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| | atpA | F1 sector of membrane-bound ATP synthase, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (513 aa) |
| | atpH | F1 sector of membrane-bound ATP synthase, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (177 aa) |
| | atpF | F0 sector of membrane-bound ATP synthase, subunit b; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (156 aa) |
| | atpE | F0 sector of membrane-bound ATP synthase, subunit c; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (79 aa) |
| | atpB | F0 sector of membrane-bound ATP synthase, subunit a; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (271 aa) |
| | kup | Potassium transporter; Responsible for the low-affinity transport of potassium into the cell, with the probable concomitant uptake of protons (symport system). Can also transport cesium; Belongs to the HAK/KUP transporter (TC 2.A.72) family. (622 aa) |
| | corA | Magnesium/nickel/cobalt transporter; Mediates influx of magnesium ions. Can also mediate cobalt and manganese uptake. Alternates between open and closed states. Activated by low cytoplasmic Mg(2+) levels. Inactive when cytoplasmic Mg(2+) levels are high (By similarity). Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family. (316 aa) |
| | rhtC | Threonine efflux pump; Conducts the efflux of threonine. Belongs to the Rht family. (206 aa) |
| | rhtB | Homoserine, homoserine lactone and S-methyl-methionine efflux pump; Conducts the efflux of homoserine and homoserine lactone. Belongs to the Rht family. (206 aa) |
| | trkH | Potassium transporter; Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA. Requires TrkE (sapD) for transport activity, 20% more uptake is seen with both SapD and SapF. Transport in the absence of SapD and SapF is dependent on a high membrane potential and a high cytoplasmic ATP concentration, suggesting this protein may be able to interact with other ATP-binding proteins. Can transport potassium and rubidium. (483 aa) |
| | frvB | Putative PTS enzyme, IIB component/IIC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FrvAB PTS system is involved in fructose transport. (483 aa) |
| | kdgT | 2-keto-3-deoxy-D-gluconate transporter; The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system; Belongs to the KdgT transporter family. (327 aa) |
| | fieF | Ferrous iron and zinc transporter; Iron-efflux transporter responsible for iron detoxification. Also able to transport Zn(2+) in a proton-dependent manner. Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. FieF subfamily. (300 aa) |
| | frwC | Putative enzyme IIC component of PTS; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. (359 aa) |
| | sthA | Pyridine nucleotide transhydrogenase, soluble; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation. (466 aa) |
| | yjbB | Putative alpha helix protein. (543 aa) |
| | xylE | D-xylose transporter; Uptake of D-xylose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Glucose is not transported, but can compete for xylose binding sites and can inhibit xylose transport (in vitro). Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (491 aa) |
| | yjcE | Putative cation/proton antiporter. (549 aa) |
| | gltP | Glutamate/aspartate:proton symporter; Catalyzes the proton-dependent, binding-protein-independent transport of glutamate and aspartate. Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. GltP subfamily. (437 aa) |
| | proP | Proline/glycine betaine transporter; Proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response; Belongs to the major facilitator superfamily. Metabolite:H+ Symporter (MHS) family (TC 2.A.1.6) family. (500 aa) |
| | adiC | Arginine:agmatine antiporter; Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach (By similarity). Exchanges extracellular arginine for its intracellular decarboxylation product agmatine (Agm) thereby expelling intracellular protons. (445 aa) |
| | melB | Melibiose:sodium symporter; Responsible for melibiose and other galactoside transport. It is capable of using hydrogen, sodium, and lithium cations as coupling cations for cotransport, depending on the particular sugar transported (symport system). (473 aa) |
| | dtpC | Dipeptide and tripeptide permease; Proton-dependent permease that transports di- and tripeptides. Shows significantly higher specificity towards dipeptides than tripeptides. Has a preference for dipeptides with a C-terminal Lys residue. Can bind Ala-Lys, Lys-Ala, Ala-Ala. Can also transport alanine and trialanine. Belongs to the PTR2/POT transporter (TC 2.A.17) family. (485 aa) |
