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hyfA hyfA hyfB hyfB hyfC hyfC hyfD hyfD hyfE hyfE hyfF hyfF hyfG hyfG hyfI hyfI hyfJ hyfJ hyfR hyfR focB focB hydN hydN hycI hycI hycH hycH hycG hycG hycF hycF hycE hycE hycD hycD hycC hycC hycB hycB hycA hycA fhlA fhlA fdhF fdhF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hyfAHydrogenase 4, 4Fe-4S subunit; Probable electron transfer protein for hydrogenase 4. (205 aa)
hyfBHydrogenase 4, membrane subunit; Possible component of hydrogenase 4. (672 aa)
hyfCHydrogenase 4, membrane subunit; Possible component of hydrogenase 4. Belongs to the complex I subunit 1 family. (315 aa)
hyfDHydrogenase 4, membrane subunit; Possible component of hydrogenase 4. Belongs to the complex I subunit 5 family. (479 aa)
hyfEHydrogenase 4, membrane subunit; Possible component of hydrogenase 4. (216 aa)
hyfFHydrogenase 4, membrane subunit; Possible component of hydrogenase 4. Belongs to the complex I subunit 5 family. (526 aa)
hyfGHydrogenase 4, subunit; Possible component of hydrogenase 4. (555 aa)
hyfIHydrogenase 4, Fe-S subunit; Possible component of hydrogenase 4. Belongs to the complex I 20 kDa subunit family. (252 aa)
hyfJPutative processing element hydrogenase 4; Possible component of hydrogenase 4. (137 aa)
hyfRHydrogenase-4 transcriptional activator; A transcriptional activator of its own operon; when overexpressed operon expression is strongly enhanced by low pH (under pH 6.0), strongly inhibited by O(2) but only weakly stimulated by fumarate. Expression in situ is very weak. (670 aa)
focBPutative formate transporter; Involved in the bidirectional transport of formate. Belongs to the FNT transporter (TC 2.A.44) family. (282 aa)
hydNFormate dehydrogenase-H, [4Fe-4S] ferredoxin subunit; Electron transport from formate to hydrogen. (175 aa)
hycIProtease involved in processing C-terminal end of HycE; Protease involved in the C-terminal processing of HycE, the large subunit of hydrogenase 3; Belongs to the peptidase A31 family. (156 aa)
hycHHydrogenase 3 maturation protein; Seems to be required for the conversion of a precursor form of the large subunit of hydrogenlyase (HycE) into a mature form. (136 aa)
hycGHydrogenase 3 and formate hydrogenase complex, HycG subunit; Hydrogenase activity; Protein involved in fermentation and anaerobic respiration. (255 aa)
hycFFormate hydrogenlyase complex iron-sulfur protein; Probable electron transfer protein for hydrogenase 3. (180 aa)
hycELarge subunit of hydrogenase 3 (part of FHL complex); Protein involved in fermentation and anaerobic respiration; Belongs to the complex I 49 kDa subunit family. (569 aa)
hycDMembrane-spanning protein of hydrogenase 3 (part of FHL complex); Protein involved in fermentation; Belongs to the complex I subunit 1 family. (307 aa)
hycCMembrane-spanning protein of hydrogenase 3 (part of FHL complex); Protein involved in fermentation; Belongs to the complex I subunit 4 family. (608 aa)
hycBHydrogenase 3, Fe-S subunit; Probable electron transfer protein for hydrogenase 3. (203 aa)
hycARegulator of the transcriptional regulator FhlA; Regulatory protein for the formate hydrogenlyase system. Could act by directly interacting with FhlA or by preventing the binding of FhlA to the upstream activatory sequence. Also down-regulates expression of the hyf operon. (153 aa)
fhlAFormate hydrogenlyase transcriptional activator; Required for induction of expression of the formate dehydrogenase H and hydrogenase-3 structural genes. Also activates expression of hyf operon (encodes the silent hydrogenase-4 gene cluster). (692 aa)
fdhFFormate dehydrogenase-H, selenopolypeptide subunit; Decomposes formic acid to hydrogen and carbon dioxide under anaerobic conditions in the absence of exogenous electron acceptors. (715 aa)
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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