STRINGSTRING
lepB lepB ibsA ibsA yfjD yfjD yjgA yjgA yihA yihA rsmJ rsmJ yhgF yhgF php php yhdE yhdE yhcN yhcN yhbY yhbY hda hda yeeX yeeX yceF yceF ybcJ ybcJ yaiP yaiP lacZ lacZ map map yaaA yaaA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lepBLeader peptidase (signal peptidase I); Belongs to the peptidase S26 family. (324 aa)
ibsAToxic membrane protein. (19 aa)
yfjDUPF0053 family inner membrane protein; Putative membrane protein. (428 aa)
yjgARibosome-associated UPF0307 family protein; Putative alpha helix protein; Protein involved in ATP-binding cassette (ABC) transporter activity. (183 aa)
yihACell division GTP-binding protein; Necessary for normal cell division and for the maintenance of normal septation. Depletion of this protein leads to a severe reduction in growth rate and to extensive filamentation, with a block beyond the stage of segregation. Essential for bacteria survival. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. (210 aa)
rsmJ16S rRNA m(2)G1516 methyltransferase, SAM-dependent; Specifically methylates the guanosine in position 1516 of 16S rRNA; Belongs to the methyltransferase superfamily. RsmJ family. (250 aa)
yhgFPutative transcriptional accessory protein. (773 aa)
phpPhosphotriesterase homology protein; Its real enzymatic activity is not yet known. It was tested for general esterase, aminopeptidase, sulfatase, phosphatase, carbonic anhydrase, phosphodiesterase, and phosphotriesterase activities with the following substrates: p-nitrophenyl acetate, L-alanine nitroanilide, p-nitrophenyl sulfate, bis(p-nitrophenyl) phosphate, paraoxon, and p-nitrophenyl phosphate. No enzymatic activity was detected with any of these non-specific substrates. (292 aa)
yhdEdTTP/UTP pyrophosphatase; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze TTP and the modified nucleotides 5-methyl-UTP (m(5)UTP), pseudo-UTP and 5-methyl-CTP (m(5)CTP). Has weak activity with CTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. Important in maintenance of cell shape. (197 aa)
yhcNCadmium and peroxide resistance protein, stress-induced. (87 aa)
yhbYRNA binding protein associated with pre-50S ribosomal subunits. (97 aa)
hdaATPase regulatory factor involved in DnaA inactivation; Mediates the interactions of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinitiation, a process called regulatory inhibition of DnaA or RIDA. ADP-binding activates Hda to hydrolyze DnaA-ATP; Hda monomers bind to ADP with about 200-fold greater affinity than for ATP. RIDA function can be genetically separated from viability, suggesting this protein has another function as well. (233 aa)
yeeXUPF0265 protein YeeX; Pseudogene, CP4-44 putative prophage remnant;Phage or Prophage Related; Belongs to the UPF0265 family. (109 aa)
yceFm(7)GTP pyrophosphatase; Nucleoside triphosphate pyrophosphatase that hydrolyzes 7- methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. Belongs to the Maf family. YceF subfamily. (194 aa)
ybcJRibosome-associated protein; Its structure and the presence of conserved basic residues indicates that it probably binds RNA. (70 aa)
yaiPPutative family 2 glycosyltransferase; Polysaccharide metabolism; Protein involved in polysaccharide biosynthetic process; Belongs to the glycosyltransferase 2 family. (398 aa)
lacZbeta-D-galactosidase; Protein involved in carbohydrate catabolic process; Belongs to the glycosyl hydrolase 2 family. (1024 aa)
mapMethionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. (264 aa)
yaaAPeroxide resistance protein, lowers intracellular iron; Involved in the cellular response to hydrogen peroxide (H(2)O(2)) stress. During H(2)O(2) stress, prevents oxidative damage to both DNA and proteins by diminishing the amount of unincorporated iron within the cell. (258 aa)
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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