node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
gstA | gstB | b1635 | b0838 | Glutathionine S-transferase; Catalyzes the conjugation of reduced glutathione (GSH) to a wide number of exogenous and endogenous hydrophobic electrophiles. Shows activity toward 1-chloro-2,4-dinitrobenzene (CDNB) and ethacrynic acid. Also possesses thiol:disulfide oxidoreductase activity, using GSH to reduce bis-(2-hydroxyethyl) disulfide (HEDS). Has a low level of glutathione-dependent peroxidase activity toward cumene hydroperoxide. Is important for defense against oxidative stress, probably via its peroxidase activity. Belongs to the GST superfamily. Beta family. | Glutathione S-transferase; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes the glutathione-dependent dehalogenation of bromoacetate. | 0.966 |
gstA | yfcF | b1635 | b2301 | Glutathionine S-transferase; Catalyzes the conjugation of reduced glutathione (GSH) to a wide number of exogenous and endogenous hydrophobic electrophiles. Shows activity toward 1-chloro-2,4-dinitrobenzene (CDNB) and ethacrynic acid. Also possesses thiol:disulfide oxidoreductase activity, using GSH to reduce bis-(2-hydroxyethyl) disulfide (HEDS). Has a low level of glutathione-dependent peroxidase activity toward cumene hydroperoxide. Is important for defense against oxidative stress, probably via its peroxidase activity. Belongs to the GST superfamily. Beta family. | Glutathione S-transferase; Exhibits glutathione (GSH) S-transferase activity toward 1- chloro-2,4-dinitrobenzene (CDNB); however this activity is as low as 1% of that of GstA. Also displays a GSH-dependent peroxidase activity toward cumene hydroperoxide. Is involved in defense against oxidative stress, probably via its peroxidase activity. | 0.938 |
gstB | gstA | b0838 | b1635 | Glutathione S-transferase; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes the glutathione-dependent dehalogenation of bromoacetate. | Glutathionine S-transferase; Catalyzes the conjugation of reduced glutathione (GSH) to a wide number of exogenous and endogenous hydrophobic electrophiles. Shows activity toward 1-chloro-2,4-dinitrobenzene (CDNB) and ethacrynic acid. Also possesses thiol:disulfide oxidoreductase activity, using GSH to reduce bis-(2-hydroxyethyl) disulfide (HEDS). Has a low level of glutathione-dependent peroxidase activity toward cumene hydroperoxide. Is important for defense against oxidative stress, probably via its peroxidase activity. Belongs to the GST superfamily. Beta family. | 0.966 |
gstB | yfcF | b0838 | b2301 | Glutathione S-transferase; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes the glutathione-dependent dehalogenation of bromoacetate. | Glutathione S-transferase; Exhibits glutathione (GSH) S-transferase activity toward 1- chloro-2,4-dinitrobenzene (CDNB); however this activity is as low as 1% of that of GstA. Also displays a GSH-dependent peroxidase activity toward cumene hydroperoxide. Is involved in defense against oxidative stress, probably via its peroxidase activity. | 0.933 |
phnC | phnF | b4106 | b4102 | Phosphonate ABC transporter ATPase; Part of the ABC transporter complex PhnCDE involved in phosphonates, phosphate esters, phosphite and phosphate import. Responsible for energy coupling to the transport system. | Putative DNA-binding transcriptional regulator of phosphonate uptake and biodegradation; Belongs to an operon involved in alkylphosphonate uptake and C-P lyase. Exact function not known. By similarity could be a transcriptional regulator. | 0.993 |
phnC | phnG | b4106 | b4101 | Phosphonate ABC transporter ATPase; Part of the ABC transporter complex PhnCDE involved in phosphonates, phosphate esters, phosphite and phosphate import. Responsible for energy coupling to the transport system. | Ribophosphonate triphosphate synthase subunit; Together with PhnH, PhnI and PhnL is required for the transfer of the ribose triphosphate moiety from ATP to methyl phosphonate. | 0.997 |
