(7 nodes) Mixed, incl. Domain of unknown function DUF3828, and Protein of unknown function DUF2645 network (Escherichia coli K12)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Your Input:
	leuO	Global transcription factor; A global transcription factor. Activates transcription of the 9 following operons; yjjQ-bglJ, yjjP, acrEF, ybdO, yjcRQP, casABCDE12, rhsD-ybbC, fepE and gltF, in most cases it probably interferes with silencing by H-NS and activates transcription. Represses transcription of the 3 following operons; uxaCA, sdaCB and btsT. H-NS repression of the bgl operon, leading to the ability to metabolize some beta- glucosides. It also directly activates the bgl operon. Activation is H- NS and BglJ-RcsB independent. (314 aa)
	ynjI	Inner membrane protein. (346 aa)
	yecT	Uncharacterized protein; To R.meliloti R02472. (162 aa)
	yqhG	DUF3828 family putative periplasmic protein. (308 aa)
	ygiZ	Inner membrane protein. (110 aa)
	yjjQ	Putative regulator. (241 aa)
	bglJ	Bgl operon transcriptional activator; A crytic transcriptional activator. When its expression is induced it relieves H-NS repression of the bgl operon. Acts independently of transcription factor LeuO. (225 aa)

Your Current Organism:

Escherichia coli K12

NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
bglJ	leuO	b4366	b0076	Bgl operon transcriptional activator; A crytic transcriptional activator. When its expression is induced it relieves H-NS repression of the bgl operon. Acts independently of transcription factor LeuO.	Global transcription factor; A global transcription factor. Activates transcription of the 9 following operons; yjjQ-bglJ, yjjP, acrEF, ybdO, yjcRQP, casABCDE12, rhsD-ybbC, fepE and gltF, in most cases it probably interferes with silencing by H-NS and activates transcription. Represses transcription of the 3 following operons; uxaCA, sdaCB and btsT. H-NS repression of the bgl operon, leading to the ability to metabolize some beta- glucosides. It also directly activates the bgl operon. Activation is H- NS and BglJ-RcsB independent.	0.920
bglJ	yecT	b4366	b1877	Bgl operon transcriptional activator; A crytic transcriptional activator. When its expression is induced it relieves H-NS repression of the bgl operon. Acts independently of transcription factor LeuO.	Uncharacterized protein; To R.meliloti R02472.	0.401
bglJ	ygiZ	b4366	b3027	Bgl operon transcriptional activator; A crytic transcriptional activator. When its expression is induced it relieves H-NS repression of the bgl operon. Acts independently of transcription factor LeuO.	Inner membrane protein.	0.812
bglJ	yjjQ	b4366	b4365	Bgl operon transcriptional activator; A crytic transcriptional activator. When its expression is induced it relieves H-NS repression of the bgl operon. Acts independently of transcription factor LeuO.	Putative regulator.	0.977
bglJ	ynjI	b4366	b1762	Bgl operon transcriptional activator; A crytic transcriptional activator. When its expression is induced it relieves H-NS repression of the bgl operon. Acts independently of transcription factor LeuO.	Inner membrane protein.	0.529
bglJ	yqhG	b4366	b3013	Bgl operon transcriptional activator; A crytic transcriptional activator. When its expression is induced it relieves H-NS repression of the bgl operon. Acts independently of transcription factor LeuO.	DUF3828 family putative periplasmic protein.	0.519
leuO	bglJ	b0076	b4366	Global transcription factor; A global transcription factor. Activates transcription of the 9 following operons; yjjQ-bglJ, yjjP, acrEF, ybdO, yjcRQP, casABCDE12, rhsD-ybbC, fepE and gltF, in most cases it probably interferes with silencing by H-NS and activates transcription. Represses transcription of the 3 following operons; uxaCA, sdaCB and btsT. H-NS repression of the bgl operon, leading to the ability to metabolize some beta- glucosides. It also directly activates the bgl operon. Activation is H- NS and BglJ-RcsB independent.	Bgl operon transcriptional activator; A crytic transcriptional activator. When its expression is induced it relieves H-NS repression of the bgl operon. Acts independently of transcription factor LeuO.	0.920
leuO	yjjQ	b0076	b4365	Global transcription factor; A global transcription factor. Activates transcription of the 9 following operons; yjjQ-bglJ, yjjP, acrEF, ybdO, yjcRQP, casABCDE12, rhsD-ybbC, fepE and gltF, in most cases it probably interferes with silencing by H-NS and activates transcription. Represses transcription of the 3 following operons; uxaCA, sdaCB and btsT. H-NS repression of the bgl operon, leading to the ability to metabolize some beta- glucosides. It also directly activates the bgl operon. Activation is H- NS and BglJ-RcsB independent.	Putative regulator.	0.743
yecT	bglJ	b1877	b4366	Uncharacterized protein; To R.meliloti R02472.	Bgl operon transcriptional activator; A crytic transcriptional activator. When its expression is induced it relieves H-NS repression of the bgl operon. Acts independently of transcription factor LeuO.	0.401
yecT	ygiZ	b1877	b3027	Uncharacterized protein; To R.meliloti R02472.	Inner membrane protein.	0.672
yecT	yjjQ	b1877	b4365	Uncharacterized protein; To R.meliloti R02472.	Putative regulator.	0.528
yecT	ynjI	b1877	b1762	Uncharacterized protein; To R.meliloti R02472.	Inner membrane protein.	0.810
yecT	yqhG	b1877	b3013	Uncharacterized protein; To R.meliloti R02472.	DUF3828 family putative periplasmic protein.	0.600
ygiZ	bglJ	b3027	b4366	Inner membrane protein.	Bgl operon transcriptional activator; A crytic transcriptional activator. When its expression is induced it relieves H-NS repression of the bgl operon. Acts independently of transcription factor LeuO.	0.812
ygiZ	yecT	b3027	b1877	Inner membrane protein.	Uncharacterized protein; To R.meliloti R02472.	0.672
ygiZ	yjjQ	b3027	b4365	Inner membrane protein.	Putative regulator.	0.461
ygiZ	ynjI	b3027	b1762	Inner membrane protein.	Inner membrane protein.	0.803
ygiZ	yqhG	b3027	b3013	Inner membrane protein.	DUF3828 family putative periplasmic protein.	0.528
yjjQ	bglJ	b4365	b4366	Putative regulator.	Bgl operon transcriptional activator; A crytic transcriptional activator. When its expression is induced it relieves H-NS repression of the bgl operon. Acts independently of transcription factor LeuO.	0.977
yjjQ	leuO	b4365	b0076	Putative regulator.	Global transcription factor; A global transcription factor. Activates transcription of the 9 following operons; yjjQ-bglJ, yjjP, acrEF, ybdO, yjcRQP, casABCDE12, rhsD-ybbC, fepE and gltF, in most cases it probably interferes with silencing by H-NS and activates transcription. Represses transcription of the 3 following operons; uxaCA, sdaCB and btsT. H-NS repression of the bgl operon, leading to the ability to metabolize some beta- glucosides. It also directly activates the bgl operon. Activation is H- NS and BglJ-RcsB independent.	0.743

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