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nupG nupG exuT exuT garP garP nanT nanT tsgA tsgA yhhS yhhS yhjE yhjE yhjX yhjX setC setC nepI nepI uhpT uhpT uhpC uhpC emrD emrD dgoT dgoT glpT glpT hsrA hsrA yihN yihN xylE xylE proP proP dtpC dtpC yjhB yjhB mdtM mdtM lgoT lgoT mdtL mdtL rhmT rhmT yfcJ yfcJ emrY emrY xapB xapB kgtP kgtP setB setB emrB emrB ygcS ygcS yqcE yqcE gudP gudP fucP fucP araE araE galP galP fsr fsr entS entS dtpD dtpD mdfA mdfA ybjJ ybjJ ycaD ycaD mdtG mdtG mdtH mdtH ydeA ydeA ydeE ydeE ynfM ynfM dtpA dtpA ydhP ydhP ydhC ydhC ydiM ydiM ydiN ydiN bcr bcr ydjE ydjE ydjK ydjK yeaN yeaN yebQ yebQ shiA shiA yaaU yaaU setA setA cynX cynX lacY lacY mhpT mhpT araJ araJ yajR yajR iceT iceT yegT yegT ampG ampG
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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nupGNucleoside transporter; Broad-specificity transporter of purine and pyrimidine nucleosides. Driven by a proton motive force. Can transport uridine, adenosine, inosine, guanosine, thymidine and cytidine. Can also transport xanthosine, but with a very low affinity. Belongs to the major facilitator superfamily. Nucleoside:H(+) symporter (NHS) (TC 2.A.1.10) family. (418 aa)
exuTHexuronate transporter; Aldohexuronate transport system. (432 aa)
garPPutative (D)-galactarate transporter; Uptake of D-galactarate; Belongs to the major facilitator superfamily. Phthalate permease family. (444 aa)
nanTSialic acid transporter; Catalyzes the proton-dependent transport of sialic acid. Can transport the common sialic acid N-acetylneuraminic acid (Neu5Ac) and the related sialic acids N- glycolylneuraminic acid (Neu5Gc) and 3-keto-3-deoxy-D-glycero-D- galactonononic acid (KDN). Functions as a bidirectional transporter in vitro. Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family. (496 aa)
tsgAPutative transport; Belongs to the major facilitator superfamily. TsgA family. (393 aa)
yhhSPutative arabinose efflux transporter; Confers high-level resistance to glyphosate when overexpressed. Overexpression has no effect on intracellular arabinose concentrations. Belongs to the major facilitator superfamily. YhhS family. (405 aa)
yhjEPutative MFS transporter; Putative transport protein. (440 aa)
yhjXPyruvate-inducible inner membrane protein, putative transporter; Part of a nutrient-sensing regulatory network composed of the two-component regulatory systems BtsS/BtsR and YpdA/YpdB, and their respective target proteins, BtsT and YhjX. Belongs to the major facilitator superfamily. (402 aa)
setCSugar efflux transporter C; Involved in the efflux of sugars. The physiological role may be the detoxification of non-metabolizable sugar analogs; Belongs to the major facilitator superfamily. Set transporter family. (394 aa)
nepIPutative transporter; Involved in the efflux of purine ribonucleosides, such as guanosine, adenosine and especially inosine. Involved in the resistance to 6-mercaptopurine. (396 aa)
uhpTHexose phosphate transporter; Mediates the exchange of external hexose 6-phosphate and internal inorganic phosphate. Can transport glucose-6-phosphate, fructose-6-phosphate and mannose-6-phosphate. Also catalyzes the neutral exchange of internal and external phosphate. (463 aa)
uhpCMembrane protein regulates uhpT expression; Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC senses external glucose-6-phosphate and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family. (439 aa)
emrDMultidrug efflux system protein; Multidrug resistance pump that participates in a low energy shock adaptive response; Belongs to the major facilitator superfamily. (394 aa)
dgoTD-galactonate transporter; Intake of galactonate into the cell; Belongs to the major facilitator superfamily. Phthalate permease family. (430 aa)
glpTSn-glycerol-3-phosphate transporter; Responsible for glycerol-3-phosphate uptake. (452 aa)
hsrAPutative multidrug or homocysteine efflux system; Putative transport protein (MFS family); high copy suppressor of RspA: relieves RspA-mediated reduction of sigma(S) levels; overexpression also reduces MetE activity; effect proposed to be via an elevation in levels of homocysteine, causing a concomitant increase in homocysteine thiolactone; overexpression has no effect on resistance to a variety of toxic compounds; overexpression has no effect on resistance to a variety of toxic compounds; Belongs to the major facilitator superfamily. EmrB family. (475 aa)
yihNMFS transporter family protein; Putative resistance protein (transport); Belongs to the major facilitator superfamily. (421 aa)
xylED-xylose transporter; Uptake of D-xylose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Glucose is not transported, but can compete for xylose binding sites and can inhibit xylose transport (in vitro). Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (491 aa)
proPProline/glycine betaine transporter; Proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response; Belongs to the major facilitator superfamily. Metabolite:H+ Symporter (MHS) family (TC 2.A.1.6) family. (500 aa)