phnC | phnI | b4106 | b4099 | Phosphonate ABC transporter ATPase; Part of the ABC transporter complex PhnCDE involved in phosphonates, phosphate esters, phosphite and phosphate import. Responsible for energy coupling to the transport system. | Ribophosphonate triphosphate synthase complex putative catalytic subunit; Together with PhnG, PhnH and PhnL is required for the transfer of the ribose triphosphate moiety from ATP to methyl phosphonate. PhnI alone has nucleosidase activity, catalyzing the hydrolysis of ATP or GTP forming alpha-D-ribose 5-triphosphate and adenine or guanine, respectively. | 0.995 |
phnC | phnJ | b4106 | b4098 | Phosphonate ABC transporter ATPase; Part of the ABC transporter complex PhnCDE involved in phosphonates, phosphate esters, phosphite and phosphate import. Responsible for energy coupling to the transport system. | Carbon-phosphorus lyase, SAM-dependent; Catalyzes the breakage of the C-P bond in alpha-D-ribose 1- methylphosphonate 5-phosphate (PRPn) forming alpha-D-ribose 1,2-cyclic phosphate 5-phosphate (PRcP). | 0.996 |
phnC | phnM | b4106 | b4095 | Phosphonate ABC transporter ATPase; Part of the ABC transporter complex PhnCDE involved in phosphonates, phosphate esters, phosphite and phosphate import. Responsible for energy coupling to the transport system. | Ribophosphonate triphosphate hydrolase; Catalyzes the hydrolysis of alpha-D-ribose 1- methylphosphonate triphosphate (RPnTP) to form alpha-D-ribose 1- methylphosphonate phosphate (PRPn) and diphosphate. Belongs to the metallo-dependent hydrolases superfamily. | 0.994 |
phnC | phnN | b4106 | b4094 | Phosphonate ABC transporter ATPase; Part of the ABC transporter complex PhnCDE involved in phosphonates, phosphate esters, phosphite and phosphate import. Responsible for energy coupling to the transport system. | Ribose 1,5-bisphosphokinase; Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP). Accepts ATP but not GTP as a phosphoryl donor, and uses ribose 1,5-bisphosphate but not ribose, ribose 1-phosphate, or ribose 5-phosphate as a phosphoryl acceptor. | 0.988 |
phnC | phnO | b4106 | b4093 | Phosphonate ABC transporter ATPase; Part of the ABC transporter complex PhnCDE involved in phosphonates, phosphate esters, phosphite and phosphate import. Responsible for energy coupling to the transport system. | Aminoalkylphosphonate N-acetyltransferase; Aminoalkylphosphonate N-acetyltransferase which is able to acetylate a range of aminoalkylphosphonic acids, including aminomethylphosphonate, (S)-1-aminoethylphosphonate and 2- aminoethyl- and 3-aminopropylphosphonate, using acetyl-CoA as acetyl donor. Is required for the utilization of aminomethylphosphonate and (S)-1-aminoethylphosphonate as a phosphate source via the C-P lyase pathway. Is also essential for the detoxification of (S)-1- aminoethylphosphonate, a structural analog of D-alanine that has bacteriocidal properties due to inhibitio [...] | 0.902 |
phnC | phnP | b4106 | b4092 | Phosphonate ABC transporter ATPase; Part of the ABC transporter complex PhnCDE involved in phosphonates, phosphate esters, phosphite and phosphate import. Responsible for energy coupling to the transport system. | 5-phospho-alpha-D-ribosyl 1,2-cyclic phosphate phosphodiesterase; Catalyzes the hydrolysis of the cyclic ribose-phosphate to form alpha-D-ribose 1,5-bisphosphate. | 0.950 |
