Your Input: | |
| | lldR | Dual role activator/repressor for lldPRD operon; May be a regulatory protein for the LCT genes. (258 aa) |
| | yjiR | Uncharacterized HTH-type transcriptional regulator YjiR; RIP347 (repetitive extragenic palindromic) element; contains 2 REP sequences and 1 IHF site; In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. (470 aa) |
| | lgoR | Putative transcriptional activator for L-galactonate catabolism; May be a positive transcriptional regulator for lgoD and/or lgoT. Is essential for growth on L-galactonate as the sole carbon source. (304 aa) |
| | yjjQ | Putative regulator. (241 aa) |
| | bglJ | Bgl operon transcriptional activator; A crytic transcriptional activator. When its expression is induced it relieves H-NS repression of the bgl operon. Acts independently of transcription factor LeuO. (225 aa) |
| | creB | Response regulator in two-component regulatory system with CreC; Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. (229 aa) |
| | arcA | Response regulator in two-component regulatory system with ArcB or CpxA; Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions. Controls the resistance of E.coli to dyes; required for expression of the alkaline phosphatase and sex factor F genes; It also may be involved in the osmoregulation of envelope proteins. When activated by ArcB, it negatively regulates the expression of genes of aerobic function. Activates the transcription of the plfB operon by binding to its promoter. (238 aa) |
| | smf | DNA recombination-mediator A family protein; Partially complements natural chromosomal DNA transformation defect of an H.influenzae dprA disruption mutant. May help load RecA onto ssDNA (By similarity). Belongs to the DprA/Smf family. (374 aa) |
| | dgoR | D-galactonate catabolism operon transcriptional repressor; Repressor for the dgoRKAT operon. Binds D-galactonate as an inducer. (229 aa) |
| | hdfR | flhDC operon transcriptional repressor; Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon. Belongs to the LysR transcriptional regulatory family. (279 aa) |
| | nhaR | Transcriptional activator of nhaA; Plays a role in the positive regulation of NhaA. Belongs to the LysR transcriptional regulatory family. (301 aa) |
| | caiF | Cai operon transcriptional activator; Potential transcriptional activator of carnitine metabolism. (131 aa) |
| | leuO | Global transcription factor; A global transcription factor. Activates transcription of the 9 following operons; yjjQ-bglJ, yjjP, acrEF, ybdO, yjcRQP, casABCDE12, rhsD-ybbC, fepE and gltF, in most cases it probably interferes with silencing by H-NS and activates transcription. Represses transcription of the 3 following operons; uxaCA, sdaCB and btsT. H-NS repression of the bgl operon, leading to the ability to metabolize some beta- glucosides. It also directly activates the bgl operon. Activation is H- NS and BglJ-RcsB independent. (314 aa) |
| | pdhR | Pyruvate dehydrogenase complex repressor; Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd. (254 aa) |
| | yafC | Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. (304 aa) |
| | perR | CP4-6 prophage; Apparent regulatory gene involved in peroxide resistance in stationary phase; Belongs to the LysR transcriptional regulatory family. (297 aa) |
| | yagI | CP4-6 prophage; Involved in regulation of xylonate catabolism. Represses the expression of both yagA and yagEF operons. Binds mainly at a single site within the spacer of the bidirectional transcription units yagA and yagEF. (252 aa) |
| | ecpR | Putative transcriptional regulator for the ecp operon; Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition. Positively regulates the expression of the ecp operon (By similarity). Also represses expression of the flagellar master operon flhDC, and consequently prevents flagellum biosynthesis and motility. Acts by binding to the regulatory region of the flhDC operon (Probable); Belongs to the EcpR/MatA family. (196 aa) |
| | yahA | c-di-GMP-specific phosphodiesterase; Acts both as an enzyme and as a c-di-GMP sensor to couple transcriptional activity to the c-di-GMP status of the cell. Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic-di-GMP (c-di-GMP) to 5'-pGpG. Also acts as a transcription factor to control its own expression. (362 aa) |
| | yahB | Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription. (310 aa) |
| | cynR | Transcriptional activator of cyn operon; Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR-cynTSX intergenic region. (299 aa) |
| | mhpR | Mhp operon transcriptional activator; Activator of the mhpABCDFE operon coding for components of the 3-hydroxyphenylpropionate degradation pathway. (277 aa) |
| | insC1 | Transposase InsC for insertion element IS2-10; Involved in the transposition of the insertion sequence IS2. (121 aa) |
| | phoB | Response regulator in two-component regulatory system with PhoR; This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited. (229 aa) |
