STRINGSTRING
leuO leuO ybcK ybcK rhsC rhsC ybfB ybfB ybfC ybfC ybiC ybiC ycgV ycgV yddW yddW ydeM ydeM ydeN ydeN ynjI ynjI yoaF yoaF yebB yebB yecT yecT yeeJ yeeJ yegI yegI yegJ yegJ yegK yegK yegL yegL yegT yegT yegU yegU yegV yegV yegW yegW yegX yegX nupX nupX yeiL yeiL eco eco yfhR yfhR csiE csiE ypjA ypjA yqeG yqeG yghQ yghQ yqhG yqhG yqhH yqhH ygiZ ygiZ yhbX yhbX sfsB sfsB yrbL yrbL yrdA yrdA yhgE yhgE rhsB rhsB yhhH yhhH yhjV yhjV yiaV yiaV yiaW yiaW rhsA rhsA yibA yibA yibG yibG yidF yidF yidG yidG yidH yidH yidI yidI yidJ yidJ yidK yidK yidL yidL yidB yidB mdtL mdtL yidZ yidZ aslB aslB aslA aslA yihL yihL yihM yihM yihN yihN yijE yijE eptC eptC yjaH yjaH adiC adiC adiY adiY yjfZ yjfZ yjiJ yjiJ yjiK yjiK yjjQ yjjQ bglJ bglJ ykfM ykfM
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
leuOGlobal transcription factor; A global transcription factor. Activates transcription of the 9 following operons; yjjQ-bglJ, yjjP, acrEF, ybdO, yjcRQP, casABCDE12, rhsD-ybbC, fepE and gltF, in most cases it probably interferes with silencing by H-NS and activates transcription. Represses transcription of the 3 following operons; uxaCA, sdaCB and btsT. H-NS repression of the bgl operon, leading to the ability to metabolize some beta- glucosides. It also directly activates the bgl operon. Activation is H- NS and BglJ-RcsB independent. (314 aa)
ybcKDLP12 prophage; putative recombinase. (508 aa)
rhsCRhs protein with putative toxin domain; Rhs elements have a nonessential function. They may play an important role in the natural ecology of the cell. (1397 aa)
ybfBPutative membrane protein. (108 aa)
ybfCUncharacterized protein YbfC; Pseudogene, Rhs family. (189 aa)
ybiCPutative dehydrogenase; Catalyzes the NAD(P)H-dependent reduction of 2-oxoglutarate, phenylpyruvate and (4-hydroxyphenyl)pyruvate, leading to the respective 2-hydroxycarboxylate in vitro. Shows a preference for NADPH over NADH as a redox partner. Do not catalyze the reverse reactions. (361 aa)
ycgVPutative adhesion and penetration protein. (955 aa)
yddWLiprotein, glycosyl hydrolase homolog. (439 aa)
ydeMPutative enzyme; Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family. (385 aa)
ydeNPutative Ser-type periplasmic non-aryl sulfatase; Putative sulfatase; Protein involved in sulfur metabolic process; Belongs to the sulfatase family. (560 aa)
ynjIInner membrane protein. (346 aa)
yoaFDUF333 family outer membrane lipoprotein. (84 aa)
yebBDUF830 family protein; To E.coli YiiX. (200 aa)
yecTUncharacterized protein; To R.meliloti R02472. (162 aa)
yeeJPutative factor; Protein involved in regulation of transcription, DNA-dependent; Belongs to the intimin/invasin family. (2358 aa)
yegIProtein kinase-related putative non-specific DNA-binding protein; Probable serine/threonine kinase. (648 aa)
yegJUncharacterized protein. (153 aa)
yegKSer/thr phosphatase-related protein; PP2C-like phosphatase that can dephosphorylate YegI. In vitro, can hydrolyze p-nitrophenyl phosphate (pNPP) to p-nitrophenol. (253 aa)
yegLVMA domain protein. (219 aa)
yegTNucleoside transporter, low affinity; Could be involved in nucleoside transport; Belongs to the major facilitator superfamily. Nucleoside:H(+) symporter (NHS) (TC 2.A.1.10) family. (425 aa)
yegUADP-ribosylglycohydrolase family protein; Belongs to the ADP-ribosylglycohydrolase family. (334 aa)
yegVPutative kinase; Belongs to the carbohydrate kinase PfkB family. (321 aa)
yegWPutative transcriptional regulator; Protein involved in transcription repressor activity and transcription. (248 aa)
yegXPutative family 25 glycosyl hydrolase; Belongs to the glycosyl hydrolase 25 family. (272 aa)
nupXPutative pyrimidine nucleoside transporter. (416 aa)
yeiLPutative transcriptional regulator; Transcription regulator involved in mid-term, stationary- phase viability under nitrogen starvation. Might control expression of the salvage pathways or in some other way repress the recycling of nucleobases to nucleic acids and enhance their use as general nitrogen sources during nitrogen-limited growth. (219 aa)
ecoEcotin, a serine protease inhibitor; General inhibitor of pancreatic serine proteases: inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases. The strength of inhibition does not appear to be correlated with a particular protease specificity. (162 aa)
yfhRPutative S9 family prolyl oligopeptidase; Putative enzyme (3.4.-). (284 aa)
csiEStationary phase inducible protein. (426 aa)
ypjAAdhesin-like autotransporter; Putative ATP-binding component of a transport system. (1526 aa)
yqeGPutative transporter protein. (409 aa)
yghQPutative inner membrane polysaccharide flippase. (355 aa)
yqhGDUF3828 family putative periplasmic protein. (308 aa)
