node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
araA | araB | b0062 | b0063 | L-arabinose isomerase; Catalyzes the conversion of L-arabinose to L-ribulose. | L-ribulokinase; Protein involved in carbohydrate catabolic process; Belongs to the ribulokinase family. | 0.999 |
araA | araC | b0062 | b0064 | L-arabinose isomerase; Catalyzes the conversion of L-arabinose to L-ribulose. | Ara regulon transcriptional activator; Transcription factor that regulates the expression of several genes involved in the transport and metabolism of L-arabinose. Functions both as a positive and a negative regulator. In the presence of arabinose, activates the expression of the araBAD, araE, araFGH and araJ promoters. In the absence of arabinose, negatively regulates the araBAD operon. Represses its own transcription. Acts by binding directly to DNA. | 0.824 |
araA | araD | b0062 | b0061 | L-arabinose isomerase; Catalyzes the conversion of L-arabinose to L-ribulose. | L-ribulose-5-phosphate 4-epimerase; Involved in the degradation of L-arabinose. Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D- xylulose 5-phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon- carbon bond cleavage analogous to a class II aldolase reaction). | 0.999 |
araA | araE | b0062 | b2841 | L-arabinose isomerase; Catalyzes the conversion of L-arabinose to L-ribulose. | Arabinose transporter; Uptake of arabinose across the boundary membrane with the concomitant transport of protons into the cell (symport system). | 0.936 |
araB | araA | b0063 | b0062 | L-ribulokinase; Protein involved in carbohydrate catabolic process; Belongs to the ribulokinase family. | L-arabinose isomerase; Catalyzes the conversion of L-arabinose to L-ribulose. | 0.999 |
araB | araC | b0063 | b0064 | L-ribulokinase; Protein involved in carbohydrate catabolic process; Belongs to the ribulokinase family. | Ara regulon transcriptional activator; Transcription factor that regulates the expression of several genes involved in the transport and metabolism of L-arabinose. Functions both as a positive and a negative regulator. In the presence of arabinose, activates the expression of the araBAD, araE, araFGH and araJ promoters. In the absence of arabinose, negatively regulates the araBAD operon. Represses its own transcription. Acts by binding directly to DNA. | 0.932 |
araB | araD | b0063 | b0061 | L-ribulokinase; Protein involved in carbohydrate catabolic process; Belongs to the ribulokinase family. | L-ribulose-5-phosphate 4-epimerase; Involved in the degradation of L-arabinose. Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D- xylulose 5-phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon- carbon bond cleavage analogous to a class II aldolase reaction). | 0.999 |
araB | araE | b0063 | b2841 | L-ribulokinase; Protein involved in carbohydrate catabolic process; Belongs to the ribulokinase family. | Arabinose transporter; Uptake of arabinose across the boundary membrane with the concomitant transport of protons into the cell (symport system). | 0.958 |
araB | lacZ | b0063 | b0344 | L-ribulokinase; Protein involved in carbohydrate catabolic process; Belongs to the ribulokinase family. | beta-D-galactosidase; Protein involved in carbohydrate catabolic process; Belongs to the glycosyl hydrolase 2 family. | 0.683 |
araC | araA | b0064 | b0062 | Ara regulon transcriptional activator; Transcription factor that regulates the expression of several genes involved in the transport and metabolism of L-arabinose. Functions both as a positive and a negative regulator. In the presence of arabinose, activates the expression of the araBAD, araE, araFGH and araJ promoters. In the absence of arabinose, negatively regulates the araBAD operon. Represses its own transcription. Acts by binding directly to DNA. | L-arabinose isomerase; Catalyzes the conversion of L-arabinose to L-ribulose. | 0.824 |
araC | araB | b0064 | b0063 | Ara regulon transcriptional activator; Transcription factor that regulates the expression of several genes involved in the transport and metabolism of L-arabinose. Functions both as a positive and a negative regulator. In the presence of arabinose, activates the expression of the araBAD, araE, araFGH and araJ promoters. In the absence of arabinose, negatively regulates the araBAD operon. Represses its own transcription. Acts by binding directly to DNA. | L-ribulokinase; Protein involved in carbohydrate catabolic process; Belongs to the ribulokinase family. | 0.932 |
araC | araD | b0064 | b0061 | Ara regulon transcriptional activator; Transcription factor that regulates the expression of several genes involved in the transport and metabolism of L-arabinose. Functions both as a positive and a negative regulator. In the presence of arabinose, activates the expression of the araBAD, araE, araFGH and araJ promoters. In the absence of arabinose, negatively regulates the araBAD operon. Represses its own transcription. Acts by binding directly to DNA. | L-ribulose-5-phosphate 4-epimerase; Involved in the degradation of L-arabinose. Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D- xylulose 5-phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon- carbon bond cleavage analogous to a class II aldolase reaction). | 0.715 |