| | cadB | Putative lysine/cadaverine transporter; Probable cadaverine/lysine antiporter or part of it. (444 aa) |
| | yjeH | Putative transporter; Catalyzes the efflux of L-methionine. Can also export L- leucine, L-isoleucine and L-valine. Activity is dependent on electrochemical potential. (418 aa) |
| | cycA | D-alanine/D-serine/glycine transporter; Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine; Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family. (470 aa) |
| | mgtA | Magnesium transporter; Mediates magnesium influx to the cytosol. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily. (898 aa) |
| | gntP | Fructuronate transporter; High-affinity gluconate transporter with fairly broad specificity, including low affinity for glucuronate, several disaccharides, and some hexoses, but not glucose. (447 aa) |
| | mdtM | Multidrug efflux system protein; Confers resistance to acriflavine, chloramphenicol, norfloxacin, ethidium bromide and TPP; Belongs to the major facilitator superfamily. (410 aa) |
| | kdpF | Potassium ion accessory transporter subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit may be involved in stabilization of the complex. (29 aa) |
| | gntU | Gluconate transporter, low affinity GNT 1 system; Part of the gluconate utilization system Gnt-I; low-affinity intake of gluconate; Belongs to the GntP permease family. (446 aa) |
| | yaaJ | Putative transporter; Inner membrane transport protein. (476 aa) |
| | satP | Succinate-acetate transporter; Uptake of acetate and succinate. Transport is energetically dependent on the protonmotive force. (188 aa) |
| | nhaA | Sodium-proton antiporter; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. Catalyzes the exchange of 2 H(+) per Na(+). Can mediate sodium uptake when a transmembrane pH gradient is applied. Active at alkaline pH. Activity is strongly down-regulated below pH 6.5; Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family. (388 aa) |
| | caiT | Putative transporter; Catalyzes the exchange of L-carnitine for gamma-butyrobetaine and related betaines. (504 aa) |
| | kefC | Potassium:proton antiporter; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. Can also export rubidium, lithium and sodium. (620 aa) |
| | thiQ | Thiamine/thiamine pyrophosphate ABC transporter ATPase; Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system (Probable); Belongs to the ABC transporter superfamily. Thiamine importer (TC 3.A.1.19.1) family. (232 aa) |
| | setA | Broad specificity sugar efflux system; Involved in the efflux of sugars. The physiological role may be the detoxification of non-metabolizable sugar analogs. Can transport IPTG, lactose and glucose. Has broad substrate specificity, with preferences for glucosides or galactosides with alkyl or aryl substituents; Belongs to the major facilitator superfamily. Set transporter family. (392 aa) |
| | aroP | Aromatic amino acid transporter; Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan). (457 aa) |
| | clcA | H(+)/Cl(-) exchange transporter; Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response. (473 aa) |
| | metI | DL-methionine transporter subunit; Part of the binding-protein-dependent transport system for D- methionine and the toxic methionine analog alpha-methyl-methionine. Probably responsible for the translocation of the substrate across the membrane. (217 aa) |
| | metN | DL-methionine transporter subunit; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. It has also been shown to be involved in formyl-L-methionine transport. Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family. (343 aa) |
| | afuC | CP4-6 prophage; Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import. Responsible for energy coupling to the transport system. (348 aa) |
| | betT | Choline transporter of high affinity; High-affinity uptake of choline driven by a proton-motive force; Belongs to the BCCT transporter (TC 2.A.15) family. (677 aa) |
| | lacY | Lactose permease; Responsible for transport of beta-galactosides into the cell, with the concomitant import of a proton (symport system). Can transport lactose, melibiose, lactulose or the analog methyl-1-thio-beta,D- galactopyranoside (TMG), but not sucrose or fructose. The substrate specificity is directed toward the galactopyranosyl moiety of the substrate. (417 aa) |
| | brnQ | Branched-chain amino acid transport system 2 carrier protein; Component of the LIV-II transport system for branched-chain amino acids. This LIV-II transport system may be H(+)-coupled. (439 aa) |
| | cyoD | Cytochrome o ubiquinol oxidase subunit IV; Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron. (109 aa) |
