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uxaB uxaB kdgR kdgR kduD kduD kduI kduI ygjV ygjV uxaA uxaA uxaC uxaC exuT exuT exuR exuR kdgT kdgT uxuA uxuA uxuB uxuB uxuR uxuR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
uxaBAltronate oxidoreductase, NAD-dependent; Altronate oxidoreductase; Protein involved in carbohydrate catabolic process. (483 aa)
kdgRKDG regulon transcriptional repressor; Transcriptional regulator of the kdgK gene for the kdg kinase and the kdgT gene for the kdg permease. (263 aa)
kduD2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase; Catalyzes the reversible reduction of 2,5-diketo-3- deoxygluconate (DKII or 4,6-dihydroxy-2,5-dioxohexanoate) into 2-keto- 3-deoxygluconate (KDG or 2-dehydro-3-deoxygluconate) with a concomitant oxidation of NADH. To a lesser extent, can also reduce 5-keto- D-gluconate and oxidize D-gluconate and 1,2-propanediol. Together with KduI, seems to play a role in the catabolism of hexuronates under osmotic stress conditions, substituting for the regular hexuronate degrading enzymes UxaABC and UxuAB whose expression is repressed in these condition [...] (253 aa)
kduIHexuronate isomerase; Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity). Plays a role in the catabolism of hexuronates under osmotic stress conditions, likely substituting for the regular hexuronate degrading enzyme UxaC whose expression is repressed in these conditions ; Belongs to the KduI family. (278 aa)
ygjVImp-YgjV family inner membrane protein. (183 aa)
uxaAAltronate hydrolase; Catalyzes the dehydration of D-altronate. (495 aa)
uxaCUronate isomerase; Protein involved in carbohydrate catabolic process; Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family. (470 aa)
exuTHexuronate transporter; Aldohexuronate transport system. (432 aa)
exuRHexuronate regulon transcriptional repressor; Repressor for the exu regulon that encode genes involved in hexuronate utilization. It regulates the ExuT, UxaCA and UxuRAB operons. Binds D-tagaturonate and D-fructuronate as inducers. (258 aa)
kdgT2-keto-3-deoxy-D-gluconate transporter; The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system; Belongs to the KdgT transporter family. (327 aa)
uxuAMannonate hydrolase; Catalyzes the dehydration of D-mannonate. (394 aa)
uxuBD-mannonate oxidoreductase, NAD-dependent; D-mannonate oxidoreductase; Protein involved in carbohydrate catabolic process; Belongs to the mannitol dehydrogenase family. UxuB subfamily. (486 aa)
uxuRFructuronate-inducible hexuronate regulon transcriptional repressor; Repressor for the uxuRBA operon. (257 aa)
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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