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satP satP yaaW yaaW yaaI yaaI insL1 insL1 fkpB fkpB rihC rihC caiF caiF caiE caiE caiD caiD caiC caiC caiB caiB caiA caiA caiT caiT fixA fixA fixB fixB fixC fixC fixX fixX yaaU yaaU yajQ yajQ pheP pheP ydiO ydiO ydiQ ydiQ ydiR ydiR ydiS ydiS ydiT ydiT yfbS yfbS yfbU yfbU yfcZ yfcZ yfgG yfgG ygcN ygcN ygcO ygcO ygcP ygcP ygcQ ygcQ ygcR ygcR ygcS ygcS ygcW ygcW yqcE yqcE yhfL yhfL yijD yijD ygcU ygcU
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
satPSuccinate-acetate transporter; Uptake of acetate and succinate. Transport is energetically dependent on the protonmotive force. (188 aa)
yaaWUPF0174 family protein; Belongs to the UPF0174 family. (237 aa)
yaaIUPF0412 family protein; Belongs to the UPF0412 family. (134 aa)
insL1IS186 transposase; Involved in the transposition of the insertion sequence IS186. (370 aa)
fkpBFKBP-type peptidyl-prolyl cis-trans isomerase (rotamase); PPIases accelerate the folding of proteins. Substrate specificity investigated with 'Suc-Ala-Xaa-Pro-Phe-4-nitroanilide' where Xaa is the amino acid tested, was found to be Phe > Leu >> Ile > Lys = Ala > Trp > His >> Gln. (149 aa)
rihCRibonucleoside hydrolase 3; Hydrolyzes both purine and pyrimidine ribonucleosides with a broad-substrate specificity with decreasing activity in the order uridine, xanthosine, inosine, adenosine, cytidine, guanosine. (304 aa)
caiFCai operon transcriptional activator; Potential transcriptional activator of carnitine metabolism. (131 aa)
caiEStimulator of CaiD and CaiB enzyme activities; Overproduction of CaiE stimulates the activity of CaiB and CaiD; Belongs to the transferase hexapeptide repeat family. (196 aa)
caiDcarnitinyl-CoA dehydratase; Catalyzes the reversible dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA. (261 aa)
caiCPutative crotonobetaine/carnitine-CoA ligase; Catalyzes the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle. Also has activity toward crotonobetaine and gamma-butyrobetaine. Belongs to the ATP-dependent AMP-binding enzyme family. (517 aa)
caiBCrotonobetainyl CoA:carnitine CoA transferase; Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl-CoA and gamma-butyrobetaine. Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA or L- carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA. Belongs to the CoA-transferase III family. CaiB subfamily. (405 aa)
caiACrotonobetaine reductase subunit II, FAD-binding; Catalyzes the reduction of crotonobetainyl-CoA to gamma- butyrobetainyl-CoA. The electron donor could be the FixA/FixB complex. (380 aa)
caiTPutative transporter; Catalyzes the exchange of L-carnitine for gamma-butyrobetaine and related betaines. (504 aa)
fixAAnaerobic carnitine reduction putative electron transfer flavoprotein subunit; Required for anaerobic carnitine reduction. May bring reductant to CaiA; Belongs to the ETF beta-subunit/FixA family. (256 aa)
fixBProtein FixB; Required for anaerobic carnitine reduction. May bring reductant to CaiA; Belongs to the ETF alpha-subunit/FixB family. (313 aa)
fixCPutative oxidoreductase; Could be part of an electron transfer system required for anaerobic carnitine reduction; Belongs to the ETF-QO/FixC family. (428 aa)
fixXPutative 4Fe-4S ferredoxin-type protein; Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster-containing protein; Belongs to the bacterial-type ferredoxin family. FixX subfamily. (95 aa)
yaaUPutative MFS sugar transporter; Putative transport protein. (443 aa)
yajQPhage Phi6 host factor, ATP/GTP binding protein; Binds nucleotides, may bind tRNA. (163 aa)
phePPhenylalanine transporter; Permease that is involved in the transport across the cytoplasmic membrane of phenylalanine; Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family. (458 aa)
ydiOPutative acyl-CoA dehydrogenase; Putative oxidoreductase; Belongs to the acyl-CoA dehydrogenase family. (383 aa)
ydiQPutative electron transfer flavoprotein subunit; May play a role in a redox process; Belongs to the ETF beta-subunit/FixA family. (254 aa)
ydiRPutative electron transfer flavoprotein, FAD-binding subunit; May play a role in a redox process; Belongs to the ETF alpha-subunit/FixB family. (312 aa)
ydiSPutative oxidoreductase; Probably accepts electrons from YdiQ/YdiR and reduces a quinone; Belongs to the ETF-QO/FixC family. (429 aa)
ydiTPutative 3Fe-4S ferredoxin-type protein; Could be a 3Fe-4S cluster-containing protein. Probably participates in a redox process with YdiQ, YdiR and YdiS. (97 aa)
yfbSPutative transport protein. (610 aa)
yfbUUPF0304 family protein. (164 aa)
yfcZUPF0381 family protein; Belongs to the UPF0381 family. (94 aa)
yfgGUncharacterized protein. (63 aa)
ygcNPutative oxidoreductase; Probably accepts electrons from YgcQ/YgcR and reduces a quinone; Belongs to the ETF-QO/FixC family. (423 aa)
ygcOPutative 4Fe-4S cluster-containing protein; Could be a 3Fe-4S cluster-containing protein. Probably participates in a redox process with YgcN, YgcQ and YgcR. (86 aa)
ygcPPutative anti-terminator regulatory protein. (191 aa)
ygcQPutative flavoprotein; May play a role in a redox process; Belongs to the ETF alpha-subunit/FixB family. (286 aa)
ygcRPutative flavoprotein; May play a role in a redox process. (259 aa)
ygcSPutative MFS sugar transporter; Putative transport protein. (445 aa)
ygcWPutative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (261 aa)
yqcEPutative MFS transporter, inner membrane protein; Putative transport protein. (425 aa)
yhfLSmall lipoprotein. (55 aa)
yijDDUF1422 family inner membrane protein. (119 aa)
ygcUPutative FAD-linked oxidoreductase; Belongs to the FAD-binding oxidoreductase/transferase type 4 family. (484 aa)
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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