| | cyoC | Cytochrome o ubiquinol oxidase subunit III; Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron. (204 aa) |
| | cyoB | Cytochrome o ubiquinol oxidase subunit I; Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron. Protons are probably pumped via D- and K- channels found in this subunit. (663 aa) |
| | cyoA | Cytochrome o ubiquinol oxidase subunit II; Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron. (315 aa) |
| | ampG | Muropeptide transporter; Permease involved in cell wall peptidoglycan recycling. Transports, from the periplasm into the cytoplasm, the disaccharide N-acetylglucosaminyl-beta-1,4-anhydro- N-acetylmuramic acid (GlcNAc-anhMurNAc) and GlcNAc-anhMurNAc-peptides. Transport is dependent on the proton motive force. AmpG is also involved in beta-lactamase induction ; Belongs to the major facilitator superfamily. (491 aa) |
| | amtB | Ammonium transporter; Involved in the uptake of ammonia; Belongs to the ammonia transporter channel (TC 1.A.11.2) family. (428 aa) |
| | ybaL | Inner membrane putative NAD(P)-binding transporter; Putative transport protein. (558 aa) |
| | copA | Copper transporter; [Copper-exporting P-type ATPase]: Exports Cu(+) from the cytoplasm to the periplasm. Binds 2 Cu(+) ions per monomer, which are transferred to periplasmic copper chaperone CusF upon ATP hydrolysis. In vitro an excess of CusF over CopA is required for efficient transfer. May also be involved in silver export. (834 aa) |
| | emrE | DLP12 prophage; Multidrug transporter that expels positively charged hydrophobic drugs across the inner membrane of E.coli., thereby conferring resistance to a wide range of toxic compounds. The drug efflux is coupled to an influx of protons. Is involved in the resistance of E.coli cells to methyl viologen, ethidium bromide and acriflavine. Is also able to transport tetraphenylphosphonium (TPP(+)) and benzalkonium. Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. (110 aa) |
| | cusA | Copper/silver efflux system, membrane component; Part of a cation efflux system that mediates resistance to copper and silver; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. (1047 aa) |
| | gltL | Glutamate/aspartate ABC transporter ATPase; Part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake. Probably responsible for energy coupling to the transport system. (241 aa) |
| | potE | Putrescine transporter PotE; Catalyzes both the uptake and excretion of putrescine. The uptake of putrescine is dependent on the membrane potential and the excretion involves putrescine-ornithine antiporter activity. (439 aa) |
| | kdpC | Potassium translocating ATPase, subunit C; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP- hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex. (190 aa) |
| | kdpB | Potassium translocating ATPase, subunit B; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. (682 aa) |
| | kdpA | Potassium translocating ATPase, subunit A; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane. (557 aa) |
| | dtpD | Dipeptide and tripeptide permease D; Probable proton-dependent permease that transports dipeptides; Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpD subfamily. (493 aa) |
| | mngA | Fused 2-O-a-mannosyl-D-glycerate specific PTS enzymes: IIA component/IIB component/IIC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in mannosyl- D-glycerate transport. Also involved in thermoinduction of ompC. (658 aa) |
| | zitB | Zinc efflux system; Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc, whereas ZntA is required for growth at more toxic concentrations; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. (313 aa) |
| | rhtA | Threonine and homoserine efflux system; Involved in the efflux of threonine and homoserine. Can also export other amino acids such as proline, serine, histidine and cysteine; Belongs to the drug/metabolite transporter (DMT) superfamily. 10 TMS drug/metabolite exporter (DME) (TC 2.A.7.3) family. (295 aa) |
| | mdfA | Multidrug efflux system protein; Efflux pump driven by the proton motive force. Confers resistance to a broad spectrum of chemically unrelated drugs. Confers resistance to a diverse group of cationic or zwitterionic lipophilic compounds such as ethidium bromide, tetraphenylphosphonium, rhodamine, daunomycin, benzalkonium, rifampicin, tetracycline, puromycin, and to chemically unrelated, clinically important antibiotics such as chloramphenicol, erythromycin, and certain aminoglycosides and fluoroquinolones. Overexpression results in isopropyl-beta-D- thiogalactopyranoside (IPTG) exclusi [...] (410 aa) |
