Your Input: | |
| | Athe_0368 | TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein; KEGG: csc:Csac_0250 thiamine biosynthesis protein ThiS. (63 aa) |
| | Athe_0312 | PFAM: LmbE family protein; KEGG: csc:Csac_0190 LmbE family protein. (487 aa) |
| | Athe_0309 | PFAM: Radical SAM domain protein; KEGG: csc:Csac_0187 radical SAM domain-containing protein. (197 aa) |
| | comB | PFAM: 2-phosphosulfolactate phosphatase; KEGG: csc:Csac_0183 2-phosphosulfolactate phosphatase; Belongs to the ComB family. (242 aa) |
| | queA | S-adenosylmethionine/tRNA-ribosyltransferase- isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (346 aa) |
| | Athe_0219 | KEGG: csc:Csac_0119 hypothetical protein. (133 aa) |
| | Athe_0212 | KEGG: csc:Csac_0112 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK. (157 aa) |
| | Athe_0210 | KEGG: csc:Csac_0110 dihydropteroate synthase; TIGRFAM: dihydropteroate synthase; PFAM: dihydropteroate synthase DHPS. (376 aa) |
| | queE | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (225 aa) |
| | Athe_0194 | PFAM: thiamineS protein; TGS domain protein; KEGG: csc:Csac_0103 thiamineS protein. (64 aa) |
| | queC | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). (221 aa) |
| | Athe_0178 | KEGG: csc:Csac_2415 hypothetical protein. (733 aa) |
| | Athe_0169 | PFAM: biotin and thiamin synthesis associated; Radical SAM domain protein; KEGG: csc:Csac_2424 thiamine biosynthesis protein ThiH. (477 aa) |
| | Athe_0061 | PFAM: glycosyl transferase family 2; KEGG: cbe:Cbei_4758 glycosyl transferase, family 2. (298 aa) |
| | Athe_0059 | PFAM: glycosyl transferase family 2; KEGG: msi:Msm_1329 glycosyl transferase. (335 aa) |
| | Athe_0057 | TIGRFAM: methyltransferase FkbM family; PFAM: glycosyl transferase family 2; KEGG: mma:MM_2213 putative glycosyltransferase. (723 aa) |
| | trpB | Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (451 aa) |
| | Athe_0832 | PFAM: GCN5-related N-acetyltransferase; KEGG: csc:Csac_0980 GCN5-related N-acetyltransferase. (128 aa) |
| | Athe_0822 | PFAM: thiamineS protein; KEGG: csc:Csac_0970 hypothetical protein. (76 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (433 aa) |
| | Athe_0749 | PFAM: dihydropteroate synthase DHPS; KEGG: csc:Csac_0898 dihydropteroate synthase, DhpS. (265 aa) |
| | lipA | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (291 aa) |
| | Athe_0666 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; KEGG: csc:Csac_0837 acetolactate synthase, large subunit, biosynthetic type. (552 aa) |
| | ilvD | KEGG: csc:Csac_0836 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (552 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (293 aa) |
| | Athe_0644 | TIGRFAM: glutamate synthase (NADPH), homotetrameric; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: cth:Cthe_0372 sulfide dehydrogenase (flavoprotein) subunit SudA. (474 aa) |
| | Athe_0641 | KEGG: csc:Csac_1209 hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (177 aa) |
| | Athe_0564 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (371 aa) |
| | Athe_0563 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: csc:Csac_0793 riboflavin synthase subunit alpha. (192 aa) |
| | Athe_0562 | KEGG: csc:Csac_0792 GTP cyclohydrolase II; TIGRFAM: 3,4-dihydroxy-2-butanone 4-phosphate synthase; PFAM: GTP cyclohydrolase II; 34-dihydroxy-2-butanone 4-phosphate synthase; In the N-terminal section; belongs to the DHBP synthase family. (402 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (155 aa) |
| | Athe_0546 | PFAM: aminotransferase class I and II; KEGG: csc:Csac_0772 aspartate aminotransferase. (411 aa) |
| | Athe_0525 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: csc:Csac_0751 isocitrate dehydrogenase (NAD(+)). (335 aa) |
| | Athe_0518 | PFAM: pyruvate carboxyltransferase; KEGG: csc:Csac_0746 pyruvate carboxyltransferase. (465 aa) |
| | Athe_0507 | TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: LeuA allosteric (dimerisation) domain; pyruvate carboxyltransferase; KEGG: csc:Csac_1146 alpha-isopropylmalate/homocitrate synthase family transferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (526 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (507 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (333 aa) |
| | Athe_0503 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: csc:Csac_1143 acetolactate synthase, small subunit. (170 aa) |
| | Athe_0502 | KEGG: csc:Csac_1142 acetolactate synthase, large subunit, biosynthetic type; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding. (535 aa) |
| | Athe_0500 | PFAM: beta-lactamase domain protein; KEGG: csc:Csac_1140 beta-lactamase domain-containing protein. (264 aa) |
