10 items (Escherichia coli K12) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
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Your Input:
	ccmH	Heme lyase, CcmH subunit; May be required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase. (350 aa)
	ccmF	Heme lyase, CcmF subunit; Required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase. (647 aa)
	ccmE	Periplasmic heme chaperone; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH; Belongs to the CcmE/CycJ family. (159 aa)
	ccmD	Cytochrome c biogenesis protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. (69 aa)
	ccmC	Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. (245 aa)
	ccmB	Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. (220 aa)
	ccmA	Heme export ABC transporter ATPase; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system. (207 aa)
	nrfA	Nitrite reductase, formate-dependent, cytochrome; Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process. Has very low activity toward hydroxylamine. Has even lower activity toward sulfite. Sulfite reductase activity is maximal at neutral pH (By similarity). (478 aa)
	hemH	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX; Belongs to the ferrochelatase family. (320 aa)
	gstA	Glutathionine S-transferase; Catalyzes the conjugation of reduced glutathione (GSH) to a wide number of exogenous and endogenous hydrophobic electrophiles. Shows activity toward 1-chloro-2,4-dinitrobenzene (CDNB) and ethacrynic acid. Also possesses thiol:disulfide oxidoreductase activity, using GSH to reduce bis-(2-hydroxyethyl) disulfide (HEDS). Has a low level of glutathione-dependent peroxidase activity toward cumene hydroperoxide. Is important for defense against oxidative stress, probably via its peroxidase activity. Belongs to the GST superfamily. Beta family. (201 aa)

Your Current Organism:

Escherichia coli K12

NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ccmA	ccmB	b2201	b2200	Heme export ABC transporter ATPase; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.	Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.	0.999
ccmA	ccmC	b2201	b2199	Heme export ABC transporter ATPase; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.	Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.	0.999
ccmA	ccmD	b2201	b2198	Heme export ABC transporter ATPase; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.	Cytochrome c biogenesis protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.	0.999
ccmA	ccmE	b2201	b2197	Heme export ABC transporter ATPase; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.	Periplasmic heme chaperone; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH; Belongs to the CcmE/CycJ family.	0.998
ccmA	ccmF	b2201	b2196	Heme export ABC transporter ATPase; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.	Heme lyase, CcmF subunit; Required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase.	0.992
ccmA	ccmH	b2201	b2194	Heme export ABC transporter ATPase; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.	Heme lyase, CcmH subunit; May be required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase.	0.991
ccmA	hemH	b2201	b0475	Heme export ABC transporter ATPase; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX; Belongs to the ferrochelatase family.	0.411
ccmB	ccmA	b2200	b2201	Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.	Heme export ABC transporter ATPase; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.	0.999
ccmB	ccmC	b2200	b2199	Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.	Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.	0.999
ccmB	ccmD	b2200	b2198	Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.	Cytochrome c biogenesis protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.	0.999
ccmB	ccmE	b2200	b2197	Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.	Periplasmic heme chaperone; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH; Belongs to the CcmE/CycJ family.	0.999
ccmB	ccmF	b2200	b2196	Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.	Heme lyase, CcmF subunit; Required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase.	0.993
ccmB	ccmH	b2200	b2194	Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.	Heme lyase, CcmH subunit; May be required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase.	0.966
ccmC	ccmA	b2199	b2201	Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.	Heme export ABC transporter ATPase; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.	0.999
ccmC	ccmB	b2199	b2200	Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.	Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.	0.999
ccmC	ccmD	b2199	b2198	Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.	Cytochrome c biogenesis protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.	0.999
ccmC	ccmE	b2199	b2197	Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.	Periplasmic heme chaperone; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH; Belongs to the CcmE/CycJ family.	0.999
ccmC	ccmF	b2199	b2196	Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.	Heme lyase, CcmF subunit; Required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase.	0.998
ccmC	ccmH	b2199	b2194	Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.	Heme lyase, CcmH subunit; May be required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase.	0.991
ccmC	hemH	b2199	b0475	Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX; Belongs to the ferrochelatase family.	0.556

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