| | ybjL | Putative transport protein. (561 aa) |
| | potG | Putrescine ABC transporter ATPase; Part of the binding-protein-dependent transport system for putrescine. Probably responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. (377 aa) |
| | ybjE | Putative transporter; Mediates export of lysine; Belongs to the LysO family. (299 aa) |
| | rutG | Pyrimidine permease; May function as a proton-driven pyrimidine uptake system. (442 aa) |
| | putP | Proline:sodium symporter; Catalyzes the sodium-dependent uptake of extracellular L- proline. This protein is also capable of using lithium as the transport cation. Also catalyzes the uptake of propionate. (502 aa) |
| | efeO | Iron uptake system component EfeO; Involved in Fe(2+) uptake. Could be an iron-binding and/or electron-transfer component. (375 aa) |
| | potA | Spermidine/putrescine ABC transporter ATPase; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family. (378 aa) |
| | nhaB | Sodium:proton antiporter; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. Catalyzes the exchange of 3 H(+) per 2 Na(+). Has a high affinity for sodium, but can also transport lithium. Activity is weakly pH-dependent. Essential for regulation of intracellular pH under alkaline conditions. (513 aa) |
| | cvrA | Putative cation/proton antiporter; K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels (By similarity). Participates in control of cell volume in low-osmolarity conditions; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. NhaP2 subfamily. (578 aa) |
| | chaA | Calcium/sodium:proton antiporter; Sodium exporter that functions mainly at alkaline pH. Can also function as a potassium/proton and calcium/proton antiporter at alkaline pH. Does not play a major role in calcium export. (366 aa) |
| | sapF | Antimicrobial peptide ABC transporter ATPase; Part of a putrescine export transport system, does not play a role in resistance to antimicrobial peptides. Does not stimulate K(+) uptake ability of TrkH on its own, but increases K(+) uptake by 20% in the presence of SapD; has no effect of TrkG ; Belongs to the ABC transporter superfamily. (268 aa) |
| | sapD | Antimicrobial peptide ABC transporter ATPase; Part of a putrescine export transport system, does not play a role in resistance to antimicrobial peptides. Stimulates K(+)-uptake proteins TrkG and TrkH to import K(+), may act via ATP-binding rather than ATP hydrolysis. (330 aa) |
| | sapC | Antimicrobial peptide transport ABC transporter permease; Part of a putrescine export transport system, does not play a role in resistance to antimicrobial peptides. (296 aa) |
| | sapB | Antimicrobial peptide transport ABC transporter permease; Part of a putrescine export transport system, does not play a role in resistance to antimicrobial peptides. (321 aa) |
| | puuP | Putrescine importer; Involved in the uptake of putrescine. Belongs to the amino acid-polyamine-organocation (APC) superfamily. (461 aa) |
| | ydaN | Putative Zn(II) transporter; Mediates efflux of zinc ions. (327 aa) |
| | trkG | Rac prophage; Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA. Requires TrkE (sapD) for maximal transport activity, low activity is seen in its absence; no further stimulation is seen with SapF. Transport in the absence of SapD is dependent on a high membrane potential and a high cytoplasmic ATP concentration, suggesting this protein may be able to interact with other ATP-binding proteins. Can transport potassium and rubidium. (485 aa) |
| | tehA | Potassium-tellurite ethidium and proflavin transporter; Responsible for potassium tellurite resistance when present in high copy number. Ion channel involved in potassium tellurite resistance (By similarity). Otherwise, phenotypically silent. Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family. (330 aa) |
| | ydfK | Cold shock protein YdfK; Cryptic prophage Qin/Kim. (77 aa) |
| | mdtI | Multidrug efflux system transporter; Catalyzes the excretion of spermidine. Can also confer resistance to deoxycholate and SDS; Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. MdtI subfamily. (109 aa) |
| | mdtJ | Multidrug efflux system transporter; Catalyzes the excretion of spermidine. Can also confer resistance to deoxycholate and SDS; Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. MdtJ subfamily. (121 aa) |
| | dtpA | Dipeptide and tripeptide permease A; Proton-dependent permease that transports di- and tripeptides as well as structurally related peptidomimetics such as aminocephalosporins into the cell. Has a clear preference for dipeptides and tripeptides composed of L-amino acids, and discriminates dipeptides on the basis of the position of charges within the substrate; Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpA subfamily. (500 aa) |
