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| | leuO | Global transcription factor; A global transcription factor. Activates transcription of the 9 following operons; yjjQ-bglJ, yjjP, acrEF, ybdO, yjcRQP, casABCDE12, rhsD-ybbC, fepE and gltF, in most cases it probably interferes with silencing by H-NS and activates transcription. Represses transcription of the 3 following operons; uxaCA, sdaCB and btsT. H-NS repression of the bgl operon, leading to the ability to metabolize some beta- glucosides. It also directly activates the bgl operon. Activation is H- NS and BglJ-RcsB independent. (314 aa) |
| | yadD | Transposase_31 family protein; A low activity DNA endonuclease yielding 3'-hydroxyl ends (Probable). Upon expression enhances RecA-independent DNA recombination 2.9-fold, concomitantly reducing viability by 59% and inducing DNA damage as measured by induction of the SOS repair response. Belongs to the Rpn/YhgA-like nuclease family. (300 aa) |
| | cdaR | Carbohydrate diacid regulon transcriptional regulator; Seems to regulate the expression of the operons for the enzymes involved in D-galactarate, D-glucarate and D-glycerate utilization. (385 aa) |
| | insI1 | Transposase InsI for insertion sequence element IS30A; Required for the transposition of the insertion element. (383 aa) |
| | insE1 | Transposase InsE for insertion sequence IS3A; Involved in the transposition of the insertion sequence IS3. (99 aa) |
| | insF1 | IS3 transposase B; Involved in the transposition of the insertion sequence IS3. (288 aa) |
| | yahD | Ankyrin repeat protein; Putative transcription factor. (201 aa) |
| | yahE | DUF2877 family protein. (287 aa) |
| | yahF | Putative NAD(P)-binding succinyl-CoA synthase; Putative oxidoreductase subunit; To E.coli FdrA and some, to bacterial SucD. (515 aa) |
| | yahG | DUF1116 family protein. (472 aa) |
| | yahJ | Putative metallo-dependent hydrolase domain deaminase; Putative deaminase; Protein involved in amine catabolic process. (460 aa) |
| | yahL | Uncharacterized protein. (271 aa) |
| | insC1 | Transposase InsC for insertion element IS2-10; Involved in the transposition of the insertion sequence IS2. (121 aa) |
| | insD1 | IS2 transposase TnpB; Involved in the transposition of the insertion sequence IS2. (301 aa) |
| | insF1-2 | Pseudogene, autotransporter family;putative structure; Not classified; interrupted by IS3; putative flagellin structural protein. (288 aa) |
| | insE1-2 | IS3 transposase A. (99 aa) |
| | ybaE | Putative ABC transporter periplasmic binding protein. (566 aa) |
| | cof | Thiamine pyrimidine pyrophosphate hydrolase; Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5- hydroxymethylpyrimidine phosphate (HMP-P). Can also hydrolyze other substrates such as MeO-HMP-PP and 4-amino-2-trifluoromethyl 5- hydroxymethylpyrimidine pyrophosphate (CF3-HMP-PP) to give MeO-HMP-P and 4-amino-2-trifluoromethyl-5-hydroxymethylpyrimidine phosphate. This hydrolysis generates resistance to the antibiotics (bacimethrin, CF3- HMP) by reducing the formation of their toxic forms, 2'-methoxythiamin pyrophosphate (M [...] (272 aa) |
| | ybaO | Putative DNA-binding transcriptional regulator; Plays a role in L-cysteine detoxification. Binds to the dlsT(yhaO)-yhaM operon promoter in the presence but not absence of L- cysteine; activates transcription from the dlsT(yhaO)-yhaM operon. No other DNA target was identified in strain K12 / BW25113. Thiosulfate does not activate its transcription function. Overexpression doubles hydrogen sulfide production in the presence of cysteine. (152 aa) |
| | mdlA | Putative multidrug ABC transporter ATPase; Protein involved in response to drug; Belongs to the ABC transporter superfamily. Drug exporter-2 (TC 3.A.1.117) family. (590 aa) |
| | mdlB | Putative multidrug ABC transporter ATPase; Belongs to the ABC transporter superfamily. Drug exporter-2 (TC 3.A.1.117) family. (593 aa) |
