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| | sgrR | Transcriptional DNA-binding transcriptional activator of sgrS sRNA; Activates the small RNA gene sgrS under glucose-phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions; this repression likely provides one measure of control over sgrR at the level of synthesis. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute- binding domain. (551 aa) |
| | setA | Broad specificity sugar efflux system; Involved in the efflux of sugars. The physiological role may be the detoxification of non-metabolizable sugar analogs. Can transport IPTG, lactose and glucose. Has broad substrate specificity, with preferences for glucosides or galactosides with alkyl or aryl substituents; Belongs to the major facilitator superfamily. Set transporter family. (392 aa) |
| | yacG | DNA gyrase inhibitor; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase. (65 aa) |
| | yacH | DUF3300 family protein; Putative membrane protein. (617 aa) |
| | yacL | UPF0231 family protein. (120 aa) |
| | yafC | Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. (304 aa) |
| | yafD | Endo/exonuclease/phosphatase family protein. (266 aa) |
| | sbmA | Peptide antibiotic transporter; Uptake of antimicrobial peptides. Required for the transport of microcin B17 (MccB17), microcin 25 (Mcc25) and proline-rich antimicrobial peptides into the cell. (406 aa) |
| | yaiW | Microcin Bac7 uptake protein; outer membrane surface-exposed lipoprotein. (364 aa) |
| | aroM | AroM family protein; This protein of unknown function is encoded by a gene that cotranscribes with the aroL gene, which codes for shikimate kinase II. (225 aa) |
| | dcuC | Anaerobic C4-dicarboxylate transport; Responsible for the transport of C4-dicarboxylates during anaerobic growth; Belongs to the DcuC/DcuD transporter (TC 2.A.61) family. (461 aa) |
| | ybfP | Lipoprotein; Putative pectinase. (164 aa) |
| | ybhC | acyl-CoA thioesterase, lipoprotein; Putative thioesterase. Does not bind pectin, and has no pectinesterase activity; Belongs to the pectinesterase family. (427 aa) |
| | ybhB | Kinase inhibitor homolog, UPF0098 family; Belongs to the UPF0098 family. (158 aa) |
| | opgE | OPG biosynthetic transmembrane phosphoethanolamine transferase; Catalyzes the addition of a phosphoethanolamine moiety to the osmoregulated periplasmic glucan (OPG) backbone. (527 aa) |
| | pqiA | Paraquat-inducible, SoxRS-regulated inner membrane protein; Component of a transport pathway that contributes to membrane integrity; Belongs to the PqiA family. (417 aa) |
| | pqiB | Paraquat-inducible, SoxRS-regulated MCE domain protein; Component of a transport pathway that contributes to membrane integrity. May directly span the intermembrane space, facilitating the transport of substrates across the periplasm (Probable); Belongs to the PqiB family. (546 aa) |
| | pqiC | DUF330 family putative lipoprotein; Component of a transport pathway that contributes to membrane integrity. (187 aa) |
| | sxy | CRP-S-dependent promoter expression factor; Induces low levels of natural DNA uptake by inducing transcription of the competence genes (the CRP-S regulon) required for DNA transformation. Induction of the CRP-S regulon also requires Sxy- activated promoter (CRP-S), cAMP receptor protein (CRP) and cAMP. Induces CRP-S site-containing genes which are involved in genome maintenance and transcription or encoding transposases and toxin-antitoxin pairs. (209 aa) |
| | ycdX | Alkaline phosphatase; Hydrolyzes p-nitrophenyl phosphate (pNPP) in vitro. Involved in the swarming motility process; Belongs to the PHP family. (245 aa) |
| | ycdY | Redox enzyme maturation protein (REMP) chaperone for YcdX; Acts as a chaperone that increases YcdX activity, maybe by facilitating the correct insertion of the zinc ions into the catalytic site of YcdX. Involved in the swarming motility process. (184 aa) |
| | ycdZ | DUF1097 family inner membrane protein. (163 aa) |
| | opgC | OPG biosynthetic transmembrane succinyltransferase; Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane. (385 aa) |
| | opgG | OPG biosynthetic periplasmic beta-1,6 branching glycosyltransferase; Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs); Belongs to the OpgD/OpgG family. (511 aa) |
| | opgH | OPG biosynthetic ACP-dependent transmembrane UDP-glucose beta-1,2 glycosyltransferase; Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs). (847 aa) |
| | yceK | Outer membrane integrity lipoprotein; To E.coli YidQ. (75 aa) |
| | yceB | Lipoprotein, DUF1439 family. (186 aa) |
| | ycfJ | Uncharacterized protein. (179 aa) |
