STRINGSTRING
waaR waaR sohB sohB nhaB nhaB msyB msyB pgaA pgaA ompA ompA yliE yliE sfmF sfmF sfmH sfmH sfmC sfmC sfmA sfmA waaY waaY ompR ompR envZ envZ kbaY kbaY yjeM yjeM nhaA nhaA yjfP yjfP nanS nanS nanM nanM waaO waaO fimA fimA fimI fimI fimC fimC fimF fimF fimH fimH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
waaRLipopolysaccharide 1,2-glucosyltransferase; Adds the glucose(II) group on the galactose(I) group of LPS. (338 aa)
sohBInner membrane protein, S49 peptidase family protein; Multicopy suppressor of the HtrA (DegP) null phenotype. It is possibly a protease, not essential for bacterial viability; Belongs to the peptidase S49 family. (349 aa)
nhaBSodium:proton antiporter; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. Catalyzes the exchange of 3 H(+) per 2 Na(+). Has a high affinity for sodium, but can also transport lithium. Activity is weakly pH-dependent. Essential for regulation of intracellular pH under alkaline conditions. (513 aa)
msyBMulticopy suppressor of secY and secA; Could participate in the normal pathway of protein export. (124 aa)
pgaABiofilm adhesin polysaccharide PGA secretin; Exports the biofilm adhesin polysaccharide poly-beta-1,6-N- acetyl-D-glucosamine (PGA) across the outer membrane. The PGA transported seems to be partially N-deacetylated since N-deacetylation of PGA by PgaB is needed for PGA export through the PgaA porin. (807 aa)
ompAOuter membrane protein A (3a;II*;G;d); With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm (Probable). Plays a role in resistance to environmental stress, and a role in outer membrane functionality and cell shape. Non-covalently binds peptidoglycan (Probable). Acts as a porin with low permeability that allows slow penetration of small solutes. A very abundant protein, there can be up to 210,000 OmpA molecules per cell. Reconstitution in unilamellar lipid vesicles shows only about 3% of the protein is in an open conformation, whic [...] (346 aa)
yliEPutative membrane-anchored cyclic-di-GMP phosphodiesterase; Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic-di-GMP (c-di-GMP) to 5'-pGpG (By similarity). Overexpression reduces biofilm formation. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. (782 aa)
sfmFFimA homolog, function unknown; Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes. (171 aa)
sfmHFimA homolog, function unknown; Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes. (327 aa)
sfmCPutative periplasmic pilus chaperone; Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes. (230 aa)
sfmAFimA homolog, function unknown; Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes. (180 aa)
waaYLipopolysaccharide core biosynthesis protein; Catalyzes the phosphorylation of heptose(II) of the outer membrane lipopolysaccharide core; Belongs to the protein kinase superfamily. RfaY/WaaY family. (232 aa)
ompRResponse regulator in two-component regulatory system with EnvZ; Member of the two-component regulatory system EnvZ/OmpR involved in osmoregulation (particularly of genes ompF and ompC) as well as other genes. Plays a central role in both acid and osmotic stress responses. Binds to the promoter of both ompC and ompF; at low osmolarity it activates ompF transcription, while at high osmolarity it represses ompF and activates ompC transcription. Involved in acid stress response; this requires EnvZ but not OmpR phosphorylation. Phosphorylated by EnvZ; this stimulates OmpR's DNA-binding abi [...] (239 aa)
envZSensory histidine kinase in two-component regulatory system with OmpR; Member of the two-component regulatory system EnvZ/OmpR involved in osmoregulation (particularly of genes ompF and ompC) as well as other genes. EnvZ functions as a membrane-associated protein kinase that phosphorylates OmpR in response to environmental signals; at low osmolarity OmpR activates ompF transcription, while at high osmolarity it represses ompF and activates ompC transcription. Also dephosphorylates OmpR in the presence of ATP. The cytoplasmic dimerization domain (CDD) forms an osmosensitive core; increa [...] (450 aa)
kbaYTagatose 6-phosphate aldolase 1, kbaY subunit; Catalytic subunit of the tagatose-1,6-bisphosphate aldolase KbaYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP). Requires KbaZ subunit for full activity and stability. (286 aa)
yjeMPutative transport. (500 aa)
nhaASodium-proton antiporter; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. Catalyzes the exchange of 2 H(+) per Na(+). Can mediate sodium uptake when a transmembrane pH gradient is applied. Active at alkaline pH. Activity is strongly down-regulated below pH 6.5; Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family. (388 aa)
yjfPAcyl CoA esterase; Displays esterase activity toward palmitoyl-CoA and pNP- butyrate. (249 aa)
nanSProbable 9-O-acetyl-N-acetylneuraminic acid deacetylase; Probably catalyzes the hydrolysis of the 9-O-acetyl group of 9-O-acetyl-N-acetylneuraminate (Neu5,9Ac2). Is required for growth of E.coli on Neu5,9Ac2, an alternative sialic acid commonly found in mammalian host mucosal sites, in particular in the human intestine. (326 aa)
nanMN-acetylneuraminic acid mutarotase; Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta- anomer, accelerating the equilibrium between the alpha- and beta- anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses; Belongs to the NanM family. (368 aa)
waaOUDP-D-galactose:(glucosyl)lipopolysaccharide- alpha-1,3-D-galactosyltransferase; Protein involved in cell surface antigen activity, host-interacting; Belongs to the glycosyltransferase 8 family. (339 aa)
fimAMajor type 1 subunit fimbrin (pilin); Fimbriae (also called pili), polar filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometers and numbering 100-300 per cell, enable bacteria to colonize the epithelium of specific host organs. (182 aa)
fimIFimbrial protein; Protein involved in glycoprotein biosynthetic process. (179 aa)
fimCPeriplasmic chaperone; Required for the biogenesis of type 1 fimbriae. Binds and interact with FimH. (241 aa)
fimFMinor component of type 1 fimbriae; Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Involved in the integration of FimH in the fimbriae; Belongs to the fimbrial protein family. (176 aa)
fimHMinor component of type 1 fimbriae; Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Adhesin responsible for the binding to D-mannose. It is laterally positioned at intervals in the structure of the type 1 fimbriae. In order to integrate FimH in the fimbriae FimF and FimG are needed. (300 aa)
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.