| | ybaK | Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase; Functions in trans to edit the amino acid from incorrectly charged Cys-tRNA(Pro) via a Cys-tRNA(Pro) deacylase activity. May compensate for the lack of Cys-tRNA(Pro) editing by ProRS. Is also able to deacylate Cys-tRNA(Cys), and displays weak deacylase activity in vitro against Gly-tRNA(Gly), as well as, at higher concentrations, some other correctly charged tRNAs. Unlike some of its orthologs it is not able to remove the amino acid moiety from incorrectly charged Ala- tRNA(Pro); Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. (159 aa) |
| | ybaP | TraB family protein; Putative ligase. (264 aa) |
| | ybaQ | Putative DNA-binding transcriptional regulator; Belongs to the VapA/VapI family. (113 aa) |
| | allS | allD operon transcriptional activator; Positive regulator essential for the expression of allD operon. Binds to the allD promoter; Belongs to the LysR transcriptional regulatory family. (308 aa) |
| | allA | Ureidoglycolate lyase, releasing urea; Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the anaerobic utilization of allantoin as sole nitrogen source. Reinforces the induction of genes involved in the degradation of allantoin and glyoxylate by producing glyoxylate. (160 aa) |
| | allR | Glyoxylate-inducible transcriptional repressor of all and gcl operons; Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS-allA intergenic region. Binding to DNA is abolished by glyoxylate. (271 aa) |
| | gcl | Glyoxylate carboligase; Catalyzes the condensation of two molecules of glyoxylate to give 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde). (593 aa) |
| | hyi | Hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde). Does not catalyze the isomerization of D-fructose to D- glucose or that of D-xylulose to D-xylose. Also does not catalyze racemization of serine, alanine, glycerate or lactate. (258 aa) |
| | glxR | Tartronate semialdehyde reductase, NADH-dependent; Protein involved in carbohydrate catabolic process, glycolate metabolic process and allantoin assimilation pathway; Belongs to the HIBADH-related family. (292 aa) |
| | ybbW | Putative allantoin transporter; Transport of allantoin. (484 aa) |
| | allB | Allantoinase; Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring; Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family. (453 aa) |
| | ybbY | Putative uracil/xanthine transporter; Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily. (433 aa) |
| | glxK | Glycerate kinase II; Protein involved in carbohydrate catabolic process, glycolate metabolic process and allantoin assimilation pathway; Belongs to the glycerate kinase type-1 family. (381 aa) |
| | allE | S-ureidoglycine aminohydrolase; Involved in the anaerobic nitrogen utilization via the assimilation of allantoin. Catalyzes the second stereospecific hydrolysis reaction (deamination) of the allantoin degradation pathway, producing S-ureidoglycolate and ammonia from S-ureidoglycine. Belongs to the UGHY family. (261 aa) |
| | allC | Allantoate amidohydrolase; Involved in the anaerobic nitrogen utilization via the assimilation of allantoin. Catalyzes specifically the hydrolysis of allantoate to yield CO2, NH3 and S- ureidoglycine, which is unstable and readily undergoes a second deamination by S-ureidoglycine aminohydrolase AllE to yield S- ureidoglycolate and NH3. In vivo, the spontaneous release of S-ureidoglycolate and ammonia from S-ureidoglycine appears to be too slow to sustain an efficient flux of nitrogen. (411 aa) |
| | allD | Ureidoglycolate dehydrogenase; AllD plays a pivotal role as a metabolic branch-point enzyme in nitrogen utilization via the assimilation of allantoin. It is able to utilize allantoin as a sole source of nitrogen under anaerobic conditions. Catalyzes the oxidation of ureidoglycolate to oxalurate. (349 aa) |
| | fdrA | Putative NAD(P)-binding acyl-CoA synthetase; Not known; multicopy suppressor of dominant negative ftsH mutations; To E.coli YahF and some, to bacterial SucD. (555 aa) |
| | ylbF | Putative anaerobic allantoin catabolic oxamate carbamoyltransferase; Putative carboxylase. (271 aa) |
| | insE1-3 | Pseudogene, DLP12 prophage;Phage or Prophage Related. (99 aa) |
| | insF1-3 | IS3 transposase B. (288 aa) |
| | ybcK | DLP12 prophage; putative recombinase. (508 aa) |
