STRINGSTRING
gadW gadW rob rob araC araC yagA yagA insE1 insE1 rclR rclR betI betI prpR prpR insC1 insC1 acrR acrR ybcM ybcM appY appY envY envY ybiH ybiH rcdA rcdA rutR rutR ycfQ ycfQ pinE pinE dhaR dhaR pspF pspF tyrR tyrR pinR pinR feaR feaR ydeO ydeO marA marA pinQ pinQ uidR uidR nemR nemR ydiP ydiP chbR chbR yeaM yeaM yebK yebK ada ada atoC atoC ypdC ypdC murR murR eutR eutR hyfR hyfR glrR glrR yfhH yfhH norR norR fhlA fhlA ygeV ygeV yqhC yqhC fis fis acrS acrS melR melR yjdC yjdC bdcR bdcR gadX gadX xylR xylR slmA slmA yidL yidL glnG glnG rhaS rhaS rhaR rhaR yijO yijO fabR fabR zraR zraR soxS soxS alsR alsR adiY adiY
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proteins of unknown 3D structure
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gadWTranscriptional activator of gadA and gadBC; Depending on the conditions (growth phase and medium), acts as a positive or negative regulator of gadA and gadBC. Repression occurs directly or via the repression of the expression of gadX. Activation occurs directly by the binding of GadW to the gadA and gadBC promoters. (242 aa)
robRight oriC-binding transcriptional activator, AraC family; Binds to the right arm of the replication origin oriC of the chromosome. Rob binding may influence the formation of the nucleoprotein structure, required for oriC function in the initiation of replication. (289 aa)
araCAra regulon transcriptional activator; Transcription factor that regulates the expression of several genes involved in the transport and metabolism of L-arabinose. Functions both as a positive and a negative regulator. In the presence of arabinose, activates the expression of the araBAD, araE, araFGH and araJ promoters. In the absence of arabinose, negatively regulates the araBAD operon. Represses its own transcription. Acts by binding directly to DNA. (292 aa)
yagAUncharacterized protein YagA; Pseudogene, CP4-6 prophage;Phage or Prophage Related. (384 aa)
insE1Transposase InsE for insertion sequence IS3A; Involved in the transposition of the insertion sequence IS3. (99 aa)
rclRReactive chlorine species (RCS)-specific activator of the rcl genes; Involved in reactive chlorine species (RCS) stress resistance. Upregulates, in response to hypochlorous acid (HOCl), the expression of three genes essential for survival of RCS stress (rclA, rclB and rclC) and its own expression. (284 aa)
betICholine-inducible betIBA-betT divergent operon transcriptional repressor; Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine. (195 aa)
prpRPropionate catabolism operon regulatory protein; Involved in the transcriptional regulation of the propionate catabolism operon. (528 aa)
insC1Transposase InsC for insertion element IS2-10; Involved in the transposition of the insertion sequence IS2. (121 aa)
acrRTranscriptional repressor; Potential regulator protein for the acrAB genes. (215 aa)
ybcMDLP12 prophage; Putative ARAC-type regulatory protein. (265 aa)
appYHTH-type transcriptional regulator AppY; Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions. (249 aa)
envYPorin thermoregulatory transcriptional activator; Influences the temperature-dependent expression of several E.coli envelope proteins, most notably the porins OmpF and OmpC and the lambda receptor, LamB. (253 aa)
ybiHDUF1956 domain-containing tetR family putative transcriptional regulator; Regulates transcription of the cecR-ybhGFSR operon and the rhlE gene, which altogether are involved in the control of sensitivity to cefoperazone and chloramphenicol. Represses the cecR-ybhGFSR operon and activates the rhlE operon. Acts by binding to a palindromic sequence within the intergenic spacer located between these two divergently transcribed operons. (223 aa)
rcdATranscriptional regulator of csgD and ybiJI; Regulates the expression of a number of genes involved in biofilm formation and stress response. Target genes include six stress- response transcriptional regulators: csgD, which is a master regulator of biofilm formation, appY, sxy, ycgF, fimB and rcdA itself. This indicates that a large number of genes must be regulated indirectly via these transcriptional regulators. Acts by binding to the upstream region of its target genes. (178 aa)
rutRRut operon transcriptional repressor for; Master transcription regulator which represses the degradation of pyrimidines (rutABCDEFG) and purines (gcl operon) for maintenance of metabolic balance between pyrimidines and purines. It also regulates the synthesis of pyrimidine nucleotides and arginine from glutamine (carAB) and the supply of glutamate (gadABWX). (212 aa)
ycfQRepressor for bhsA(ycfR); Represses expression of BhsA/ComC by binding to its promoter region in the absence of copper. (210 aa)
pinESerine recombinase PinE; This protein catalyzes the inversion of an 1800-bp E.coli DNA fragment, the P region, which can exist in either orientation. The function of the inversion is not yet clear. (184 aa)