| | Athe_0440 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: csc:Csac_0210 putative 6-pyruvoyl tetrahydropterin synthase. (120 aa) |
| | Athe_0428 | PFAM: ferredoxin; KEGG: csc:Csac_0451 ferredoxin. (605 aa) |
| | Athe_2694 | KEGG: pau:PA14_28910 putative radical activating enzyme. (194 aa) |
| | Athe_2647 | PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: tte:TTE1073 biotin synthase. (351 aa) |
| | queF | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (131 aa) |
| | metE | 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (757 aa) |
| | bioD | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (243 aa) |
| | bioA | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (449 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (337 aa) |
| | Athe_2361 | PFAM: glutamine amidotransferase class-II; KEGG: csc:Csac_0577 glutamine amidotransferase, class-II. (364 aa) |
| | Athe_2360 | PFAM: ferredoxin-dependent glutamate synthase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: csc:Csac_0578 glutamate synthase (NADPH); Belongs to the glutamate synthase family. (502 aa) |
| | Athe_2357 | PFAM: glutamate synthase alpha subunit domain protein; KEGG: csc:Csac_0547 glutamate synthase alpha subunit. (250 aa) |
| | Athe_2254 | TIGRFAM: serine O-acetyltransferase; KEGG: csc:Csac_0707 serine O-acetyltransferase. (234 aa) |
| | Athe_2226 | PFAM: pyruvate carboxyltransferase; KEGG: csc:Csac_0724 pyruvate carboxyltransferase. (452 aa) |
| | Athe_2217 | Anthranilate synthase; PFAM: Chorismate binding-like; Anthranilate synthase component I domain protein; KEGG: tex:Teth514_0615 para-aminobenzoate synthase, subunit I. (439 aa) |
| | Athe_2216 | PFAM: aminotransferase class IV; KEGG: tex:Teth514_0616 aminotransferase, class IV. (250 aa) |
| | Athe_2136 | TIGRFAM: Cof-like hydrolase; HAD-superfamily hydrolase, subfamily IIB; PFAM: Haloacid dehalogenase domain protein hydrolase type 3; Haloacid dehalogenase domain protein hydrolase; sucrose-6F-phosphate phosphohydrolase; KEGG: csc:Csac_1293 Cof-like hydrolase. (279 aa) |
| | Athe_2125 | TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein; KEGG: csc:Csac_1304 D-3-phosphoglycerate dehydrogenase. (531 aa) |
| | Athe_2123 | TIGRFAM: Cof-like hydrolase; HAD-superfamily hydrolase, subfamily IIB; PFAM: Haloacid dehalogenase domain protein hydrolase type 3; sucrose-6F-phosphate phosphohydrolase; Haloacid dehalogenase domain protein hydrolase; KEGG: csc:Csac_1306 Cof-like hydrolase. (266 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (278 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (429 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (166 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (355 aa) |
| | Athe_2064 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: csc:Csac_1348 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein. (229 aa) |
| | fabZ | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (140 aa) |
| | Athe_2034 | PFAM: ferredoxin-dependent glutamate synthase; KEGG: csc:Csac_1377 ferredoxin-dependent glutamate synthase. (529 aa) |
| | Athe_1994 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: lwe:lwe0350 phosphoglycerate dehydrogenase family protein. (365 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (264 aa) |
| | panC | Pantoate/beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (282 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (128 aa) |
| | Athe_1961 | KEGG: csc:Csac_0991 aspartate kinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (409 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (307 aa) |
| | Athe_1959 | PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; KEGG: csc:Csac_0993 homoserine dehydrogenase. (418 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (175 aa) |
| | Athe_1937 | TIGRFAM: C_GCAxxG_C_C family protein; KEGG: dth:DICTH_1787 redox family protein. (148 aa) |
| | Athe_1911 | Amidohydrolase; KEGG: csc:Csac_1034 amidohydrolase; TIGRFAM: amidohydrolase; PFAM: peptidase M20; peptidase dimerisation domain protein. (375 aa) |
| | pdxS | Pyridoxine biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (296 aa) |
| | pdxT | SNO glutamine amidotransferase; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (188 aa) |
| | acpS | Holo-acyl-carrier-protein synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (121 aa) |
| | Athe_1903 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (390 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (288 aa) |
| | argD | TIGRFAM: acetylornithine and succinylornithine aminotransferase; PFAM: aminotransferase class-III; KEGG: csc:Csac_2379 acetylornithine and succinylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (401 aa) |
| | Athe_1812 | Undecaprenyl diphosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (248 aa) |
