STRINGSTRING
nanE nanE priC priC sfmC sfmC icd icd rsxB rsxB wcaL wcaL wcaK wcaK wcaC wcaC wcaA wcaA yfjK yfjK recA recA sdaC sdaC nanT nanT nanA nanA glpD glpD dnaB dnaB soxR soxR fimC fimC dnaT dnaT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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nanEPutative N-acetylmannosamine-6-P epimerase; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P). (229 aa)
priCPrimosomal replication protein N'; PriA recognizes a specific hairpin sequence on bacteriophage phi X174 ssDNA. This structure is then recognized and bound by proteins PriB and PriC. Formation of the primosome proceeds with the subsequent actions of DnaB, DnaC, DnaT and primase. (175 aa)
sfmCPutative periplasmic pilus chaperone; Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes. (230 aa)
icdIsocitrate dehydrogenase, specific for NADP+; Protein involved in tricarboxylic acid cycle and anaerobic respiration; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (416 aa)
rsxBSoxR iron-sulfur cluster reduction factor component; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane (By similarity). Required to maintain the reduced state of SoxR. Probably transfers electron from NAD(P)H to SoxR. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily. (192 aa)
wcaLPutative colanic acid biosynthesis glycosyl transferase; Protein involved in colanic acid biosynthetic process. (406 aa)
wcaKPutative galactokinase; Protein involved in colanic acid biosynthetic process. (426 aa)
wcaCPutative glycosyl transferase; Protein involved in colanic acid biosynthetic process. (405 aa)
wcaAPutative glycosyl transferase; Putative regulator; Protein involved in colanic acid biosynthetic process. (279 aa)
yfjKRadiation resistance protein; DEAD/H helicase-like protein; CP4-57 putative defective prophage. (729 aa)
recADNA recombination and repair protein; Required for homologous recombination and the bypass of mutagenic DNA lesions by the SOS response. Catalyzes ATP-driven homologous pairing and strand exchange of DNA molecules necessary for DNA recombinational repair. Catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single- stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. The SOS response controls an apoptotic-like death (ALD) induced (in the absence of the mazE-mazF toxin-antitoxin module) in resp [...] (353 aa)
sdaCPutative serine transporter; Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity. (429 aa)
nanTSialic acid transporter; Catalyzes the proton-dependent transport of sialic acid. Can transport the common sialic acid N-acetylneuraminic acid (Neu5Ac) and the related sialic acids N- glycolylneuraminic acid (Neu5Gc) and 3-keto-3-deoxy-D-glycero-D- galactonononic acid (KDN). Functions as a bidirectional transporter in vitro. Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family. (496 aa)
nanAN-acetylneuraminate lyase; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate; Belongs to the DapA family. NanA subfamily. (297 aa)
glpDSn-glycerol-3-phosphate dehydrogenase, aerobic, FAD/NAD(P)-binding; Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses molecular oxygen or nitrate as electron acceptor. (501 aa)
dnaBReplicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. (471 aa)
soxRRedox-sensitive transcriptional activator of soxS; Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron- sulfur cluster that may act as a redox sensor system that recognizes superoxide. The variable redox state of the Fe-S cluster is employed in vivo to modulate the transcriptional activity of SoxR in response to specific types of oxidative stress. Upon reduction of 2Fe-2S cluster, SoxR reversibly loses its transcriptional activity, but retains its DNA binding affinity. (154 aa)
fimCPeriplasmic chaperone; Required for the biogenesis of type 1 fimbriae. Binds and interact with FimH. (241 aa)
dnaTDNA biosynthesis protein (primosomal protein I); This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'; Belongs to the DnaT family. (179 aa)
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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