| | ybaO | Putative DNA-binding transcriptional regulator; Plays a role in L-cysteine detoxification. Binds to the dlsT(yhaO)-yhaM operon promoter in the presence but not absence of L- cysteine; activates transcription from the dlsT(yhaO)-yhaM operon. No other DNA target was identified in strain K12 / BW25113. Thiosulfate does not activate its transcription function. Overexpression doubles hydrogen sulfide production in the presence of cysteine. (152 aa) |
| | ybaZ | Excision repair protein, alkyltransferase-like protein ATL; Involved in DNA damage recognition. Binds DNA containing O(6)-methylguanine and larger O(6)-alkylguanine adducts, and to double- stranded DNA that contains an AP (apurinic/apyrimidinic) site. Binds to the damaged base and flips the base out of the DNA duplex into an extrahelical conformation, which allows processing by repair proteins. Works in partnership with the nucleotide excision repair (NER) pathway to enhance the repair of the O(6)- alkylguanine adducts larger than the methyl adduct. Also prevents methyl-directed mismat [...] (129 aa) |
| | allS | allD operon transcriptional activator; Positive regulator essential for the expression of allD operon. Binds to the allD promoter; Belongs to the LysR transcriptional regulatory family. (308 aa) |
| | allR | Glyoxylate-inducible transcriptional repressor of all and gcl operons; Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS-allA intergenic region. Binding to DNA is abolished by glyoxylate. (271 aa) |
| | nohD | DLP12 prophage; Bacteriophage DNA packaging protein. (181 aa) |
| | cusR | Response regulator in two-component regulatory system with CusS; Member of the two-component regulatory system CusS/CusR involved in response to copper and silver. Activates the expression of cusCFBA, hiuH and plasmid pRJ1004 gene pcoE in response to increasing levels of copper or silver ions. Can also increase the basal-level expression of copper resistance gene operon pcoABCD. (227 aa) |
| | ybdO | Putative transcriptional regulator LYSR-type; Protein involved in transcription and regulation of transcription, DNA-dependent; Belongs to the LysR transcriptional regulatory family. (300 aa) |
| | ybeF | Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. (317 aa) |
| | nagC | N-acetylglucosamine-inducible nag divergent operon transcriptional repressor; Acts as a repressor of the nagEBACD operon and acts both as an activator and a repressor for the transcription of the glmSU operon. Belongs to the ROK (NagC/XylR) family. (406 aa) |
| | fur | Ferric iron uptake regulon transcriptional repressor; Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes. Regulates the expression of several outer-membrane proteins including the iron transport operon; Belongs to the Fur family. (148 aa) |
| | kdpE | Response regulator in two-component regulatory system with KdpD; Member of the two-component regulatory system KdpD/KdpE involved in the regulation of the kdp operon. (225 aa) |
| | mngR | Transcriptional repressor for the mannosyl-D-glycerate catabolic operon; Represses mngA and mngB. Regulates its own expression. (240 aa) |
| | modE | Transcriptional repressor for the molybdenum transport operon modABC; Functions as an intracellular molybdate sensor. The ModE-Mo complex acts as a repressor of the modABC operon, which is involved in the transport of molybdate. Binds modA promoter DNA in the absence of molybdate, however molybdate binding confers increased DNA affinity. Binds the promoter of moaA activating its transcription; binding is not enhanced by molybdate. The protein dimer binds the consensus palindrome sequence 5'-TATAT-N7-TAYAT-3' and a variant 5'-TGTGT-N7-TGYGT-3'. Acts as a regulator of the expression of 6 [...] (262 aa) |
| | ybhD | Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. (317 aa) |
| | mntR | Mn(2+)-responsive manganese regulon transcriptional regulator; In the presence of manganese, represses expression of mntH and mntS. Up-regulates expression of mntP. (155 aa) |
| | lrp | Leucine-responsive global transcriptional regulator; Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes. (164 aa) |
| | ftsK | DNA translocase at septal ring sorting daughter chromsomes; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (K [...] (1329 aa) |
| | ycaN | Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. (302 aa) |
| | mukF | Chromosome condensin MukBEF, kleisin-like subunit, binds calcium; Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity; Belongs to the MukF family. (440 aa) |
| | torR | Response regulator in two-component regulatory system with TorS; Member of the two-component regulatory system TorS/TorR involved in the anaerobic utilization of trimethylamine-N-oxide (TMAO). Phosphorylated TorR activates the transcription of the torCAD operon by binding to four decameric boxes located in the torCAD promoter. Box1, 2 and 4 contain the DNA sequence 5'-CTGTTCATAT-3' and box3 contains the DNA sequence 5'-CCGTTCATCC-3'. Phosphorylated as well as unphosphorylated TorR negatively regulates its own expression by binding to box1 and 2. (230 aa) |