| | Athe_1805 | TIGRFAM: thiamine pyrophosphokinase; PFAM: Thiamin pyrophosphokinase catalytic region; KEGG: csc:Csac_2348 thiamine pyrophosphokinase. (211 aa) |
| | Athe_1784 | PFAM: CobB/CobQ domain protein glutamine amidotransferase; KEGG: csc:Csac_2327 glutamine amidotransferase. (237 aa) |
| | Athe_1782 | Methylthioadenosine phosphorylase; Purine nucleoside phosphorylase involved in purine salvage. (244 aa) |
| | Athe_1711 | KEGG: csc:Csac_2251 HisJ family histidinol phosphate phosphatase; TIGRFAM: histidinol phosphate phosphatase HisJ family; PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein; Belongs to the PHP hydrolase family. HisK subfamily. (266 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (172 aa) |
| | aroQ | 3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (145 aa) |
| | Athe_1696 | PFAM: Chorismate binding-like; KEGG: csc:Csac_2236 anthranilate synthase. (456 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (336 aa) |
| | Athe_1693 | PFAM: Indole-3-glycerol phosphate synthase; KEGG: csc:Csac_2233 indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (260 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: csc:Csac_2232 phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (204 aa) |
| | trpB-2 | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (393 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (256 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (266 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (419 aa) |
| | Athe_1617 | PFAM: ABC-1 domain protein; KEGG: csc:Csac_1734 hypothetical protein. (547 aa) |
| | Athe_1615 | TIGRFAM: cysteine synthase A; cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: csc:Csac_1736 cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. (308 aa) |
| | thiI | Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (392 aa) |
| | Athe_1542 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (308 aa) |
| | carB-2 | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; protein of unknown function DUF201; phosphoribosylglycinamide synthetase; RimK domain protein ATP-grasp; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; KEGG: csc:Csac_2228 carbamoyl-phosphate synthase, large subunit. (1077 aa) |
| | carA | TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; KEGG: csc:Csac_2227 carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (356 aa) |
| | Athe_1539 | KEGG: csc:Csac_2226 asparagine synthase (glutamine-hydrolyzing); TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: asparagine synthase; glutamine amidotransferase class-II. (611 aa) |
| | hisZ | tRNA synthetase class II (G H P and S); Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (393 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (209 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (431 aa) |
| | hisC-2 | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: csc:Csac_2024 aminotransferase, class I and II; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (357 aa) |
| | hisB | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: csc:Csac_2023 imidazoleglycerol-phosphate dehydratase. (194 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (201 aa) |
| | hisA | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: csc:Csac_2021 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (237 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (250 aa) |
| | hisI | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: csc:Csac_2019 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; In the N-terminal section; belongs to the PRA-CH family. (205 aa) |
| | purC | KEGG: csc:Csac_1999 phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (239 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; protein of unknown function DUF201; phosphoribosylglycinamide synthetase; MGS domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; KEGG: csc:Csac_1934 carbamoyl phosphate synthase large subunit; Belongs to the CarB family. (1075 aa) |
| | Athe_1361 | Methylthioadenosine phosphorylase; Purine nucleoside phosphorylase involved in purine salvage. (257 aa) |
| | mtnA | Translation initiation factor, aIF-2BI family; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (342 aa) |
| | Athe_1350 | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (361 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (260 aa) |
| | argR | Arginine repressor, ArgR; Regulates arginine biosynthesis genes. (152 aa) |
| | Athe_1324 | Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis. (124 aa) |
| | Athe_1316 | PFAM: carboxyl transferase; KEGG: csc:Csac_1881 carboxyl transferase. (514 aa) |
