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| | AMIS_10490 | Putative thymidylate kinase. (247 aa) |
| | AMIS_11050 | Putative aminopeptidase. (854 aa) |
| | purA | Putative adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (429 aa) |
| | purD | Putative phosphoribosylglycinamide synthetase; Belongs to the GARS family. (413 aa) |
| | ndk | Putative nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (138 aa) |
| | AMIS_11490 | Putative aminopeptidase. (834 aa) |
| | AMIS_1150 | Putative adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (473 aa) |
| | purS | Putative phosphoribosylformylglycinamidine synthase PurS component; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and [...] (87 aa) |
| | purQ | Putative phosphoribosylformylglycinamidine synthetase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (235 aa) |
| | purL | Putative phosphoribosyl formylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (792 aa) |
| | purF | Putative phosphoribosylpyrophosphate amidotransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (517 aa) |
| | purM | Putative phosphoribosylaminoimidazole synthetase. (383 aa) |
| | AMIS_1270 | Putative Glu/Leu/Phe/Val dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (354 aa) |
| | AMIS_12900 | Putative 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Belongs to the 5'-nucleotidase family. (596 aa) |
| | surE | Putative stationary phase survival protein SurE. (278 aa) |
| | AMIS_13500 | Putative glutamine synthetase. (452 aa) |
| | AMIS_13650 | Putative glutamine synthetase. (474 aa) |
| | pepA | Putative leucyl aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. (510 aa) |
| | gcvT | Putative glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (363 aa) |
| | AMIS_14110 | Putative PfkB-family carbohydrate kinase. (325 aa) |
| | AMIS_14780 | Putative 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (307 aa) |
| | AMIS_15710 | Putative glutamate synthase large subunit. (1523 aa) |
| | AMIS_15720 | Putative glutamate synthase small subunit. (489 aa) |
| | AMIS_16860 | Putative flavohemoprotein. (590 aa) |
| | AMIS_17000 | Putative 5-methyltetrahydrofolate--homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1214 aa) |
| | AMIS_18550 | Putative ribonucleoside-diphosphate reductase small subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (331 aa) |
| | AMIS_18560 | Putative ribonucleoside-diphosphate reductase large subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (786 aa) |
| | fprA | Putative ferredoxin/ferredoxin-NADP reductase. (449 aa) |
| | AMIS_24140 | Putative FAD-dependent oxidoreductase. (383 aa) |
| | AMIS_28770 | Putative phosphoribulokinase/uridine kinase. (220 aa) |
| | tmk | Putative thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (665 aa) |
| | AMIS_34280 | Putative glutamylcysteine synthetase. (364 aa) |
| | AMIS_36960 | Hypothetical protein; CBS domain. (145 aa) |
| | AMIS_37080 | Putative glutamine synthetase. (333 aa) |
| | AMIS_37240 | Putative pyridine nucleotide-disulfide oxidoreductase. (452 aa) |
| | AMIS_39110 | Putative thymidine kinase. (205 aa) |
| | AMIS_39380 | Putative glutamate--cysteine ligase; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily. (362 aa) |
| | gcvP | Putative glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (936 aa) |
| | AMIS_43110 | Putative inositol-5'-monophosphate dehydrogenase. (496 aa) |
| | AMIS_44910 | Putative phosphoribulokinase/uridine kinase. (222 aa) |
| | glyA | Putative serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (478 aa) |
| | AMIS_46640 | Putative glutamate decarboxylase; Belongs to the group II decarboxylase family. (455 aa) |
| | gcvH | Putative glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (123 aa) |
| | gcvT-2 | Putative glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (393 aa) |
| | AMIS_47030 | Putative adenosine deaminase. (333 aa) |
| | AMIS_47270 | Putative glutamate synthase; Belongs to the glutamate synthase family. (523 aa) |
| | AMIS_47380 | Putative glutamate--cysteine ligase. (300 aa) |
| | AMIS_5080 | Putative 5'-nucleotidase. (1590 aa) |
| | purU | Putative formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (301 aa) |
