STRINGSTRING
sgrR sgrR setA setA yacG yacG yacH yacH yacL yacL aroM aroM opgE opgE opgC opgC opgG opgG opgH opgH yceK yceK ycfJ ycfJ ydbH ydbH ydcJ ydcJ opgD opgD ydgD ydgD tqsA tqsA ydgA ydgA yecF yecF yeeO yeeO yeeA yeeA sbmC sbmC asmA asmA yehE yehE nudI nudI ypfG ypfG yfgH yfgH yfgI yfgI sseB sseB aaeB aaeB aaeA aaeA aaeX aaeX yhfA yhfA yhfK yhfK tsgA tsgA yhhS yhhS yhhT yhhT acpT acpT yhjD yhjD yhjG yhjG yicH yicH pldB pldB yigL yigL yigM yigM opgB opgB yhdP yhdP sgrT sgrT
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
sgrRTranscriptional DNA-binding transcriptional activator of sgrS sRNA; Activates the small RNA gene sgrS under glucose-phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions; this repression likely provides one measure of control over sgrR at the level of synthesis. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute- binding domain. (551 aa)
setABroad specificity sugar efflux system; Involved in the efflux of sugars. The physiological role may be the detoxification of non-metabolizable sugar analogs. Can transport IPTG, lactose and glucose. Has broad substrate specificity, with preferences for glucosides or galactosides with alkyl or aryl substituents; Belongs to the major facilitator superfamily. Set transporter family. (392 aa)
yacGDNA gyrase inhibitor; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase. (65 aa)
yacHDUF3300 family protein; Putative membrane protein. (617 aa)
yacLUPF0231 family protein. (120 aa)
aroMAroM family protein; This protein of unknown function is encoded by a gene that cotranscribes with the aroL gene, which codes for shikimate kinase II. (225 aa)
opgEOPG biosynthetic transmembrane phosphoethanolamine transferase; Catalyzes the addition of a phosphoethanolamine moiety to the osmoregulated periplasmic glucan (OPG) backbone. (527 aa)
opgCOPG biosynthetic transmembrane succinyltransferase; Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane. (385 aa)
opgGOPG biosynthetic periplasmic beta-1,6 branching glycosyltransferase; Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs); Belongs to the OpgD/OpgG family. (511 aa)
opgHOPG biosynthetic ACP-dependent transmembrane UDP-glucose beta-1,2 glycosyltransferase; Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs). (847 aa)
yceKOuter membrane integrity lipoprotein; To E.coli YidQ. (75 aa)
ycfJUncharacterized protein. (179 aa)
ydbHPutative membrane-anchored protein, function unknown. (879 aa)
ydcJPutative metalloenzyme; To M.tuberculosis Rv3292. (447 aa)
opgDOPG biosynthetic periplasmic protein; Probably involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans (OPGs). (551 aa)
ydgDPutative peptidase; Belongs to the peptidase S1B family. (273 aa)
tqsAPheromone AI-2 transporter; Controls the transport of the quorum-sensing signal AI-2 either by enhancing its secretion or inhibiting its uptake and consequently represses biofilm formation and motility and affects the global gene expression in biofilms. (344 aa)
ydgADUF945 family protein. (502 aa)
yecFDUF2594 family protein. (74 aa)
yeeOPutative multdrug exporter, MATE family; A transporter able to export peptides and flavins. When overexpressed allows cells deleted for multiple peptidases (pepA, pepB, pepD and pepN) to grow in the presence of dipeptides Ala-Gln or Gly-Tyr which otherwise inhibit growth. Cells overexpressing this protein have decreased intracellular levels of Ala-Gln dipeptide, and in a system that produces the Ala-Gln dipeptide, overproduction of this protein increases its export. When overexpressed increases secretion of FMN and FAD but not riboflavin; intracellular concentrations of FMN and ribofla [...] (495 aa)
yeeAPutative transporter, FUSC family inner membrane protein. (352 aa)
