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acrB acrB cusC cusC ybhR ybhR ybhS ybhS ybhF ybhF rhtA rhtA ybjE ybjE macA macA narK narK ydaN ydaN tehA tehA narU narU eamA eamA tqsA tqsA mdtA mdtA rcnA rcnA acrD acrD eamB eamB alaE alaE tolC tolC tdcC tdcC acrF acrF mdtF mdtF rhtC rhtC rhtB rhtB fieF fieF mdtP mdtP yohP yohP
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
acrBMultidrug efflux system protein; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. (1049 aa)
cusCCopper/silver efflux system, outer membrane component; Forms pores that allow passive diffusion of cations across the outer membrane. Part of a cation efflux system that mediates resistance to copper and silver. In pathogenic strains it allows the bacteria to invade brain microvascular endothelial cells (BMEC) thus allowing it to cross the blood-brain barrier and cause neonatal meningitis. (457 aa)
ybhRPutative ABC transporter permease; Part of the ABC transporter complex YbhFSR that could be involved in efflux of cefoperazone. Probably involved in the translocation of the substrate across the membrane. Belongs to the ABC-2 integral membrane protein family. (368 aa)
ybhSPutative ABC transporter permease; Part of the ABC transporter complex YbhFSR that could be involved in efflux of cefoperazone. Probably involved in the translocation of the substrate across the membrane. Belongs to the ABC-2 integral membrane protein family. (377 aa)
ybhFPutative ABC transporter ATPase; Part of the ABC transporter complex YbhFSR that could be involved in efflux of cefoperazone. Probably responsible for energy coupling to the transport system. (578 aa)
rhtAThreonine and homoserine efflux system; Involved in the efflux of threonine and homoserine. Can also export other amino acids such as proline, serine, histidine and cysteine; Belongs to the drug/metabolite transporter (DMT) superfamily. 10 TMS drug/metabolite exporter (DME) (TC 2.A.7.3) family. (295 aa)
ybjEPutative transporter; Mediates export of lysine; Belongs to the LysO family. (299 aa)
macAMacrolide transporter membrane fusion protein (MFP) component; Part of the tripartite efflux system MacAB-TolC. MacA stimulates the ATPase activity of MacB by promoting the closed ATP- bound state of MacB, increases the capacity of MacB to bind macrolides such as erythromycin, and provides a physical link between MacB and TolC. When overexpressed, the system confers resistance against macrolides composed of 14- and 15-membered lactones but no or weak resistance against 16-membered ones. In addition, MacA binds tightly rough-core lipopolysaccharide (R-LPS), suggesting that the system co [...] (371 aa)
narKNitrate/nitrite transporter; Catalyzes nitrate uptake, nitrite uptake and nitrite export across the cytoplasmic membrane. Functions as a nitrate/nitrite exchanger, and protons are probably not co-transported with the substrate. (463 aa)
ydaNPutative Zn(II) transporter; Mediates efflux of zinc ions. (327 aa)
tehAPotassium-tellurite ethidium and proflavin transporter; Responsible for potassium tellurite resistance when present in high copy number. Ion channel involved in potassium tellurite resistance (By similarity). Otherwise, phenotypically silent. Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family. (330 aa)
narUNitrate/nitrite transporter; Catalyzes nitrate uptake, nitrite uptake and nitrite export across the cytoplasmic membrane. May function as a nitrate/H(+) and nitrite/H(+) channel. Could confer a selective advantage during severe nutrient starvation or slow growth. (462 aa)
eamACysteine and O-acetyl-L-serine efflux system; May be an export pump for cysteine and other metabolites of the cysteine pathway (such as N-acetyl-L-serine (NAS) and O-acetyl-L- serine (OAS)), and for other amino acids and their metabolites. Belongs to the EamA transporter family. (299 aa)
tqsAPheromone AI-2 transporter; Controls the transport of the quorum-sensing signal AI-2 either by enhancing its secretion or inhibiting its uptake and consequently represses biofilm formation and motility and affects the global gene expression in biofilms. (344 aa)
mdtAMultidrug efflux system, subunit A; The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate. MdtABC requires TolC for its function. Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (415 aa)
rcnAMembrane protein conferring nickel and cobalt resistance; Efflux system for nickel and cobalt. (274 aa)
acrDAminoglycoside/multidrug efflux system; Participates in the efflux of aminoglycosides. Confers resistance to a variety of these substances. Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. (1037 aa)
eamBCysteine and O-acetylserine exporter; Exporter of O-acetylserine (OAS) and cysteine. Belongs to the Rht family. (195 aa)
alaEAlanine exporter, alanine-inducible, stress-responsive; Exports L-alanine; Belongs to the AlaE exporter family. (149 aa)
tolCTransport channel; Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells. (493 aa)
tdcCL-threonine/L-serine transporter; Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system). Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily. (443 aa)
acrFMultidrug efflux system protein; Part of the tripartite efflux system AcrEF-TolC. Involved in the efflux of indole and organic solvents. Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. (1034 aa)
mdtFAnaerobic multidrug efflux transporter, ArcA-regulated; Part of the tripartite efflux system MdtEF-TolC, which confers resistance to compounds such as rhodamine 6G, erythromycin, doxorubicin, ethidium bromide, TPP, SDS, deoxycholate, crystal violet and benzalkonium; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. (1037 aa)
rhtCThreonine efflux pump; Conducts the efflux of threonine. Belongs to the Rht family. (206 aa)
rhtBHomoserine, homoserine lactone and S-methyl-methionine efflux pump; Conducts the efflux of homoserine and homoserine lactone. Belongs to the Rht family. (206 aa)
fieFFerrous iron and zinc transporter; Iron-efflux transporter responsible for iron detoxification. Also able to transport Zn(2+) in a proton-dependent manner. Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. FieF subfamily. (300 aa)
mdtPOuter membrane factor of efflux pump; Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride. (488 aa)
yohPUncharacterized membrane protein YohP; Pseudogene; putative channel/filament proteins. (27 aa)
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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