STRINGSTRING
yphG yphG lacY lacY lacZ lacZ tauD tauD sfmH sfmH mngB mngB galM galM ybiX ybiX opgG opgG ycjT ycjT opgD opgD lsrR lsrR uidA uidA yeaD yeaD araF araF mglB mglB glk glk hcaT hcaT yphB yphB yphF yphF fucU fucU ebgA ebgA chiA chiA malT malT xylF xylF yiaO yiaO yicI yicI rbsD rbsD rbsB rbsB yihQ yihQ yihR yihR rhaA rhaA pfkA pfkA pgi pgi malE malE alsB alsB ulaR ulaR ytfQ ytfQ yjhU yjhU fimH fimH
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
yphGDUF4380 domain-containing TPR repeat protein. (1093 aa)
lacYLactose permease; Responsible for transport of beta-galactosides into the cell, with the concomitant import of a proton (symport system). Can transport lactose, melibiose, lactulose or the analog methyl-1-thio-beta,D- galactopyranoside (TMG), but not sucrose or fructose. The substrate specificity is directed toward the galactopyranosyl moiety of the substrate. (417 aa)
lacZbeta-D-galactosidase; Protein involved in carbohydrate catabolic process; Belongs to the glycosyl hydrolase 2 family. (1024 aa)
tauDTaurine dioxygenase, 2-oxoglutarate-dependent; Catalyzes the alpha-ketoglutarate-dependent hydroxylation of taurine yielding sulfite and aminoacetaldehyde after decomposition of an unstable intermediate. Is required for the utilization of taurine (2-aminoethanesulfonate) as an alternative sulfur source for growth in the absence of sulfate. To a lesser extent, pentanesulfonate, 3-(N-morpholino)propanesulfonate and 1,3-dioxo-2-isoindolineethanesulfonate are also desulfonated by this enzyme in vitro; however, desulfonation by TauD of organosulfonates other than taurine seem to be of littl [...] (283 aa)
sfmHFimA homolog, function unknown; Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes. (327 aa)
mngBAlpha-mannosidase; May hydrolyze 6-phospho-mannosyl-D-glycerate to mannose-6- phosphate and glycerate; Belongs to the glycosyl hydrolase 38 family. (877 aa)
galMAldose 1-epimerase; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose. (346 aa)
ybiXFe(II)-dependent oxygenase superfamily protein; Putative enzyme. (225 aa)
opgGOPG biosynthetic periplasmic beta-1,6 branching glycosyltransferase; Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs); Belongs to the OpgD/OpgG family. (511 aa)
ycjTPutative family 65 glycosyl hydrolase; In vitro catalyzes the phosphorolysis of D-kojibiose into beta-D-glucose 1-phosphate and D-glucose. No other disaccharides tested substitute for D-kojibiose. In the reverse direction disaccharides can be formed from beta-D-glucose 1-phosphate plus D-glucose, L-sorbose, D- sorbitol, L-iditol or 1,5-anhydro-D-glucitol, but with low efficiency. The beta-D-glucose 1-phosphate product is the substrate for YcjU (AC P77366), the next apparent enzyme in the putative biochemical pathway encoded in this locus (yjcM to ycjW). (755 aa)
opgDOPG biosynthetic periplasmic protein; Probably involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans (OPGs). (551 aa)
lsrRLsr operon transcriptional repressor; Regulates transcription of many different genes. In the absence of autoinducer 2 (AI-2), represses transcription of the lsrACDBFG operon and its own transcription. In the presence of AI-2, LsrR is inactivated by binding phospho-AI-2, leading to the transcription of the lsr genes. (317 aa)
uidAbeta-D-glucuronidase; Protein involved in carbohydrate catabolic process; Belongs to the glycosyl hydrolase 2 family. (603 aa)
yeaDD-hexose-6-phosphate epimerase-like protein; Belongs to the glucose-6-phosphate 1-epimerase family. (294 aa)
araFL-arabinose ABC transporter periplasmic binding protein; Involved in the high-affinity L-arabinose membrane transport system. Binds with high affinity to arabinose, but can also bind D- galactose (approximately 2-fold reduction) and D-fucose (approximately 40-fold reduction). (329 aa)
mglBMethyl-galactoside transporter subunit; This protein is involved in the active transport of galactose and glucose. It plays a role in the chemotaxis towards the two sugars by interacting with the trg chemoreceptor. (332 aa)
glkGlucokinase; Not highly important in E.coli as glucose is transported into the cell by the PTS system already as glucose 6-phosphate. (321 aa)
hcaTPutative 3-phenylpropionic transporter; Probable permease involved in the uptake of 3-phenylpropionic acid; Belongs to the major facilitator superfamily. Phenyl propionate permease (PPP) (TC 2.A.1.27) family. (379 aa)
yphBMutarotase superfamily protein, YphB family. (290 aa)
yphFPutative sugar ABC transporter periplasmic binding protein; Probably part of the binding-protein-dependent transport system YphDEF; Belongs to the bacterial solute-binding protein 2 family. (327 aa)