| | rhsC | Rhs protein with putative toxin domain; Rhs elements have a nonessential function. They may play an important role in the natural ecology of the cell. (1397 aa) |
| | ybfB | Putative membrane protein. (108 aa) |
| | ybfC | Uncharacterized protein YbfC; Pseudogene, Rhs family. (189 aa) |
| | ybiA | DUF1768 family protein; Catalyzes the hydrolysis of the N-glycosidic bond in the first two intermediates of riboflavin biosynthesis, which are highly reactive metabolites, yielding relatively innocuous products. Thus, can divert a surplus of harmful intermediates into relatively harmless products and pre-empt the damage these intermediates would otherwise do. Helps maintain flavin levels. May act on other substrates in vivo. Has no activity against GTP, nucleoside monophosphates or ADP-ribose. Is Required for swarming motility. (160 aa) |
| | ybiB | Putative family 3 glycosyltransferase; Putative enzyme; Belongs to the anthranilate phosphoribosyltransferase family. (320 aa) |
| | ybiC | Putative dehydrogenase; Catalyzes the NAD(P)H-dependent reduction of 2-oxoglutarate, phenylpyruvate and (4-hydroxyphenyl)pyruvate, leading to the respective 2-hydroxycarboxylate in vitro. Shows a preference for NADPH over NADH as a redox partner. Do not catalyze the reverse reactions. (361 aa) |
| | insF1-4 | IS3 transposase B. (288 aa) |
| | insE1-4 | IS3 transposase A. (99 aa) |
| | ycdU | Uncharacterized protein YcdU; Pseudogene. (328 aa) |
| | mcrA | Putative 5-methylcytosine/5-hydroxymethylcytosine-specific restriction nuclease; Restriction of 5-methyl and 5-hydroxymethylcytosines at the specific DNA sequence C(me)CGG. (277 aa) |
| | ycgV | Putative adhesion and penetration protein. (955 aa) |
| | ynbE | Lipoprotein. (61 aa) |
| | ydbL | DUF1318 family protein. (108 aa) |
| | insD1-2 | Pseudogene, autotransporter homolog; interrupted by IS2 and IS30. (301 aa) |
| | insC1-2 | IS2 repressor TnpA. (121 aa) |
| | insI1-2 | IS30 transposase; Required for the transposition of the insertion element. (383 aa) |
| | ydbD | PF10971 family putative periplasmic methylglyoxal resistance protein; To E.coli YkiA. (768 aa) |
| | ynbA | Inner membrane protein. (201 aa) |
| | ynbB | Putative CDP-diglyceride synthase; Putative phosphatidate cytidiltransferase; Protein involved in nucleobase, nucleoside and nucleotide interconversion. (298 aa) |
| | ynbC | Putative esterase. (585 aa) |
| | ynbD | Putative phosphatase inner membrane protein; Putative enzymes; Belongs to the protein-tyrosine phosphatase family. (430 aa) |
| | yddW | Liprotein, glycosyl hydrolase homolog. (439 aa) |
| | ydeM | Putative enzyme; Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family. (385 aa) |
| | ydeN | Putative Ser-type periplasmic non-aryl sulfatase; Putative sulfatase; Protein involved in sulfur metabolic process; Belongs to the sulfatase family. (560 aa) |
| | cho | Endonuclease of nucleotide excision repair; Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. In vitro, the incision activity of Cho is UvrA and UvrB dependent. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair. (295 aa) |
| | ynjI | Inner membrane protein. (346 aa) |
| | yeaK | aminoacyl-tRNA editing domain protein. (167 aa) |
| | yoaF | DUF333 family outer membrane lipoprotein. (84 aa) |
| | yebB | DUF830 family protein; To E.coli YiiX. (200 aa) |
| | yecT | Uncharacterized protein; To R.meliloti R02472. (162 aa) |
| | vsr | DNA mismatch endonuclease of very short patch repair; Deamination of 5-methylcytosine in DNA results in T/G mismatches. If unrepaired, these mismatches can lead to C-to-C transition mutations. The very short patch (VSP) repair process in E.coli counteracts the mutagenic process by repairing the mismatches in favor of the G-containing strand. This enzyme is an endonuclease that nicks double-stranded DNA within the sequence CT(AT)GN or NT(AT)GG next to the thymidine residue that is mismatched to 2'-deoxyguanosine. The incision is mismatch-dependent and strand-specific; Belongs to the vsr [...] (156 aa) |
| | dcm | DNA cytosine methyltransferase; This methylase recognizes the double-stranded sequence CCWGG, causes specific methylation on C-2 on both strands. (472 aa) |
| | yedJ | Putative HD superfamily phosphohydrolase. (231 aa) |
