc wzb wzb wza wza wecA wecA wzzE wzzE wecB wecB wecC wecC rffG rffG rffH rffH wecD wecD wecE wecE wzxE wzxE wzyE wzyE wecG wecG yifK yifK wecF wecF
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
wzzBRegulator of length of O-antigen component of lipopolysaccharide chains; Confers a modal distribution of chain length on the O-antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules; Belongs to the WzzB/Cld/Rol family. (326 aa)
ugdUDP-glucose 6-dehydrogenase; Protein involved in cell surface antigen activity, host-interacting, colanic acid biosynthetic process and response to desiccation. (388 aa)
wbbKLipopolysaccharide biosynthesis protein; May be a glycosyltransferase involved in the transfer of UDP- GalF and UDP-glucose. (372 aa)
wbbJPutative lipopolysaccharide biosynthesis O-acetyl transferase; Putative O-acetyltransferase that transfers an O-acetyl group to the O antigen; Belongs to the transferase hexapeptide repeat family. (196 aa)
wbbId-Galf:alpha-d-Glc beta-1,6-galactofuranosyltransferase; Involved in the transfer of galactofuranose (Galf) onto an alpha-D-gluco-configured acceptor substrate to form a beta-1,6-linkage. It uses n-octyl alpha-D-glucopyranoside as an acceptor substrate for the addition of galactofuranose from the donor substrate UDP- galactofuranose. It is not able to use beta-D-glucopyranoside isomers. (330 aa)
wbbHO-antigen polymerase; May link the O-antigen tetrasaccharide units into long chains, giving rise to typical smooth LPS. (388 aa)
glfUDP-galactopyranose mutase, FAD/NAD(P)-binding; Catalyzes the interconversion through a 2-keto intermediate of uridine diphosphogalactopyranose (UDP-GalP) into uridine diphosphogalactofuranose (UDP-GalF); Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family. (367 aa)
wzxBPutative polisoprenol-linked O-antigen transporter; May be involved in the translocation process of the nascent O-polysaccharide molecules and/or its ligation to lipid A core units. (415 aa)
rfbCdTDP-4-deoxyrhamnose-3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (185 aa)
rfbAGlucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (293 aa)
rfbDdTDP-L-rhamnose synthase, NAD(P)-dependent dTDP-4-dehydrorhamnose reductase subunit; Involved in the biosynthesis of the dTDP-L-rhamnose which is an important component of lipopolysaccharide (LPS) (Probable). Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose (By similarity). RmlD uses NADH and NADPH nearly equally well (By similarity); Belongs to the dTDP-4-dehydrorhamnose reductase family. (299 aa)
rfbBdTDP-glucose 4,6 dehydratase, NAD(P)-binding; Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6- deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (361 aa)
wcaNPutative regulatory subunit for GalU; Protein involved in nucleotide-sugar biosynthetic process. (297 aa)
wcaMPutative colanic acid biosynthesis protein; Protein involved in colanic acid biosynthetic process. (464 aa)
wcaLPutative colanic acid biosynthesis glycosyl transferase; Protein involved in colanic acid biosynthetic process. (406 aa)
wcaKPutative galactokinase; Protein involved in colanic acid biosynthetic process. (426 aa)
wzxCPutative colanic acid exporter; Probable export protein; Belongs to the polysaccharide synthase family. (492 aa)
wcaJColanic biosynthesis UDP-glucose lipid carrier transferase; Is the initiating enzyme for colanic acid (CA) synthesis. Catalyzes the transfer of the glucose-1-phosphate moiety from UDP-Glc onto the carrier lipid undecaprenyl phosphate (C55-P), forming a phosphoanhydride bond yielding to glucosyl-pyrophosphoryl-undecaprenol (Glc-PP-C55). Also possesses a weak galactose-1-P transferase activity. Belongs to the bacterial sugar transferase family. (464 aa)
cpsGPhosphomannomutase; Involved in the biosynthesis of the capsular polysaccharide colanic acid; Belongs to the phosphohexose mutase family. (456 aa)
cpsBMannose-1-phosphate guanyltransferase; Involved in the biosynthesis of the capsular polysaccharide colanic acid. (478 aa)
wcaIPutative colanic biosynthesis glycosyl transferase; Protein involved in colanic acid biosynthetic process. (407 aa)
wcaHGDP-mannose mannosyl hydrolase; Hydrolyzes both GDP-mannose and GDP-glucose. Could participate in the regulation of cell wall biosynthesis by influencing the concentration of GDP-mannose or GDP-glucose in the cell. Might also be involved in the biosynthesis of the slime polysaccharide colanic acid; Belongs to the Nudix hydrolase family. (159 aa)
wcaGGDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily. (321 aa)