fucUL-fucose mutarotase; Involved in the anomeric conversion of L-fucose. Catalyzes also the interconversion of beta-pyran and beta-furan forms of D- ribose; Belongs to the RbsD / FucU family. FucU mutarotase subfamily. (140 aa)
ebgAEvolved beta-D-galactosidase, alpha subunit; The wild-type enzyme is an ineffective lactase. Two classes of point mutations dramatically improve activity of the enzyme; Belongs to the glycosyl hydrolase 2 family. (1030 aa)
chiAPeriplasmic endochitinase; Bifunctional enzyme with lysozyme/chitinase activity. (897 aa)
malTMal regulon transcriptional activator; Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto- oligosaccharides. Specifically binds to the promoter region of its target genes, recognizing a short DNA motif called the MalT box (5'- GGA[TG]GA-3'). Displays weak ATPase activity, but this activity is not required for promoter binding. (901 aa)
xylFD-xylose transporter subunit; Involved in the high-affinity D-xylose membrane transport system. Binds with high affinity to xylose. (330 aa)
yiaO2,3-diketo-L-gulonate-binding periplasmic protein; Part of the tripartite ATP-independent periplasmic (TRAP) transport system YiaMNO involved in the uptake of 2,3-diketo-L- gulonate. This protein specifically binds 2,3-diketo-L-gulonate. Is not able to bind either L-ascorbate or dehydroascorbate. Belongs to the bacterial solute-binding protein 7 family. (328 aa)
yicIPutative alpha-glucosidase; Can catalyze the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose and trehalose. Belongs to the glycosyl hydrolase 31 family. (772 aa)
rbsDD-ribose pyranase; Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose. It also catalyzes the conversion between beta- allofuranose and beta-allopyranose; Belongs to the RbsD / FucU family. RbsD subfamily. (139 aa)
rbsBD-ribose ABC transporter periplasmic binding protein; Part of the ABC transporter complex RbsABC involved in ribose import. Binds ribose. Also serves as the primary chemoreceptor for chemotaxis; Belongs to the bacterial solute-binding protein 2 family. (296 aa)
yihQPutative sulpholipid alpha-glucosidase; Catalyzes the hydrolysis of sulfoquinovosyl diacylglycerides (SQDG) to sulfoquinovose (SQ), which is then degraded by E.coli through the SQ Embden-Meyerhof-Parnas (SQ-EMP) sulfoglycolysis pathway as a source of carbon and sulfur. Therefore, is likely involved in the utilization of the sulfoquinovose headgroup found in ubiquitous plant sulfolipids. Is also able to hydrolyze simple sulfoquinovosides such as 1-sulfoquinovosylglycerol (SQGro). Is a retaining glycoside hydrolase, since it forms the alpha anomer of SQ. Also exhibits some alpha-glucosid [...] (678 aa)
yihRPutative sulphoquinovose mutarotase; Putative aldose-1-epimerase. (308 aa)
rhaAL-rhamnose isomerase; Protein involved in carbohydrate catabolic process. (419 aa)
pfkA6-phosphofructokinase I; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub- subfamily. (320 aa)
pgiGlucosephosphate isomerase; Protein involved in glycolysis and gluconeogenesis; Belongs to the GPI family. (549 aa)
malEMaltose transporter subunit; Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Binds maltose and higher maltodextrins such as maltotriose. Belongs to the bacterial solute-binding protein 1 family. (396 aa)
alsBD-allose ABC transporter periplasmic binding protein; Part of the binding-protein-dependent transport system AlsBAC for D-allose; Belongs to the bacterial solute-binding protein 2 family. (311 aa)
ulaRTranscriptional repressor for the L-ascorbate utilization divergent operon; Represses ulaG and the ulaABCDEF operon. Two ulaR binding sites have been identified in each promoter. Full activity requires simultaneous interaction of UlaR with both divergent promoters and seems to be dependent on repressor-mediated DNA loop formation, which is helped by the action of integration host factor. (251 aa)
ytfQGalactofuranose ABC transporter periplasmic binding protein; Part of the ABC transporter complex YtfQRT-YjfF involved in galactofuranose transport (Probable). Binds to both alpha- and beta- galactofuranose. (318 aa)
yjhUUncharacterized transcriptional regulator YjhU; IS1 transposase B;IS, phage, Tn; Transposon-related functions; extrachromosomal; transposon related; Belongs to the SorC transcriptional regulatory family. (328 aa)
fimHMinor component of type 1 fimbriae; Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Adhesin responsible for the binding to D-mannose. It is laterally positioned at intervals in the structure of the type 1 fimbriae. In order to integrate FimH in the fimbriae FimF and FimG are needed. (300 aa)
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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