STRINGSTRING
ivy ivy yahM yahM deoR deoR yccX yccX ycgJ ycgJ pliG pliG mcbR mcbR uxaB uxaB rspR rspR ydfZ ydfZ rspB rspB rspA rspA ynfA ynfA ynfB ynfB speG speG uidC uidC uidB uidB uidA uidA uidR uidR hdhA hdhA malI malI mliC mliC kdgR kdgR hcaT hcaT kduD kduD kduI kduI ygjH ygjH ygjV ygjV uxaA uxaA uxaC uxaC exuT exuT exuR exuR gntT gntT gntK gntK gntR gntR dtpB dtpB dgoT dgoT dgoK dgoK yidX yidX mioC mioC asnC asnC hsrA hsrA yieP yieP kdgT kdgT idnT idnT idnO idnO idnD idnD idnK idnK gntP gntP uxuA uxuA uxuB uxuB uxuR uxuR iadA iadA yjiG yjiG yjiH yjiH lgoT lgoT lgoR lgoR lgoD lgoD gntU gntU dgoA dgoA dgoD dgoD dgoR dgoR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ivyInhibitor of c-type lysozyme, periplasmic; Strong inhibitor of lysozyme C. (157 aa)
yahMUncharacterized protein. (81 aa)
deoRDeoxyribose-5-phosphate-inducible deoxyribose operon transcriptional repressor; This protein is one of the repressors that regulate the expression of deoCABD genes, which encode nucleotide and deoxy ribonucleotide catabolizing enzymes. It also negatively regulates the expression of nupG (a transport protein) and tsx (a pore-forming protein). The inducer is deoxyribose-5-phosphate. (252 aa)
yccXWeak acylphosphatase. (92 aa)
ycgJUncharacterized protein. (122 aa)
pliGPeriplasmic inhibitor of g-type lysozyme; Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium. (133 aa)
mcbRColanic acid and biofilm gene transcriptional regulator, MqsR-controlled; Important for biofilm formation. Represses expression of McbA by binding to its promoter region, which prevents colanic acid overproduction and mucoidy. (221 aa)
uxaBAltronate oxidoreductase, NAD-dependent; Altronate oxidoreductase; Protein involved in carbohydrate catabolic process. (483 aa)
rspRTranscriptional repressor for rspAB; Repressor of the rspAB operon. Acts by binding directly to the upstream region of rspA. (228 aa)
ydfZSelenoprotein, function unknown. (67 aa)
rspBStarvation-sensing protein RspB; Not known; probable catabolic enzyme. (339 aa)
rspABifunctional D-altronate/D-mannonate dehydratase; Probably involved in the degradation of homoserine lactone (HSL) or of a metabolite of HSL that signals starvation. (404 aa)
ynfAUPF0060 family inner membrane protein. (108 aa)
ynfBUPF0482 family putative periplasmic protein. (113 aa)
speGSpermidine N(1)-acetyltransferase; Involved in the protection against polyamine toxicity by regulating their concentration. Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to the primary amino groups of spermidine to yield N(1)- and N(8)-acetylspermidine. It can also use polyamines such as spermine, but not putrescine. (186 aa)
uidCPutative outer membrane porin for beta-glucuronides porin protein; Enhances the activity of the UidB (GusB) glucuronide transporter, on its own however it has no transport activity. Glucuronide transport does not occur in strain K12 due to a variant at position 100 of the UidB (GusB, AC P0CE44, AC P0CE45) protein. (421 aa)
uidBGlucuronide permease; Protein involved in carbohydrate catabolic process. (457 aa)
uidAbeta-D-glucuronidase; Protein involved in carbohydrate catabolic process; Belongs to the glycosyl hydrolase 2 family. (603 aa)
uidRTranscriptional repressor; Repressor for the uidRABC (gusRABC) operon. (196 aa)
hdhA7-alpha-hydroxysteroid dehydrogenase, NAD-dependent; Catalyzes the oxidation of the 7-alpha-hydroxy group of primary bile acids such as cholate, chenodeoxycholate and taurochenodeoxycholate. To a lesser extent, also able to use taurocholate and glycocholate. (255 aa)
malITranscriptional repressor of Mal regulon; Repressor for the malX and malY genes. Also regulates its own expression. Binds maltose as an inducer. (342 aa)
mliCInhibitor of c-type lysozyme, membrane-bound; Specifically inhibits C-type lysozymes. Belongs to the MliC family. Type 1 subfamily. (109 aa)
kdgRKDG regulon transcriptional repressor; Transcriptional regulator of the kdgK gene for the kdg kinase and the kdgT gene for the kdg permease. (263 aa)
