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yaeI yaeI yafT yafT maa maa hha hha tomB tomB ybbC ybbC quuD quuD essD essD rrrD rrrD rzpD rzpD insL1-2 insL1-2 ybfD ybfD cspH cspH cspG cspG ymcE ymcE stfR stfR tfaR tfaR pinR pinR ynaE ynaE ydfK ydfK pinQ pinQ tfaQ tfaQ stfQ stfQ ynfN ynfN cspI cspI rzpQ rzpQ rrrQ rrrQ ydfR ydfR essQ essQ cspB cspB cspF cspF quuQ quuQ rem rem flxA flxA clcB clcB yhhI yhhI ldrA ldrA ldrB ldrB ldrC ldrC rzoD rzoD gnsA gnsA rzoR rzoR rzoQ rzoQ iroK iroK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
yaeIPhosphodiesterase with model substrate bis-pNPP; Shows phosphodiesterase activity, hydrolyzing phosphodiester bond in the artificial chromogenic substrate bis-p-nitrophenyl phosphate (bis-pNPP); Belongs to the metallophosphoesterase superfamily. (270 aa)
yafTLipoprotein; Putative aminopeptidase. (261 aa)
maaMaltose O-acetyltransferase; Catalyzes the CoA-dependent transfer of an acetyl group to maltose and other sugars. Acetylates glucose exclusively at the C6 position and maltose at the C6 position of the non-reducing end glucosyl moiety. Is able to acetylate maltooligosaccharides ; Belongs to the transferase hexapeptide repeat family. (183 aa)
hhaModulator of gene expression, with H-NS; Down-regulates hemolysin (hly) expression in complex with H- NS. Stimulates transposition events in vivo. Modifies the set of genes regulated by H-NS; Hha and Cnu (YdgT) increase the number of genes DNA bound by H-NS/StpA and may also modulate the oligomerization of the H-NS/StpA-complex. Binds DNA and influences DNA topology in response to environmental stimuli; does not however interact with DNA in the absence of H-NS. Involved in persister cell formation, acting downstream of mRNA interferase (toxin) MqsR. Decreases biofilm formation by repre [...] (72 aa)
tomBHha toxicity attenuator; Attenuates Hha toxicity and regulates biofilm formation. Binds to various coding and intergenic regions of genomic DNA. (124 aa)
ybbCPutative immunity protein. (122 aa)
quuDDLP12 prophage; Positively regulate expression of some phage genes. Bacterial host RNA polymerase modified by antitermination proteins transcribes through termination sites that otherwise prevent expression of the regulated genes (By similarity); Belongs to the phage antitermination Q type 1 family. (127 aa)
essDDLP12 prophage; putative phage lysis protein. (71 aa)
rrrDDLP12 prophage; Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity. Exhibits lytic activity against E.coli and S.typhi cell wall substrate; Belongs to the glycosyl hydrolase 24 family. (165 aa)
rzpDDLP12 prophage; Necessary for host cell lysis. It is believed to code for an endopeptidase that cleaves the amino-carboxyl cross-link between the diaminopimelic acid and D-alanine residues in the murein component of the bacterial cell wall (By similarity). (153 aa)
insL1-2IS186 transposase. (370 aa)
ybfDH repeat-associated putative transposase YbfD; Pseudogene, DDE domain transposase family;putative factor; Not classified; putative receptor protein; Belongs to the transposase 11 family. (253 aa)
cspHStress protein, member of the CspA-family; Cold shock-like protein; Protein involved in response to temperature stimulus. (70 aa)
cspGHomolog of Salmonella cold shock protein; Protein involved in response to temperature stimulus. (70 aa)
ymcECold shock gene; Suppresses fabA and ts growth mutation. (76 aa)
stfRRac prophage; putative tail fiber protein; Belongs to the tail fiber family. (1120 aa)
tfaRRac prophage; Tail fiber assembly protein homolog from lambdoid prophage Rac; Belongs to the tfa family. (191 aa)
pinRRac prophage; putative site-specific recombinase. (196 aa)
ynaECold shock protein, Rac prophage. (77 aa)
ydfKCold shock protein YdfK; Cryptic prophage Qin/Kim. (77 aa)
pinQQin prophage; putative site-specific recombinase; Belongs to the site-specific recombinase resolvase family. (196 aa)
tfaQQin prophage; Tail fiber assembly protein homolog from lambdoid prophage Qin; Belongs to the tfa family. (191 aa)
stfQQin prophage; putative side tail fibre assembly protein; Belongs to the tail fiber family. (320 aa)
ynfNQin prophage; cold shock-induced protein. (51 aa)
cspIQin prophage; Cold shock-like protein. (70 aa)
rzpQRz-like protein, Qin prophage; Completely contained in another CDS. (165 aa)
rrrQQin prophage; Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity; Belongs to the glycosyl hydrolase 24 family. (177 aa)
ydfRQin prophage; uncharacterized protein. (103 aa)
essQQin prophage; putative S lysis protein; Belongs to the lambda phage S protein family. (71 aa)
cspBQin prophage; cold shock protein. (71 aa)
cspFQin prophage; cold shock protein. (70 aa)
quuQQin prophage; Positively regulate expression of some phage genes. Bacterial host RNA polymerase modified by antitermination proteins transcribes through termination sites that otherwise prevent expression of the regulated genes (By similarity). (250 aa)
remQin prophage; uncharacterized protein. (83 aa)
flxAQin prophage; uncharacterized protein. (110 aa)
clcBH(+)/Cl(-) exchange transporter; Probably acts as an electrical shunt for an outwardly- directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response. Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily. (418 aa)
yhhIH repeat-associated putative transposase YhhI; Pseudogene fragment; Belongs to the transposase 11 family. (378 aa)
ldrAToxic polypeptide, small; Toxic component of a type I toxin-antitoxin (TA) system. Inhibits ATP synthesis possibly due to its insertion in the cell inner membrane, ATP levels drop over 50% 2 minutes after induction. Overexpression is toxic leading to cell death, it inhibits cell growth within 30 minutes; C-terminally tagged versions of the protein are toxic while N-terminally tagged versions are not. (35 aa)
ldrBToxic polypeptide, small; Toxic component of a type I toxin-antitoxin (TA) system. Overexpression causes rapid cell killing, probably by disrupting the cell inner membrane and disruption of ATP synthesis. (35 aa)
ldrCSmall toxic polypeptide. (35 aa)
rzoDDLP12 prophage; Component of the spanin complex that disrupts the outer membrane and causes cell lysis during virus exit. The spanin complex conducts the final step in cell lysis by disrupting the outer membrane after holin and endolysin action have permeabilized the inner membrane and degraded the host peptidoglycans (By similarity); Belongs to the lambdalikevirus o-spanin family. (60 aa)
gnsAPutative phosphatidylethanolamine synthesis regulator; Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold- sensitive secG null mutation; Belongs to the gns family. (57 aa)
rzoRProphage outer membrane lipoprotein RzoR; Component of the spanin complex that disrupts the outer membrane and causes cell lysis during virus exit. The spanin complex conducts the final step in cell lysis by disrupting the outer membrane after holin and endolysin action have permeabilized the inner membrane and degraded the host peptidoglycans (By similarity). (61 aa)
rzoQPutative Rz1-like lipoprotein, Qin prophage; Completely contained in another CDS. (84 aa)
iroK3-hydroxypropionic acid resistance peptide; Completely contained in another CDS. (21 aa)
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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