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fimA fimA yhaJ yhaJ gntR gntR yhjC yhjC yiaG yiaG yiaJ yiaJ yiaU yiaU yidL yidL yidP yidP yidC yidC yieP yieP rho rho yihL yihL yihW yihW yiiF yiiF yijO yijO iclR iclR hfq hfq ytfH ytfH sgcR sgcR yddM yddM ydcR ydcR ydcI ydcI ycjW ycjW rutR rutR ycaN ycaN deoR deoR ybhD ybhD nagC nagC ybeF ybeF ybdO ybdO ybcM ybcM sfmA sfmA ybaO ybaO lacI lacI yahB yahB yagI yagI yagA yagA yafC yafC dksA dksA araC araC ygfI ygfI yjiR yjiR galR galR ygbI ygbI yfjR yfjR yfiE yfiE yfhH yfhH yphH yphH yfeD yfeD yfeC yfeC yeiL yeiL yegW yegW yeeY yeeY fliA fliA ydhB ydhB purR purR ynfL ynfL dicA dicA yneJ yneJ
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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fimAMajor type 1 subunit fimbrin (pilin); Fimbriae (also called pili), polar filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometers and numbering 100-300 per cell, enable bacteria to colonize the epithelium of specific host organs. (182 aa)
yhaJLysR family putative transcriptional regulator; Positive regulator, may be partially responsible for expression of neighboring gene dlsT (yhaO) (By similarity). (298 aa)
gntRD-gluconate inducible gluconate regulon transcriptional repressor; Negative regulator for the gluconate utilization system GNT- I, the gntUKR operon. (331 aa)
yhjCPutative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. (299 aa)
yiaGHTH_CROC1 family putative transcriptional regulator; Protein involved in regulation of transcription, DNA-dependent. (96 aa)
yiaJTranscriptional repressor for the yiaKLMNO-lyxK-sgbHUE operon; Negatively controls the transcription of the yiaKLMNOPQRS operon, which may be involved in the utilization of 2,3-diketo-L- gulonate. (282 aa)
yiaUPutative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. (324 aa)
yidLPutative ARAC-type regulatory protein; Protein involved in transcription activator activity and transcription. (297 aa)
yidPUncharacterized HTH-type transcriptional regulator YidP; Pseudogene, arbutin specific enzyme IIC component of PTS;enzyme; Transport of small molecules: Carbohydrates, organic acids, alcohols; PTS system, arbutin-like IIB component; PTS system, arbutin-like IIC component. (238 aa)
yidCMembrane protein insertase; Inner membrane protein required for the insertion and/or proper folding and/or complex formation of integral inner membrane proteins. Involved in integration of membrane proteins that insert dependently and independently of the Sec translocase complex, as well as at least 2 lipoproteins. Its own insertion requires SRP and is Sec translocase-dependent. Essential for the integration of Sec-dependent subunit a of the F(0)ATP synthase, FtsQ and SecE proteins and for Sec- independent subunit c of the F(0)ATP synthase, M13 phage procoat and the N-terminus of leade [...] (548 aa)
yiePPutative transcriptional regulator. (230 aa)
rhoTranscription termination factor; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. RNA-dependent NTPase which utilizes all four ribonucleoside triphosphates as substrates. (419 aa)
yihLPutative transcriptional regulator; Protein involved in transcription repressor activity and transcription. (236 aa)
yihWPutative transcriptional regulator for sulphoquinovose utilization; Involved in the regulation of the sulfoquinovose operon. Represses the expression of the yihUTS operon and of the yihV and csqR genes. Binds DNA inside the spacer between the bidirectional transcription units comprising the yihUTS operon and the yihV gene, and upstream the csqR gene itself. (261 aa)
yiiFPutative thymol sensitivity protein, CopG family putative transcriptional regulator; To E.coli YiiE. (72 aa)
yijOPutative ARAC-type regulatory protein; Protein involved in transcription activator activity and transcription. (283 aa)
iclRTranscriptional repressor; Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyruvate enhances promoter binding by stabilizing the tetrameric form. (274 aa)
hfqGlobal sRNA chaperone; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Involved in the regulation of stress responses mediated by the sigma factors RpoS, sigma-E and sigma-32. Binds with high specificity to tRNAs. Binds sRNA antitoxin RalA. In vitro, stimulates synthesis of long tails by poly(A) polymerase I. Required for RNA phage Qbeta replication. Seems to play a role in persister cell formation; upon overexpression decreases pers [...] (102 aa)
ytfHDUF24 family HxlR-type putative transcriptional regulator; Protein involved in regulation of transcription, DNA-dependent. (126 aa)
sgcRPutative DNA-binding transcriptional regulator; Putative transcriptional regulator for the sgcREAQCX region. (260 aa)
yddMPutative DNA-binding transcriptional regulator; Protein involved in regulation of transcription, DNA-dependent; Belongs to the VapA/VapI family. (94 aa)
ydcRMulti modular; putative transcriptional regulator; also putative ATP-binding component of a transport system; Protein involved in ATP-binding cassette (ABC) transporter activity and regulation of transcription, DNA-dependent; In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. (468 aa)
ydcIPutative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. (307 aa)
ycjWPutative LACI-type transcriptional regulator; Protein involved in transcription repressor activity and transcription. (332 aa)
rutRRut operon transcriptional repressor for; Master transcription regulator which represses the degradation of pyrimidines (rutABCDEFG) and purines (gcl operon) for maintenance of metabolic balance between pyrimidines and purines. It also regulates the synthesis of pyrimidine nucleotides and arginine from glutamine (carAB) and the supply of glutamate (gadABWX). (212 aa)
ycaNPutative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. (302 aa)