gmdGDP-D-mannose dehydratase, NAD(P)-binding; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily. (373 aa)
wcaFPutative transferase; Protein involved in colanic acid biosynthetic process. (182 aa)
wcaEPutative colanic acid biosynthesis glycosyl transferase; Protein involved in colanic acid biosynthetic process. (248 aa)
wcaDPutative colanic acid polymerase. (405 aa)
wcaCPutative glycosyl transferase; Protein involved in colanic acid biosynthetic process. (405 aa)
wcaBPutative transferase; Protein involved in colanic acid biosynthetic process. (162 aa)
wcaAPutative glycosyl transferase; Putative regulator; Protein involved in colanic acid biosynthetic process. (279 aa)
wzcColanic acid production tyrosine-protein kinase; Required for the extracellular polysaccharide colanic acid synthesis. The autophosphorylated form is inactive. Probably involved in the export of colanic acid from the cell to medium. Phosphorylates udg. (720 aa)
wzbColanic acid production protein-tyrosine-phosphatase; Dephosphorylates Wzc. Required for the extracellular polysaccharide colanic acid synthesis, probably involved in the export of colanic acid from the cell to medium. Involved in protection of cells against contact- dependent growth inhibition (CDI), probably due to the loss of a physical impediment to cell-cell contact; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (147 aa)
wzaColanic acid export protein; Probably involved in the export of the extracellular polysaccharide colanic acid from the cell to medium. (379 aa)
wecAUDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). It is the first lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis, and an acceptor for the addition of subsequent sugars to complete the biosynthesis of O-antigen lipopolysaccharide (LPS) in many E.coli O types. The apparent affinity of WecA for the polyisoprenyl phosphate substrates increases with the [...] (367 aa)
wzzEEntobacterial Common Antigen (ECA) polysaccharide chain length modulation protein; Modulates the polysaccharide chain length of enterobacterial common antigen (ECA). Required for the assembly of the phosphoglyceride-linked form of ECA (ECA(PG)) and the water-soluble cyclic form of ECA (ECA(CYC)). (348 aa)
wecBUDP-N-acetyl glucosamine-2-epimerase; Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP- N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues. Also involved in bacteriophage N4 adsorption. (376 aa)
wecCUDP-N-acetyl-D-mannosaminuronic acid dehydrogenase; Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA). (420 aa)
rffGdTDP-glucose 4,6-dehydratase; Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6- deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (355 aa)
rffHGlucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (293 aa)
wecDTDP-fucosamine acetyltransferase; Catalyzes the acetylation of dTDP-fucosamine (dTDP-4-amino- 4,6-dideoxy-D-galactose) to dTDP-Fuc4NAc, which is utilized in the biosynthesis of the enterobacterial common antigen (ECA). Belongs to the WecD family. (224 aa)
wecETDP-4-oxo-6-deoxy-D-glucose transaminase; Catalyzes the synthesis of dTDP-4-amino-4,6-dideoxy-D- galactose (dTDP-Fuc4N) from dTDP-4-keto-6-deoxy-D-glucose (dTDP-D- Glc4O) and L-glutamate. (376 aa)
wzxEO-antigen translocase; Mediates the transbilayer movement of Und-PP-GlcNAc-ManNAcA- Fuc4NAc (lipid III) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of enterobacterial common antigen (ECA). Required for the assembly of the phosphoglyceride-linked form of ECA (ECA(PG)) and the water-soluble cyclic form of ECA (ECA(CYC)). Could also mediate the translocation of Und-PP-GlcNAc. (416 aa)
wzyEPutative ECA polysaccharide chain elongation protein; Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units. Required for the assembly of the phosphoglyceride-linked form of ECA (ECA(PG)) and the water-soluble cyclic form of ECA (ECA(CYC)). Belongs to the WzyE family. (450 aa)
wecGUDP-N-acetyl-D-mannosaminuronic acid transferase; Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis. (246 aa)
yifKPutative APC family amino acid transporter; Probable amino-acid or metabolite transport protein; Belongs to the amino acid-polyamine-organocation (APC) superfamily. (461 aa)
wecFTDP-Fuc4NAc:lipidIIFuc4NAc transferase; Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis; Belongs to the glycosyltransferase 56 family. (359 aa)
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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