hcaTPutative 3-phenylpropionic transporter; Probable permease involved in the uptake of 3-phenylpropionic acid; Belongs to the major facilitator superfamily. Phenyl propionate permease (PPP) (TC 2.A.1.27) family. (379 aa)
kduD2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase; Catalyzes the reversible reduction of 2,5-diketo-3- deoxygluconate (DKII or 4,6-dihydroxy-2,5-dioxohexanoate) into 2-keto- 3-deoxygluconate (KDG or 2-dehydro-3-deoxygluconate) with a concomitant oxidation of NADH. To a lesser extent, can also reduce 5-keto- D-gluconate and oxidize D-gluconate and 1,2-propanediol. Together with KduI, seems to play a role in the catabolism of hexuronates under osmotic stress conditions, substituting for the regular hexuronate degrading enzymes UxaABC and UxuAB whose expression is repressed in these condition [...] (253 aa)
kduIHexuronate isomerase; Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity). Plays a role in the catabolism of hexuronates under osmotic stress conditions, likely substituting for the regular hexuronate degrading enzyme UxaC whose expression is repressed in these conditions ; Belongs to the KduI family. (278 aa)
ygjHPutative tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation. (110 aa)
ygjVImp-YgjV family inner membrane protein. (183 aa)
uxaAAltronate hydrolase; Catalyzes the dehydration of D-altronate. (495 aa)
uxaCUronate isomerase; Protein involved in carbohydrate catabolic process; Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family. (470 aa)
exuTHexuronate transporter; Aldohexuronate transport system. (432 aa)
exuRHexuronate regulon transcriptional repressor; Repressor for the exu regulon that encode genes involved in hexuronate utilization. It regulates the ExuT, UxaCA and UxuRAB operons. Binds D-tagaturonate and D-fructuronate as inducers. (258 aa)
gntTGluconate transporter, high-affinity GNT I system; Part of the gluconate utilization system Gnt-I; high-affinity intake of gluconate. (438 aa)
gntKGluconokinase 2, thermoresistant; gluconate transport, GNT I system; Protein involved in glucose metabolic process; Belongs to the gluconokinase GntK/GntV family. (175 aa)
gntRD-gluconate inducible gluconate regulon transcriptional repressor; Negative regulator for the gluconate utilization system GNT- I, the gntUKR operon. (331 aa)
dtpBDipeptide and tripeptide permease B; Proton-dependent permease that transports di- and tripeptides. Has a clear preference for dipeptides and tripeptides composed of L-amino acids, and discriminates dipeptides on the basis of the position of charges within the substrate. Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpB subfamily. (489 aa)
dgoTD-galactonate transporter; Intake of galactonate into the cell; Belongs to the major facilitator superfamily. Phthalate permease family. (430 aa)
dgoK2-oxo-3-deoxygalactonate kinase; Protein involved in carbohydrate catabolic process; Belongs to the DgoK family. (292 aa)
yidXPutative replicase EC 2.7.-. (218 aa)
mioCFMN-binding protein MioC; Probable electron transporter required for biotin synthase activity. (147 aa)
asnCTranscriptional activator of asnA; Activator of asnA transcription; autogenous regulator of its own transcription; and repressor of the expression of gidA at a post- transcriptional level. (152 aa)
hsrAPutative multidrug or homocysteine efflux system; Putative transport protein (MFS family); high copy suppressor of RspA: relieves RspA-mediated reduction of sigma(S) levels; overexpression also reduces MetE activity; effect proposed to be via an elevation in levels of homocysteine, causing a concomitant increase in homocysteine thiolactone; overexpression has no effect on resistance to a variety of toxic compounds; overexpression has no effect on resistance to a variety of toxic compounds; Belongs to the major facilitator superfamily. EmrB family. (475 aa)