| | csgD | csgBAC operon transcriptional regulator; The master regulator for adhesive curli fimbriae expression; necessary for transcription of the csgBAC/ymdA operon. Plays a positive role in biofilm formation. May have the capability to respond to starvation and/or high cell density by activating csgBA transcription. Low-level constitutive expression confers an adherent curli fimbriae- expressing phenotype, up-regulates 10 genes and down-regulates 14 others. (216 aa) |
| | yceH | UPF0502 family protein; Belongs to the UPF0502 family. (215 aa) |
| | phoP | Response regulator in two-component regulatory system with PhoQ; Member of the two-component regulatory system PhoP/PhoQ involved in adaptation to low Mg(2+) environments and the control of acid resistance genes. In low periplasmic Mg(2+), PhoQ phosphorylates PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), PhoQ dephosphorylates phospho-PhoP, resulting in the repression of PAG and may lead to expression of some PRG (By similarity). Mediates magnesium influx to the cytosol by activation of MgtA. Pro [...] (223 aa) |
| | fadR | Fatty acid metabolism regulon transcriptional regulator; Multifunctional regulator of fatty acid metabolism. Represses transcription of at least eight genes required for fatty acid transport and beta-oxidation including fadA, fadB, fadD, fadL and fadE. Activates transcription of at least three genes required for unsaturated fatty acid biosynthesis: fabA, fabB and iclR, the gene encoding the transcriptional regulator of the aceBAK operon encoding the glyoxylate shunt enzymes. (239 aa) |
| | narL | Response regulator in two-component regulatory system with NarX; This protein activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal transmitted by either the NarX or NarQ proteins. (216 aa) |
| | cysB | N-acetylserine-responsive cysteine regulon transcriptional activator; This protein is a positive regulator of gene expression for the cysteine regulon, a system of 10 or more loci involved in the biosynthesis of L-cysteine from inorganic sulfate. The inducer for CysB is N-acetylserine. CysB inhibits its own transcription. (324 aa) |
| | yciT | Putative DEOR-type transcriptional regulator; Protein involved in transcription repressor activity and transcription. (249 aa) |
| | pgrR | Murein peptide degradation regulator; Regulates the expression of genes involved in peptidoglycan (PG) degradation. Could play a role in switch control between recycling and degradation of PG peptides. Negatively regulates the expression of the ycjY-ymjD-ymjC-mpaA operon by binding to the PgrR-box. In addition, other genes are predicted to be under the control of PgrR, including genes related to membrane formation and function. (299 aa) |
| | fnr | Oxygen-sensing anaerobic growth regulon transcriptional regulator FNR; Global transcription factor that controls the expression of over 100 target genes in response to anoxia. It facilitates the adaptation to anaerobic growth conditions by regulating the expression of gene products that are involved in anaerobic energy metabolism. When the terminal electron acceptor, O(2), is no longer available, it represses the synthesis of enzymes involved in aerobic respiration and increases the synthesis of enzymes required for anaerobic respiration. (250 aa) |
| | ogt | O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (171 aa) |
| | abgR | Putative DNA-binding transcriptional regulator of abgABT operon; Could be the regulator of the abg operon; Belongs to the LysR transcriptional regulatory family. (302 aa) |
| | paaX | Transcriptional repressor of phenylacetic acid degradation paa operon, phenylacetyl-CoA inducer; Negative regulator of the paaZ and paaABCDEFGHIJK catabolic operons. Binds the consensus sequence 5'-WWTRTGATTCGYGWT-3'. Binding of PaaX is specifically inhibited by phenylacetyl-coenzyme A (PA-CoA). (316 aa) |
| | ydcI | Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. (307 aa) |
| | ydcR | Multi modular; putative transcriptional regulator; also putative ATP-binding component of a transport system; Protein involved in ATP-binding cassette (ABC) transporter activity and regulation of transcription, DNA-dependent; In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. (468 aa) |
| | mcbR | Colanic acid and biofilm gene transcriptional regulator, MqsR-controlled; Important for biofilm formation. Represses expression of McbA by binding to its promoter region, which prevents colanic acid overproduction and mucoidy. (221 aa) |
| | lsrR | Lsr operon transcriptional repressor; Regulates transcription of many different genes. In the absence of autoinducer 2 (AI-2), represses transcription of the lsrACDBFG operon and its own transcription. In the presence of AI-2, LsrR is inactivated by binding phospho-AI-2, leading to the transcription of the lsr genes. (317 aa) |
