node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
mpaA | pgrR | b1326 | b1328 | Murein peptide amidase A; Involved in muropeptide degradation. Catalyzes the hydrolysis of the gamma-D-glutamyl-diaminopimelic acid (gamma-D-Glu-Dap) amide bond in the murein tripeptide L-alanyl-gamma-D-glutamyl-meso- diaminopimelic acid, leading to the formation of L-Ala-gamma-D-Glu and Dap. Has weak activity with L-Ala- gamma-D-Glu-L-Lys, MurNAc-tripeptide and gamma-D-Glu-meso-Dap. Cannot hydrolyze murein tetrapeptide ; Belongs to the peptidase M14 family. | Murein peptide degradation regulator; Regulates the expression of genes involved in peptidoglycan (PG) degradation. Could play a role in switch control between recycling and degradation of PG peptides. Negatively regulates the expression of the ycjY-ymjD-ymjC-mpaA operon by binding to the PgrR-box. In addition, other genes are predicted to be under the control of PgrR, including genes related to membrane formation and function. | 0.689 |
mpaA | ycjG | b1326 | b1325 | Murein peptide amidase A; Involved in muropeptide degradation. Catalyzes the hydrolysis of the gamma-D-glutamyl-diaminopimelic acid (gamma-D-Glu-Dap) amide bond in the murein tripeptide L-alanyl-gamma-D-glutamyl-meso- diaminopimelic acid, leading to the formation of L-Ala-gamma-D-Glu and Dap. Has weak activity with L-Ala- gamma-D-Glu-L-Lys, MurNAc-tripeptide and gamma-D-Glu-meso-Dap. Cannot hydrolyze murein tetrapeptide ; Belongs to the peptidase M14 family. | L-Ala-D/L-Glu epimerase; Catalyzes the epimerization of L-Ala-D-Glu to L-Ala-L-Glu and has a role in the recycling of the murein peptide, of which L-Ala-D-Glu is a component. Is also able to catalyze the reverse reaction and the epimerization of all the L-Ala-X dipeptides, except L-Ala-L-Arg, L-Ala- L-Lys and L-Ala-L-Pro. Is also active with L-Gly-L-Glu, L-Phe-L-Glu, and L-Ser-L-Glu, but not with L-Glu-L-Glu, L-Lys-L-Glu, L-Pro-L-Glu, L- Lys-L-Ala, or D-Ala-D-Ala; Belongs to the mandelate racemase/muconate lactonizing enzyme family. | 0.955 |
mpaA | ycjY | b1326 | b1327 | Murein peptide amidase A; Involved in muropeptide degradation. Catalyzes the hydrolysis of the gamma-D-glutamyl-diaminopimelic acid (gamma-D-Glu-Dap) amide bond in the murein tripeptide L-alanyl-gamma-D-glutamyl-meso- diaminopimelic acid, leading to the formation of L-Ala-gamma-D-Glu and Dap. Has weak activity with L-Ala- gamma-D-Glu-L-Lys, MurNAc-tripeptide and gamma-D-Glu-meso-Dap. Cannot hydrolyze murein tetrapeptide ; Belongs to the peptidase M14 family. | Uncharacterized protein YcjY; Pseudogene fragment, MhpC family. | 0.784 |
pgrR | mpaA | b1328 | b1326 | Murein peptide degradation regulator; Regulates the expression of genes involved in peptidoglycan (PG) degradation. Could play a role in switch control between recycling and degradation of PG peptides. Negatively regulates the expression of the ycjY-ymjD-ymjC-mpaA operon by binding to the PgrR-box. In addition, other genes are predicted to be under the control of PgrR, including genes related to membrane formation and function. | Murein peptide amidase A; Involved in muropeptide degradation. Catalyzes the hydrolysis of the gamma-D-glutamyl-diaminopimelic acid (gamma-D-Glu-Dap) amide bond in the murein tripeptide L-alanyl-gamma-D-glutamyl-meso- diaminopimelic acid, leading to the formation of L-Ala-gamma-D-Glu and Dap. Has weak activity with L-Ala- gamma-D-Glu-L-Lys, MurNAc-tripeptide and gamma-D-Glu-meso-Dap. Cannot hydrolyze murein tetrapeptide ; Belongs to the peptidase M14 family. | 0.689 |
pgrR | ycjG | b1328 | b1325 | Murein peptide degradation regulator; Regulates the expression of genes involved in peptidoglycan (PG) degradation. Could play a role in switch control between recycling and degradation of PG peptides. Negatively regulates the expression of the ycjY-ymjD-ymjC-mpaA operon by binding to the PgrR-box. In addition, other genes are predicted to be under the control of PgrR, including genes related to membrane formation and function. | L-Ala-D/L-Glu epimerase; Catalyzes the epimerization of L-Ala-D-Glu to L-Ala-L-Glu and has a role in the recycling of the murein peptide, of which L-Ala-D-Glu is a component. Is also able to catalyze the reverse reaction and the epimerization of all the L-Ala-X dipeptides, except L-Ala-L-Arg, L-Ala- L-Lys and L-Ala-L-Pro. Is also active with L-Gly-L-Glu, L-Phe-L-Glu, and L-Ser-L-Glu, but not with L-Glu-L-Glu, L-Lys-L-Glu, L-Pro-L-Glu, L- Lys-L-Ala, or D-Ala-D-Ala; Belongs to the mandelate racemase/muconate lactonizing enzyme family. | 0.400 |