| | pepT | Peptidase T; Cleaves the N-terminal amino acid of tripeptides. Belongs to the peptidase M20B family. (408 aa) |
| | hlyE | Hemolysin E; Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells. (303 aa) |
| | ydbH | Putative membrane-anchored protein, function unknown. (879 aa) |
| | ydcJ | Putative metalloenzyme; To M.tuberculosis Rv3292. (447 aa) |
| | opgD | OPG biosynthetic periplasmic protein; Probably involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans (OPGs). (551 aa) |
| | tehA | Potassium-tellurite ethidium and proflavin transporter; Responsible for potassium tellurite resistance when present in high copy number. Ion channel involved in potassium tellurite resistance (By similarity). Otherwise, phenotypically silent. Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family. (330 aa) |
| | tehB | Tellurite, selenium methyltransferase, SAM-dependent; S-adenosyl-L-methionine dependent methyltransferase that catalyzes the methylation of tellurite and is responsible for tellurite resistance when present in high copy number. Can also methylate selenite and selenium dioxide. Is thus able to detoxify different chalcogens. Cannot methylate arsenic compounds. Belongs to the TehB family. (197 aa) |
| | ydcL | Lipoprotein. (222 aa) |
| | ydgD | Putative peptidase; Belongs to the peptidase S1B family. (273 aa) |
| | tqsA | Pheromone AI-2 transporter; Controls the transport of the quorum-sensing signal AI-2 either by enhancing its secretion or inhibiting its uptake and consequently represses biofilm formation and motility and affects the global gene expression in biofilms. (344 aa) |
| | ydgA | DUF945 family protein. (502 aa) |
| | dtpA | Dipeptide and tripeptide permease A; Proton-dependent permease that transports di- and tripeptides as well as structurally related peptidomimetics such as aminocephalosporins into the cell. Has a clear preference for dipeptides and tripeptides composed of L-amino acids, and discriminates dipeptides on the basis of the position of charges within the substrate; Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpA subfamily. (500 aa) |
| | slyB | Putative outer membrane protein; Belongs to the Pcp/SlyB lipoprotein family. (155 aa) |
| | slyA | Global transcriptional regulator; Transcription regulator that can specifically activate or repress expression of target genes. Activates expression of genes such as molecular chaperones (groL, groS, dnaK, grpE, and cbpA), proteins involved in acid resistance (hdeA, hdeB, and gadA), the starvation lipoprotein slp, virulence protein hlyE/clyA. Represses expression of genes involved in the histidine biosynthetic pathway such as hisA, hisB, hisD, hisF and hisG. Required for the activation of virulence genes; Belongs to the SlyA family. (144 aa) |
| | ydhI | DUF1656 family putative inner membrane efflux pump associated protein. (78 aa) |
| | ydhJ | Putative membrane fusion protein (MFP) of YdhJK efflux pump; Putative membrane protein. (285 aa) |
| | ydhK | Putative efflux protein (PET) component of YdhJK efflux pump. (670 aa) |
| | yeaY | Slp family lipoprotein, RpoE-regulated; Putative outer membrane protein. (193 aa) |
| | yebS | Inner membrane PqiA domain protein; Component of a transport pathway that contributes to membrane integrity; Belongs to the PqiA family. (427 aa) |
| | yebT | MCE domain protein; Component of a transport pathway that contributes to membrane integrity. May directly span the intermembrane space, facilitating the transport of substrates across the periplasm (Probable); Belongs to the PqiB family. (877 aa) |
| | cutC | Copper homeostasis protein; Participates in the control of copper homeostasis. Belongs to the CutC family. (248 aa) |
| | yecM | Putative metal-binding enzyme; To H.influenzae HI_1582/HI_1581. (188 aa) |
| | yecF | DUF2594 family protein. (74 aa) |
| | yeeO | Putative multdrug exporter, MATE family; A transporter able to export peptides and flavins. When overexpressed allows cells deleted for multiple peptidases (pepA, pepB, pepD and pepN) to grow in the presence of dipeptides Ala-Gln or Gly-Tyr which otherwise inhibit growth. Cells overexpressing this protein have decreased intracellular levels of Ala-Gln dipeptide, and in a system that produces the Ala-Gln dipeptide, overproduction of this protein increases its export. When overexpressed increases secretion of FMN and FAD but not riboflavin; intracellular concentrations of FMN and ribofla [...] (495 aa) |
| | yeeA | Putative transporter, FUSC family inner membrane protein. (352 aa) |