| | yneJ | Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. (293 aa) |
| | marR | Transcriptional repressor of multiple antibiotic resistance; Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes. Binds to the marO operator/promoter site. (144 aa) |
| | rspR | Transcriptional repressor for rspAB; Repressor of the rspAB operon. Acts by binding directly to the upstream region of rspA. (228 aa) |
| | mlc | Glucosamine anaerobic growth regulon transcriptional repressor; Transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. Regulates the expression of malT. (406 aa) |
| | ynfL | Putative transcriptional regulator LYSR-type; Protein involved in regulation of transcription, DNA-dependent; Belongs to the LysR transcriptional regulatory family. (297 aa) |
| | rstA | Response regulator of RstAB two-component system; Member of the two-component regulatory system RstB/RstA. (239 aa) |
| | slyA | Global transcriptional regulator; Transcription regulator that can specifically activate or repress expression of target genes. Activates expression of genes such as molecular chaperones (groL, groS, dnaK, grpE, and cbpA), proteins involved in acid resistance (hdeA, hdeB, and gadA), the starvation lipoprotein slp, virulence protein hlyE/clyA. Represses expression of genes involved in the histidine biosynthetic pathway such as hisA, hisB, hisD, hisF and hisG. Required for the activation of virulence genes; Belongs to the SlyA family. (144 aa) |
| | ydhB | Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. (310 aa) |
| | ydjF | Putative DEOR-type transcriptional regulator; Protein involved in transcription and regulation of transcription, DNA-dependent. (252 aa) |
| | dmlR | Transcriptional activator of dmlA; Transcriptional regulator required for the aerobic growth on D-malate as the sole carbon source. Induces the expression of dmlA in response to D-malate or L- or meso-tartrate. Negatively regulates its own expression. (307 aa) |
| | kdgR | KDG regulon transcriptional repressor; Transcriptional regulator of the kdgK gene for the kdg kinase and the kdgT gene for the kdg permease. (263 aa) |
| | yebK | Putative DNA-binding transcriptional regulator; Represses the expression of the hex regulon (zwf, eda, glp and gap). (289 aa) |
| | ruvB | ATP-dependent DNA helicase, component of RuvABC resolvasome; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. Belongs to the RuvB family. (336 aa) |
| | sdiA | Quorum-sensing transcriptional activator; Activates cell division by specifically increasing transcription from one of the two promoters that lie immediately upstream of the ftsQAZ gene cluster. Activates ydiV expression in response to extracellular autoinducer AI-1 (Vibrio fischeri autoinducer oxoC6). (240 aa) |
| | rcsA | Transcriptional regulator of colanic acid capsular biosynthesis; Component of the Rcs signaling system, which controls transcription of numerous genes. Binds, with RcsB, to the RcsAB box to regulate expression of genes involved in colanic acid capsule synthesis. (207 aa) |
| | yedW | Response regulator family protein; Member of a two-component regulatory system HprR/HprS involved in response to hydrogen peroxide. Regulates the expression of at least 5 operons, cyoABCDE, hprRS, hiuH, cusRS and cusCFBA. Bifunctional regulator that acts as an activator and a repressor. (223 aa) |
| | cbl | ssuEADCB/tauABCD operon transcriptional activator; May be an accessory regulatory protein within the cys regulon. (316 aa) |
| | nac | Nitrogen assimilation regulon transcriptional regulator; Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation. Negative regulator of its own expression (By similarity). (305 aa) |
| | yeeY | Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. (309 aa) |
| | baeR | Response regulator in two-component regulatory system with BaeS; Member of the two-component regulatory system BaeS/BaeR which responds to envelope stress. Activates expression of periplasmic chaperone spy in response to spheroplast formation, indole and P pili protein PapG overexpression. Activates the mdtABCD and probably the CRISPR-Cas casABCDE-ygbT-ygbF operon. (240 aa) |
| | yegW | Putative transcriptional regulator; Protein involved in transcription repressor activity and transcription. (248 aa) |
| | yeiE | Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. (293 aa) |
| | yeiI | Putative kinase; Belongs to the carbohydrate kinase PfkB family. (362 aa) |
| | ada | Fused DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs O6-methylguanine (O6-MeG) and O4- methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme (Cys-321). Also specifically repairs the Sp diastereomer of DNA methylphosphotriester lesions by the same mechanism, although the methyl transfer occurs onto a different cysteine residue (Cys-38). Cannot demeth [...] (354 aa) |
