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leuO leuO ybcK ybcK ybfB ybfB ybfC ybfC ybiC ybiC ynjI ynjI yecT yecT yqhG yqhG yqhH yqhH ygiZ ygiZ sfsB sfsB rhsB rhsB yhhH yhhH yibG yibG yjaH yjaH yjjQ yjjQ bglJ bglJ
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
leuOGlobal transcription factor; A global transcription factor. Activates transcription of the 9 following operons; yjjQ-bglJ, yjjP, acrEF, ybdO, yjcRQP, casABCDE12, rhsD-ybbC, fepE and gltF, in most cases it probably interferes with silencing by H-NS and activates transcription. Represses transcription of the 3 following operons; uxaCA, sdaCB and btsT. H-NS repression of the bgl operon, leading to the ability to metabolize some beta- glucosides. It also directly activates the bgl operon. Activation is H- NS and BglJ-RcsB independent. (314 aa)
ybcKDLP12 prophage; putative recombinase. (508 aa)
ybfBPutative membrane protein. (108 aa)
ybfCUncharacterized protein YbfC; Pseudogene, Rhs family. (189 aa)
ybiCPutative dehydrogenase; Catalyzes the NAD(P)H-dependent reduction of 2-oxoglutarate, phenylpyruvate and (4-hydroxyphenyl)pyruvate, leading to the respective 2-hydroxycarboxylate in vitro. Shows a preference for NADPH over NADH as a redox partner. Do not catalyze the reverse reactions. (361 aa)
ynjIInner membrane protein. (346 aa)
yecTUncharacterized protein; To R.meliloti R02472. (162 aa)
yqhGDUF3828 family putative periplasmic protein. (308 aa)
yqhHOuter membrane lipoprotein, Lpp paralog. (85 aa)
ygiZInner membrane protein. (110 aa)
sfsBmalPQ operon transcriptional activator; This protein is involved in positive regulation of the metabolism of sugars. (92 aa)
rhsBRhs protein with DUF4329 family putative toxin domain; Rhs elements have a nonessential function. They may play an important role in the natural ecology of the cell; Belongs to the RHS family. (1411 aa)
yhhHPutative NTF2 fold immunity protein for polymorphic toxin RhsB. (127 aa)
yibGUncharacterized protein YibG; Rhs-family protein. (153 aa)
yjaHDUF1481 family putative lipoprotein. (231 aa)
yjjQPutative regulator. (241 aa)
bglJBgl operon transcriptional activator; A crytic transcriptional activator. When its expression is induced it relieves H-NS repression of the bgl operon. Acts independently of transcription factor LeuO. (225 aa)
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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