yqhHOuter membrane lipoprotein, Lpp paralog. (85 aa)
ygiZInner membrane protein. (110 aa)
yhbXPutative EptAB family phosphoethanolamine transferase, inner membrane protein; Probably does not transfer phosphoethanolamine to lipid A. Belongs to the phosphoethanolamine transferase family. (541 aa)
sfsBmalPQ operon transcriptional activator; This protein is involved in positive regulation of the metabolism of sugars. (92 aa)
yrbLMg(2+)-starvation-stimulated protein. (210 aa)
yrdABacterial transferase hexapeptide domain protein; Putative transferase; Belongs to the gamma-class carbonic anhydrase family. (184 aa)
yhgEDUF4153 family putative inner membrane protein; Putative transport. (574 aa)
rhsBRhs protein with DUF4329 family putative toxin domain; Rhs elements have a nonessential function. They may play an important role in the natural ecology of the cell; Belongs to the RHS family. (1411 aa)
yhhHPutative NTF2 fold immunity protein for polymorphic toxin RhsB. (127 aa)
yhjVPutative transporter protein. (423 aa)
yiaVSignal-anchored membrane fusion protein (MFP) component of efflux pump; Putative membrane protein. (378 aa)
yiaWDUF3302 family inner membrane protein. (107 aa)
rhsARhs protein with putative toxin 55 domain; Rhs elements have a nonessential function. They may play an important role in the natural ecology of the cell; Belongs to the RHS family. (1377 aa)
yibAPutative immunity protein for polymorphic toxin RhsA; HEAT-domain protein; lethality reduction protein. (280 aa)
yibGUncharacterized protein YibG; Rhs-family protein. (153 aa)
yidFPutative Cys-type oxidative YidJ-maturating enzyme; Putative transcriptional regulator. (165 aa)
yidGInner membrane protein. (120 aa)
yidHDUF202 family inner membrane protein. (115 aa)
yidIInner membrane protein. (149 aa)
yidJSulfatase/phosphatase superfamily protein; Putative sulfatase; Protein involved in sulfur metabolic process; Belongs to the sulfatase family. (497 aa)
yidKPutative cotransporter. (571 aa)
yidLPutative ARAC-type regulatory protein; Protein involved in transcription activator activity and transcription. (297 aa)
yidBDUF937 family protein. (132 aa)
mdtLMultidrug efflux system protein; Confers resistance to chloramphenicol. Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2.A.1.2.22) subfamily. (391 aa)
yidZPutative DNA-binding transcriptional regulator; Involved in anaerobic NO protection. (319 aa)
aslBPutative AslA-specific sulfatase-maturating enzyme; Putative arylsulfatase regulator; Protein involved in sulfur metabolic process and protein folding; Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family. (411 aa)
aslAPutative Ser-type periplasmic non-aryl sulfatase; No E.coli strains have been observed to have an arylsulfatase activity. A 'latent' activity has been observed by heterologous expression of a genomic region linked to tynA, but it does not map near aslA; Belongs to the sulfatase family. (551 aa)
yihLPutative transcriptional regulator; Protein involved in transcription repressor activity and transcription. (236 aa)
yihMPutative sugar phosphate isomerase. (326 aa)
yihNMFS transporter family protein; Putative resistance protein (transport); Belongs to the major facilitator superfamily. (421 aa)
yijEEamA-like transporter family protein; Involved in response to cystine. Overexpression confers tolerance to excess cystine; Belongs to the EamA transporter family. (301 aa)
eptCLPS heptose I phosphoethanolamine transferase; Catalyzes the addition of a phosphoethanolamine moiety to the outer membrane lipopolysaccharide core; Belongs to the phosphoethanolamine transferase family. EptC/CptA subfamily. (577 aa)
yjaHDUF1481 family putative lipoprotein. (231 aa)
adiCArginine:agmatine antiporter; Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach (By similarity). Exchanges extracellular arginine for its intracellular decarboxylation product agmatine (Agm) thereby expelling intracellular protons. (445 aa)
adiYAdi system transcriptional activator; Putative ARAC-type regulatory protein; Protein involved in transcription activator activity and transcription. (253 aa)
yjfZUncharacterized protein. (264 aa)
yjiJDUF1228 family putative inner membrane MFS superfamily transporter; Putative transport protein. (392 aa)
yjiKSdiA-regulated family putative membrane-anchored protein; putative phytase-like esterase. (286 aa)
yjjQPutative regulator. (241 aa)
bglJBgl operon transcriptional activator; A crytic transcriptional activator. When its expression is induced it relieves H-NS repression of the bgl operon. Acts independently of transcription factor LeuO. (225 aa)
ykfMLethality reduction protein, putative inner membrane protein. (159 aa)
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.