| | rcsB | Response regulator in two-component regulatory system with RcsC and YojN; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions. Can function both in an RcsA-dependent or RcsA-independent manner. The system regulates expression of numerous genes, including genes involved in colanic acid capsule synthesis, biofilm formation, cell division and outer membrane proteins synthesis. Also involved, with GadE, in control of glutamate-dependent acid resistance, and, with BglJ, in derepression of [...] (216 aa) |
| | rhmR | Putative DNA-binding transcriptional regulator for the rhm operon; Putative regulator; Protein involved in transcription and regulation of transcription, DNA-dependent. (260 aa) |
| | lrhA | Transcriptional repressor of flagellar, motility and chemotaxis genes; Not known, does not seem to act on the proton translocating NADH dehydrogenase genes (nuoA-N) which are part of the lrhA operon. (312 aa) |
| | dsdC | Dsd operon activator; Regulates the expression of the dsdX-dsdA operon. (311 aa) |
| | evgA | Response regulator in two-component regulatory system with EvgS; Member of the two-component regulatory system EvgS/EvgA. Regulates the expression of emrKY operon and yfdX. Seems also to control expression of at least one other multidrug efflux operon. (204 aa) |
| | xapR | Transcriptional activator of xapAB; Positive regulator required for the expression of xapA and xapB. Binds to the inducer xanthosine. (294 aa) |
| | yfeR | Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. (308 aa) |
| | murR | Repressor for murPQ, MurNAc 6-P inducible; Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6- phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator. Also represses its own transcription. (285 aa) |
| | eutK | Putative ethanol utilization carboxysome structural protein; May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place; Belongs to the bacterial microcompartments protein family. (166 aa) |
| | iscR | Isc operon transcriptional repressor; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. Transcriptional repressor of the iscRSUA operon, which is involved in the assembly of Fe-S clusters into Fe-S proteins. In its apoform, under conditions of oxidative stress or iron deprivation, it activates the suf operon, which is a second operon involved in the assembly of Fe-S clusters. Represses its own transcription as well as that of toxin rnlA. (162 aa) |
| | hcaR | Hca operon transcriptional regulator; Transcriptional activator of the hca operon for 3- phenylpropionic acid catabolism. (296 aa) |
| | yphH | Putative NAGC-like transcriptional regulator; Protein involved in regulation of transcription, DNA-dependent; Belongs to the ROK (NagC/XylR) family. (397 aa) |
| | yfhH | Putative DNA-binding transcriptional regulator. (282 aa) |
| | rpoE | RNA polymerase sigma E factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase (RNAP) to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma-E controls the envelope stress response, responding to periplasmic protein stress, increased levels of periplasmic lipopolysaccharide (LPS) as well as heat shock and oxidative stress; it controls protein processing in the extracytoplasmic compartment. The 90 member regulon consists of the genes necessary for the synthesis and maintenance of both proteins and LPS of the outer me [...] (191 aa) |
| | yfiE | Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. (293 aa) |
| | csiR | Transcriptional repressor of csiD; Negatively regulates the expression of the glaH-lhgD-gabDTP operon in a temporal manner during entry into stationary phase or during the first few hours of carbon starvation. Thereby is involved in the regulation of a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2- hydroxyglutarate. Binds to two primary and two secondary sites in the promoter region of the glaH operon with the consensus sequences TTGTN5TTTT and ATGTN5TTTT of the primary sites, each separated by six nucleotides. (220 aa) |
| | ygaV | Tributyltin-inducible repressor of ygaVP; Functions as transcription repressor. (99 aa) |
| | mprA | Transcriptional repressor of microcin B17 synthesis and multidrug efflux; Negative regulator of the multidrug operon emrAB. (176 aa) |
| | recX | Regulatory protein for RecA; Modulates RecA activity through direct physical interaction. Can inhibit both RecA recombinase and coprotease activities. May have a regulatory role during the SOS response. Inhibits DNA strand exchange in vitro; Belongs to the RecX family. (166 aa) |
| | srlR | Sorbitol-inducible srl operon transcriptional repressor; Regulator for gut (srl), glucitol operon; Protein involved in carbohydrate catabolic process, transcription and regulation of transcription, DNA-dependent. (257 aa) |
| | ygbI | Putative DEOR-type transcriptional regulator; Protein involved in transcription repressor activity and transcription. (255 aa) |
| | rpoS | RNA polymerase, sigma S (sigma 38) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. Controls, positively or negatively, the expression of several hundred genes, which are mainly involved in metabolism, transport, regulation and stress management. (330 aa) |