| | Athe_1310 | PFAM: Thiamin pyrophosphokinase catalytic region; KEGG: csc:Csac_1875 thiamin pyrophosphokinase, catalytic region. (371 aa) |
| | mgsA | Methylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. (141 aa) |
| | dxs | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (616 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (383 aa) |
| | Athe_1267 | PFAM: thioesterase superfamily protein; KEGG: csc:Csac_1832 thioesterase superfamily protein. (139 aa) |
| | argG | KEGG: csc:Csac_1814 argininosuccinate synthase; TIGRFAM: argininosuccinate synthase; PFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (403 aa) |
| | argH | TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: csc:Csac_1813 argininosuccinate lyase. (462 aa) |
| | nadA | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (303 aa) |
| | Athe_1185 | TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein; KEGG: csc:Csac_1634 thiamine biosynthesis protein ThiS. (69 aa) |
| | Athe_1176 | KEGG: csc:Csac_1628 hypothetical protein. (622 aa) |
| | Athe_1165 | Cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: cth:Cthe_1840 cysteine synthase. (199 aa) |
| | Athe_1158 | 3-oxoacyl-(acyl-carrier-protein) synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (412 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (78 aa) |
| | Athe_1155 | TIGRFAM: malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase; KEGG: csc:Csac_1604 malonyl CoA-acyl carrier protein transacylase. (303 aa) |
| | fabH | 3-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (328 aa) |
| | plsX | Fatty acid/phospholipid synthesis protein PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (334 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (333 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (295 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (252 aa) |
| | Athe_1132 | PFAM: amino acid-binding ACT domain protein; KEGG: csc:Csac_1581 amino acid-binding ACT domain-containing protein. (155 aa) |
| | metXA | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (381 aa) |
| | queH | Protein of unknown function DUF208; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (174 aa) |
| | Athe_1113 | PFAM: GCN5-related N-acetyltransferase; KEGG: csc:Csac_1563 GCN5-related N-acetyltransferase. (160 aa) |
| | Athe_1105 | PFAM: GCN5-related N-acetyltransferase; KEGG: csc:Csac_1563 GCN5-related N-acetyltransferase. (158 aa) |
| | Athe_1081 | TIGRFAM: Cof-like hydrolase; HAD-superfamily hydrolase, subfamily IIB; PFAM: Haloacid dehalogenase domain protein hydrolase type 3; sucrose-6F-phosphate phosphohydrolase; KEGG: csc:Csac_1533 Cof-like hydrolase. (284 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (343 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (293 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (415 aa) |
| | Athe_1055 | TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: Riboflavin kinase; FAD synthetase; cytidylyltransferase; KEGG: csc:Csac_2066 riboflavin biosynthesis protein RibF; Belongs to the ribF family. (305 aa) |
| | folD | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (289 aa) |
| | pheA | PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; KEGG: csc:Csac_1462 prephenate dehydratase. (277 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (420 aa) |
| | hisC | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: csc:Csac_2697 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (358 aa) |
| | Athe_0845 | KEGG: csc:Csac_2698 phospho-2-dehydro-3-deoxyheptonate aldolase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I/KDSA. (337 aa) |
| | Athe_0844 | PFAM: Prephenate dehydrogenase; KEGG: csc:Csac_2699 prephenate dehydrogenase. (280 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (433 aa) |
| | pckG | Phosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (588 aa) |
| | Athe_0390 | PFAM: Radical SAM domain protein; KEGG: csc:Csac_0271 radical SAM domain-containing protein. (331 aa) |
| | tgt | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (357 aa) |
| | Athe_0381 | KEGG: csc:Csac_0256 phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1. (259 aa) |
| | Athe_0373 | TIGRFAM: thiamine biosynthesis protein ThiC; PFAM: thiamine biosynthesis protein ThiC; KEGG: csc:Csac_0255 thiamine biosynthesis protein ThiC. (420 aa) |
| | thiE | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (219 aa) |
| | Athe_0370 | PFAM: biotin and thiamin synthesis associated; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: csc:Csac_0252 thiamine biosynthesis protein ThiH. (369 aa) |
| | Athe_0369 | Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (254 aa) |
| | Athe_0324 | PFAM: homocysteine S-methyltransferase; KEGG: csc:Csac_1164 homocysteine S-methyltransferase. (413 aa) |
