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yadD yadD ybaE ybaE cof cof ybaO ybaO mdlA mdlA mdlB mdlB ybaK ybaK ybaP ybaP ybaQ ybaQ yeaK yeaK yfaD yfaD yjjJ yjjJ
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Your Input:
yadDTransposase_31 family protein; A low activity DNA endonuclease yielding 3'-hydroxyl ends (Probable). Upon expression enhances RecA-independent DNA recombination 2.9-fold, concomitantly reducing viability by 59% and inducing DNA damage as measured by induction of the SOS repair response. Belongs to the Rpn/YhgA-like nuclease family. (300 aa)
ybaEPutative ABC transporter periplasmic binding protein. (566 aa)
cofThiamine pyrimidine pyrophosphate hydrolase; Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5- hydroxymethylpyrimidine phosphate (HMP-P). Can also hydrolyze other substrates such as MeO-HMP-PP and 4-amino-2-trifluoromethyl 5- hydroxymethylpyrimidine pyrophosphate (CF3-HMP-PP) to give MeO-HMP-P and 4-amino-2-trifluoromethyl-5-hydroxymethylpyrimidine phosphate. This hydrolysis generates resistance to the antibiotics (bacimethrin, CF3- HMP) by reducing the formation of their toxic forms, 2'-methoxythiamin pyrophosphate (M [...] (272 aa)
ybaOPutative DNA-binding transcriptional regulator; Plays a role in L-cysteine detoxification. Binds to the dlsT(yhaO)-yhaM operon promoter in the presence but not absence of L- cysteine; activates transcription from the dlsT(yhaO)-yhaM operon. No other DNA target was identified in strain K12 / BW25113. Thiosulfate does not activate its transcription function. Overexpression doubles hydrogen sulfide production in the presence of cysteine. (152 aa)
mdlAPutative multidrug ABC transporter ATPase; Protein involved in response to drug; Belongs to the ABC transporter superfamily. Drug exporter-2 (TC 3.A.1.117) family. (590 aa)
mdlBPutative multidrug ABC transporter ATPase; Belongs to the ABC transporter superfamily. Drug exporter-2 (TC 3.A.1.117) family. (593 aa)
ybaKCys-tRNA(Pro)/Cys-tRNA(Cys) deacylase; Functions in trans to edit the amino acid from incorrectly charged Cys-tRNA(Pro) via a Cys-tRNA(Pro) deacylase activity. May compensate for the lack of Cys-tRNA(Pro) editing by ProRS. Is also able to deacylate Cys-tRNA(Cys), and displays weak deacylase activity in vitro against Gly-tRNA(Gly), as well as, at higher concentrations, some other correctly charged tRNAs. Unlike some of its orthologs it is not able to remove the amino acid moiety from incorrectly charged Ala- tRNA(Pro); Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. (159 aa)
ybaPTraB family protein; Putative ligase. (264 aa)
ybaQPutative DNA-binding transcriptional regulator; Belongs to the VapA/VapI family. (113 aa)
yeaKaminoacyl-tRNA editing domain protein. (167 aa)
yfaDTransposase_31 family protein; Upon expression has no effect on RecA-independent DNA recombination, cell viability or DNA damage. (299 aa)
yjjJPutative protein kinase; Toxic when overexpressed in E.coli, leading to long filamentous cells. The toxic effect is neutralized by non-cognate antitoxin HipB. Does not seem to inhibit DNA, RNA or protein synthesis, and unlike paralogous toxin HipA its toxic activity is not counteracted by overexpression of GltX. Binds DNA. Might be a protein kinase (By similarity). (443 aa)
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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