| | fucR | L-fucose operon activator; Transcriptional activator of the fuc operon. (243 aa) |
| | gcvA | Glycine cleavage system transcriptional activator; Regulatory protein for the glycine cleavage system operon (gcv). Mediates activation of gcv by glycine and repression by purines. GcvA is negatively autoregulated. Binds to three sites upstream of the gcv promoter; Belongs to the LysR transcriptional regulatory family. (305 aa) |
| | lysR | Transcriptional activator of lysA; This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression; Belongs to the LysR transcriptional regulatory family. (311 aa) |
| | yqeI | Putative transcriptional regulator; Putative sensory transducer; To V.cholerae cholera toxin transcriptional activator (ToxR). (269 aa) |
| | ygeH | Putative transcriptional regulator; Putative invasion protein. (458 aa) |
| | argP | HTH-type transcriptional regulator ArgP; Controls the transcription of genes involved in arginine and lysine metabolism. Activates transcription of several genes, including argO, lysP, lysC, asd, dapB, dapD, lysA, gdhA and argK. Acts by binding directly to their promoter or control region. ArgP dimer by itself is able to bind the argO promoter-operator region to form a binary complex, but the formation of a ternary complex with RNA polymerase is greatly stimulated only in presence of a coeffector. Both arginine and lysine are coeffectors at the argO promoter, but only arginine is compe [...] (297 aa) |
| | ygfI | Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. (298 aa) |
| | glcC | Glycolate-inducible glc operon transcriptional repressor; Transcriptional activator of the glcDEFGB operon which is associated with glycolate utilization, and encodes malate synthase G and the genes needed for glycolate oxidase activity. Also negatively regulates the transcription of its own gene. Glycolate acts as an effector, but GlcC can also use acetate as an alternative effector. (254 aa) |
| | qseB | Quorum sensing DNA-binding response regulator in two-component regulatory system with QseC; Member of a two-component regulatory system QseB/QseC. Activates the flagella regulon by activating transcription of FlhDC. Currently it is not known whether this effect is direct or not. (219 aa) |
| | ttdR | Transcriptional activator of ttdABT; Positive regulator required for L-tartrate-dependent anaerobic growth on glycerol. Induces expression of the ttdA-ttdB-ygjE operon. (310 aa) |
| | rpoD | RNA polymerase, sigma 70 (sigma D) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. Preferentially transcribes genes associated with fast growth, such as ribosomal operons, other protein-synthesis related genes, rRNA- and tRNA-encoding genes and prfB. Belongs to the sigma-70 factor family. RpoD/SigA subfamily. (613 aa) |
| | yqjI | PadR family putative transcriptional regulator; Represses the expression of YqjH which is involved in iron homeostasis under excess nickel conditions. Also represses its own expression. (207 aa) |
| | exuR | Hexuronate regulon transcriptional repressor; Repressor for the exu regulon that encode genes involved in hexuronate utilization. It regulates the ExuT, UxaCA and UxuRAB operons. Binds D-tagaturonate and D-fructuronate as inducers. (258 aa) |
| | yhaJ | LysR family putative transcriptional regulator; Positive regulator, may be partially responsible for expression of neighboring gene dlsT (yhaO) (By similarity). (298 aa) |
| | tdcA | Tdc operon transcriptional activator; Transcriptional activator for the tdcABCDE operon. Belongs to the LysR transcriptional regulatory family. (312 aa) |
| | agaR | Transcriptional repressor of the aga regulon; Probable repressor for the aga operon for N-acetyl galactosamine transport and metabolism. (269 aa) |
| | nanR | Sialic acid-inducible nan operon repressor; Transcriptional repressor that controls expression of the genes required for the catabolism of sialic acids. Represses expression of the nanATEK- yhcH, nanCMS and yjhBC operons. Acts by binding directly to the Nan box, a region of approximately 30 bp covering the promoter region. (263 aa) |
| | argR | L-arginine-responsive arginine metabolism regulon transcriptional regulator; Negatively controls the expression of the four operons of arginine biosynthesis in addition to the carAB operon. Predominantly interacts with A/T residues in ARG boxes. It also binds to a specific site in cer locus. Thus it is essential for cer-mediated site-specific recombination in ColE1. It is necessary for monomerization of the plasmid ColE1; Belongs to the ArgR family. (156 aa) |
| | aaeR | Transcriptional regulator for aaeXAB operon; Activates transcription of the aaeXAB operon. (309 aa) |
