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acrD acrD bcp bcp emrA emrA emrB emrB yghU yghU tolC tolC acrE acrE acrF acrF zntA zntA gor gor yhjA yhjA acrA acrA adeD adeD emrD emrD mdtL mdtL yihU yihU sodA sodA yiiM yiiM katG katG mdtN mdtN sugE sugE mdtM mdtM mdtG mdtG grxB grxB tpx tpx cueO cueO mtn mtn paoC paoC paoB paoB paoA paoA rclA rclA frmB frmB frmA frmA acrB acrB grxC grxC copA copA emrE emrE cusB cusB ahpC ahpC ahpF ahpF flc flc acrZ acrZ ybhR ybhR ybhS ybhS ybhF ybhF mdfA mdfA grxA grxA hcp hcp macA macA macB macB trxB trxB ycbX ycbX cybB cybB osmC osmC mdtI mdtI mdtJ mdtJ sodC sodC efeB efeB sodB sodB ydhC ydhC mdtK mdtK btuE btuE katE katE ynjA ynjA mdtA mdtA mdtB mdtB mdtC mdtC yeiG yeiG bcr bcr yfcF yfcF yfcG yfcG dsdA dsdA emrY emrY emrK emrK yfeX yfeX
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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acrDAminoglycoside/multidrug efflux system; Participates in the efflux of aminoglycosides. Confers resistance to a variety of these substances. Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. (1037 aa)
bcpPeroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. (156 aa)
emrAMultidrug efflux system; Part of the tripartite efflux system EmrAB-TolC, which confers resistance to antibiotics such as CCCP, FCCP, 2,4-dinitrophenol and nalidixic acid. EmrA is a drug-binding protein that provides a physical link between EmrB and TolC; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (390 aa)
emrBMultidrug efflux system protein; Part of the tripartite efflux system EmrAB-TolC, which confers resistance to antibiotics such as CCCP, FCCP, 2,4-dinitrophenol and nalidixic acid. (512 aa)
yghUPutative S-transferase; Exhibits a robust glutathione (GSH)-dependent disulfide-bond reductase activity toward the model substrate, 2-hydroxyethyl disulfide; the actual physiological substrates are not known. Also displays a modest GSH-dependent peroxidase activity toward several organic hydroperoxides, such as cumene hydroperoxide and linoleic acid 13(S)-hydroperoxide, but does not reduce H(2)O(2) or tert-butyl hydroperoxide at appreciable rates. Exhibits little or no GSH transferase activity with most typical electrophilic substrates, and has no detectable transferase activity toward [...] (288 aa)
tolCTransport channel; Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells. (493 aa)
acrECytoplasmic membrane lipoprotein; Part of the tripartite efflux system AcrEF-TolC. Involved in the efflux of indole and organic solvents. Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (385 aa)
acrFMultidrug efflux system protein; Part of the tripartite efflux system AcrEF-TolC. Involved in the efflux of indole and organic solvents. Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. (1034 aa)
zntAZinc, cobalt and lead efflux system; Confers resistance to zinc, cadmium and lead. Couples the hydrolysis of ATP with the export of zinc, cadmium or lead, with highest activity when the metals are present as metal-thiolate complexes. Can also bind nickel, copper, cobalt and mercury. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. (732 aa)
gorGlutathione oxidoreductase; Maintains high levels of reduced glutathione in the cytosol; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (450 aa)
yhjAProtein involved in cytochrome complex assembly. (465 aa)
acrAMultidrug efflux system; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together. It is elongated in shape, being long enough to span the periplasm. (397 aa)
adeDCryptic adenine deaminase; Protein involved in metabolic process; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. (588 aa)
emrDMultidrug efflux system protein; Multidrug resistance pump that participates in a low energy shock adaptive response; Belongs to the major facilitator superfamily. (394 aa)
mdtLMultidrug efflux system protein; Confers resistance to chloramphenicol. Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2.A.1.2.22) subfamily. (391 aa)
yihU3-sulpholactaldehyde (SLA) reductase, NADH-dependent; Reduces 3-sulfolactaldehyde (SLA) to 2,3-dihydroxypropane 1- sulfonate (DHPS). (298 aa)
sodASuperoxide dismutase, Mn; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismutase family. (206 aa)
yiiM6-N-hydroxylaminopurine resistance protein. (224 aa)
katGCatalase-peroxidase HPI, heme b-containing; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. Displays also NADH oxidase, INH lyase and isonicotinoyl-NAD synthase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (726 aa)
mdtNMembrane fusion protein of efflux pump; Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (343 aa)