dtpCDipeptide and tripeptide permease; Proton-dependent permease that transports di- and tripeptides. Shows significantly higher specificity towards dipeptides than tripeptides. Has a preference for dipeptides with a C-terminal Lys residue. Can bind Ala-Lys, Lys-Ala, Ala-Ala. Can also transport alanine and trialanine. Belongs to the PTR2/POT transporter (TC 2.A.17) family. (485 aa)
yjhBPutative MFS transporter, membrane protein; Putative transport protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (405 aa)
mdtMMultidrug efflux system protein; Confers resistance to acriflavine, chloramphenicol, norfloxacin, ethidium bromide and TPP; Belongs to the major facilitator superfamily. (410 aa)
lgoTPutative L-galactonate:H+ symporter; Probably responsible for the transport of L-galactonate from the periplasm across the inner membrane. Is essential for growth on L- galactonate as the sole carbon source; Belongs to the major facilitator superfamily. Phthalate permease family. (453 aa)
mdtLMultidrug efflux system protein; Confers resistance to chloramphenicol. Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2.A.1.2.22) subfamily. (391 aa)
rhmTPutative L-rhamnonate transporter; Putative transport protein; Belongs to the major facilitator superfamily. Phthalate permease family. (429 aa)
yfcJPutative arabinose efflux transporter; Overexpression has no effect on intracellular arabinose concentrations. (392 aa)
emrYPutative multidrug efflux system; Part of the tripartite efflux system EmrYK-TolC, which confers resistance to various drugs. (512 aa)
xapBXanthosine transporter; Uptake of xanthosine. Driven by a proton motive force. Can also transport other nucleosides such as inosine, adenosine, cytidine, uridine and thymidine. (418 aa)
kgtPAlpha-ketoglutarate transporter; Uptake of alpha-ketoglutarate across the boundary membrane with the concomitant import of a cation (symport system). Belongs to the major facilitator superfamily. Metabolite:H+ Symporter (MHS) family (TC 2.A.1.6) family. (432 aa)
setBLactose/glucose efflux system; Involved in the efflux of sugars. The physiological role may be the detoxification of non-metabolizable sugar analogs. Can transport lactose and glucose; Belongs to the major facilitator superfamily. Set transporter family. (393 aa)
emrBMultidrug efflux system protein; Part of the tripartite efflux system EmrAB-TolC, which confers resistance to antibiotics such as CCCP, FCCP, 2,4-dinitrophenol and nalidixic acid. (512 aa)
ygcSPutative MFS sugar transporter; Putative transport protein. (445 aa)
yqcEPutative MFS transporter, inner membrane protein; Putative transport protein. (425 aa)
gudPPutative D-glucarate transporter; Uptake of D-glucarate; Belongs to the major facilitator superfamily. Phthalate permease family. (450 aa)
fucPL-fucose transporter; Mediates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Can also transport L-galactose and D-arabinose, but at reduced rates compared with L-fucose. Is not able to transport L-rhamnose and L-arabinose. (438 aa)
araEArabinose transporter; Uptake of arabinose across the boundary membrane with the concomitant transport of protons into the cell (symport system). (472 aa)
galPD-galactose transporter; Uptake of galactose across the boundary membrane with the concomitant transport of protons into the cell (symport system); Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (464 aa)
fsrPutative fosmidomycin efflux system protein; Confers the resistance against fosmidomycin; Belongs to the major facilitator superfamily. (406 aa)
entSEnterobactin exporter, iron-regulated; Component of an export pathway for enterobactin. Overexpression reduces intracellular arabinose concentrations. (416 aa)
dtpDDipeptide and tripeptide permease D; Probable proton-dependent permease that transports dipeptides; Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpD subfamily. (493 aa)
mdfAMultidrug efflux system protein; Efflux pump driven by the proton motive force. Confers resistance to a broad spectrum of chemically unrelated drugs. Confers resistance to a diverse group of cationic or zwitterionic lipophilic compounds such as ethidium bromide, tetraphenylphosphonium, rhodamine, daunomycin, benzalkonium, rifampicin, tetracycline, puromycin, and to chemically unrelated, clinically important antibiotics such as chloramphenicol, erythromycin, and certain aminoglycosides and fluoroquinolones. Overexpression results in isopropyl-beta-D- thiogalactopyranoside (IPTG) exclusi [...] (410 aa)
ybjJPutative drug efflux MFS transporter, inner membrane protein; Putative DEOR-type transcriptional regulator. (402 aa)
ycaDPutative MFS transporter, inner membrane protein. (382 aa)
mdtGPutative drug efflux system protein; Confers resistance to fosfomycin and deoxycholate. Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily. (408 aa)
mdtHMultidrug resistance protein MdtH; Confers resistance to norfloxacin and enoxacin. (402 aa)
ydeAArabinose efflux transporter, arabinose-inducible; Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites. Transports L-arabinose and to a lesser extent IPTG. Seems to contribute to the control of the arabinose regulon; Belongs to the major facilitator superfamily. SotB (TC 2.A.1.2) family. (396 aa)