araC | araE | b0064 | b2841 | Ara regulon transcriptional activator; Transcription factor that regulates the expression of several genes involved in the transport and metabolism of L-arabinose. Functions both as a positive and a negative regulator. In the presence of arabinose, activates the expression of the araBAD, araE, araFGH and araJ promoters. In the absence of arabinose, negatively regulates the araBAD operon. Represses its own transcription. Acts by binding directly to DNA. | Arabinose transporter; Uptake of arabinose across the boundary membrane with the concomitant transport of protons into the cell (symport system). | 0.877 |
araC | crp | b0064 | b3357 | Ara regulon transcriptional activator; Transcription factor that regulates the expression of several genes involved in the transport and metabolism of L-arabinose. Functions both as a positive and a negative regulator. In the presence of arabinose, activates the expression of the araBAD, araE, araFGH and araJ promoters. In the absence of arabinose, negatively regulates the araBAD operon. Represses its own transcription. Acts by binding directly to DNA. | cAMP-activated global transcription factor, mediator of catabolite repression; A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding (to consensus sequence 5'-AAATGTGATCTAGATCACATTT-3') to directly regulate the transcription of about 300 genes in about 200 operons and indirectly regulate the expression of about half the genome. There are 3 classes of CRP promoters; class I promoters have a single CRP-binding site upstream of the RNA polymerase (RNAP)-binding site, whereas in class II promoters the single CRP- and RNAP-binding site [...] | 0.877 |
araC | lacZ | b0064 | b0344 | Ara regulon transcriptional activator; Transcription factor that regulates the expression of several genes involved in the transport and metabolism of L-arabinose. Functions both as a positive and a negative regulator. In the presence of arabinose, activates the expression of the araBAD, araE, araFGH and araJ promoters. In the absence of arabinose, negatively regulates the araBAD operon. Represses its own transcription. Acts by binding directly to DNA. | beta-D-galactosidase; Protein involved in carbohydrate catabolic process; Belongs to the glycosyl hydrolase 2 family. | 0.891 |
araD | araA | b0061 | b0062 | L-ribulose-5-phosphate 4-epimerase; Involved in the degradation of L-arabinose. Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D- xylulose 5-phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon- carbon bond cleavage analogous to a class II aldolase reaction). | L-arabinose isomerase; Catalyzes the conversion of L-arabinose to L-ribulose. | 0.999 |
araD | araB | b0061 | b0063 | L-ribulose-5-phosphate 4-epimerase; Involved in the degradation of L-arabinose. Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D- xylulose 5-phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon- carbon bond cleavage analogous to a class II aldolase reaction). | L-ribulokinase; Protein involved in carbohydrate catabolic process; Belongs to the ribulokinase family. | 0.999 |
araD | araC | b0061 | b0064 | L-ribulose-5-phosphate 4-epimerase; Involved in the degradation of L-arabinose. Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D- xylulose 5-phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon- carbon bond cleavage analogous to a class II aldolase reaction). | Ara regulon transcriptional activator; Transcription factor that regulates the expression of several genes involved in the transport and metabolism of L-arabinose. Functions both as a positive and a negative regulator. In the presence of arabinose, activates the expression of the araBAD, araE, araFGH and araJ promoters. In the absence of arabinose, negatively regulates the araBAD operon. Represses its own transcription. Acts by binding directly to DNA. | 0.715 |
araD | araE | b0061 | b2841 | L-ribulose-5-phosphate 4-epimerase; Involved in the degradation of L-arabinose. Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D- xylulose 5-phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon- carbon bond cleavage analogous to a class II aldolase reaction). | Arabinose transporter; Uptake of arabinose across the boundary membrane with the concomitant transport of protons into the cell (symport system). | 0.935 |
araD | lacZ | b0061 | b0344 | L-ribulose-5-phosphate 4-epimerase; Involved in the degradation of L-arabinose. Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D- xylulose 5-phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon- carbon bond cleavage analogous to a class II aldolase reaction). | beta-D-galactosidase; Protein involved in carbohydrate catabolic process; Belongs to the glycosyl hydrolase 2 family. | 0.405 |