sugEMultidrug efflux system protein; Guanidinium ion exporter. Couples guanidinium export to the proton motive force, exchanging one guanidinium ion for two protons. Overexpression leads to resistance to a subset of toxic quaternary ammonium compounds such as cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations. Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. Gdx/SugE subfamily. (105 aa)
mdtMMultidrug efflux system protein; Confers resistance to acriflavine, chloramphenicol, norfloxacin, ethidium bromide and TPP; Belongs to the major facilitator superfamily. (410 aa)
mdtGPutative drug efflux system protein; Confers resistance to fosfomycin and deoxycholate. Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily. (408 aa)
grxBGlutaredoxin 2 (Grx2); Involved in reducing some disulfide bonds in a coupled system with glutathione reductase. Does not act as hydrogen donor for ribonucleotide reductase. (215 aa)
tpxLipid hydroperoxide peroxidase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Has a preference for alkyl hydroperoxides and acts as lipid peroxidase to inhibit bacterial membrane oxidation. Acts as principal antioxidant during anaerobic growth. (168 aa)
cueOMulticopper oxidase (laccase); Probably involved in periplasmic detoxification of copper by oxidizing Cu(+) to Cu(2+) and thus preventing its uptake into the cytoplasm. Possesses phenoloxidase and ferroxidase activities and might be involved in the production of polyphenolic compounds and the prevention of oxidative damage in the periplasm. (516 aa)
mtn5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5- deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulati [...] (232 aa)
paoCPaoABC aldehyde oxidoreductase, Moco-containing subunit; Oxidizes aldehydes to the corresponding carboxylic acids with a preference for aromatic aldehydes. It might play a role in the detoxification of aldehydes to avoid cell damage. Belongs to the xanthine dehydrogenase family. (732 aa)
paoBPaoABC aldehyde oxidoreductase, FAD-containing subunit; Oxidizes aldehydes to the corresponding carboxylic acids with a preference for aromatic aldehydes. It might play a role in the detoxification of aldehydes to avoid cell damage. (318 aa)
paoAPaoABC aldehyde oxidoreductase, 2Fe-2S subunit; Oxidizes aldehydes to the corresponding carboxylic acids with a preference for aromatic aldehydes. It might play a role in the detoxification of aldehydes to avoid cell damage. (229 aa)
rclAReactive chlorine stress species (RCS) resistance protein; Probably involved in reactive chlorine species (RCS) stress resistance. (441 aa)
frmBS-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate. Shows also esterase activity against two pNP-esters (pNP- acetate and pNP-propionate), alpha-naphthyl acetate and lactoylglutathione. (277 aa)
frmAAlcohol dehydrogenase class III; Has high formaldehyde dehydrogenase activity in the presence of glutathione and catalyzes the oxidation of normal alcohols in a reaction that is not GSH-dependent. In addition, hemithiolacetals other than those formed from GSH, including omega-thiol fatty acids, also are substrates; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (369 aa)
acrBMultidrug efflux system protein; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. (1049 aa)
grxCGlutaredoxin 3; The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfide bonds in a coupled system with glutathione reductase; Belongs to the glutaredoxin family. (83 aa)
copACopper transporter; [Copper-exporting P-type ATPase]: Exports Cu(+) from the cytoplasm to the periplasm. Binds 2 Cu(+) ions per monomer, which are transferred to periplasmic copper chaperone CusF upon ATP hydrolysis. In vitro an excess of CusF over CopA is required for efficient transfer. May also be involved in silver export. (834 aa)
emrEDLP12 prophage; Multidrug transporter that expels positively charged hydrophobic drugs across the inner membrane of E.coli., thereby conferring resistance to a wide range of toxic compounds. The drug efflux is coupled to an influx of protons. Is involved in the resistance of E.coli cells to methyl viologen, ethidium bromide and acriflavine. Is also able to transport tetraphenylphosphonium (TPP(+)) and benzalkonium. Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. (110 aa)
cusBCopper/silver efflux system, membrane fusion protein; Part of a cation efflux system that mediates resistance to copper and silver. (407 aa)
ahpCAlkyl hydroperoxide reductase, C22 subunit; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Is the primary scavenger for endogenously generated hydrogen peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. (187 aa)