| | leuE | Leucine efflux protein; Exporter of leucine. Can also transport its natural analog L- alpha-amino-n-butyric acid and some other structurally unrelated amino acids. (212 aa) |
| | mntP | Putative Mn(2+) efflux pump, mntR-regulated; Probably functions as a manganese efflux pump. Belongs to the MntP (TC 9.B.29) family. (188 aa) |
| | znuC | Zinc ABC transporter ATPase; Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family. (251 aa) |
| | znuB | Zinc ABC transporter permease; Involved in the high-affinity zinc uptake transport system; Belongs to the ABC-3 integral membrane protein family. (261 aa) |
| | motB | Protein that enables flagellar motor rotation; MotA and MotB comprise the stator element of the flagellar motor complex. Required for the rotation of the flagellar motor. Probably a linker that fastens the torque-generating machinery to the cell wall. Overexpression of this protein with MotA improves motility in a pdeH disruption, (a c-di-GMP phosphodiesterase) suggesting there is an interaction (direct or indirect) between the c-di-GMP-binding flagellar brake protein YcgR and the flagellar stator. (308 aa) |
| | motA | Proton conductor component of flagella motor; MotA and MotB comprise the stator element of the flagellar motor complex. Required for rotation of the flagellar motor. Probable transmembrane proton channel. Overexpression of MotA, with or without MotB, restores motility in a pdeH disruption, (a c-di-GMP phosphodiesterase) suggesting there is an interaction (direct or indirect) between the c-di-GMP-binding flagellar brake protein YcgR and the flagellar stator. (295 aa) |
| | fliI | Flagellum-specific ATP synthase; Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum. May be involved in a specialized protein export pathway that proceeds without signal peptide cleavage; Belongs to the ATPase alpha/beta chains family. (457 aa) |
| | plaP | Putrescine importer, low affinity; Putrescine importer. Required for induction of type 1 pili- driven surface motility. (452 aa) |
| | rcnA | Membrane protein conferring nickel and cobalt resistance; Efflux system for nickel and cobalt. (274 aa) |
| | lysP | Lysine transporter; Permease that is involved in the transport across the cytoplasmic membrane of lysine; Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family. (489 aa) |
| | fruA | Fused fructose-specific PTS enzymes: IIBcomponent/IIC components; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FruAB PTS system is involved in fructose transport. (563 aa) |
| | setB | Lactose/glucose efflux system; Involved in the efflux of sugars. The physiological role may be the detoxification of non-metabolizable sugar analogs. Can transport lactose and glucose; Belongs to the major facilitator superfamily. Set transporter family. (393 aa) |
| | bcr | Bicyclomycin/cysteine/sulfonamide efflux transporter; Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance. Probable membrane translocase. A transporter able to export peptides. When overexpressed, allows cells deleted for multiple peptidases (pepA, pepB, pepD and pepN) to grow in the presence of dipeptides Ala-Gln or Gly-Tyr which otherwise inhibit growth. Cells overexpressing this protein have decreased intracellular levels of Ala-Gln dipeptide, and in a system that produces the Ala-Gln dipeptide overproduction of this protein increases export of the dipeptide. Belongs [...] (396 aa) |
| | yfbS | Putative transport protein. (610 aa) |
| | hisP | Histidine ABC transporter ATPase; Part of the histidine permease ABC transporter. Also part of a lysine/arginine/ornithine transporter. Responsible for energy coupling to the transport system (By similarity). (257 aa) |
| | hisQ | Histidine ABC transporter permease; Part of the histidine permease ABC transporter. Also part of a lysine/arginine/ornithine transporter. Probably responsible for the translocation of the substrate across the membrane. Required to relay the ATPase-inducing signal from the solute-binding protein to HisP (By similarity). (228 aa) |
| | dsdX | D-serine transporter; A D-serine-specific transporter, may function as a H(+) symporter. (445 aa) |
| | mntH | Manganese/divalent cation transporter; H(+)-stimulated, divalent metal cation uptake system. Involved in manganese and iron uptake. Can also transport cadmium, cobalt, zinc and to a lesser extent nickel and copper. Involved in response to reactive oxygen. (412 aa) |