dhaRdhaKLM operon transcription activator; Positively regulates the dhaKLM operon from a sigma-70 promoter. Represses its own expression. (639 aa)
pspFPsp operon transcriptional activator; Transcriptional activator for the phage shock protein (psp) operon (pspABCDE) and pspG gene. (325 aa)
tyrRAromatic amino acid biosynthesis and transport regulon transcriptional regulator; Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport. Modulates the expression of at least 8 unlinked operons. Seven of these operons are regulated in response to changes in the concentration of the three aromatic amino acids (phenylalanine, tyrosine and tryptophan). These amino acids are suggested to act as co-effectors which bind to the TyrR protein to form an active regulatory protein. In most cases TyrR causes negative regulation, but positive effects on the tyrP ge [...] (513 aa)
pinRRac prophage; putative site-specific recombinase. (196 aa)
feaRTranscriptional activator for tynA and feaB; Positive regulator of tynA/maoA and feaB/padA, the genes for 2-phenylethylamine catabolism. (301 aa)
ydeOUV-inducible global regulator, EvgA-, GadE-dependent; Induces the expression of gadE and mdtEF. Could also regulate the expression of other genes involved in acid resistance. (253 aa)
marAMultiple antibiotic resistance transcriptional regulator; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. (127 aa)
pinQQin prophage; putative site-specific recombinase; Belongs to the site-specific recombinase resolvase family. (196 aa)
uidRTranscriptional repressor; Repressor for the uidRABC (gusRABC) operon. (196 aa)
nemRTranscriptional repressor for the nemRA-gloA operon, quinone-, glyoxal-, and HOCl-activated; Involved in response to both electrophiles and reactive chlorine species (RCS). Represses the transcription of the nemRA-gloA operon by binding to the NemR box. May sense electrophiles, primarily quinones and glyoxals, as redox signals and regulate the redox state by modulating the expression of nemA and gloA. Also uses the oxidation status of HOCl-sensitive cysteine residues to respond to bleach and related RCS. Involved in response to methylglyoxal. (199 aa)
ydiPPutative ARAC-type regulatory protein; Protein involved in transcription and regulation of transcription, DNA-dependent. (303 aa)
chbRRepressor of chb operon for N,N'-diacetylchitobiose utilization; Dual-function repressor/activator of the chbBCARFG operon. In the absence of the inducing sugar chitobiose, together with NagC, represses the chbBCARFG operon for the uptake and metabolism of chitobiose. In association with Crp, and probably in the presence of chitobiose 6-phosphate, induces the transcription of the chbBCARFG operon. (280 aa)
yeaMPutative DNA-binding transcriptional regulator; Negatively regulates expression of the nimT operon and its own expression. Acts by binding to the nimR-nimT intergenic region. (273 aa)
yebKPutative DNA-binding transcriptional regulator; Represses the expression of the hex regulon (zwf, eda, glp and gap). (289 aa)
adaFused DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs O6-methylguanine (O6-MeG) and O4- methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme (Cys-321). Also specifically repairs the Sp diastereomer of DNA methylphosphotriester lesions by the same mechanism, although the methyl transfer occurs onto a different cysteine residue (Cys-38). Cannot demeth [...] (354 aa)
atoCRegulatory protein AtoC; Member of the two-component regulatory system AtoS/AtoC. In the presence of acetoacetate, AtoS/AtoC stimulates the expression of the atoDAEB operon, leading to short chain fatty acid catabolism and activation of the poly-(R)-3-hydroxybutyrate (cPHB) biosynthetic pathway. Also induces the operon in response to spermidine. Involved in the regulation of motility and chemotaxis, via transcriptional induction of the flagellar regulon. AtoC acts by binding directly to the promoter region of the target genes. In addition to its role as a transcriptional regulator, fun [...] (461 aa)
ypdCPutative ARAC-type regulatory protein; Protein involved in transcription activator activity and transcription. (285 aa)
murRRepressor for murPQ, MurNAc 6-P inducible; Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6- phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator. Also represses its own transcription. (285 aa)
eutREut operon transcriptional activator, AraC family; Activates the transcription of the eut operon. Also positively regulates its own transcription. Probably binds ethanolamine and vitamin B12 as effectors (By similarity). (350 aa)
hyfRHydrogenase-4 transcriptional activator; A transcriptional activator of its own operon; when overexpressed operon expression is strongly enhanced by low pH (under pH 6.0), strongly inhibited by O(2) but only weakly stimulated by fumarate. Expression in situ is very weak. (670 aa)