ahpFAlkyl hydroperoxide reductase, F52a subunit, FAD/NAD(P)-binding; Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein; Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family. (521 aa)
flcFluoride efflux channel, dual topology membrane protein; Important for reducing fluoride concentration in the cell, thus reducing its toxicity. (127 aa)
acrZAcrAB-TolC efflux pump accessory protein, membrane-associated; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export. (49 aa)
ybhRPutative ABC transporter permease; Part of the ABC transporter complex YbhFSR that could be involved in efflux of cefoperazone. Probably involved in the translocation of the substrate across the membrane. Belongs to the ABC-2 integral membrane protein family. (368 aa)
ybhSPutative ABC transporter permease; Part of the ABC transporter complex YbhFSR that could be involved in efflux of cefoperazone. Probably involved in the translocation of the substrate across the membrane. Belongs to the ABC-2 integral membrane protein family. (377 aa)
ybhFPutative ABC transporter ATPase; Part of the ABC transporter complex YbhFSR that could be involved in efflux of cefoperazone. Probably responsible for energy coupling to the transport system. (578 aa)
mdfAMultidrug efflux system protein; Efflux pump driven by the proton motive force. Confers resistance to a broad spectrum of chemically unrelated drugs. Confers resistance to a diverse group of cationic or zwitterionic lipophilic compounds such as ethidium bromide, tetraphenylphosphonium, rhodamine, daunomycin, benzalkonium, rifampicin, tetracycline, puromycin, and to chemically unrelated, clinically important antibiotics such as chloramphenicol, erythromycin, and certain aminoglycosides and fluoroquinolones. Overexpression results in isopropyl-beta-D- thiogalactopyranoside (IPTG) exclusi [...] (410 aa)
grxAGlutaredoxin 1, redox coenzyme for ribonucleotide reductase (RNR1a); The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfide bonds in a coupled system with glutathione reductase; Belongs to the glutaredoxin family. (85 aa)
hcpHybrid-cluster [4Fe-2S-2O] subunit of anaerobic terminal reductases; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. Is also able to reduce hydroxylamine analogs such as methylhydroxylamine and hydroxyquinone. Might have a role as a scavenger of potentially toxic by-products of nitrate metabolism. Belongs to the HCP family. (550 aa)
macAMacrolide transporter membrane fusion protein (MFP) component; Part of the tripartite efflux system MacAB-TolC. MacA stimulates the ATPase activity of MacB by promoting the closed ATP- bound state of MacB, increases the capacity of MacB to bind macrolides such as erythromycin, and provides a physical link between MacB and TolC. When overexpressed, the system confers resistance against macrolides composed of 14- and 15-membered lactones but no or weak resistance against 16-membered ones. In addition, MacA binds tightly rough-core lipopolysaccharide (R-LPS), suggesting that the system co [...] (371 aa)
macBMacrolide ABC transporter peremase/ATPase; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. When overexpressed, the system confers resistance against macrolides composed of 14- and 15-membered lactones but no or weak resistance against 16-membered ones. In addition, the system could also transport R-LPS or a similar glycolipid. Belongs to the ABC transporter superfamily. Macrolide exporte [...] (648 aa)
trxBThioredoxin reductase, FAD/NAD(P)-binding; Thioredoxin reductase; Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family. (321 aa)
ycbX6-N-hydroxylaminopurine detoxification oxidoreductase; Protein involved in electron carrier activity. (369 aa)
cybBCytochrome b561; B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm. (176 aa)
osmCLipoyl-dependent Cys-based peroxidase, hydroperoxide resistance; Preferentially metabolizes organic hydroperoxides over inorganic hydrogen peroxide; Belongs to the OsmC/Ohr family. (143 aa)
mdtIMultidrug efflux system transporter; Catalyzes the excretion of spermidine. Can also confer resistance to deoxycholate and SDS; Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. MdtI subfamily. (109 aa)
mdtJMultidrug efflux system transporter; Catalyzes the excretion of spermidine. Can also confer resistance to deoxycholate and SDS; Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. MdtJ subfamily. (121 aa)
sodCSuperoxide dismutase, Cu, Zn, periplasmic; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. (173 aa)