| | yedR | Inner membrane protein. (121 aa) |
| | yeeJ | Putative factor; Protein involved in regulation of transcription, DNA-dependent; Belongs to the intimin/invasin family. (2358 aa) |
| | insD1-3 | CP4-44 prophage; putative disrupted hemin or colicin receptor;Phage or Prophage Related; interrupted by IS2 and C-terminal deletion. (301 aa) |
| | insC1-3 | IS2 repressor TnpA. (121 aa) |
| | yegI | Protein kinase-related putative non-specific DNA-binding protein; Probable serine/threonine kinase. (648 aa) |
| | yegJ | Uncharacterized protein. (153 aa) |
| | yegK | Ser/thr phosphatase-related protein; PP2C-like phosphatase that can dephosphorylate YegI. In vitro, can hydrolyze p-nitrophenyl phosphate (pNPP) to p-nitrophenol. (253 aa) |
| | yegL | VMA domain protein. (219 aa) |
| | insE1-5 | Pseudogene, repressor for gat operon; interrupted by IS3; split galactitol utilization operon repressor, fragment 2; split galactitol utilization operon repressor, interrupted. (99 aa) |
| | insF1-5 | IS3 transposase B. (288 aa) |
| | yegT | Nucleoside transporter, low affinity; Could be involved in nucleoside transport; Belongs to the major facilitator superfamily. Nucleoside:H(+) symporter (NHS) (TC 2.A.1.10) family. (425 aa) |
| | yegU | ADP-ribosylglycohydrolase family protein; Belongs to the ADP-ribosylglycohydrolase family. (334 aa) |
| | yegV | Putative kinase; Belongs to the carbohydrate kinase PfkB family. (321 aa) |
| | yegW | Putative transcriptional regulator; Protein involved in transcription repressor activity and transcription. (248 aa) |
| | yegX | Putative family 25 glycosyl hydrolase; Belongs to the glycosyl hydrolase 25 family. (272 aa) |
| | yehI | Uncharacterized protein YehI; DUF4132 family pseudogene; defective yehI paralog; molybdate metabolism regulator, first fragment; molybdate metabolism regulator, second fragment 2; yehI' molR mutations have phenotypes and the N-terminal molR fragment of yehI' may be expressed and may have retained or evolved MolR function. (1210 aa) |
| | yehL | Putative hexameric AAA+ MoxR family ATPase; Protein involved in ATP-binding cassette (ABC) transporter activity. (362 aa) |
| | yehM | Uncharacterized protein. (759 aa) |
| | yehP | VMA domain putative YehL ATPase stimulator. (378 aa) |
| | nupX | Putative pyrimidine nucleoside transporter. (416 aa) |
| | yeiL | Putative transcriptional regulator; Transcription regulator involved in mid-term, stationary- phase viability under nitrogen starvation. Might control expression of the salvage pathways or in some other way repress the recycling of nucleobases to nucleic acids and enhance their use as general nitrogen sources during nitrogen-limited growth. (219 aa) |
| | eco | Ecotin, a serine protease inhibitor; General inhibitor of pancreatic serine proteases: inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases. The strength of inhibition does not appear to be correlated with a particular protease specificity. (162 aa) |
| | yfaP | DUF2135 family protein, putative host defense protein. (258 aa) |
| | yfaQ | Tandem DUF2300 domain protein, putative host defense protein. (549 aa) |
| | yfaT | Uncharacterized protein YfaT; Pseudogene, bacterial alpha2-macroglobulin YfaS variant family; putative membrane protein; To P.aeruginosa PA4490 and T.maritima TM0986. (207 aa) |
| | yfaA | DUF2138 family protein, putative host defense protein. (562 aa) |
| | yfaD | Transposase_31 family protein; Upon expression has no effect on RecA-independent DNA recombination, cell viability or DNA damage. (299 aa) |
| | yfcI | Transposase_31 family protein; A low activity DNA endonuclease yielding 3'-hydroxyl ends (Probable). Upon expression enhances RecA-independent DNA recombination 19-fold, concomitantly reducing viability by 98% and inducing DNA damage as measured by induction of the SOS repair response. Belongs to the Rpn/YhgA-like nuclease family. (296 aa) |
| | pbpC | Penicillin-insensitive murein repair transglycosylase; Cell wall formation. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional. (770 aa) |