| | crp | cAMP-activated global transcription factor, mediator of catabolite repression; A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding (to consensus sequence 5'-AAATGTGATCTAGATCACATTT-3') to directly regulate the transcription of about 300 genes in about 200 operons and indirectly regulate the expression of about half the genome. There are 3 classes of CRP promoters; class I promoters have a single CRP-binding site upstream of the RNA polymerase (RNAP)-binding site, whereas in class II promoters the single CRP- and RNAP-binding site [...] (210 aa) |
| | frlR | Putative DNA-binding transcriptional regulator; May regulate the transcription of the frlABCDR operon, involved in the utilization of fructoselysine and psicoselysine. (243 aa) |
| | ompR | Response regulator in two-component regulatory system with EnvZ; Member of the two-component regulatory system EnvZ/OmpR involved in osmoregulation (particularly of genes ompF and ompC) as well as other genes. Plays a central role in both acid and osmotic stress responses. Binds to the promoter of both ompC and ompF; at low osmolarity it activates ompF transcription, while at high osmolarity it represses ompF and activates ompC transcription. Involved in acid stress response; this requires EnvZ but not OmpR phosphorylation. Phosphorylated by EnvZ; this stimulates OmpR's DNA-binding abi [...] (239 aa) |
| | feoC | Putative DNA-binding transcriptional regulator; May function as a transcriptional regulator that controls feoABC expression; Belongs to the FeoC family. (78 aa) |
| | malT | Mal regulon transcriptional activator; Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto- oligosaccharides. Specifically binds to the promoter region of its target genes, recognizing a short DNA motif called the MalT box (5'- GGA[TG]GA-3'). Displays weak ATPase activity, but this activity is not required for promoter binding. (901 aa) |
| | arsR | Arsenical resistance operon transcriptional repressor; Transcriptional repressor for the arsEFG operon. ArsE is a trans-acting regulatory protein which controls its own expression. The repressive effect of ArsE is alleviated by oxyions of +III oxidation state of arsenic, antimony, and bismuth, as well as arsenate (As(V)) (By similarity). (117 aa) |
| | dctR | Putative LuxR family repressor for dicarboxylate transport; May act as a transcriptional regulator of dctA. (176 aa) |
| | gadE | Gad regulon transcriptional activator; Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci. (175 aa) |
| | yhjC | Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. (299 aa) |
| | insJ | IS150 transposase A; Belongs to the IS150/IS1296 orfA family. (173 aa) |
| | yiaJ | Transcriptional repressor for the yiaKLMNO-lyxK-sgbHUE operon; Negatively controls the transcription of the yiaKLMNOPQRS operon, which may be involved in the utilization of 2,3-diketo-L- gulonate. (282 aa) |
| | yiaU | Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. (324 aa) |
| | selB | selenocysteinyl-tRNA-specific translation factor; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. SelB subfamily. (614 aa) |
| | yidP | Uncharacterized HTH-type transcriptional regulator YidP; Pseudogene, arbutin specific enzyme IIC component of PTS;enzyme; Transport of small molecules: Carbohydrates, organic acids, alcohols; PTS system, arbutin-like IIB component; PTS system, arbutin-like IIC component. (238 aa) |
| | yidZ | Putative DNA-binding transcriptional regulator; Involved in anaerobic NO protection. (319 aa) |
| | asnC | Transcriptional activator of asnA; Activator of asnA transcription; autogenous regulator of its own transcription; and repressor of the expression of gidA at a post- transcriptional level. (152 aa) |
| | yieP | Putative transcriptional regulator. (230 aa) |
| | ilvY | Transcriptional activator of ilvC; This protein activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate. IlvY is also a negative regulator of its own expression; Belongs to the LysR transcriptional regulatory family. (297 aa) |
| | recQ | ATP-dependent DNA helicase; Involved in the RecF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase; Belongs to the helicase family. RecQ subfamily. (609 aa) |
| | metR | Methionine biosynthesis regulon transcriptional regulator; Control of the last step in methionine biosynthesis; MetR is a positive activator of the metA, metE and metH genes. MetR is also a negative regulator of its own expression. Binds homocysteine as an inducer; Belongs to the LysR transcriptional regulatory family. (317 aa) |
| | yihL | Putative transcriptional regulator; Protein involved in transcription repressor activity and transcription. (236 aa) |
| | yihW | Putative transcriptional regulator for sulphoquinovose utilization; Involved in the regulation of the sulfoquinovose operon. Represses the expression of the yihUTS operon and of the yihV and csqR genes. Binds DNA inside the spacer between the bidirectional transcription units comprising the yihUTS operon and the yihV gene, and upstream the csqR gene itself. (261 aa) |
| | frvR | Putative frv operon regulator; Could be involved in the regulation of the transcription of the FRV operon. (582 aa) |