deoRDeoxyribose-5-phosphate-inducible deoxyribose operon transcriptional repressor; This protein is one of the repressors that regulate the expression of deoCABD genes, which encode nucleotide and deoxy ribonucleotide catabolizing enzymes. It also negatively regulates the expression of nupG (a transport protein) and tsx (a pore-forming protein). The inducer is deoxyribose-5-phosphate. (252 aa)
ybhDPutative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. (317 aa)
nagCN-acetylglucosamine-inducible nag divergent operon transcriptional repressor; Acts as a repressor of the nagEBACD operon and acts both as an activator and a repressor for the transcription of the glmSU operon. Belongs to the ROK (NagC/XylR) family. (406 aa)
ybeFPutative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. (317 aa)
ybdOPutative transcriptional regulator LYSR-type; Protein involved in transcription and regulation of transcription, DNA-dependent; Belongs to the LysR transcriptional regulatory family. (300 aa)
ybcMDLP12 prophage; Putative ARAC-type regulatory protein. (265 aa)
sfmAFimA homolog, function unknown; Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes. (180 aa)
ybaOPutative DNA-binding transcriptional regulator; Plays a role in L-cysteine detoxification. Binds to the dlsT(yhaO)-yhaM operon promoter in the presence but not absence of L- cysteine; activates transcription from the dlsT(yhaO)-yhaM operon. No other DNA target was identified in strain K12 / BW25113. Thiosulfate does not activate its transcription function. Overexpression doubles hydrogen sulfide production in the presence of cysteine. (152 aa)
lacILactose-inducible lac operon transcriptional repressor; Repressor of the lactose operon. Binds allolactose as an inducer. (360 aa)
yahBPutative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription. (310 aa)
yagICP4-6 prophage; Involved in regulation of xylonate catabolism. Represses the expression of both yagA and yagEF operons. Binds mainly at a single site within the spacer of the bidirectional transcription units yagA and yagEF. (252 aa)
yagAUncharacterized protein YagA; Pseudogene, CP4-6 prophage;Phage or Prophage Related. (384 aa)
yafCPutative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. (304 aa)
dksATranscriptional regulator of rRNA transcription; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. Binding to RNAP disrupts interaction of RNAP with DNA, inhibits formation of initiation complexes, and amplifies effects of ppGpp and the initiating NTP on rRNA transcription. Inhibits transcript elongation, exonucleolytic RNA cleavage and pyrophosphorolysis, and increases intrinsic terminat [...] (151 aa)
araCAra regulon transcriptional activator; Transcription factor that regulates the expression of several genes involved in the transport and metabolism of L-arabinose. Functions both as a positive and a negative regulator. In the presence of arabinose, activates the expression of the araBAD, araE, araFGH and araJ promoters. In the absence of arabinose, negatively regulates the araBAD operon. Represses its own transcription. Acts by binding directly to DNA. (292 aa)
ygfIPutative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. (298 aa)
yjiRUncharacterized HTH-type transcriptional regulator YjiR; RIP347 (repetitive extragenic palindromic) element; contains 2 REP sequences and 1 IHF site; In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. (470 aa)
galRGalactose-inducible d-galactose regulon transcriptional repressor; Repressor of the galactose operon. Binds galactose as an inducer. (343 aa)
ygbIPutative DEOR-type transcriptional regulator; Protein involved in transcription repressor activity and transcription. (255 aa)
yfjRCP4-57 prophage; putative DNA-binding transcriptional regulator. (233 aa)
yfiEPutative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. (293 aa)
yfhHPutative DNA-binding transcriptional regulator. (282 aa)
yphHPutative NAGC-like transcriptional regulator; Protein involved in regulation of transcription, DNA-dependent; Belongs to the ROK (NagC/XylR) family. (397 aa)
yfeDDUF1323 family putative DNA-binding protein. (130 aa)
yfeCDUF1323 family putative DNA-binding protein; To E.coli YfiI and P.aeruginosa RluD. (114 aa)
yeiLPutative transcriptional regulator; Transcription regulator involved in mid-term, stationary- phase viability under nitrogen starvation. Might control expression of the salvage pathways or in some other way repress the recycling of nucleobases to nucleic acids and enhance their use as general nitrogen sources during nitrogen-limited growth. (219 aa)
yegWPutative transcriptional regulator; Protein involved in transcription repressor activity and transcription. (248 aa)
yeeYPutative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. (309 aa)
fliARNA polymerase, sigma 28 (sigma F) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes. (239 aa)
ydhBPutative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. (310 aa)
purRTranscriptional repressor, hypoxanthine-binding; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. In addition, it participates in the regulation or coregulation of genes involved in de novo pyrimidine nucleotide biosynthesis, salvage and uptake (pyrC, pyrD, carAB and codBA), and of several genes encoding enzymes necessary for nucleotide and polyamine biosynthesis (prsA, glyA, gcvTHP, speA, glnB). Binds to a 16-bp palindromic sequence located within the promoter region [...] (341 aa)
ynfLPutative transcriptional regulator LYSR-type; Protein involved in regulation of transcription, DNA-dependent; Belongs to the LysR transcriptional regulatory family. (297 aa)
dicAQin prophage; This protein is a repressor of division inhibition gene dicB. (135 aa)
yneJPutative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulatory family. (293 aa)
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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