| | nupC | Nucleoside (except guanosine) transporter; Transports nucleosides with a high affinity except guanosine and deoxyguanosine. Driven by a proton motive force. Transports cytidine, uridine, thymidine, adenosine and inosine. Can also transport xanthosine, but with a very low affinity. (400 aa) |
| | cysZ | Sulfate transporter, sulfite inhibited; High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway. Does not transport thiosulfate. Belongs to the CysZ family. (253 aa) |
| | eutH | Ethanolamine transporter; Possibly involved in the transport of ethanolamine from the periplasm to the cytoplasm. (408 aa) |
| | uraA | Uracil permease; Transport of uracil in the cell. Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily. (429 aa) |
| | hcaT | Putative 3-phenylpropionic transporter; Probable permease involved in the uptake of 3-phenylpropionic acid; Belongs to the major facilitator superfamily. Phenyl propionate permease (PPP) (TC 2.A.1.27) family. (379 aa) |
| | kgtP | Alpha-ketoglutarate transporter; Uptake of alpha-ketoglutarate across the boundary membrane with the concomitant import of a cation (symport system). Belongs to the major facilitator superfamily. Metabolite:H+ Symporter (MHS) family (TC 2.A.1.6) family. (432 aa) |
| | proW | Glycine betaine/proline ABC transporter permease; Part of the ProU ABC transporter complex involved in glycine betaine and proline betaine uptake. Probably responsible for the translocation of the substrate across the membrane (Probable); Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (354 aa) |
| | sdaC | Putative serine transporter; Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity. (429 aa) |
| | fucP | L-fucose transporter; Mediates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Can also transport L-galactose and D-arabinose, but at reduced rates compared with L-fucose. Is not able to transport L-rhamnose and L-arabinose. (438 aa) |
| | lplT | Lysophospholipid transporter; Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell. Belongs to the major facilitator superfamily. LplT (TC 2.A.1.42) family. (397 aa) |
| | argO | Arginine transporter; Involved in the export of arginine. Important to control the intracellular level of arginine and the correct balance between arginine and lysine. May also be involved in the export of canavanine (a plant-derived antimetabolite). (211 aa) |
| | galP | D-galactose transporter; Uptake of galactose across the boundary membrane with the concomitant transport of protons into the cell (symport system); Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (464 aa) |
| | nupG | Nucleoside transporter; Broad-specificity transporter of purine and pyrimidine nucleosides. Driven by a proton motive force. Can transport uridine, adenosine, inosine, guanosine, thymidine and cytidine. Can also transport xanthosine, but with a very low affinity. Belongs to the major facilitator superfamily. Nucleoside:H(+) symporter (NHS) (TC 2.A.1.10) family. (418 aa) |
| | glcA | Glycolate transporter; Transports glycolate across the membrane. Can also transport L-lactate and D-lactate. Seems to be driven by a proton motive force. (560 aa) |
| | zupT | Zinc transporter; Mediates zinc uptake. May also transport other divalent cations such as copper and cadmium ions; Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily. (257 aa) |
| | sstT | Sodium:serine/threonine symporter; Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system). (414 aa) |
| | tdcC | L-threonine/L-serine transporter; Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system). Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily. (443 aa) |
| | mtr | Tryptophan transporter of high affinity; Involved in transporting tryptophan across the cytoplasmic membrane. (414 aa) |
| | yrbG | Putative calcium/sodium:proton antiporter; Protein involved in calcium:sodium antiporter activity. (325 aa) |
| | nanT | Sialic acid transporter; Catalyzes the proton-dependent transport of sialic acid. Can transport the common sialic acid N-acetylneuraminic acid (Neu5Ac) and the related sialic acids N- glycolylneuraminic acid (Neu5Gc) and 3-keto-3-deoxy-D-glycero-D- galactonononic acid (KDN). Functions as a bidirectional transporter in vitro. Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family. (496 aa) |
| | panF | Pantothenate:sodium symporter; Catalyzes the sodium-dependent uptake of extracellular pantothenate; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (483 aa) |
| | trkA | NAD-binding component of TrK potassium transporter; Part of the constitutive potassium transport systems TrkG and TrkH. May regulate the transport activity of TrkG and TrkH systems. Binds to NAD(+) and NADH. (458 aa) |
