STRINGSTRING
M4C8J2_BRARP M4C8J2_BRARP MCM7 MCM7 M4CB75_BRARP M4CB75_BRARP M4CEX3_BRARP M4CEX3_BRARP M4CIQ0_BRARP M4CIQ0_BRARP M4CLA3_BRARP M4CLA3_BRARP M4CW91_BRARP M4CW91_BRARP M4CYH9_BRARP M4CYH9_BRARP FEN1 FEN1 M4D2I9_BRARP M4D2I9_BRARP M4D6M3_BRARP M4D6M3_BRARP M4D9A8_BRARP M4D9A8_BRARP M4D9K9_BRARP M4D9K9_BRARP M4DC21_BRARP M4DC21_BRARP M4DKK4_BRARP M4DKK4_BRARP M4DM72_BRARP M4DM72_BRARP M4DPD6_BRARP M4DPD6_BRARP M4DQ50_BRARP M4DQ50_BRARP M4DQ59_BRARP M4DQ59_BRARP M4DUH5_BRARP M4DUH5_BRARP M4DZM3_BRARP M4DZM3_BRARP M4DZT0_BRARP M4DZT0_BRARP M4E649_BRARP M4E649_BRARP M4E7Z8_BRARP M4E7Z8_BRARP M4E8C0_BRARP M4E8C0_BRARP M4E8E9_BRARP M4E8E9_BRARP M4E994_BRARP M4E994_BRARP M4E9K2_BRARP M4E9K2_BRARP M4ECQ2_BRARP M4ECQ2_BRARP M4EI97_BRARP M4EI97_BRARP M4EL04_BRARP M4EL04_BRARP M4ERZ3_BRARP M4ERZ3_BRARP M4ES34_BRARP M4ES34_BRARP M4EW71_BRARP M4EW71_BRARP M4EY65_BRARP M4EY65_BRARP M4EYU5_BRARP M4EYU5_BRARP M4EYW4_BRARP M4EYW4_BRARP M4F4E5_BRARP M4F4E5_BRARP MCM7-2 MCM7-2 M4F8N0_BRARP M4F8N0_BRARP M4FGS3_BRARP M4FGS3_BRARP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
M4C8J2_BRARPDNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (523 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (718 aa)
M4CB75_BRARPDNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (210 aa)
M4CEX3_BRARPDNA ligase. (1206 aa)
M4CIQ0_BRARPDNA polymerase. (1822 aa)
M4CLA3_BRARPProtein kinase domain-containing protein. (646 aa)
M4CW91_BRARPSld5 domain-containing protein. (198 aa)
M4CYH9_BRARPRibonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (725 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (363 aa)
M4D2I9_BRARPRibonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (815 aa)
M4D6M3_BRARPDNA polymerase. (1225 aa)
M4D9A8_BRARPDNA helicase; Belongs to the MCM family. (825 aa)
M4D9K9_BRARPDNA helicase; Belongs to the MCM family. (727 aa)
M4DC21_BRARPDNA helicase; Belongs to the MCM family. (927 aa)
M4DKK4_BRARPSld5 domain-containing protein. (184 aa)
M4DM72_BRARPReplication protein A subunit; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses. (805 aa)
M4DPD6_BRARPProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (263 aa)
M4DQ50_BRARPDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2128 aa)
M4DQ59_BRARPDNA ligase. (732 aa)
M4DUH5_BRARPReplication factor C subunit 1. (965 aa)
M4DZM3_BRARPReplication protein A subunit; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses. (803 aa)
M4DZT0_BRARPDNA helicase; Belongs to the MCM family. (776 aa)
M4E649_BRARPDNA polymerase. (1150 aa)
M4E7Z8_BRARPOrigin of replication complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (427 aa)
M4E8C0_BRARPDNA helicase; Belongs to the MCM family. (771 aa)
M4E8E9_BRARPRibonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (843 aa)
M4E994_BRARPFACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (658 aa)
M4E9K2_BRARPDNA primase; Belongs to the eukaryotic-type primase small subunit family. (458 aa)
M4ECQ2_BRARPDNA polymerase. (1329 aa)
M4EI97_BRARPDNA primase; Belongs to the eukaryotic-type primase small subunit family. (431 aa)
M4EL04_BRARPOrigin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (813 aa)
M4ERZ3_BRARPProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (263 aa)
M4ES34_BRARPDNA ligase. (757 aa)
M4EW71_BRARPFACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (623 aa)
M4EY65_BRARPDNA helicase; Belongs to the MCM family. (825 aa)
M4EYU5_BRARPDNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (621 aa)
M4EYW4_BRARPDNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (454 aa)
M4F4E5_BRARPReplication protein A subunit; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses. (623 aa)
MCM7-2DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (711 aa)
M4F8N0_BRARPDNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (219 aa)
M4FGS3_BRARPDNA helicase; Belongs to the MCM family. (931 aa)
Your Current Organism:
Brassica rapa
NCBI taxonomy Id: 51351
Other names: B. rapa subsp. pekinensis, Brassica campestris (Pekinensis Group), Brassica campestris subsp. pekinensis, Brassica campestris subsp. pekinensis (Lour.) G.Olsson, Brassica campestris var. pekinensis, Brassica pekinensis, Brassica rapa Chinese Cabbage Group, Brassica rapa subsp. pekinensis, Brassica rapa subsp. pekinensis (Lour.) Hanelt ex Mansf., Brassica rapa var. glabra, Brassica rapa var. glabra Regel, Brassica rapa var. pekinensis, Chinese cabbage, bai cai, celery cabbage, pe-tsai
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