yiePPutative transcriptional regulator. (230 aa)
kdgT2-keto-3-deoxy-D-gluconate transporter; The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system; Belongs to the KdgT transporter family. (327 aa)
idnTL-idonate and D-gluconate transporter; Transports L-idonate, D-gluconate and 5-keto-D-gluconate, from the periplasm across the inner membrane. (439 aa)
idnO5-keto-D-gluconate-5-reductase; Catalyzes the reduction of 5-keto-D-gluconate to D-gluconate, using either NADH or NADPH. Is likely involved in an L-idonate degradation pathway that allows E.coli to utilize L-idonate as the sole carbon and energy source. Is also able to catalyze the reverse reaction in vitro, but the D-gluconate oxidation by the enzyme can only proceed with NAD; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (254 aa)
idnDL-idonate 5-dehydrogenase, NAD-binding; Catalyzes the NADH/NADPH-dependent oxidation of L-idonate to 5-ketogluconate (5KG); Belongs to the zinc-containing alcohol dehydrogenase family. (343 aa)
idnKD-gluconate kinase, thermosensitive; Protein involved in carbohydrate catabolic process; Belongs to the gluconokinase GntK/GntV family. (187 aa)
gntPFructuronate transporter; High-affinity gluconate transporter with fairly broad specificity, including low affinity for glucuronate, several disaccharides, and some hexoses, but not glucose. (447 aa)
uxuAMannonate hydrolase; Catalyzes the dehydration of D-mannonate. (394 aa)
uxuBD-mannonate oxidoreductase, NAD-dependent; D-mannonate oxidoreductase; Protein involved in carbohydrate catabolic process; Belongs to the mannitol dehydrogenase family. UxuB subfamily. (486 aa)
uxuRFructuronate-inducible hexuronate regulon transcriptional repressor; Repressor for the uxuRBA operon. (257 aa)
iadAIsoaspartyl dipeptidase; Catalyzes the hydrolytic cleavage of a subset of L- isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation. The best substrate for the enzyme reported thus far is iso-Asp-Leu. (390 aa)
yjiGSpmB family inner membrane protein. (153 aa)
yjiHNucleoside recognition pore and gate family putative inner membrane transporter. (227 aa)
lgoTPutative L-galactonate:H+ symporter; Probably responsible for the transport of L-galactonate from the periplasm across the inner membrane. Is essential for growth on L- galactonate as the sole carbon source; Belongs to the major facilitator superfamily. Phthalate permease family. (453 aa)
lgoRPutative transcriptional activator for L-galactonate catabolism; May be a positive transcriptional regulator for lgoD and/or lgoT. Is essential for growth on L-galactonate as the sole carbon source. (304 aa)
lgoDL-galactonate oxidoreductase; Catalyzes the oxidation of L-galactonate to D-tagaturonate. Required for growth on L-galactonate as the sole carbon source. In vitro, can also use L-gulonate. (340 aa)
gntUGluconate transporter, low affinity GNT 1 system; Part of the gluconate utilization system Gnt-I; low-affinity intake of gluconate; Belongs to the GntP permease family. (446 aa)
dgoA2-oxo-3-deoxygalactonate 6-phosphate aldolase; Involved in the degradation of galactose via the DeLey- Doudoroff pathway. Catalyzes the reversible, stereospecific retro-aldol cleavage of 2-keto-3-deoxy-6-phosphogalactonate (KDPGal) to pyruvate and D-glyceraldehyde-3-phosphate. In the synthetic direction, it catalyzes the addition of pyruvate to electrophilic aldehydes with re- facial selectivity. It can use a limited number of aldehyde substrates, including D-glyceraldehyde-3-phosphate (natural substrate), D- glyceraldehyde, glycolaldehyde, 2-pyridinecarboxaldehyde, D-ribose, D- erythr [...] (205 aa)
dgoDD-galactonate dehydratase; Catalyzes the dehydration of D-galactonate to 2-keto-3-deoxy- D-galactonate. (382 aa)
dgoRD-galactonate catabolism operon transcriptional repressor; Repressor for the dgoRKAT operon. Binds D-galactonate as an inducer. (229 aa)
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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