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mnmH mnmH fdnG fdnG fdnH fdnH fdnI fdnI selD selD hyfA hyfA hyfB hyfB hyfC hyfC hyfD hyfD hyfE hyfE hyfF hyfF hyfG hyfG hyfI hyfI hyfJ hyfJ hyfR hyfR focB focB hydN hydN hycI hycI hycH hycH hycG hycG hycF hycF hycE hycE hycD hycD hycC hycC hycB hycB hycA hycA fhlA fhlA selB selB selA selA fdhE fdhE fdoI fdoI fdoH fdoH fdoG fdoG fdhD fdhD fdhF fdhF
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Your Input:
mnmHtRNA 2-selenouridine synthase; Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2-selenouridine (Se2U-RNA). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain. (364 aa)
fdnGFormate dehydrogenase-N, alpha subunit, nitrate-inducible; Formate dehydrogenase allows E.coli to use formate as major electron donor during anaerobic respiration, when nitrate is used as electron acceptor. The alpha subunit FdnG contains the formate oxidation site. Electrons are transferred from formate to menaquinone in the gamma subunit (FdnI), through the 4Fe-4S clusters in the beta subunit (FdnH). Formate dehydrogenase-N is part of a system that generates proton motive force, together with the dissimilatory nitrate reductase (Nar). (1015 aa)
fdnHFormate dehydrogenase-N, Fe-S (beta) subunit, nitrate-inducible; Formate dehydrogenase allows E.coli to use formate as major electron donor during anaerobic respiration, when nitrate is used as electron acceptor. The beta subunit FdnH is an electron transfer unit containing 4 iron-sulfur clusters; it serves as a conduit for electrons that are transferred from the formate oxidation site in the alpha subunit (FdnG) to the menaquinone associated with the gamma subunit (FdnI) of formate dehydrogenase-N. Formate dehydrogenase-N is part of a system that generates proton motive force, togethe [...] (294 aa)
fdnIFormate dehydrogenase-N, cytochrome B556 (gamma) subunit, nitrate-inducible; Formate dehydrogenase allows E.coli to use formate as major electron donor during anaerobic respiration, when nitrate is used as electron acceptor. Subunit gamma is the cytochrome b556 component of the formate dehydrogenase-N, and also contains a menaquinone reduction site that receives electrons from the beta subunit (FdnH), through its hemes. Formate dehydrogenase-N is part of a system that generates proton motive force, together with the dissimilatory nitrate reductase (Nar). (217 aa)
selDSelenophosphate synthase; Synthesizes selenophosphate from selenide and ATP; Belongs to the selenophosphate synthase 1 family. Class I subfamily. (347 aa)
hyfAHydrogenase 4, 4Fe-4S subunit; Probable electron transfer protein for hydrogenase 4. (205 aa)
hyfBHydrogenase 4, membrane subunit; Possible component of hydrogenase 4. (672 aa)
hyfCHydrogenase 4, membrane subunit; Possible component of hydrogenase 4. Belongs to the complex I subunit 1 family. (315 aa)
hyfDHydrogenase 4, membrane subunit; Possible component of hydrogenase 4. Belongs to the complex I subunit 5 family. (479 aa)
hyfEHydrogenase 4, membrane subunit; Possible component of hydrogenase 4. (216 aa)
hyfFHydrogenase 4, membrane subunit; Possible component of hydrogenase 4. Belongs to the complex I subunit 5 family. (526 aa)
hyfGHydrogenase 4, subunit; Possible component of hydrogenase 4. (555 aa)
hyfIHydrogenase 4, Fe-S subunit; Possible component of hydrogenase 4. Belongs to the complex I 20 kDa subunit family. (252 aa)
hyfJPutative processing element hydrogenase 4; Possible component of hydrogenase 4. (137 aa)
hyfRHydrogenase-4 transcriptional activator; A transcriptional activator of its own operon; when overexpressed operon expression is strongly enhanced by low pH (under pH 6.0), strongly inhibited by O(2) but only weakly stimulated by fumarate. Expression in situ is very weak. (670 aa)
focBPutative formate transporter; Involved in the bidirectional transport of formate. Belongs to the FNT transporter (TC 2.A.44) family. (282 aa)
hydNFormate dehydrogenase-H, [4Fe-4S] ferredoxin subunit; Electron transport from formate to hydrogen. (175 aa)
hycIProtease involved in processing C-terminal end of HycE; Protease involved in the C-terminal processing of HycE, the large subunit of hydrogenase 3; Belongs to the peptidase A31 family. (156 aa)
hycHHydrogenase 3 maturation protein; Seems to be required for the conversion of a precursor form of the large subunit of hydrogenlyase (HycE) into a mature form. (136 aa)
hycGHydrogenase 3 and formate hydrogenase complex, HycG subunit; Hydrogenase activity; Protein involved in fermentation and anaerobic respiration. (255 aa)
hycFFormate hydrogenlyase complex iron-sulfur protein; Probable electron transfer protein for hydrogenase 3. (180 aa)
hycELarge subunit of hydrogenase 3 (part of FHL complex); Protein involved in fermentation and anaerobic respiration; Belongs to the complex I 49 kDa subunit family. (569 aa)
hycDMembrane-spanning protein of hydrogenase 3 (part of FHL complex); Protein involved in fermentation; Belongs to the complex I subunit 1 family. (307 aa)
hycCMembrane-spanning protein of hydrogenase 3 (part of FHL complex); Protein involved in fermentation; Belongs to the complex I subunit 4 family. (608 aa)
hycBHydrogenase 3, Fe-S subunit; Probable electron transfer protein for hydrogenase 3. (203 aa)
hycARegulator of the transcriptional regulator FhlA; Regulatory protein for the formate hydrogenlyase system. Could act by directly interacting with FhlA or by preventing the binding of FhlA to the upstream activatory sequence. Also down-regulates expression of the hyf operon. (153 aa)
fhlAFormate hydrogenlyase transcriptional activator; Required for induction of expression of the formate dehydrogenase H and hydrogenase-3 structural genes. Also activates expression of hyf operon (encodes the silent hydrogenase-4 gene cluster). (692 aa)
selBselenocysteinyl-tRNA-specific translation factor; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. SelB subfamily. (614 aa)
selASelenocysteine synthase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. Requires selenophosphate as the selenium-donor molecule; Belongs to the SelA family. (463 aa)
fdhEFormate dehydrogenase formation protein; Necessary for formate dehydrogenase activity. (309 aa)
fdoIFormate dehydrogenase-O, cytochrome b556 subunit; Allows to use formate as major electron donor during aerobic respiration. Subunit gamma is probably the cytochrome b556(FDO) component of the formate dehydrogenase. (211 aa)
fdoHFormate dehydrogenase-O, Fe-S subunit; Allows to use formate as major electron donor during aerobic respiration. The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. Electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit (By similarity). (300 aa)
fdoGFormate dehydrogenase-O, large subunit; Allows to use formate as major electron donor during aerobic respiration. Subunit alpha possibly forms the active site; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1016 aa)
fdhDFormate dehydrogenase formation protein; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Specifically interacts with IscS and stimulates its cysteine desulfurase activity. Also binds the molybdenum cofactor. Required for activity of formate dehydrogenase N (FDH-N), formate dehydrogenase O (FDH-O) and formate dehydrogenase H (FDH-H). (277 aa)
fdhFFormate dehydrogenase-H, selenopolypeptide subunit; Decomposes formic acid to hydrogen and carbon dioxide under anaerobic conditions in the absence of exogenous electron acceptors. (715 aa)
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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