STRINGSTRING
Athe_0168 Athe_0168 Athe_0169 Athe_0169 Athe_0194 Athe_0194 Athe_0208 Athe_0208 birA birA Athe_0210 Athe_0210 Athe_0211 Athe_0211 Athe_0212 Athe_0212 Athe_0213 Athe_0213 Athe_0214 Athe_0214 Athe_0215 Athe_0215 Athe_0216 Athe_0216 Athe_0219 Athe_0219 Athe_0220 Athe_0220 Athe_0221 Athe_0221 Athe_0368 Athe_0368 Athe_0369 Athe_0369 Athe_0370 Athe_0370 Athe_0371 Athe_0371 thiE thiE Athe_0373 Athe_0373 Athe_0381 Athe_0381 Athe_0473 Athe_0473 coaX coaX ribH ribH Athe_0562 Athe_0562 Athe_0563 Athe_0563 Athe_0564 Athe_0564 Athe_0861 Athe_0861 Athe_1037 Athe_1037 nrdR nrdR Athe_1568 Athe_1568 Athe_1976 Athe_1976 Athe_1977 Athe_1977 Athe_1978 Athe_1978 panD panD panC panC panB panB Athe_1982 Athe_1982 Athe_2207 Athe_2207 Athe_2395 Athe_2395 bioB bioB bioA bioA bioD bioD Athe_2647 Athe_2647
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
Athe_0168KEGG: csc:Csac_2425 CopG family transcriptional regulator. (81 aa)
Athe_0169PFAM: biotin and thiamin synthesis associated; Radical SAM domain protein; KEGG: csc:Csac_2424 thiamine biosynthesis protein ThiH. (477 aa)
Athe_0194PFAM: thiamineS protein; TGS domain protein; KEGG: csc:Csac_0103 thiamineS protein. (64 aa)
Athe_0208PFAM: protein of unknown function DUF1284; KEGG: csc:Csac_0108 hypothetical protein. (137 aa)
birAbiotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. (314 aa)
Athe_0210KEGG: csc:Csac_0110 dihydropteroate synthase; TIGRFAM: dihydropteroate synthase; PFAM: dihydropteroate synthase DHPS. (376 aa)
Athe_0211KEGG: csc:Csac_0111 hypothetical protein. (71 aa)
Athe_0212KEGG: csc:Csac_0112 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK. (157 aa)
Athe_0213PFAM: short-chain dehydrogenase/reductase SDR; KEGG: csc:Csac_0113 short-chain dehydrogenase/reductase SDR. (264 aa)
Athe_0214PFAM: protein of unknown function DUF820; KEGG: csc:Csac_0114 hypothetical protein. (184 aa)
Athe_0215KEGG: csc:Csac_0115 hypothetical protein. (444 aa)
Athe_0216Phage shock protein A, PspA; PFAM: PspA/IM30 family protein; KEGG: csc:Csac_0116 phage shock protein A, PspA. (222 aa)
Athe_0219KEGG: csc:Csac_0119 hypothetical protein. (133 aa)
Athe_0220KEGG: csc:Csac_0120 hypothetical protein. (186 aa)
Athe_0221KEGG: csc:Csac_0121 hypothetical protein. (312 aa)
Athe_0368TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein; KEGG: csc:Csac_0250 thiamine biosynthesis protein ThiS. (63 aa)
Athe_0369Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (254 aa)
Athe_0370PFAM: biotin and thiamin synthesis associated; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: csc:Csac_0252 thiamine biosynthesis protein ThiH. (369 aa)
Athe_0371TIGRFAM: thiamine biosynthesis protein ThiF; PFAM: UBA/THIF-type NAD/FAD binding protein; KEGG: csc:Csac_0253 thiamine biosynthesis protein ThiF. (203 aa)
thiEThiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (219 aa)
Athe_0373TIGRFAM: thiamine biosynthesis protein ThiC; PFAM: thiamine biosynthesis protein ThiC; KEGG: csc:Csac_0255 thiamine biosynthesis protein ThiC. (420 aa)
Athe_0381KEGG: csc:Csac_0256 phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1. (259 aa)
Athe_0473TIGRFAM: small GTP-binding protein; PFAM: GTP-binding protein HSR1-related; Miro domain protein; KEGG: csc:Csac_1123 small GTP-binding protein. (403 aa)
coaXPutative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (262 aa)
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (155 aa)
Athe_0562KEGG: csc:Csac_0792 GTP cyclohydrolase II; TIGRFAM: 3,4-dihydroxy-2-butanone 4-phosphate synthase; PFAM: GTP cyclohydrolase II; 34-dihydroxy-2-butanone 4-phosphate synthase; In the N-terminal section; belongs to the DHBP synthase family. (402 aa)
Athe_0563TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: csc:Csac_0793 riboflavin synthase subunit alpha. (192 aa)
Athe_0564Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (371 aa)
Athe_0861KEGG: csc:Csac_2681 nicotinate phosphoribosyltransferase. (39 aa)
Athe_1037Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (400 aa)
nrdRATP-cone domain protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (153 aa)
Athe_1568PFAM: nitroreductase; KEGG: csc:Csac_0665 nitroreductase. (191 aa)
Athe_1976PFAM: Coat F domain protein; KEGG: csc:Csac_2706 coat F domain-containing protein. (93 aa)
Athe_1977Hypothetical protein. (66 aa)
Athe_1978PFAM: ErfK/YbiS/YcfS/YnhG family protein; Peptidoglycan-binding domain 1 protein; KEGG: csc:Csac_2707 ErfK/YbiS/YcfS/YnhG family protein. (223 aa)
panDAspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (128 aa)
panCPantoate/beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (282 aa)
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (264 aa)
Athe_1982KEGG: csc:Csac_2711 6-phosphogluconate dehydrogenase, NAD-binding. (282 aa)
Athe_2207PFAM: aminotransferase class I and II; glycine hydroxymethyltransferase; aminotransferase class-III; Orn/Lys/Arg decarboxylase major region; aminotransferase class V; Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: csc:Csac_1225 glycine C-acetyltransferase. (416 aa)
Athe_2395PFAM: CMP/dCMP deaminase zinc-binding; KEGG: csc:Csac_0345 CMP/dCMP deaminase, zinc-binding. (143 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (337 aa)
bioAAdenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (449 aa)
bioDDethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (243 aa)
Athe_2647PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: tte:TTE1073 biotin synthase. (351 aa)
Your Current Organism:
Caldicellulosiruptor bescii
NCBI taxonomy Id: 521460
Other names: Anaerocellum thermophilum DSM 6725, C. bescii DSM 6725, Caldicellulosiruptor becscii str. DSM 6725, Caldicellulosiruptor bescii DSM 6725, Caldicellulosiruptor bescii strain DSM 6725
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