| | yfhM | Bacterial alpha2-macroglobulin colonization factor ECAM; Protects the bacterial cell from host peptidases. Acts by a 'trapping' mechanism. Cleavage of the bait-region domain by host peptidases leads to a global conformational change, which results in entrapment of the host peptidase and activation of the thioester bond that covalently binds the attacking host peptidase. Trapped peptidases are still active except against very large substrates. May protect the entire periplam, including the lipoproteins anchored to the periplasmic side of the outer membrane, against intruding endopeptidases. (1653 aa) |
| | yfhR | Putative S9 family prolyl oligopeptidase; Putative enzyme (3.4.-). (284 aa) |
| | csiE | Stationary phase inducible protein. (426 aa) |
| | yfjW | Uncharacterized protein YfjW; Pseudogene, CP4-57 prophage;Phage or Prophage Related; putative pump protein. (567 aa) |
| | ypjA | Adhesin-like autotransporter; Putative ATP-binding component of a transport system. (1526 aa) |
| | pphB | Serine/threonine-specific protein phosphatase 2; Has been shown, in vitro, to act on Ser, Thr and Tyr- phosphorylated substrates; Belongs to the PPP phosphatase family. (218 aa) |
| | gudD | D-glucarate dehydratase 1; Catalyzes the dehydration of glucarate to 5-keto-4-deoxy-D- glucarate (5-kdGluc). Also acts on L-idarate; Belongs to the mandelate racemase/muconate lactonizing enzyme family. GlucD subfamily. (446 aa) |
| | gudX | Glucarate dehydratase-related protein, substrate unknown; Does not seem to have an in-vivo activity on glucarate or idarate. Its real substrate is unknown. (446 aa) |
| | gudP | Putative D-glucarate transporter; Uptake of D-glucarate; Belongs to the major facilitator superfamily. Phthalate permease family. (450 aa) |
| | yqeG | Putative transporter protein. (409 aa) |
| | insD1-4 | Pseudogene, orgA family, part of T3SS PAI ETT2 remnant. (301 aa) |
| | insC1-4 | IS2 repressor TnpA. (121 aa) |
| | xerD | Site-specific tyrosine recombinase; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from XerC binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids at ColE1 xer (or cer) and pSC101 (or [...] (298 aa) |
| | yggM | DUF1202 family putative secreted protein; Putative alpha helix chain. (335 aa) |
| | yghQ | Putative inner membrane polysaccharide flippase. (355 aa) |
| | yqhG | DUF3828 family putative periplasmic protein. (308 aa) |
| | yqhH | Outer membrane lipoprotein, Lpp paralog. (85 aa) |
| | ygiZ | Inner membrane protein. (110 aa) |
| | insC1-5 | Pseudogene; fimbrial export usher family;putative membrane; Not classified; putative membrane protein. (121 aa) |
| | insD1-5 | IS2 transposase TnpB. (301 aa) |
| | garR | Tartronate semialdehyde reductase; Catalyzes the reduction of tatronate semialdehyde to D- glycerate. (294 aa) |
| | garL | alpha-dehydro-beta-deoxy-D-glucarate aldolase; Catalyzes the reversible retro-aldol cleavage of both 5-keto- 4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde; Belongs to the HpcH/HpaI aldolase family. KDGluc aldolase subfamily. (256 aa) |
| | garP | Putative (D)-galactarate transporter; Uptake of D-galactarate; Belongs to the major facilitator superfamily. Phthalate permease family. (444 aa) |
| | garD | D-galactarate dehydrogenase; Catalyzes the dehydration of galactarate to form 5-dehydro-4- deoxy-D-glucarate. (523 aa) |
| | yhbX | Putative EptAB family phosphoethanolamine transferase, inner membrane protein; Probably does not transfer phosphoethanolamine to lipid A. Belongs to the phosphoethanolamine transferase family. (541 aa) |
| | sfsB | malPQ operon transcriptional activator; This protein is involved in positive regulation of the metabolism of sugars. (92 aa) |
| | yrbL | Mg(2+)-starvation-stimulated protein. (210 aa) |
| | yrdA | Bacterial transferase hexapeptide domain protein; Putative transferase; Belongs to the gamma-class carbonic anhydrase family. (184 aa) |
| | yhgE | DUF4153 family putative inner membrane protein; Putative transport. (574 aa) |
| | rtcB | RNA-splicing ligase; GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair. Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends. Also acts as a DNA ligase in case of DNA damage by splicing 'dirty' DNA breaks, characterized by 3'- phosphate (or cyclic-phosphate) and 5'-hydroxy ends that cannot be sealed by classical DNA ligases. (408 aa) |