| | gcvH-2 | Putative glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa) |
| | AMIS_5530 | Putative gamma-glutamyltranspeptidase. (463 aa) |
| | AMIS_56960 | Putative thymidine kinase. (202 aa) |
| | dcd | Putative deoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (193 aa) |
| | pyrG | Putative CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (564 aa) |
| | AMIS_620 | Putative phosphoribosyltransferase. (180 aa) |
| | gmk | Putative guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (199 aa) |
| | pyrF | Putative orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (276 aa) |
| | pyrD | Putative dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (342 aa) |
| | carB | Putative carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. (1105 aa) |
| | carA | Putative carbamoyl-phosphate synthase small subunit; Belongs to the CarA family. (383 aa) |
| | pyrC | Putative dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (420 aa) |
| | pyrB | Putative aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (306 aa) |
| | pyrR | Putative pyrimidine operon regulatory protein; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. (194 aa) |
| | apt | Putative adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (176 aa) |
| | AMIS_64070 | Putative gamma-glutamyltranspeptidase. (597 aa) |
| | AMIS_65960 | Putative glutamate--cysteine ligase; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily. (957 aa) |
| | glmS | Putative L-glutamine-D-fructose-6-phosphate amidotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (627 aa) |
| | AMIS_66480 | Putative FAD-dependent oxidoreductase. (383 aa) |
| | AMIS_66490 | Putative FAD-dependent oxidoreductase; Belongs to the GcvT family. (772 aa) |
| | AMIS_68230 | Putative dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (166 aa) |
| | thyA | Putative thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (265 aa) |
| | folD | Putative methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa) |
| | dut | Putative deoxyuridine 5'-triphosphate pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (168 aa) |
| | AMIS_68910 | Putative vitamin B12-dependent ribonucleotide reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (972 aa) |
| | guaB | Putative inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (495 aa) |
| | AMIS_6920 | Putative inosine-5'-monophosphate dehydrogenase. (372 aa) |
| | guaA | Putative GMP synthase; Catalyzes the synthesis of GMP from XMP. (515 aa) |
| | AMIS_69780 | Putative glutamine synthetase. (451 aa) |
| | AMIS_7110 | Putative 5'-nucleotidase; Belongs to the 5'-nucleotidase family. (608 aa) |
| | AMIS_71600 | Putative NAD-specific glutamate dehydrogenase. (1645 aa) |
| | purN | Putative phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (205 aa) |
| | glyA-2 | Putative serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (429 aa) |
| | purH | Putative bifunctional purine biosynthesis protein. (521 aa) |
| | glmS-2 | Putative L-glutamine-D-fructose-6-phosphate amidotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (609 aa) |
| | AMIS_72560 | Putative glutamate--cysteine ligase; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily. (388 aa) |
| | AMIS_72980 | Putative phosphosugar isomerase. (344 aa) |
| | AMIS_74680 | Putative uracil phosphoribosyltransferase; Belongs to the UPRTase family. (210 aa) |
| | add | Putative adenosine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (373 aa) |
| | AMIS_74810 | Putative thymidine phosphorylase. (425 aa) |
| | AMIS_74820 | Putative cytidine/deoxycytidine deaminase. (238 aa) |
| | AMIS_75620 | Putative leucyl aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. Belongs to the peptidase M17 family. (477 aa) |
| | pyrE | Putative orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (174 aa) |
| | AMIS_78590 | Putative purine nucleoside phosphorylase. (237 aa) |
| | purC | Putative phosphoribosylaminoimidazole-succinocarboxamide synthetase; Belongs to the SAICAR synthetase family. (279 aa) |
| | purK | Putative phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (380 aa) |
| | purE | Putative phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (165 aa) |
| | AMIS_8970 | Hypothetical protein; Belongs to the UPF0301 (AlgH) family. (199 aa) |
