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rluA rluA rsmH rsmH rlmH rlmH rlmF rlmF rlmC rlmC rlmL rlmL rluC rluC rlmI rlmI rsmC rsmC rlmB rlmB rluF rluF rsmG rsmG rlmJ rlmJ rsmJ rsmJ rsmD rsmD rsmB rsmB rlmE rlmE rsmI rsmI rlmG rlmG rsmE rsmE rlmM rlmM truC truC rlmD rlmD rluD rluD rlmN rlmN rsuA rsuA rsmF rsmF rlmA rlmA ydcP ydcP rluB rluB rluE rluE rsmA rsmA
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rluADual-specificity RNA pseudouridine synthase RluA; Dual specificity enzyme that catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs. (219 aa)
rsmH16S rRNA m(4)C1402 methyltransferase, SAM-dependent; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. In vitro, active on the assembled 30S subunit, but not naked 16S rRNA or 70S ribosomes. (313 aa)
rlmH23S rRNA m(3)Psi1915 pseudouridine methyltransferase, SAM-dependent; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA. Specific for fully assembled 70S ribosomes. Belongs to the RNA methyltransferase RlmH family. (155 aa)
rlmF23S rRNA m(6)A1618 methyltransferase, SAM-dependent; Specifically methylates the adenine in position 1618 of 23S rRNA; Belongs to the methyltransferase superfamily. METTL16/RlmF family. (308 aa)
rlmC23S rRNA m(5)U747 methyltransferase, SAM-dependent; Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily. (375 aa)
rlmL23S rRNA m(2)G2445 and m(7)G2069 methyltransferases, SAM-dependent; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Methylation occurs before assembly of 23S rRNA into 50S subunits. Belongs to the methyltransferase superfamily. RlmKL family. (702 aa)
rluC23S rRNA pseudouridine(955,2504,2580) synthase; Responsible for synthesis of pseudouridine from uracil at positions 955, 2504 and 2580 in 23S ribosomal RNA. (319 aa)
rlmI23S rRNA m(5)C1962 methyltransferase, SAM-dependent; Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA. Methylation occurs before assembly of 23S rRNA into 50S subunits; Belongs to the methyltransferase superfamily. RlmI family. (396 aa)
rsmC16S rRNA m(2)G1207 methyltransferase, SAM-dependent; Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle. (343 aa)
rlmB23S rRNA mG2251 2'-O-ribose methyltransferase, SAM-dependent; Specifically methylates the ribose of guanosine 2251 in 23S rRNA. (243 aa)
rluF23S rRNA pseudouridine(2604) synthase; Dual specificity enzyme that catalyzes the synthesis of pseudouridine from uracil-2604 in 23S ribosomal RNA and from uracil-35 in the anticodon of tRNA(Tyr). Can, to a small extent, also react with uracil-2605. Belongs to the pseudouridine synthase RsuA family. (290 aa)
rsmG16S rRNA m(7)G527 methyltransferase, SAM-dependent; Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. Requires the intact 30S subunit for methylation; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family. (207 aa)
rlmJ23S rRNA m(6)A2030 methyltransferase, SAM-dependent; Specifically methylates the adenine in position 2030 of 23S rRNA. Nascent 23S rRNA seems to be the natural substrate. Appears to be not necessary for ribosome assembly. Required for the utilization of extracellular DNA as the sole source of carbon and energy. Belongs to the RlmJ family. (280 aa)
rsmJ16S rRNA m(2)G1516 methyltransferase, SAM-dependent; Specifically methylates the guanosine in position 1516 of 16S rRNA; Belongs to the methyltransferase superfamily. RsmJ family. (250 aa)
rsmD16S rRNA m(2)G966 methyltransferase, SAM-dependent; Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle. (198 aa)
rsmB16S rRNA m(5)C967 methyltransferase, SAM-dependent; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. (429 aa)
rlmE23S rRNA U2552 2'-O-ribose methyltransferase, SAM-dependent; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. (209 aa)
rsmI16S rRNA C1402 2'-O-ribose methyltransferase, SAM-dependent; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. In vitro, active on the assembled 30S subunit, but not naked 16S rRNA or 70S ribosomes; Belongs to the methyltransferase superfamily. RsmI family. (286 aa)
rlmG23S rRNA m(2)G1835 methyltransferase, SAM-dependent; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA. (378 aa)
rsmE16S rRNA m(3)U1498 methyltransferase, SAM-dependent; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. (243 aa)
rlmM23S rRNA C2498 2'-O-ribose methyltransferase, SAM-dependent; Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA. Modifies C2498 in naked 23S rRNA, but not in assembled 50S subunits or ribosomes. (366 aa)
truCtRNA(Ile1,Asp) pseudouridine(65) synthase; Responsible for synthesis of pseudouridine from uracil-65 in transfer RNAs; Belongs to the pseudouridine synthase RluA family. (260 aa)
rlmD23S rRNA m(5)U1939 methyltransferase, SAM-dependent; Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily. (433 aa)
rluD23S rRNA pseudouridine(1911,1915,1917) synthase; Responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA. Isomerization occurs as a late step during the assembly of the large ribosomal subunit. (326 aa)
rlmNDual specificity 23S rRNA m(2)A2503, tRNA m(2)A37 methyltransferase, SAM-dependent; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity. Unmodified tRNA is not a suitable substrate for RlmN, which suggests that RlmN works in a late step during tRNA maturation. Belongs to the radical SAM superfamily. RlmN family. (384 aa)
rsuA16S rRNA pseudouridine(516) synthase; Responsible for synthesis of pseudouridine from uracil-516 in 16S ribosomal RNA; Belongs to the pseudouridine synthase RsuA family. (231 aa)
rsmF16S rRNA m(5)C1407 methyltransferase, SAM-dependent; Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA. (479 aa)
rlmA23S rRNA m(1)G745 methyltransferase, SAM-dependent; Specifically methylates the guanosine in position 745 of 23S rRNA. (269 aa)
ydcPPutative peptidase; Responsible for the formation of the 5-hydroxycytidine modification at the C2501 position (ho5C2501) of 23S rRNA. May be a Fe- S protein that catalyzes ho5C2501 formation using prephenate as a hydroxyl group donor. (653 aa)
rluB23S rRNA pseudouridine(2605) synthase; Responsible for synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA. (291 aa)
rluE23S rRNA pseudouridine(2457) synthase; Responsible for synthesis of pseudouridine from uracil-2457 in 23S ribosomal RNA; Belongs to the pseudouridine synthase RsuA family. (217 aa)
rsmA16S rRNA m(6)A1518, m(6)A1519 dimethyltransferase, SAM-dependent; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. Has also a DNA glycosylase/AP lyase activity that removes C mispaired with oxidized T from DNA, and may play a role in protection of DNA against oxidative stress. (273 aa)
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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