N-acetylgalactosamine-specific enzyme IIB component of PTS; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylgalactosamine transport.

C4-dicarboxylic acid, orotate and citrate transporter; Responsible for the aerobic transport of the dicarboxylates fumarate, L- and D-malate and to a lesser extent succinate, from the periplasm across the inner membrane; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.

Aldehyde dehydrogenase A, NAD-linked; Acts on lactaldehyde as well as other aldehydes.

C4-dicarboxylic acid, orotate and citrate transporter; Responsible for the aerobic transport of the dicarboxylates fumarate, L- and D-malate and to a lesser extent succinate, from the periplasm across the inner membrane; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.

Aldehyde dehydrogenase A, NAD-linked; Acts on lactaldehyde as well as other aldehydes.

L-fuculose-1-phosphate aldolase; Involved in the degradation of L-fucose and D-arabinose. Catalyzes the reversible cleavage of L-fuculose 1- phosphate (Fuc1P) to yield dihydroxyacetone phosphate (DHAP) and L- lactaldehyde (Ref.8, Ref.9,. Also able to catalyze the reversible cleavage of D- ribulose 1-phosphate, but FucA has a higher affinity for L-fuculose 1- phosphate and L-lactaldehyde than for D-ribulose 1-phosphate and glycolaldehyde, respectively. FucA possesses a high specificity for the dihydroxyacetone phosphate (DHAP), but accepts a great variety of different aldehydes and has [...]

Aldehyde dehydrogenase A, NAD-linked; Acts on lactaldehyde as well as other aldehydes.

Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. It also catalyzes the phosphorylation of dihydroxyacetone, L-glyceraldehyde and D-glyceraldehyde. It uses only ATP; Belongs to the FGGY kinase family.

Aldehyde dehydrogenase A, NAD-linked; Acts on lactaldehyde as well as other aldehydes.

L-lactate dehydrogenase, FMN-linked; Catalyzes the conversion of L-lactate to pyruvate. Seems to be a primary dehydrogenase in the respiratory chain. To a lesser extent, can also oxidize DL-alpha-hydroxybutyrate, but not D-lactate.

Aldehyde dehydrogenase A, NAD-linked; Acts on lactaldehyde as well as other aldehydes.

Pyruvate kinase I (formerly F), fructose stimulated; Protein involved in glycolysis, fermentation and anaerobic respiration.

Aldehyde dehydrogenase A, NAD-linked; Acts on lactaldehyde as well as other aldehydes.

L-serine dehydratase 1; Deaminates also threonine, particularly when it is present in high concentration; Belongs to the iron-sulfur dependent L-serine dehydratase family.

Periplasmic L-asparaginase 2; Protein involved in cellular amino acid catabolic process; Belongs to the asparaginase 1 family.

Aspartate ammonia-lyase (aspartase); Protein involved in cellular amino acid metabolic process, asparagine biosynthetic process and lysine biosynthetic process via diaminopimelate.

Periplasmic L-asparaginase 2; Protein involved in cellular amino acid catabolic process; Belongs to the asparaginase 1 family.

Aspartate carbamoyltransferase, catalytic subunit; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

Periplasmic L-asparaginase 2; Protein involved in cellular amino acid catabolic process; Belongs to the asparaginase 1 family.

L-serine dehydratase 1; Deaminates also threonine, particularly when it is present in high concentration; Belongs to the iron-sulfur dependent L-serine dehydratase family.

Aspartate ammonia-lyase (aspartase); Protein involved in cellular amino acid metabolic process, asparagine biosynthetic process and lysine biosynthetic process via diaminopimelate.

Periplasmic L-asparaginase 2; Protein involved in cellular amino acid catabolic process; Belongs to the asparaginase 1 family.

Aspartate ammonia-lyase (aspartase); Protein involved in cellular amino acid metabolic process, asparagine biosynthetic process and lysine biosynthetic process via diaminopimelate.

Aspartate carbamoyltransferase, catalytic subunit; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

Aspartate ammonia-lyase (aspartase); Protein involved in cellular amino acid metabolic process, asparagine biosynthetic process and lysine biosynthetic process via diaminopimelate.

L-serine dehydratase 1; Deaminates also threonine, particularly when it is present in high concentration; Belongs to the iron-sulfur dependent L-serine dehydratase family.

malonyl-ACP O-methyltransferase, SAM-dependent; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. E.coli employs a methylation and demethylation strategy to allow elongation of a temporarily disguised malonate moiety to a pimelate moiety by the fatty acid synthetic enzymes.

8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. Can also use pimeloyl-CoA instead of pimeloyl-ACP as substrate, but it is believed that pimeloyl- ACP rather than pimeloyl-CoA is the physiological substrate of BioF. Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.

8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. Can also use pimeloyl-CoA instead of pimeloyl-ACP as substrate, but it is believed that pimeloyl- ACP rather than pimeloyl-CoA is the physiological substrate of BioF. Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.

malonyl-ACP O-methyltransferase, SAM-dependent; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. E.coli employs a methylation and demethylation strategy to allow elongation of a temporarily disguised malonate moiety to a pimelate moiety by the fatty acid synthetic enzymes.

C4-dicarboxylic acid, orotate and citrate transporter; Responsible for the aerobic transport of the dicarboxylates fumarate, L- and D-malate and to a lesser extent succinate, from the periplasm across the inner membrane; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.

N-acetylgalactosamine-specific enzyme IIB component of PTS; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylgalactosamine transport.

C4-dicarboxylic acid, orotate and citrate transporter; Responsible for the aerobic transport of the dicarboxylates fumarate, L- and D-malate and to a lesser extent succinate, from the periplasm across the inner membrane; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.

Aldehyde dehydrogenase A, NAD-linked; Acts on lactaldehyde as well as other aldehydes.

Protein involved in gluconeogenesis.

Sn-glycerol-3-phosphate dehydrogenase, aerobic, FAD/NAD(P)-binding; Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses molecular oxygen or nitrate as electron acceptor.

Protein involved in gluconeogenesis.

Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. It also catalyzes the phosphorylation of dihydroxyacetone, L-glyceraldehyde and D-glyceraldehyde. It uses only ATP; Belongs to the FGGY kinase family.

Protein involved in gluconeogenesis.

6-phosphofructokinase I; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub- subfamily.