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acrF acrF acrB acrB acrA acrA cusS cusS cusR cusR cusC cusC cusF cusF cusB cusB cusA cusA rarA rarA marA marA sdiA sdiA tolC tolC rpsD rpsD soxS soxS
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
acrFMultidrug efflux system protein; Part of the tripartite efflux system AcrEF-TolC. Involved in the efflux of indole and organic solvents. Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. (1034 aa)
acrBMultidrug efflux system protein; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. (1049 aa)
acrAMultidrug efflux system; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together. It is elongated in shape, being long enough to span the periplasm. (397 aa)
cusSCopper-sensing histidine kinase in two-component regulatory system with CusR; Member of the two-component regulatory system CusS/CusR involved in response to copper and silver. Acts as a copper/silver ion sensor. Activates CusR by phosphorylation. (480 aa)
cusRResponse regulator in two-component regulatory system with CusS; Member of the two-component regulatory system CusS/CusR involved in response to copper and silver. Activates the expression of cusCFBA, hiuH and plasmid pRJ1004 gene pcoE in response to increasing levels of copper or silver ions. Can also increase the basal-level expression of copper resistance gene operon pcoABCD. (227 aa)
cusCCopper/silver efflux system, outer membrane component; Forms pores that allow passive diffusion of cations across the outer membrane. Part of a cation efflux system that mediates resistance to copper and silver. In pathogenic strains it allows the bacteria to invade brain microvascular endothelial cells (BMEC) thus allowing it to cross the blood-brain barrier and cause neonatal meningitis. (457 aa)
cusFPeriplasmic copper- and silver-binding protein; Part of a cation efflux system that mediates resistance to copper and silver. Binds one copper per polypeptide. (110 aa)
cusBCopper/silver efflux system, membrane fusion protein; Part of a cation efflux system that mediates resistance to copper and silver. (407 aa)
cusACopper/silver efflux system, membrane component; Part of a cation efflux system that mediates resistance to copper and silver; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. (1047 aa)
rarARecombination intermediate processing DNA-dependent ATPase; DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes. (447 aa)
marAMultiple antibiotic resistance transcriptional regulator; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. (127 aa)
sdiAQuorum-sensing transcriptional activator; Activates cell division by specifically increasing transcription from one of the two promoters that lie immediately upstream of the ftsQAZ gene cluster. Activates ydiV expression in response to extracellular autoinducer AI-1 (Vibrio fischeri autoinducer oxoC6). (240 aa)
tolCTransport channel; Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells. (493 aa)
rpsD30S ribosomal subunit protein S4; One of two assembly initiator proteins for the 30S subunit, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. Plays a role in mRNA unwinding by the ribosome, possibly by forming part of a processivity clamp. Also functions as a rho-dependent antiterminator of rRNA transcription, increasing the synthesis of rRNA under conditions of excess protein, allowing a more rapid return to homeostasis. Binds directly to RNA polymerase; Belongs to the universal ribosomal protein uS4 family. (206 aa)
soxSSuperoxide response regulon transcriptional activator; Transcriptional activator of the superoxide response regulon of E.coli that includes at least 10 genes such as sodA, nfo, zwf and micF. Binds the DNA sequence 5'-GCACN(7)CAA-3'. It also facilitates the subsequent binding of RNA polymerase to the micF and the nfo promoters. (107 aa)
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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