sbmCDNA gyrase inhibitor; Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell. Protects cells against the natural plasmid-encoded toxins microcin B17 (MccB17) and CcdB, and synthetic quinolones. Can also protect cells against alkylating agents that act independently of DNA gyrase, suggesting a more general role in protectin [...] (157 aa)
asmASuppressor of OmpF assembly mutants; Involved in the inhibition of assembly of mutant ompF proteins. In general, could be involved in the assembly of outer membrane proteins; Belongs to the AsmA family. (617 aa)
yehEDUF2574 family protein. (93 aa)
nudINucleoside triphosphatase; Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP). (141 aa)
ypfGDUF1176 family protein. (347 aa)
yfgHPutative outer membrane lipoprotein. (172 aa)
yfgINalidixic acid resistance protein, putative periplasmic protein; Putative membrane protein. (179 aa)
sseBRhodanase-like enzyme, sulfur transfer from thiosulfate; May be involved in the enhancement of serine-sensitivity. (258 aa)
aaeBP-hydroxybenzoic acid efflux system component; Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell. Substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. (655 aa)
aaeAP-hydroxybenzoic acid efflux system component; Forms an efflux pump with AaeB. (310 aa)
aaeXDUF1656 family putative inner membrane efflux pump associated protein; Belongs to the AaeX family. (67 aa)
yhfAOsmC family protein. (134 aa)
yhfKPutative transporter, FUSC superfamily inner membrane protein; Protein involved in metabolic process. (700 aa)
tsgAPutative transport; Belongs to the major facilitator superfamily. TsgA family. (393 aa)
yhhSPutative arabinose efflux transporter; Confers high-level resistance to glyphosate when overexpressed. Overexpression has no effect on intracellular arabinose concentrations. Belongs to the major facilitator superfamily. YhhS family. (405 aa)
yhhTUPF0118 family putative transporter. (349 aa)
acpT4'-phosphopantetheinyl transferase; May be involved in an alternative pathway for phosphopantetheinyl transfer and holo-ACP synthesis in E.coli. The native apo-protein substrate is unknown. Is able to functionally replace AcpS in vivo but only when expressed at high levels. Belongs to the P-Pant transferase superfamily. Gsp/Sfp/HetI/AcpT family. (195 aa)
yhjDInner membrane putative BrbK family alternate lipid exporter. (337 aa)
yhjGPutative inner membrane-anchored periplasmic AsmA family protein. (686 aa)
yicHPutative inner membrane-anchored periplasmic AsmA family protein; Belongs to the AsmA family. (569 aa)
pldBLysophospholipase L2; Protein involved in phosphorus metabolic process. (340 aa)
yigLPyridoxal phosphate phosphatase; Catalyzes Strongly the dephosphorylation of pyridoxal- phosphate (PLP) and moderately the dephosphorylation of 2-deoxyglucose 6-phosphate (2bGLU6P) and beta-glucose 6-phosphate (bGlu6P). Also hydrolyzes both purines (GMP and IMP) and pyrimidines as secondary substrates. (266 aa)
yigMPutative inner membrane EamA-like transporter; Uptake of biotin. Acts probably by facilitated diffusion. Belongs to the drug/metabolite transporter (DMT) superfamily. 10 TMS drug/metabolite exporter (DME) (TC 2.A.7.3) family. (299 aa)
opgBOPG periplasmic biosynthetic phosphoglycerol transferases I (membrane-bound) and II (soluble); Transfers a phosphoglycerol residue from phosphatidylglycerol to the membrane-bound nascent glucan backbones. Belongs to the OpgB family. (763 aa)
yhdPDUF3971-AsmA2 domains protein. (1266 aa)
sgrTInhibitor of glucose uptake; Acts to promote recovery from glucose-phosphate stress due to intracellular accumulation of glucose-6-phosphate caused by disruption of glycolytic flux or in the presence of (toxic) non-metabolizable glucose phosphate analogs. It may do so by inhibiting the transporter activity for glucose uptake (PtsG) as cells that overexpress this protein do not seem to import glucose although they have nearly wild- type levels of PtsG. (43 aa)
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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