phnC | phoB | b4106 | b0399 | Phosphonate ABC transporter ATPase; Part of the ABC transporter complex PhnCDE involved in phosphonates, phosphate esters, phosphite and phosphate import. Responsible for energy coupling to the transport system. | Response regulator in two-component regulatory system with PhoR; This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited. | 0.723 |
phnC | phoR | b4106 | b0400 | Phosphonate ABC transporter ATPase; Part of the ABC transporter complex PhnCDE involved in phosphonates, phosphate esters, phosphite and phosphate import. Responsible for energy coupling to the transport system. | Sensory histidine kinase in two-component regulatory system with PhoB; Member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoB in response to environmental signals. | 0.560 |
phnF | phnC | b4102 | b4106 | Putative DNA-binding transcriptional regulator of phosphonate uptake and biodegradation; Belongs to an operon involved in alkylphosphonate uptake and C-P lyase. Exact function not known. By similarity could be a transcriptional regulator. | Phosphonate ABC transporter ATPase; Part of the ABC transporter complex PhnCDE involved in phosphonates, phosphate esters, phosphite and phosphate import. Responsible for energy coupling to the transport system. | 0.993 |
phnF | phnG | b4102 | b4101 | Putative DNA-binding transcriptional regulator of phosphonate uptake and biodegradation; Belongs to an operon involved in alkylphosphonate uptake and C-P lyase. Exact function not known. By similarity could be a transcriptional regulator. | Ribophosphonate triphosphate synthase subunit; Together with PhnH, PhnI and PhnL is required for the transfer of the ribose triphosphate moiety from ATP to methyl phosphonate. | 0.999 |
phnF | phnI | b4102 | b4099 | Putative DNA-binding transcriptional regulator of phosphonate uptake and biodegradation; Belongs to an operon involved in alkylphosphonate uptake and C-P lyase. Exact function not known. By similarity could be a transcriptional regulator. | Ribophosphonate triphosphate synthase complex putative catalytic subunit; Together with PhnG, PhnH and PhnL is required for the transfer of the ribose triphosphate moiety from ATP to methyl phosphonate. PhnI alone has nucleosidase activity, catalyzing the hydrolysis of ATP or GTP forming alpha-D-ribose 5-triphosphate and adenine or guanine, respectively. | 0.998 |
phnF | phnJ | b4102 | b4098 | Putative DNA-binding transcriptional regulator of phosphonate uptake and biodegradation; Belongs to an operon involved in alkylphosphonate uptake and C-P lyase. Exact function not known. By similarity could be a transcriptional regulator. | Carbon-phosphorus lyase, SAM-dependent; Catalyzes the breakage of the C-P bond in alpha-D-ribose 1- methylphosphonate 5-phosphate (PRPn) forming alpha-D-ribose 1,2-cyclic phosphate 5-phosphate (PRcP). | 0.998 |
phnF | phnM | b4102 | b4095 | Putative DNA-binding transcriptional regulator of phosphonate uptake and biodegradation; Belongs to an operon involved in alkylphosphonate uptake and C-P lyase. Exact function not known. By similarity could be a transcriptional regulator. | Ribophosphonate triphosphate hydrolase; Catalyzes the hydrolysis of alpha-D-ribose 1- methylphosphonate triphosphate (RPnTP) to form alpha-D-ribose 1- methylphosphonate phosphate (PRPn) and diphosphate. Belongs to the metallo-dependent hydrolases superfamily. | 0.997 |
phnF | phnN | b4102 | b4094 | Putative DNA-binding transcriptional regulator of phosphonate uptake and biodegradation; Belongs to an operon involved in alkylphosphonate uptake and C-P lyase. Exact function not known. By similarity could be a transcriptional regulator. | Ribose 1,5-bisphosphokinase; Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP). Accepts ATP but not GTP as a phosphoryl donor, and uses ribose 1,5-bisphosphate but not ribose, ribose 1-phosphate, or ribose 5-phosphate as a phosphoryl acceptor. | 0.995 |