STRINGSTRING
xylB xylB araD araD araA araA araB araB uvrC uvrC gnd gnd fucK fucK prkB prkB rpe rpe glpD glpD gntK gntK xylA xylA lyxK lyxK rhaD rhaD rhaA rhaA rhaB rhaB glpK glpK glpF glpF idnO idnO
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
xylBXylulokinase; Catalyzes the phosphorylation of D-xylulose to D-xylulose 5- phosphate. Also catalyzes the phosphorylation of 1- deoxy-D-xylulose to 1-deoxy-D-xylulose 5-phosphate, with lower efficiency. Can also use D-ribulose, xylitol and D- arabitol, but D-xylulose is preferred over the other substrates. Has a weak substrate-independent Mg-ATP-hydrolyzing activity ; Belongs to the FGGY kinase family. (484 aa)
araDL-ribulose-5-phosphate 4-epimerase; Involved in the degradation of L-arabinose. Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D- xylulose 5-phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon- carbon bond cleavage analogous to a class II aldolase reaction). (231 aa)
araAL-arabinose isomerase; Catalyzes the conversion of L-arabinose to L-ribulose. (500 aa)
araBL-ribulokinase; Protein involved in carbohydrate catabolic process; Belongs to the ribulokinase family. (566 aa)
uvrCExcinuclease UvrABC, endonuclease subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (610 aa)
gnd6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (468 aa)
fucKL-fuculokinase; Catalyzes the phosphorylation of L-fuculose. Can also phosphorylate, with lower efficiency, D-ribulose, D-xylulose and D- fructose. (472 aa)
prkBProbable phosphoribulokinase; Protein involved in glucose metabolic process. (289 aa)
rpeD-ribulose-5-phosphate 3-epimerase; Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate. (225 aa)
glpDSn-glycerol-3-phosphate dehydrogenase, aerobic, FAD/NAD(P)-binding; Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses molecular oxygen or nitrate as electron acceptor. (501 aa)
gntKGluconokinase 2, thermoresistant; gluconate transport, GNT I system; Protein involved in glucose metabolic process; Belongs to the gluconokinase GntK/GntV family. (175 aa)
xylAD-xylose isomerase; Protein involved in carbohydrate catabolic process and glucose metabolic process; Belongs to the xylose isomerase family. (440 aa)
lyxKL-xylulose kinase; Catalyzes the phosphorylation of L-xylulose and 3-keto-L- gulonate. Is involved in L-lyxose utilization via xylulose, and may also be involved in the utilization of 2,3-diketo-L-gulonate. (498 aa)
rhaDRhamnulose-1-phosphate aldolase; Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde. Also catalyzes the dephosphorylation of phospho- serine in vitro ; Belongs to the aldolase class II family. RhaD subfamily. (274 aa)
rhaAL-rhamnose isomerase; Protein involved in carbohydrate catabolic process. (419 aa)
rhaBRhamnulokinase; Involved in the catabolism of L-rhamnose (6-deoxy-L-mannose). It could also play a role in the metabolism of some rare sugars such as L-fructose. Catalyzes the transfer of the gamma-phosphate group from ATP to the 1-hydroxyl group of L-rhamnulose to yield L-rhamnulose 1- phosphate. Uridine triphosphate (UTP), cytidine 5-triphosphate (CTP), guanosine 5-triphosphate (GTP), and thymidine triphosphate (TTP) also can act as phosphoryl donors. It can also phosphorylate L-fuculose and L-xylulose. Belongs to the rhamnulokinase family. (489 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. It also catalyzes the phosphorylation of dihydroxyacetone, L-glyceraldehyde and D-glyceraldehyde. It uses only ATP; Belongs to the FGGY kinase family. (502 aa)
glpFGlycerol facilitator; Transporter of glycerol across the cytoplasmic membrane, with limited permeability to water and small uncharged compounds such as polyols; Belongs to the MIP/aquaporin (TC 1.A.8) family. (281 aa)
idnO5-keto-D-gluconate-5-reductase; Catalyzes the reduction of 5-keto-D-gluconate to D-gluconate, using either NADH or NADPH. Is likely involved in an L-idonate degradation pathway that allows E.coli to utilize L-idonate as the sole carbon and energy source. Is also able to catalyze the reverse reaction in vitro, but the D-gluconate oxidation by the enzyme can only proceed with NAD; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (254 aa)
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.