| | kefB | Potassium:proton antiporter; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. KefB subfamily. (601 aa) |
| | feoB | Ferrous iron transporter protein B and GTP-binding protein; Transporter of a GTP-driven Fe(2+) uptake system, probably couples GTP-binding to channel opening and Fe(2+) uptake. A guanine nucleotide-binding protein (G proteins) in which the guanine nucleotide binding site alternates between an active, GTP-bound state and an inactive, GDP- bound state. This protein has fast intrinsic GDP release, mediated by the G5 loop (about residues 149-158). Presumably GTP hydrolysis leads to conformational changes and channel closing. A GDP release mechanism involving a conformational change of the [...] (773 aa) |
| | livF | Branched-chain amino acid ABC transporter ATPase; Component of the leucine-specific transport system. (237 aa) |
| | livG | Branched-chain amino acid ABC transporter ATPase; Component of the leucine-specific transport system. (255 aa) |
| | livM | Branched-chain amino acid ABC transporter permease; Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane; Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily. (425 aa) |
| | livH | Branched-chain amino acid ABC transporter permease; Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane; Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily. (308 aa) |
| | zntA | Zinc, cobalt and lead efflux system; Confers resistance to zinc, cadmium and lead. Couples the hydrolysis of ATP with the export of zinc, cadmium or lead, with highest activity when the metals are present as metal-thiolate complexes. Can also bind nickel, copper, cobalt and mercury. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. (732 aa) |
| | nikB | Nickel ABC transporter permease; Involved in a nickel transport system, probably translocates nickel through the bacterial inner membrane. (314 aa) |
| | nikC | Nickel ABC transporter permease; Involved in a nickel transport system, probably translocates nickel through the bacterial inner membrane. (277 aa) |
| | nikD | Nickel ABC transporter ATPase; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family. (254 aa) |
| | nikE | Nickel ABC transporter ATPase; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family. (268 aa) |
| | pitA | Phosphate transporter, low-affinity; Low-affinity inorganic phosphate transport. Can also transport arsenate; Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. Pit subfamily. (499 aa) |
| | dtpB | Dipeptide and tripeptide permease B; Proton-dependent permease that transports di- and tripeptides. Has a clear preference for dipeptides and tripeptides composed of L-amino acids, and discriminates dipeptides on the basis of the position of charges within the substrate. Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpB subfamily. (489 aa) |
| | dctA | C4-dicarboxylic acid, orotate and citrate transporter; Responsible for the aerobic transport of the dicarboxylates fumarate, L- and D-malate and to a lesser extent succinate, from the periplasm across the inner membrane; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. (428 aa) |
| | lldP | L-lactate permease; Transports L-lactate across the membrane. Can also transport D-lactate and glycolate. Seems to be driven by a proton motive force. (551 aa) |
| | gltS | Glutamate transporter; Catalyzes the sodium-dependent, binding-protein-independent transport of glutamate. Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family. (401 aa) |
| | setC | Sugar efflux transporter C; Involved in the efflux of sugars. The physiological role may be the detoxification of non-metabolizable sugar analogs; Belongs to the major facilitator superfamily. Set transporter family. (394 aa) |
| | yidK | Putative cotransporter. (571 aa) |
| | yidE | Putative transport protein. (553 aa) |
| | dgoT | D-galactonate transporter; Intake of galactonate into the cell; Belongs to the major facilitator superfamily. Phthalate permease family. (430 aa) |
| | adeP | Adenine permease, high affinity; High-affinity transporter for adenine. Belongs to the xanthine/uracil permease family. AzgA purine transporter (TC 2.A.1.40) subfamily. (445 aa) |
| | atpC | F1 sector of membrane-bound ATP synthase, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane; Belongs to the ATPase epsilon chain family. (139 aa) |
| | atpD | F1 sector of membrane-bound ATP synthase, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (460 aa) |
| | atpG | F1 sector of membrane-bound ATP synthase, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (287 aa) |
