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yafV yafV iraP iraP ybaM ybaM ybcL ybcL ybcM ybcM ybcN ybcN ninE ninE ybcO ybcO rusA rusA ybcV ybcV ybcW ybcW appY appY ycaQ ycaQ ycaR ycaR ycbJ ycbJ yceO yceO iraM iraM ycgX ycgX bluR bluR bluF bluF ycgZ ycgZ ymgA ymgA ariR ariR ymgC ymgC tpr tpr rssB rssB yciN yciN ydfO ydfO ydfU ydfU yniB yniB yoaI yoaI yegH yegH yqgB yqgB ilvY ilvY iraD iraD yjjY yjjY blr blr ylcG ylcG ymgF ymgF yniD yniD yohO yohO ylcH ylcH yneM yneM ypfM ypfM ythA ythA azuC azuC yjeV yjeV ykgR ykgR ymiB ymiB ynbG ynbG yoaJ yoaJ yoaK yoaK yobI yobI yoeI yoeI yohP yohP ypdK ypdK yqcG yqcG yqeL yqeL yqfG yqfG yrbN yrbN yshB yshB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
yafVOmega-amidase YafV; Hydrolyzes alpha-ketoglutaramate (a-KGM) to alpha- ketoglutarate (alpha-KG) and ammonia, has weak activity on L-glutamine, almost no activity on deaminated glutathione (dGSH) and none on glutathione (By similarity). May function as a metabolite repair enzyme (By similarity); Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family. (256 aa)
iraPanti-RssB factor, RpoS stabilzer during Pi starvation; Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during phosphate starvation, but also in stationary phase and during nitrogen starvation. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway; Belongs to the IraP family. (86 aa)
ybaMDUF2496 family protein. (53 aa)
ybcLInactive polymorphonuclear leukocyte migration suppressor; DLP12 prophage; UPF0098 family secreted protein. (183 aa)
ybcMDLP12 prophage; Putative ARAC-type regulatory protein. (265 aa)
ybcNDLP12 prophage; uncharacterized protein. (151 aa)
ninEDLP12 prophage; Similar to phage 82 and lambda proteins. (56 aa)
ybcODLP12 prophage; Based on its fold and a conserved His residue, has been predicted to be a nuclease; Belongs to the YbcO family. (96 aa)
rusADLP12 prophage; Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of CC dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC. (120 aa)
ybcVDLP12 prophage; Putative an envelop protein. (136 aa)
ybcWDLP12 prophage; uncharacterized protein. (68 aa)
appYHTH-type transcriptional regulator AppY; Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions. (249 aa)
ycaQDUF1006 family protein with C-terminal wHTH domain. (410 aa)
ycaRPeroxide and acid resistance protein, UPF0434 family; Belongs to the UPF0434 family. (60 aa)
ycbJProtein kinase-like domain protein. (297 aa)
yceOUncharacterized protein. (46 aa)
iraMAnti-adapter protein IraM; Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during magnesium starvation. May also be involved in the early steps of isoprenoid biosynthesis, possibly through its role as RssB regulator. (107 aa)
ycgXDUF1398 family protein; To E.coli YbcV and YdfO. (134 aa)
bluRRepressor of blue light-responsive genes; Controls the expression of several small proteins that may play a role in biofilm maturation. Binds to and represses the operator of the ycgZ-ymgA-ariR-ymgC operon and also regulates ynaK. Binding is antagonized by BluF upon blue light (470 nm) irradiation. Blue light may increase the affinity of BluF for BluR, allowing it to be released from its operator. (243 aa)
bluFAnti-repressor for YcgE, blue light-responsive; Binds to and releases the BluR repressor from its bound DNA target in a blue light-dependent (470 nm) fashion. A shift to low temperature also triggers a BluF-mediated relief of repression by BluR, suggesting BluF may serve as a thermometer. Blue light may act to increase the affinity of BluF for BluR, allowing it to be released from its operator. The protein has a reversible photocycle, and undergoes structural changes, probably in the EAL domain, in response to light. (403 aa)
ycgZRcsB connector protein for regulation of biofilm and acid-resistance; Probably a connector protein for RcsB/C regulation of biofilm formation, providing additional signal input into the two-component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component. (78 aa)
ymgARcsB connector protein for regulation of biofilm; Probably a connector protein for RcsB/C regulation of biofilm formation, providing additional signal input into the two-component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB. (90 aa)
