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iaaA iaaA gsiA gsiA gsiB gsiB gsiC gsiC gsiD gsiD oppA oppA oppB oppB oppC oppC oppD oppD oppF oppF sapF sapF sapD sapD sapC sapC sapB sapB sapA sapA mppA mppA ddpF ddpF ddpD ddpD ddpC ddpC ddpB ddpB ddpA ddpA yejA yejA yejB yejB yejE yejE yejF yejF ygiS ygiS nikA nikA nikB nikB nikC nikC nikD nikD nikE nikE nikR nikR dppF dppF dppD dppD dppC dppC dppB dppB dppA dppA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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iaaAIsoaspartyl peptidase; Degrades proteins damaged by L-isoaspartyl residue formation (also known as beta-Asp residues). Degrades L-isoaspartyl-containing di- and maybe also tripeptides. Also has L-asparaginase activity, although this may not be its principal function. Belongs to the Ntn-hydrolase family. (321 aa)
gsiAGlutathione ABC transporter ATPase; Part of the ABC transporter complex GsiABCD involved in glutathione import. Responsible for energy coupling to the transport system. (623 aa)
gsiBGlutathione ABC transporter periplasmic binding protein; Part of the ABC transporter complex GsiABCD involved in glutathione import. Binds glutathione ; Belongs to the bacterial solute-binding protein 5 family. (512 aa)
gsiCGlutathione ABC transporter permease; Part of the ABC transporter complex GsiABCD involved in glutathione import. Probably responsible for the translocation of the substrate across the membrane. (306 aa)
gsiDGlutathione ABC transporter permease; Part of the ABC transporter complex GsiABCD involved in glutathione import. Probably responsible for the translocation of the substrate across the membrane. (303 aa)
oppAOligopeptide ABC transporter periplasmic binding protein; This protein is a component of the oligopeptide permease, a binding protein-dependent transport system, it binds peptides up to five amino acids long with high affinity; Belongs to the bacterial solute-binding protein 5 family. (543 aa)
oppBOligopeptide ABC transporter permease; Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily. (306 aa)
oppCOligopeptide ABC transporter permease; Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily. (302 aa)
oppDOligopeptide ABC transporter ATPase; Part of the binding-protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system. (337 aa)
oppFOligopeptide ABC transporter ATPase; Part of the binding-protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. (334 aa)
sapFAntimicrobial peptide ABC transporter ATPase; Part of a putrescine export transport system, does not play a role in resistance to antimicrobial peptides. Does not stimulate K(+) uptake ability of TrkH on its own, but increases K(+) uptake by 20% in the presence of SapD; has no effect of TrkG ; Belongs to the ABC transporter superfamily. (268 aa)
sapDAntimicrobial peptide ABC transporter ATPase; Part of a putrescine export transport system, does not play a role in resistance to antimicrobial peptides. Stimulates K(+)-uptake proteins TrkG and TrkH to import K(+), may act via ATP-binding rather than ATP hydrolysis. (330 aa)
sapCAntimicrobial peptide transport ABC transporter permease; Part of a putrescine export transport system, does not play a role in resistance to antimicrobial peptides. (296 aa)
sapBAntimicrobial peptide transport ABC transporter permease; Part of a putrescine export transport system, does not play a role in resistance to antimicrobial peptides. (321 aa)
sapAAntimicrobial peptide transport ABC transporter periplasmic binding protein; Not part of a putrescine export system. Very similar to a S.typhimurium protein implicated in antimicrobial peptide resistance, but the SapBCDF operon in E.coli is implicated in putrescine export. (547 aa)
mppAMurein tripeptide (L-ala-gamma-D-glutamyl-meso-DAP) transporter subunit; Essential for the uptake of the murein peptide L-alanyl- gamma-D-glutamyl-meso-diaminopimelate. Also transports some alpha- linked peptides such as Pro-Phe-Lys with low affinity. The transport is effected by the oligopeptide permease system; Belongs to the bacterial solute-binding protein 5 family. (537 aa)
ddpFD,D-dipeptide ABC transporter ATPase; Part of the ABC transporter complex DdpABCDF, which is probably involved in D,D-dipeptide transport. Probably responsible for energy coupling to the transport system. (308 aa)
ddpDD,D-dipeptide ABC transporter ATPase; Part of the ABC transporter complex DdpABCDF, which is probably involved in D,D-dipeptide transport. Probably responsible for energy coupling to the transport system. (328 aa)
ddpCD,D-dipeptide ABC transporter permease; Part of the ABC transporter complex DdpABCDF, which is probably involved in D,D-dipeptide transport. Probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily. (298 aa)
ddpBD,D-dipeptide ABC transporter permease; Part of the ABC transporter complex DdpABCDF, which is probably involved in D,D-dipeptide transport. Probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily. (340 aa)
ddpAD,D-dipeptide ABC transporter periplasmic binding protein; Part of the ABC transporter complex DdpABCDF, which is probably involved in D,D-dipeptide transport; Belongs to the bacterial solute-binding protein 5 family. (516 aa)
yejAPeriplasmic-binding component of ABC superfamily; To H.influenzae HbpA. (604 aa)
yejBMicrocin C ABC transporter permease; Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily. (364 aa)
yejEMicrocin C ABC transporter permease; Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily. (341 aa)
yejFMicrocin C ABC transporter ATPase; Putative ATP-binding component of a transport system. (529 aa)
ygiSPutative ABC transporter permease; Probably part of a deoxycholate transport system. Its expression in the presence of deoxycholate in a ygiS deletion mutant increases intracellular deoxycholate levels and decreases cell growth; higher expression in the presence of deoxycholate inhibits cell growth completely. Bile acid detergents such as deoxycholate are important for host defense against bacterial growth in the gall bladder and duodenum. Belongs to the bacterial solute-binding protein 5 family. (535 aa)
nikANickel/heme ABC transporter periplasmic binding protein; Involved in a nickel transport system, probably represents the nickel binder. (524 aa)
nikBNickel ABC transporter permease; Involved in a nickel transport system, probably translocates nickel through the bacterial inner membrane. (314 aa)
nikCNickel ABC transporter permease; Involved in a nickel transport system, probably translocates nickel through the bacterial inner membrane. (277 aa)
nikDNickel ABC transporter ATPase; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family. (254 aa)
nikENickel ABC transporter ATPase; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family. (268 aa)
nikRTranscriptional repressor, Ni-binding; Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel; Belongs to the transcriptional regulatory CopG/NikR family. (133 aa)
dppFDipeptide/heme ABC transporter ATPas; Part of the binding-protein-dependent transport system for dipeptides. Probably responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. (334 aa)
dppDDipeptide/heme ABC transporter ATPas; Part of the binding-protein-dependent transport system for dipeptides. Probably responsible for energy coupling to the transport system. (327 aa)
dppCDipeptide/heme ABC transporter permease; Part of the binding-protein-dependent transport system for dipeptides; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily. (300 aa)
dppBDipeptide/heme ABC transporter permease; Part of the binding-protein-dependent transport system for dipeptides; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily. (339 aa)
dppADipeptide/heme ABC transporter periplasmic binding protein; Dipeptide-binding protein of a transport system that can be subject to osmotic shock. DppA is also required for peptide chemotaxis; Belongs to the bacterial solute-binding protein 5 family. (535 aa)
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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