| | sbmC | DNA gyrase inhibitor; Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell. Protects cells against the natural plasmid-encoded toxins microcin B17 (MccB17) and CcdB, and synthetic quinolones. Can also protect cells against alkylating agents that act independently of DNA gyrase, suggesting a more general role in protectin [...] (157 aa) |
| | asmA | Suppressor of OmpF assembly mutants; Involved in the inhibition of assembly of mutant ompF proteins. In general, could be involved in the assembly of outer membrane proteins; Belongs to the AsmA family. (617 aa) |
| | yehE | DUF2574 family protein. (93 aa) |
| | nudI | Nucleoside triphosphatase; Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP). (141 aa) |
| | mlaA | ABC transporter maintaining OM lipid asymmetry, OM lipoprotein component; Involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Belongs to the MlaA family. (251 aa) |
| | yfeO | Putative ion channel protein. (418 aa) |
| | yfeK | Uncharacterized protein. (124 aa) |
| | yfeS | WGR domain protein. (244 aa) |
| | ypfG | DUF1176 family protein. (347 aa) |
| | yfgH | Putative outer membrane lipoprotein. (172 aa) |
| | yfgI | Nalidixic acid resistance protein, putative periplasmic protein; Putative membrane protein. (179 aa) |
| | sseB | Rhodanase-like enzyme, sulfur transfer from thiosulfate; May be involved in the enhancement of serine-sensitivity. (258 aa) |
| | yqfB | UPF0267 family protein; Belongs to the UPF0267 family. (103 aa) |
| | pepP | Proline aminopeptidase P II. (441 aa) |
| | ygfB | UPF0149 family protein; Belongs to the UPF0149 family. (192 aa) |
| | yggN | DUF2884 family putative periplasmic protein. (239 aa) |
| | yggL | DUF469 family protein; To H.influenzae HI_0341. (108 aa) |
| | yghD | Putative membrane-anchored secretion pathway M-type protein; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of folded proteins across the outer membrane. (178 aa) |
| | glnE | Fused deadenylyltransferase/adenylyltransferase for glutamine synthetase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase inactivates GlnA by covalent transfer of an adenylyl group from ATP to 'Tyr-398' of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N- terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signa [...] (946 aa) |
| | ygiF | Inorganic triphosphatase; Involved in the hydrolysis of the beta-gamma-phosphoanhydride linkage of triphosphate-containing substrates (inorganic or nucleoside- linked). Catalyzes the hydrolysis of inorganic triphosphate (PPPi), which could be cytotoxic because of its high affinity for calcium ion, thereby interfering with calcium signaling. It also hydrolyzes slowly thiamine triphosphate (ThTP). YgiF is a specific PPPase, but it contributes only marginally to the total PPPase activity in E.coli, where the main enzyme responsible for hydrolysis of PPPi is inorganic pyrophosphatase (PPase). (433 aa) |
| | ygiM | SH3 domain protein. (206 aa) |
| | cca | Fused tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase and phosphatase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows highest phosphatase activity in the presence of Ni(2+) and hydrolyzes pyrophosphate, canonical 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi. Displays a metal-independent [...] (412 aa) |
| | mlaB | ABC transporter maintaining OM lipid asymmetry, cytoplasmic STAS component; Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. MlaB plays critical roles in both the assembly and activity of the complex. May act by modulating MlaF structure and stability. (97 aa) |
| | mlaC | ABC transporter maintaining OM lipid asymmetry, periplasmic binding protein; Involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. May transfer phospholipid across the periplasmic space and deliver it to the MlaFEDB complex at the inner membrane. Belongs to the MlaC/ttg2D family. (211 aa) |
| | mlaD | OM lipid asymmetry maintenance protein; Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. MlaD functions in substrate binding with strong affinity for phospholipids and modulates ATP hydrolytic activity of the complex. (183 aa) |
| | mlaE | ABC transporter maintaining OM lipid asymmetry, inner membrane permease protein; Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Probably responsible for the translocation of the substrate across the membrane. Belongs to the MlaE permease family. (260 aa) |
| | mlaF | ABC transporter maintaining OM lipid asymmetry, ATP-binding protein; Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Responsible for energy coupling to the transport system. (269 aa) |
| | yrbG | Putative calcium/sodium:proton antiporter; Protein involved in calcium:sodium antiporter activity. (325 aa) |
