(39 nodes) Preribosome, large subunit precursor, and Ribosomal large subunit biogenesis network (Podospora anserina)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	A0A090C9K2	Brix domain-containing protein. (324 aa)
	A0A090CFP5	Putative Ribosomal RNA-processing protein 1. (276 aa)
	A0A090CFX2	Uncharacterized protein. (292 aa)
	A0A090CT33	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (285 aa)
	A0A090CXA7	Putative ribosome production factor similar to RPF1 of Saccharomyces cerevisiae. (423 aa)
	A0A090D5P3	Putative GTP-binding protein. (651 aa)
	A0A090D6I5	RNA helicase. (529 aa)
	PODANS_1_8310	Podospora anserina S mat+ genomic DNA chromosome 1, supercontig 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (747 aa)
	NOP7	Pescadillo homolog; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (665 aa)
	PODANS_1_3240	Podospora anserina S mat+ genomic DNA chromosome 1, supercontig 1. (789 aa)
	PODANS_1_5670	Podospora anserina S mat+ genomic DNA chromosome 1, supercontig 1. (511 aa)
	PODANS_1_6480	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (604 aa)
	PODANS_1_6710	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (199 aa)
	PODANS_3_670	60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. (606 aa)
	PODANS_0_70	Podospora anserina S mat+ genomic DNA chromosome 6, supercontig 3. (401 aa)
	PODANS_5_8580	Podospora anserina S mat+ genomic DNA chromosome 5, supercontig 9. (594 aa)
	PODANS_1_14150	Podospora anserina S mat+ genomic DNA chromosome 1, supercontig 3. (676 aa)
	PODANS_1_24250	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (440 aa)
	PODANS_1_24270	Podospora anserina S mat+ genomic DNA chromosome 1, supercontig 6. (222 aa)
	PODANS_1_16580	Podospora anserina S mat+ genomic DNA chromosome 1, supercontig 4. (261 aa)
	PODANS_7_1700	Nucleolar complex-associated protein 3; Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm. Belongs to the CBF/MAK21 family. (683 aa)
	TIF6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export; Belongs to the eIF-6 family. (246 aa)
	PODANS_7_8440	Podospora anserina S mat+ genomic DNA chromosome 7, supercontig 1. (401 aa)
	PODANS_7_8530	60S ribosome subunit biogenesis protein NIP7; Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (183 aa)
	PODANS_1_9260	rRNA-processing protein; Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit. Belongs to the CGR1 family. (99 aa)
	ERB1	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (784 aa)
	PODANS_1_12050	Podospora anserina S mat+ genomic DNA chromosome 1, supercontig 2. (553 aa)
	PODANS_3_4270	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (660 aa)
	PODANS_3_5060	Podospora anserina S mat+ genomic DNA chromosome 3, supercontig 2. (321 aa)
	PODANS_3_7140	Podospora anserina S mat+ genomic DNA chromosome 3, supercontig 2. (388 aa)
	PODANS_3_9680	Protein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. (751 aa)
	PODANS_6_7030	Podospora anserina S mat+ genomic DNA chromosome 6, supercontig 2. (490 aa)
	PODANS_2_2240	Podospora anserina S mat+ genomic DNA chromosome 2, supercontig 2. (411 aa)
	SPB1	AdoMet-dependent rRNA methyltransferase SPB1; Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. (954 aa)
	YTM1	Ribosome biogenesis protein YTM1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (487 aa)
	PODANS_2_6310	Podospora anserina S mat+ genomic DNA chromosome 2, supercontig 2. (332 aa)
	PODANS_2_8510	Podospora anserina S mat+ genomic DNA chromosome 2, supercontig 2. (222 aa)
	PODANS_2_10430	Protein MAK16; Belongs to the MAK16 family. (323 aa)
	PODANS_5_5960	Podospora anserina S mat+ genomic DNA chromosome 5, supercontig 6. (115 aa)

Your Current Organism:

Podospora anserina

NCBI taxonomy Id: 515849
Other names: P. anserina S mat+, Podospora anserina FGSC #10383, Podospora anserina S mat+

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A090C9K2	A0A090CFP5	A0A090C9K2	A0A090CFP5	Brix domain-containing protein.	Putative Ribosomal RNA-processing protein 1.	0.961
A0A090C9K2	A0A090CFX2	A0A090C9K2	A0A090CFX2	Brix domain-containing protein.	Uncharacterized protein.	0.927
A0A090C9K2	A0A090CT33	A0A090C9K2	A0A090CT33	Brix domain-containing protein.	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.	0.996
A0A090C9K2	A0A090CXA7	A0A090C9K2	A0A090CXA7	Brix domain-containing protein.	Putative ribosome production factor similar to RPF1 of Saccharomyces cerevisiae.	0.970
A0A090C9K2	A0A090D5P3	A0A090C9K2	A0A090D5P3	Brix domain-containing protein.	Putative GTP-binding protein.	0.900
A0A090C9K2	A0A090D6I5	A0A090C9K2	A0A090D6I5	Brix domain-containing protein.	RNA helicase.	0.983
A0A090C9K2	ERB1	A0A090C9K2	B2AY28	Brix domain-containing protein.	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.991
A0A090C9K2	NOP7	A0A090C9K2	B2A9S6	Brix domain-containing protein.	Pescadillo homolog; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.991
A0A090C9K2	PODANS_0_70	A0A090C9K2	B2AFU2	Brix domain-containing protein.	Podospora anserina S mat+ genomic DNA chromosome 6, supercontig 3.	0.991
A0A090C9K2	PODANS_1_12050	A0A090C9K2	B2AYS3	Brix domain-containing protein.	Podospora anserina S mat+ genomic DNA chromosome 1, supercontig 2.	0.995
A0A090C9K2	PODANS_1_14150	A0A090C9K2	B2AM38	Brix domain-containing protein.	Podospora anserina S mat+ genomic DNA chromosome 1, supercontig 3.	0.986
A0A090C9K2	PODANS_1_16580	A0A090C9K2	B2ATQ1	Brix domain-containing protein.	Podospora anserina S mat+ genomic DNA chromosome 1, supercontig 4.	0.994
A0A090C9K2	PODANS_1_24250	A0A090C9K2	B2ASQ0	Brix domain-containing protein.	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family.	0.983
A0A090C9K2	PODANS_1_24270	A0A090C9K2	B2ASQ2	Brix domain-containing protein.	Podospora anserina S mat+ genomic DNA chromosome 1, supercontig 6.	0.996
A0A090C9K2	PODANS_1_3240	A0A090C9K2	B2AA89	Brix domain-containing protein.	Podospora anserina S mat+ genomic DNA chromosome 1, supercontig 1.	0.992
A0A090C9K2	PODANS_1_5670	A0A090C9K2	B2AAZ6	Brix domain-containing protein.	Podospora anserina S mat+ genomic DNA chromosome 1, supercontig 1.	0.949
A0A090C9K2	PODANS_1_6480	A0A090C9K2	B2AB86	Brix domain-containing protein.	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.	0.994
A0A090C9K2	PODANS_1_6710	A0A090C9K2	B2ABB0	Brix domain-containing protein.	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.	0.999
A0A090C9K2	PODANS_1_8310	A0A090C9K2	B2A939	Brix domain-containing protein.	Podospora anserina S mat+ genomic DNA chromosome 1, supercontig 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	0.992
A0A090C9K2	PODANS_1_9260	A0A090C9K2	B2AXY6	Brix domain-containing protein.	rRNA-processing protein; Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit. Belongs to the CGR1 family.	0.961