| | rtcR | Sigma 54-dependent transcriptional regulator of rtcBA expression; Transcriptional repressor of the rtcAB genes. Interacts with sigma-54. (532 aa) |
| | rhsB | Rhs protein with DUF4329 family putative toxin domain; Rhs elements have a nonessential function. They may play an important role in the natural ecology of the cell; Belongs to the RHS family. (1411 aa) |
| | yhhH | Putative NTF2 fold immunity protein for polymorphic toxin RhsB. (127 aa) |
| | yhjV | Putative transporter protein. (423 aa) |
| | insJ | IS150 transposase A; Belongs to the IS150/IS1296 orfA family. (173 aa) |
| | insK | IS150 transposase B; Involved in the transposition of the insertion sequence IS150; Belongs to the transposase IS3/IS150/IS904 family. (283 aa) |
| | yiaV | Signal-anchored membrane fusion protein (MFP) component of efflux pump; Putative membrane protein. (378 aa) |
| | yiaW | DUF3302 family inner membrane protein. (107 aa) |
| | rhsA | Rhs protein with putative toxin 55 domain; Rhs elements have a nonessential function. They may play an important role in the natural ecology of the cell; Belongs to the RHS family. (1377 aa) |
| | yibA | Putative immunity protein for polymorphic toxin RhsA; HEAT-domain protein; lethality reduction protein. (280 aa) |
| | yibG | Uncharacterized protein YibG; Rhs-family protein. (153 aa) |
| | yidF | Putative Cys-type oxidative YidJ-maturating enzyme; Putative transcriptional regulator. (165 aa) |
| | yidG | Inner membrane protein. (120 aa) |
| | yidH | DUF202 family inner membrane protein. (115 aa) |
| | yidI | Inner membrane protein. (149 aa) |
| | yidJ | Sulfatase/phosphatase superfamily protein; Putative sulfatase; Protein involved in sulfur metabolic process; Belongs to the sulfatase family. (497 aa) |
| | yidK | Putative cotransporter. (571 aa) |
| | yidL | Putative ARAC-type regulatory protein; Protein involved in transcription activator activity and transcription. (297 aa) |
| | yidB | DUF937 family protein. (132 aa) |
| | mdtL | Multidrug efflux system protein; Confers resistance to chloramphenicol. Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2.A.1.2.22) subfamily. (391 aa) |
| | yidZ | Putative DNA-binding transcriptional regulator; Involved in anaerobic NO protection. (319 aa) |
| | aslB | Putative AslA-specific sulfatase-maturating enzyme; Putative arylsulfatase regulator; Protein involved in sulfur metabolic process and protein folding; Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family. (411 aa) |
| | aslA | Putative Ser-type periplasmic non-aryl sulfatase; No E.coli strains have been observed to have an arylsulfatase activity. A 'latent' activity has been observed by heterologous expression of a genomic region linked to tynA, but it does not map near aslA; Belongs to the sulfatase family. (551 aa) |
| | xerC | Site-specific tyrosine recombinase; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from XerD binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids at ColE1 xer (or cer) and pSC101 (or [...] (298 aa) |
| | yihL | Putative transcriptional regulator; Protein involved in transcription repressor activity and transcription. (236 aa) |
| | yihM | Putative sugar phosphate isomerase. (326 aa) |
| | yihN | MFS transporter family protein; Putative resistance protein (transport); Belongs to the major facilitator superfamily. (421 aa) |
| | yijE | EamA-like transporter family protein; Involved in response to cystine. Overexpression confers tolerance to excess cystine; Belongs to the EamA transporter family. (301 aa) |
| | eptC | LPS heptose I phosphoethanolamine transferase; Catalyzes the addition of a phosphoethanolamine moiety to the outer membrane lipopolysaccharide core; Belongs to the phosphoethanolamine transferase family. EptC/CptA subfamily. (577 aa) |
| | yjaH | DUF1481 family putative lipoprotein. (231 aa) |
| | adiC | Arginine:agmatine antiporter; Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach (By similarity). Exchanges extracellular arginine for its intracellular decarboxylation product agmatine (Agm) thereby expelling intracellular protons. (445 aa) |