pgrR | ycjY | b1328 | b1327 | Murein peptide degradation regulator; Regulates the expression of genes involved in peptidoglycan (PG) degradation. Could play a role in switch control between recycling and degradation of PG peptides. Negatively regulates the expression of the ycjY-ymjD-ymjC-mpaA operon by binding to the PgrR-box. In addition, other genes are predicted to be under the control of PgrR, including genes related to membrane formation and function. | Uncharacterized protein YcjY; Pseudogene fragment, MhpC family. | 0.980 |
ybdM | ybdN | b0601 | b0602 | Spo0J family protein, ParB-like nuclease domain. | PAPS reductase-like domain protein. | 0.998 |
ybdM | ybdO | b0601 | b0603 | Spo0J family protein, ParB-like nuclease domain. | Putative transcriptional regulator LYSR-type; Protein involved in transcription and regulation of transcription, DNA-dependent; Belongs to the LysR transcriptional regulatory family. | 0.490 |
ybdN | ybdM | b0602 | b0601 | PAPS reductase-like domain protein. | Spo0J family protein, ParB-like nuclease domain. | 0.998 |
ybdN | ybdO | b0602 | b0603 | PAPS reductase-like domain protein. | Putative transcriptional regulator LYSR-type; Protein involved in transcription and regulation of transcription, DNA-dependent; Belongs to the LysR transcriptional regulatory family. | 0.774 |
ybdN | yejG | b0602 | b2181 | PAPS reductase-like domain protein. | Uncharacterized protein. | 0.644 |
ybdO | ybdM | b0603 | b0601 | Putative transcriptional regulator LYSR-type; Protein involved in transcription and regulation of transcription, DNA-dependent; Belongs to the LysR transcriptional regulatory family. | Spo0J family protein, ParB-like nuclease domain. | 0.490 |
ybdO | ybdN | b0603 | b0602 | Putative transcriptional regulator LYSR-type; Protein involved in transcription and regulation of transcription, DNA-dependent; Belongs to the LysR transcriptional regulatory family. | PAPS reductase-like domain protein. | 0.774 |
ybdO | ydfV | b0603 | b1565 | Putative transcriptional regulator LYSR-type; Protein involved in transcription and regulation of transcription, DNA-dependent; Belongs to the LysR transcriptional regulatory family. | Qin prophage; uncharacterized protein. | 0.457 |
ybdO | yejG | b0603 | b2181 | Putative transcriptional regulator LYSR-type; Protein involved in transcription and regulation of transcription, DNA-dependent; Belongs to the LysR transcriptional regulatory family. | Uncharacterized protein. | 0.570 |
ybdO | ymfA | b0603 | b1122 | Putative transcriptional regulator LYSR-type; Protein involved in transcription and regulation of transcription, DNA-dependent; Belongs to the LysR transcriptional regulatory family. | DUF3592 family inner membrane protein. | 0.628 |
ybdO | yqiI | b0603 | b3048 | Putative transcriptional regulator LYSR-type; Protein involved in transcription and regulation of transcription, DNA-dependent; Belongs to the LysR transcriptional regulatory family. | Fimbrial protein; May be involved in a fimbrial system chaperoned by YqiH and exported by YqiG. | 0.514 |
ycfZ | ymfA | b1121 | b1122 | Inner membrane protein. | DUF3592 family inner membrane protein. | 0.811 |
ychE | yejG | b1242 | b2181 | UPF0056 family inner membrane protein; Putative channel protein. | Uncharacterized protein. | 0.451 |
ychE | yhcC | b1242 | b3211 | UPF0056 family inner membrane protein; Putative channel protein. | Putative Fe-S oxidoreductase, Radical SAM superfamily protein; In vitro, can cleave S-adenosyl-L-methionine into methionine and 5'-deoxyadenosine (AdoH); Belongs to the radical SAM superfamily. | 0.531 |