ydeEPutative transporter; A transporter able to export peptides. When overexpressed, allows cells deleted for multiple peptidases (pepA, pepB, pepD and pepN) to grow in the presence of dipeptides Ala-Gln or Gly-Tyr which otherwise inhibit growth. Cells overexpressing this protein have decreased intracellular levels of Ala-Gln dipeptide, and in a system that produces the Ala-Gln dipeptide overproduction of this protein increases export of the dipeptide. Belongs to the major facilitator superfamily. (395 aa)
ynfMPutative arabinose efflux transporter; Putative transport protein. (417 aa)
dtpADipeptide and tripeptide permease A; Proton-dependent permease that transports di- and tripeptides as well as structurally related peptidomimetics such as aminocephalosporins into the cell. Has a clear preference for dipeptides and tripeptides composed of L-amino acids, and discriminates dipeptides on the basis of the position of charges within the substrate; Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpA subfamily. (500 aa)
ydhPPutative MFS transporter, inner membrane protein; Putative transport protein. (389 aa)
ydhCPutative arabinose efflux transporter; Putative transport protein. (403 aa)
ydiMPutative MFS transporter, membrane protein; Putative transport system permease protein. (404 aa)
ydiNPutative MFS transporter, membrane protein; Putative amino acid/amine transport protein. (421 aa)
bcrBicyclomycin/cysteine/sulfonamide efflux transporter; Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance. Probable membrane translocase. A transporter able to export peptides. When overexpressed, allows cells deleted for multiple peptidases (pepA, pepB, pepD and pepN) to grow in the presence of dipeptides Ala-Gln or Gly-Tyr which otherwise inhibit growth. Cells overexpressing this protein have decreased intracellular levels of Ala-Gln dipeptide, and in a system that produces the Ala-Gln dipeptide overproduction of this protein increases export of the dipeptide. Belongs [...] (396 aa)
ydjEPutative MFS sugar transporter, membrane protein; Putative transport protein. (452 aa)
ydjKPutative MFS sugar transporter, membrane protein; Putative transport protein. (459 aa)
yeaNPutative MFS transporter, inner membrane protein; Involved in efflux of 2-nitroimidazole. Belongs to the major facilitator superfamily. Cyanate porter (TC 2.A.1.17) family. (393 aa)
yebQPutative transport protein. (457 aa)
shiAShikimate transporter; Pseudogene, glycosyltransferase homology. (438 aa)
yaaUPutative MFS sugar transporter; Putative transport protein. (443 aa)
setABroad specificity sugar efflux system; Involved in the efflux of sugars. The physiological role may be the detoxification of non-metabolizable sugar analogs. Can transport IPTG, lactose and glucose. Has broad substrate specificity, with preferences for glucosides or galactosides with alkyl or aryl substituents; Belongs to the major facilitator superfamily. Set transporter family. (392 aa)
cynXPutative cyanate transporter; This protein is part of an active transport system that transports exogenous cyanate into E.coli cells; Belongs to the major facilitator superfamily. Cyanate porter (TC 2.A.1.17) family. (384 aa)
lacYLactose permease; Responsible for transport of beta-galactosides into the cell, with the concomitant import of a proton (symport system). Can transport lactose, melibiose, lactulose or the analog methyl-1-thio-beta,D- galactopyranoside (TMG), but not sucrose or fructose. The substrate specificity is directed toward the galactopyranosyl moiety of the substrate. (417 aa)
mhpT3-hydroxyphenylpropionic transporter; Uptake of 3-(3-hydroxyphenyl)propionate (3HPP) across the cytoplasmic membrane. Transport is driven by the proton motive force. Does not transport benzoate, 3-hydroxybenzoate or gentisate. Belongs to the major facilitator superfamily. Aromatic acid:H(+) symporter (AAHS) (TC 2.A.1.15) family. (403 aa)
araJL-arabinose-inducible putative transporter, MFS family; May be involved in either the transport or processing of arabinose polymers; Belongs to the major facilitator superfamily. (394 aa)
yajRPutative transport protein; Protein involved in response to drug. (454 aa)
iceTPutative citrate/iron-citrate/zinc-citrate efflux transporter; Putative transport protein; Belongs to the major facilitator superfamily. TCR/Tet family. (471 aa)
yegTNucleoside transporter, low affinity; Could be involved in nucleoside transport; Belongs to the major facilitator superfamily. Nucleoside:H(+) symporter (NHS) (TC 2.A.1.10) family. (425 aa)
ampGMuropeptide transporter; Permease involved in cell wall peptidoglycan recycling. Transports, from the periplasm into the cytoplasm, the disaccharide N-acetylglucosaminyl-beta-1,4-anhydro- N-acetylmuramic acid (GlcNAc-anhMurNAc) and GlcNAc-anhMurNAc-peptides. Transport is dependent on the proton motive force. AmpG is also involved in beta-lactamase induction ; Belongs to the major facilitator superfamily. (491 aa)
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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