| | adiY | Adi system transcriptional activator; Putative ARAC-type regulatory protein; Protein involved in transcription activator activity and transcription. (253 aa) |
| | yjfZ | Uncharacterized protein. (264 aa) |
| | insC1-6 | Pseudogene, integrase homology;IS, phage, Tn; Phage-related functions and prophages; KpLE2 phage-like element; P4-like integrase. (121 aa) |
| | insD1-6 | IS2 transposase TnpB. (301 aa) |
| | insI1-3 | Pseudogene, IS911 transposase B;IS, phage, Tn; Transposon-related functions; extrachromosomal; transposon related. (383 aa) |
| | kptA | RNA 2'-phosphotransferase; Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''- cyclic phosphate (APPR>P). May function as an ADP-ribosylase. (184 aa) |
| | yjiJ | DUF1228 family putative inner membrane MFS superfamily transporter; Putative transport protein. (392 aa) |
| | yjiK | SdiA-regulated family putative membrane-anchored protein; putative phytase-like esterase. (286 aa) |
| | mcrC | Protein McrC; Modifies the specificity of McrB restriction by expanding the range of modified sequences restricted. Does not bind to DNA. (348 aa) |
| | mcrB | 5-methylcytosine-specific restriction enzyme McrBC, subunit McrB; Recognizes N4- and C5-methylcytosine (and 5-hydroxy- methylcytosines) produced by a broad range of DNA methylases and appears to act against 5-methylcytosine preceded by a purine residue. Binds to DNA containing methylated cytosines; also binds to GTP. Isoform 33 kDa is less active than isoform 51 kDa and may play a role in regulating the activity of isoform 51 kDa by competing with it in DNA and protein binding abilities. (459 aa) |
| | hsdS | Specificity determinant for hsdM and hsdR; The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. In the presence of the R subunit the complex can also act as an endonuclease, binding to the same target sequence but cutting the DNA some distance from this site. Whether the DNA is cut or modified depends on the methylation state of the target sequence. When the target site is unmodified, the DNA is cut. When the target site is hemimethylated, the complex acts as a maintenance M [...] (464 aa) |
| | hsdM | DNA methyltransferase M; The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. In the presence of the R subunit the complex can also act as an endonuclease, binding to the same target sequence but cutting the DNA some distance from this site. Whether the DNA is cut or modified depends on the methylation state of the target sequence. When the target site is unmodified, the DNA is cut. When the target site is hemimethylated, the complex acts as a maintenance MTase modifying the [...] (529 aa) |
| | hsdR | Endonuclease R Type I restriction enzyme; The EcoKI enzyme recognizes 5'-AACN(6)GTGC-3'. Subunit R is required for both nuclease and ATPase activities, but not for modification; Belongs to the HsdR family. (1170 aa) |
| | mrr | Methylated adenine and cytosine restriction protein; Involved in the acceptance of foreign DNA which is modified. Restricts both adenine- and cytosine-methylated DNA. (304 aa) |
| | yjjQ | Putative regulator. (241 aa) |
| | bglJ | Bgl operon transcriptional activator; A crytic transcriptional activator. When its expression is induced it relieves H-NS repression of the bgl operon. Acts independently of transcription factor LeuO. (225 aa) |
| | yjjJ | Putative protein kinase; Toxic when overexpressed in E.coli, leading to long filamentous cells. The toxic effect is neutralized by non-cognate antitoxin HipB. Does not seem to inhibit DNA, RNA or protein synthesis, and unlike paralogous toxin HipA its toxic activity is not counteracted by overexpression of GltX. Binds DNA. Might be a protein kinase (By similarity). (443 aa) |
| | rtcA | RNA 3'-terminal phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing; Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily. (338 aa) |
| | yehK | Uncharacterized protein. (105 aa) |
| | ylbE | NO-induced DUF1116 protein; To E.coli YahG. (419 aa) |
| | ykfM | Lethality reduction protein, putative inner membrane protein. (159 aa) |
| | ybfK | Uncharacterized protein. (85 aa) |
