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hofC hofC hofB hofB ppdD ppdD yacC yacC ppdC ppdC ygdB ygdB ppdB ppdB ppdA ppdA yggR yggR yggS yggS yggT yggT yggU yggU rdgB rdgB yggW yggW yghG yghG pppA pppA gspB gspB gspA gspA gspC gspC gspD gspD gspE gspE gspF gspF gspG gspG gspH gspH gspI gspI gspJ gspJ gspK gspK gspL gspL gspM gspM gspO gspO hofQ hofQ hofP hofP hofO hofO hofN hofN hofM hofM sslE sslE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hofCAssembly protein in type IV pilin biogenesis, transmembrane protein; Putative integral membrane protein involved in biogenesis of fimbriae, protein transport, DNA uptake. (400 aa)
hofBT2SE secretion family protein; Putative integral membrane protein involved in biogenesis of fimbriae, protein transport, DNA uptake; Belongs to the GSP E family. (461 aa)
ppdDPutative prepilin peptidase-dependent pilin; Not yet known; Belongs to the N-Me-Phe pilin family. (146 aa)
yacCPulS_OutS family protein. (115 aa)
ppdCPutative prepilin peptidase-dependent protein; Not yet known. (107 aa)
ygdBDUF2509 family protein. (135 aa)
ppdBPutative prepilin peptidase-dependent protein; Not yet known. (187 aa)
ppdAPutative prepilin peptidase-dependent protein; Not yet known. (156 aa)
yggRPutative PilT family AAA+ ATPase; Putative protein transport. (326 aa)
yggSUPF0001 family protein, PLP-binding; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. May have a carrier function to deliver PLP to the target enzymes or a protective function so that PLP does not inactivate essential lysines in proteins. Does not have amino acid racemase activity. (234 aa)
yggTConserved hypothetical integral membrane protein. (188 aa)
yggUUPF0235 family protein; Belongs to the UPF0235 family. (96 aa)
rdgBdITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Can also efficiently hydrolyze 2'- deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP). Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. To a much lesser extent, is als [...] (197 aa)
yggWHemN family putative oxidoreductase; Probably acts as a heme chaperone, transferring heme to the NarI subunit of the respiratory enzyme nitrate reductase; transfer may be stimulated by NADH. Binds one molecule of heme per monomer, possibly covalently. Heme binding is not affected by either [4Fe-4S] or S- adenosyl-L-methionine (SAM)-binding. Does not have coproporphyrinogen III dehydrogenase activity in vitro. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (Probable). (378 aa)
yghGLipoprotein YghG; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of folded proteins across the outer membrane. In a functional T2SS this subunit helps assemble the outer membrane channel; Belongs to the GspS/AspS pilotin family. (136 aa)
pppABifunctional prepilin leader peptidase/ methylase; A pre-pilin peptidase involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of folded proteins across the outer membrane. (269 aa)
gspBPart of gsp divergon involved in type II protein secretion; Part of a cryptic operon that encodes proteins involved in type II secretion pathway in other organisms, but is not expressed in strain K12 under standard laboratory conditions. May play a regulatory role under conditions of derepressed gsp gene expression. (139 aa)
gspAGeneral secretory pathway component, cryptic; May play a regulatory role under conditions of derepressed gsp gene expression; Belongs to the ExeA family. (489 aa)
gspCGeneral secretory pathway component, cryptic; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. (271 aa)
gspDGeneral secretory pathway component, cryptic; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of folded proteins across the outer membrane. This subunit would form the outer membrane channel. (650 aa)
gspEGeneral secretory pathway component, cryptic; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. (493 aa)
gspFGeneral secretory pathway component, cryptic; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. (398 aa)
gspGPseudopilin, cryptic, general secretion pathway; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. (145 aa)
gspHPutative general secretory pathway component, cryptic; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. (169 aa)
gspIGeneral secretory pathway component, cryptic; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. (125 aa)
gspJPutative general secretory pathway component, cryptic; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. (195 aa)
gspKGeneral secretory pathway component, cryptic; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. Belongs to the GSP K family. (327 aa)
gspLGeneral secretory pathway component, cryptic; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. (387 aa)
gspMGeneral secretory pathway component, cryptic; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. (153 aa)
gspOBifunctional prepilin leader peptidase/ methylase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. (225 aa)
hofQDNA catabolic putative fimbrial transporter; Required for the use of extracellular DNA as a nutrient. Could be the porin responsible for transport of DNA across the outer membrane. (412 aa)
hofPDNA catabolic protein; Required for the use of extracellular DNA as a nutrient. (134 aa)
hofODNA catabolic protein; Required for the use of extracellular DNA as a nutrient. (146 aa)
hofNDNA catabolic putative fimbrial assembly protein; Required for the use of extracellular DNA as a nutrient. (179 aa)
hofMDNA catabolic putative pilus assembly protein; Required for the use of extracellular DNA as a nutrient. (259 aa)
sslEPutative secreted and surface-associated lipoprotein mucinase; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of folded proteins across the outer membrane. (1520 aa)
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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