efeBDeferrrochelatase, periplasmic; Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact. Also displays peroxidase activity on guaiacol in vitro. (423 aa)
sodBSuperoxide dismutase, Fe; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismutase family. (193 aa)
ydhCPutative arabinose efflux transporter; Putative transport protein. (403 aa)
mdtKMultidrug efflux system transporter; Multidrug efflux pump that probably functions as a Na(+)/drug antiporter. Confers resistance to many drugs such as fluoroquinolones (norfloxacin, ciprofloxacin, enoxacin) and tetraphenylphosphonium ion (TPP). Also to deoxycholate, doxorubicin, trimethoprim, chloramphenicol, fosfomycin, ethidium bromide and benzalkonium. Also able to export peptides; when overexpressed, allows cells deleted for multiple peptidases (pepA, pepB, pepD and pepN) to grow in the presence of dipeptides Ala-Gln or Gly-Tyr which otherwise inhibit growth. Cells overexpressing [...] (457 aa)
btuEGlutathione peroxidase; Non-specific peroxidase that can use thioredoxin or glutathione as a reducing agent. In vitro, utilizes preferentially thioredoxin A to decompose hydrogen peroxide as well as cumene-, tert- butyl-, and linoleic acid hydroperoxides, suggesting that it may have one or more organic hydroperoxide as its physiological substrate. Belongs to the glutathione peroxidase family. BtuE subfamily. (183 aa)
katECatalase HPII, heme d-containing; Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide. (753 aa)
ynjACarboxymuconolactone decarboxylase family protein; To M.tuberculosis Rv2313c. (182 aa)
mdtAMultidrug efflux system, subunit A; The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate. MdtABC requires TolC for its function. Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (415 aa)
mdtBMultidrug efflux system, subunit B; The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate. MdtABC requires TolC for its function. (1040 aa)
mdtCMultidrug efflux system, subunit C; The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate. MdtABC requires TolC for its function. (1025 aa)
yeiGS-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate. Shows also esterase activity against alpha-naphthyl acetate, lactoylglutathione, palmitoyl-CoA and several pNP-esters of short chain fatty acids. (278 aa)
bcrBicyclomycin/cysteine/sulfonamide efflux transporter; Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance. Probable membrane translocase. A transporter able to export peptides. When overexpressed, allows cells deleted for multiple peptidases (pepA, pepB, pepD and pepN) to grow in the presence of dipeptides Ala-Gln or Gly-Tyr which otherwise inhibit growth. Cells overexpressing this protein have decreased intracellular levels of Ala-Gln dipeptide, and in a system that produces the Ala-Gln dipeptide overproduction of this protein increases export of the dipeptide. Belongs [...] (396 aa)
yfcFGlutathione S-transferase; Exhibits glutathione (GSH) S-transferase activity toward 1- chloro-2,4-dinitrobenzene (CDNB); however this activity is as low as 1% of that of GstA. Also displays a GSH-dependent peroxidase activity toward cumene hydroperoxide. Is involved in defense against oxidative stress, probably via its peroxidase activity. (214 aa)
yfcGGSH-dependent disulfide bond oxidoreductase; Exhibits a very robust glutathione (GSH)-dependent disulfide- bond reductase activity toward the model substrate, 2-hydroxyethyl disulfide; the actual physiological substrates are not known. Has also a low GSH-dependent hydroperoxidase activity toward cumene hydroperoxide, but does not reduce H(2)O(2), tert-butyl hydroperoxide, benzyl peroxide, or lauroyl peroxide. Exhibits little or no GSH transferase activity with most typical electrophilic substrates, and has no detectable transferase activity using glutathionylspermidine (GspSH) as the n [...] (215 aa)
dsdAD-serine dehydratase (deaminase); Protein involved in cellular amino acid catabolic process. (442 aa)
emrYPutative multidrug efflux system; Part of the tripartite efflux system EmrYK-TolC, which confers resistance to various drugs. (512 aa)
emrKMultidrug resistance efflux pump membrane fusion protein; Part of the tripartite efflux system EmrYK-TolC, which confers resistance to various drugs. (387 aa)
yfeXPorphyrinogen oxidase, cytoplasmic; Has both general peroxidase activity and dye-decolorizing activity. Can catalyze the oxidation of both protoporphyrinogen IX and coproporphyrinogen III to their corresponding porphyrins. Also efficiently decolorizes the dyes alizarin red and Cibacron blue F3GA. (299 aa)
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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