ariRRcsB connector protein for regulation of biofilm and acid-resistance; Probably a connector protein for RcsB/C regulation of biofilm and acid-resistance, providing additional signal input into the two- component signaling pathway. May serve to stimulate biofilm maturation, via the Rcs phosphorelay. Regulates expression of genes involved in acid-resistance and biofilm formation, including the RcsB/C two- component system. May be a non-specific DNA-binding protein that binds genes and/or intergenic regions via a geometric recognition. Also confers resistance to H(2)O(2). Overexpression at [...] (88 aa)
ymgCBlue light, low temperature and stress induced protein. (82 aa)
tprA protamine-like protein. (29 aa)
rssBPcnB-degradosome interaction factor; Regulates the turnover of the sigma S factor (RpoS) by promoting its proteolysis in exponentially growing cells. Acts by binding and delivering RpoS to the ClpXP protease. RssB is not co- degraded with RpoS, but is released from the complex and can initiate a new cycle of RpoS recognition and degradation. In stationary phase, could also act as an anti-sigma factor and reduce the ability of RpoS to activate gene expression. Is also involved in the regulation of the mRNA polyadenylation pathway during stationary phase, probably by maintaining the asso [...] (337 aa)
yciNDUF2498 protein YciN. (83 aa)
ydfOQin prophage; uncharacterized protein; To E.coli YbcV and YcgX. (136 aa)
ydfUQin prophage; uncharacterized protein. (349 aa)
yniBPutative inner membrane protein. (178 aa)
yoaIUncharacterized protein. (34 aa)
yegHInner membrane protein; Putative transport protein. (527 aa)
yqgBUncharacterized protein; Belongs to the YqgB family. (43 aa)
ilvYTranscriptional activator of ilvC; This protein activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate. IlvY is also a negative regulator of its own expression; Belongs to the LysR transcriptional regulatory family. (297 aa)
iraDRpoS stabilzer after DNA damage, anti-RssB factor; Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during oxidative stress. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway; Belongs to the GpW/Gp25 family. IraD subfamily. (130 aa)
yjjYUncharacterized protein. (46 aa)
blrBeta-lactam resistance membrane protein; Component of the cell division machinery, which is probably involved in the stabilization of the divisome under certain stress conditions. (41 aa)
ylcGUncharacterized protein, DLP12 prophage. (46 aa)
ymgFInner membrane division septum protein; Could be involved in cell division. May participate in the stabilization of the cell divisome under specific conditions. (72 aa)
yniDUncharacterized protein YniD; Pseudogene, ankyrin repeats. (35 aa)
yohOPutative membrane protein; Belongs to the UPF0387 family. (35 aa)
ylcHUncharacterized protein, DLP12 prophage. (33 aa)
yneMInner membrane-associated protein; Modulates intracellular Mg(2+) levels to maintain cellular integrity upon Mg(2+) limitation. Acts by binding and stabilizing the Mg(2+) transporter MgtA, thereby leading to increased intracellular level of Mg(2+). May inhibit FtsH proteolysis of MgtA. (31 aa)
ypfMStress-induced small enterobacterial protein. (19 aa)
ythAUncharacterized protein. (41 aa)
azuCAcid-inducible small membrane-associated protein. (28 aa)
yjeVUncharacterized protein. (17 aa)
ykgRUncharacterized protein. (33 aa)
ymiBUncharacterized protein. (34 aa)
ynbGUncharacterized protein. (21 aa)
yoaJInner membrane-associated protein. (24 aa)
yoaKInner membrane-associated protein. (32 aa)
yobIUncharacterized protein. (21 aa)
yoeIUncharacterized protein. (20 aa)
yohPUncharacterized membrane protein YohP; Pseudogene; putative channel/filament proteins. (27 aa)
ypdKInner membrane protein. (23 aa)
yqcGMembrane stress resistance protein. (46 aa)
yqeLUncharacterized protein. (26 aa)
yqfGUncharacterized protein. (41 aa)
yrbNUncharacterized protein. (26 aa)
yshBUncharacterized protein. (36 aa)
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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