glrRResponse regulator regulating glmY sRNA in two-component system with sensor protein GlrK; Member of the two-component regulatory system GlrR/GlrK that up-regulates transcription of the glmY sRNA when cells enter the stationary growth phase. Regulates glmY transcription by binding to three conserved sites in the purL-glmY intergenic region. (444 aa)
yfhHPutative DNA-binding transcriptional regulator. (282 aa)
norRAnaerobic nitric oxide reductase DNA-binding transcriptional activator; Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54. Not required for induction of the aerobic NO-detoxifying enzyme NO dioxygenase. Binds to the promoter region of norVW, to a consensus target sequence, GT-(N7)-AC, which is highly conserved among proteobacteria. (504 aa)
fhlAFormate hydrogenlyase transcriptional activator; Required for induction of expression of the formate dehydrogenase H and hydrogenase-3 structural genes. Also activates expression of hyf operon (encodes the silent hydrogenase-4 gene cluster). (692 aa)
ygeVPutative transcriptional regulator; Protein involved in transcription activator activity and transcription. (592 aa)
yqhCTranscriptional activator of yqhD; Putative ARAC-type regulatory protein; Protein involved in transcription activator activity and transcription. (318 aa)
fisGlobal DNA-binding transcriptional dual regulator; Activates ribosomal RNA transcription, as well other genes. Plays a direct role in upstream activation of rRNA promoters. Binds to a recombinational enhancer sequence that is required to stimulate hin- mediated DNA inversion. Prevents initiation of DNA replication from oriC. Binds to hundreds of transcriptionally active and inactive AT- rich sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome. Belongs to the transcriptional regulatory Fis family. (98 aa)
acrSacrAB operon transcriptional repressor; Potential regulator protein for the acrEF/envCD genes. (220 aa)
melRMelibiose operon transcriptional regulator; Transcription activator for the expression of the melAB operon. MelR binds at two sites located upstream of the melAB transcription site. (302 aa)
yjdCtRNA-Phe; Anticodon: GAA. (191 aa)
bdcRTranscriptional repressor for divergent bdcA; Negatively regulates expression of bdcA. (197 aa)
gadXAcid resistance regulon transcriptional activator; Positively regulates the expression of about fifteen genes involved in acid resistance such as gadA, gadB and gadC. Depending on the conditions (growth phase and medium), can repress gadW. (274 aa)
xylRXylose divergent operon transcriptional activator; Regulatory protein for the xylBAFGHR operon. (392 aa)
slmANucleoid occlusion factor, anti-FtsZ division inhibitor; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. (198 aa)
yidLPutative ARAC-type regulatory protein; Protein involved in transcription activator activity and transcription. (297 aa)
glnGDNA-binding transcriptional regulator NtrC; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. Activates transcription of many genes and operons whose products minimize the slowing of growth under nitrogen-limiting conditions, including genes coding for glutamine synthetase (glnA), transporters, amino acid permeases and catabolic enzymes. (469 aa)
rhaSTranscriptional activator of rhaBAD and rhaT; Activates expression of the rhaBAD and rhaT operons. (278 aa)
rhaRTranscriptional activator of rhaSR; Activates expression of the rhaSR operon in response to L- rhamnose. (282 aa)
yijOPutative ARAC-type regulatory protein; Protein involved in transcription activator activity and transcription. (283 aa)
fabRTranscriptional repressor of fabA and fabB; Binds the promoter region of at least fabA and fabB, but probably not yqfA. Represses the transcription of fabA and fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer. (215 aa)
zraRTranscriptional regulatory protein ZraR; Member of the two-component regulatory system ZraS/ZraR. When activated by ZraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon. (441 aa)
soxSSuperoxide response regulon transcriptional activator; Transcriptional activator of the superoxide response regulon of E.coli that includes at least 10 genes such as sodA, nfo, zwf and micF. Binds the DNA sequence 5'-GCACN(7)CAA-3'. It also facilitates the subsequent binding of RNA polymerase to the micF and the nfo promoters. (107 aa)
alsRD-allose-inducible als operon transcriptional repressor; Regulatory protein involved in rpiB gene repression. Also involved in als operon repression. (296 aa)
adiYAdi system transcriptional activator; Putative ARAC-type regulatory protein; Protein involved in transcription activator activity and transcription. (253 aa)
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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