| | cpxR | Response regulator in two-component regulatory system with CpxA; Response regulator member of the two-component regulatory system CpxA/CpxR which responds to envelope stress response by activating expression of downstream genes including cpxP, degP, dsbA and ppiA. Required for efficient binding of stationary phase cells to hydrophobic surfaces, part of the process of biofilm formation. Induced upon cell surface binding, subsequently induces genes it controls (cpxP, dsbA and spy, degP is only partially induced). Binds and activates transcription from the degP promoter ; binding is enhan [...] (232 aa) |
| | oxyR | Oxidative and nitrosative stress transcriptional regulator; Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. OxyR expression is negatively autoregulated by binding to a 43 bp region upstream of its own coding sequence. OxyR is inactivated by reduction of its essential disulfide bond by the product of GrxA, itself positively regulated by OxyR. Has also a positive regulatory effect on the production of surface proteins that control the colony morphology and auto- [...] (305 aa) |
| | birA | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. (321 aa) |
| | iclR | Transcriptional repressor; Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyruvate enhances promoter binding by stabilizing the tetrameric form. (274 aa) |
| | lexA | Transcriptional repressor of SOS regulon; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single- stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. Implicated in hydroxy radical-mediated cell death induced by hydroxyurea treatment .The SOS response controls an apoptotic-like death (ALD) induced (in the absence [...] (202 aa) |
| | zur | Transcriptional repressor, Zn(II)-binding; Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes (znuACB); Belongs to the Fur family. (171 aa) |
| | alsR | D-allose-inducible als operon transcriptional repressor; Regulatory protein involved in rpiB gene repression. Also involved in als operon repression. (296 aa) |
| | phnF | Putative DNA-binding transcriptional regulator of phosphonate uptake and biodegradation; Belongs to an operon involved in alkylphosphonate uptake and C-P lyase. Exact function not known. By similarity could be a transcriptional regulator. (241 aa) |
| | basR | Response regulator in two-component regulatory system with BasS; Member of the two-component regulatory system BasS/BasR. BasR induces the transcription of the ugd, ais, arnBCADTEF and eptA-basRS loci, all involved in resistance to polymyxin (By similarity). (222 aa) |
| | cadC | cadBA operon transcriptional activator; Required for Pcad induction, a promoter upstream of cadBA that is responsible for the pH-regulated expression of CadA and CadB. Probably acts as an activating transcription factor. (512 aa) |
| | nsrR | Nitric oxide-sensitive repressor for NO regulon; Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress, such as ytfE, hmpA and ygbA. May require iron for activity. Does not regulates its own transcription. (141 aa) |
| | ulaR | Transcriptional repressor for the L-ascorbate utilization divergent operon; Represses ulaG and the ulaABCDEF operon. Two ulaR binding sites have been identified in each promoter. Full activity requires simultaneous interaction of UlaR with both divergent promoters and seems to be dependent on repressor-mediated DNA loop formation, which is helped by the action of integration host factor. (251 aa) |
| | ytfH | DUF24 family HxlR-type putative transcriptional regulator; Protein involved in regulation of transcription, DNA-dependent. (126 aa) |
| | fecI | RNA polymerase sigma-19 factor, fec operon-specific; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor regulates the fec genes for iron dicitrate transport (Probable); Belongs to the sigma-70 factor family. ECF subfamily. (173 aa) |
| | yjhU | Uncharacterized transcriptional regulator YjhU; IS1 transposase B;IS, phage, Tn; Transposon-related functions; extrachromosomal; transposon related; Belongs to the SorC transcriptional regulatory family. (328 aa) |
| | yjhI | Putative regulator; Protein involved in transcription repressor activity and transcription. (262 aa) |
| | sgcR | Putative DNA-binding transcriptional regulator; Putative transcriptional regulator for the sgcREAQCX region. (260 aa) |
| | uxuR | Fructuronate-inducible hexuronate regulon transcriptional repressor; Repressor for the uxuRBA operon. (257 aa) |
| | hypT | Hypochlorite-responsive transcription factor; Protects cells from HOCl (hypochlorite) stress but not peroxide or diamide stress. Decreases the intracellular load of reactive oxygen species by up-regulating genes involved in methionine and cysteine biosynthesis and down-regulating Fur-regulated genes involved in iron acquisition. Has also been suggested to down-regulate expression of the flagellar regulon, decreasing motility, but this activity was not confirmed in a second study. Belongs to the LysR transcriptional regulatory family. (303 aa) |