| | aaeB | P-hydroxybenzoic acid efflux system component; Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell. Substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. (655 aa) |
| | aaeA | P-hydroxybenzoic acid efflux system component; Forms an efflux pump with AaeB. (310 aa) |
| | aaeX | DUF1656 family putative inner membrane efflux pump associated protein; Belongs to the AaeX family. (67 aa) |
| | yheO | Putative PAS domain-containing DNA-binding transcriptional regulator; To H.influenzae HI_0575. (240 aa) |
| | yhfA | OsmC family protein. (134 aa) |
| | yhfK | Putative transporter, FUSC superfamily inner membrane protein; Protein involved in metabolic process. (700 aa) |
| | tsgA | Putative transport; Belongs to the major facilitator superfamily. TsgA family. (393 aa) |
| | yhhS | Putative arabinose efflux transporter; Confers high-level resistance to glyphosate when overexpressed. Overexpression has no effect on intracellular arabinose concentrations. Belongs to the major facilitator superfamily. YhhS family. (405 aa) |
| | yhhT | UPF0118 family putative transporter. (349 aa) |
| | acpT | 4'-phosphopantetheinyl transferase; May be involved in an alternative pathway for phosphopantetheinyl transfer and holo-ACP synthesis in E.coli. The native apo-protein substrate is unknown. Is able to functionally replace AcpS in vivo but only when expressed at high levels. Belongs to the P-Pant transferase superfamily. Gsp/Sfp/HetI/AcpT family. (195 aa) |
| | yhjD | Inner membrane putative BrbK family alternate lipid exporter. (337 aa) |
| | yhjG | Putative inner membrane-anchored periplasmic AsmA family protein. (686 aa) |
| | yicH | Putative inner membrane-anchored periplasmic AsmA family protein; Belongs to the AsmA family. (569 aa) |
| | yidE | Putative transport protein. (553 aa) |
| | yidQ | DUF1375 family outer membrane protein; To E.coli YceK. (110 aa) |
| | yidR | DUF3748 family protein. (415 aa) |
| | pldB | Lysophospholipase L2; Protein involved in phosphorus metabolic process. (340 aa) |
| | yigL | Pyridoxal phosphate phosphatase; Catalyzes Strongly the dephosphorylation of pyridoxal- phosphate (PLP) and moderately the dephosphorylation of 2-deoxyglucose 6-phosphate (2bGLU6P) and beta-glucose 6-phosphate (bGlu6P). Also hydrolyzes both purines (GMP and IMP) and pyrimidines as secondary substrates. (266 aa) |
| | yigM | Putative inner membrane EamA-like transporter; Uptake of biotin. Acts probably by facilitated diffusion. Belongs to the drug/metabolite transporter (DMT) superfamily. 10 TMS drug/metabolite exporter (DME) (TC 2.A.7.3) family. (299 aa) |
| | pepQ | Proline dipeptidase; Splits dipeptides with a prolyl residue in the C-terminal position and a polar or nonpolar amino acid at the N-terminal position. With much lower efficiency, also catalyzes the stereoselective hydrolysis of a wide variety of organophosphate triesters and organophosphonate diesters. Is able to hydrolyze the organophosphorus insecticide paraoxon and the p-nitrophenyl analogs of the nerve agents GB (sarin), GD (soman), GF, Vx and rVX. (443 aa) |
| | yigZ | UPF0029 family protein; Protein involved in translation; Belongs to the IMPACT family. (204 aa) |
| | cytR | Anti-activator for CytR-CRP nucleoside utilization regulon; This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors. (341 aa) |
| | pepE | Peptidase E, alpha-aspartyl dipeptidase; Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids; Belongs to the peptidase S51 family. (229 aa) |
| | ytfJ | Putative transcriptional regulator. (184 aa) |
| | ytfK | DUF1107 family protein. (68 aa) |
| | opgB | OPG periplasmic biosynthetic phosphoglycerol transferases I (membrane-bound) and II (soluble); Transfers a phosphoglycerol residue from phosphatidylglycerol to the membrane-bound nascent glucan backbones. Belongs to the OpgB family. (763 aa) |
| | yjjA | Putative DUF2501 family periplasmic protein; Putative glycoprotein/receptor. (164 aa) |
| | yjjB | DUF3815 family inner membrane protein. (157 aa) |
| | yjjP | DUF1212 family inner membrane protein; Putative structural protein; To H.influenzae HI_0108. (256 aa) |
| | yhdP | DUF3971-AsmA2 domains protein. (1266 aa) |
| | ysaB | Uncharacterized protein. (99 aa) |
| | sgrT | Inhibitor of glucose uptake; Acts to promote recovery from glucose-phosphate stress due to intracellular accumulation of glucose-6-phosphate caused by disruption of glycolytic flux or in the presence of (toxic) non-metabolizable glucose phosphate analogs. It may do so by inhibiting the transporter activity for glucose uptake (PtsG) as cells that overexpress this protein do not seem to import glucose although they have nearly wild- type levels of PtsG. (43 aa) |
