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Athe_2713 Athe_2713 Athe_2647 Athe_2647 Athe_0604 Athe_0604 Athe_0212 Athe_0212 Athe_0440 Athe_0440 leuA leuA Athe_0518 Athe_0518 Athe_0507 Athe_0507 Athe_0819 Athe_0819 argB argB argC argC Athe_1158 Athe_1158 Athe_1234 Athe_1234 Athe_1315 Athe_1315 Athe_1547 Athe_1547 iscS iscS Athe_2226 Athe_2226 bioB bioB
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
Athe_2713PFAM: Rhomboid family protein; KEGG: chy:CHY_0820 rhomboid family protein. (227 aa)
Athe_2647PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: tte:TTE1073 biotin synthase. (351 aa)
Athe_0604KEGG: csc:Csac_0687 hypothetical protein. (235 aa)
Athe_0212KEGG: csc:Csac_0112 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK. (157 aa)
Athe_0440PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: csc:Csac_0210 putative 6-pyruvoyl tetrahydropterin synthase. (120 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (507 aa)
Athe_0518PFAM: pyruvate carboxyltransferase; KEGG: csc:Csac_0746 pyruvate carboxyltransferase. (465 aa)
Athe_0507TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: LeuA allosteric (dimerisation) domain; pyruvate carboxyltransferase; KEGG: csc:Csac_1146 alpha-isopropylmalate/homocitrate synthase family transferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (526 aa)
Athe_0819PFAM: fumarylacetoacetate (FAA) hydrolase; KEGG: csc:Csac_0967 5-carboxymethyl-2-hydroxymuconate delta-isomerase. (249 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (293 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (343 aa)
Athe_11583-oxoacyl-(acyl-carrier-protein) synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (412 aa)
Athe_1234PFAM: Electron transfer flavoprotein alpha subunit; KEGG: csc:Csac_1799 electron transfer flavoprotein, alpha subunit. (334 aa)
Athe_1315TIGRFAM: agmatinase; PFAM: Arginase/agmatinase/formiminoglutamase; KEGG: csc:Csac_1880 putative agmatinase; Belongs to the arginase family. (285 aa)
Athe_1547PFAM: aminotransferase class V; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: csc:Csac_1756 aminotransferase, class V. (382 aa)
iscSCysteine desulfurase NifS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (394 aa)
Athe_2226PFAM: pyruvate carboxyltransferase; KEGG: csc:Csac_0724 pyruvate carboxyltransferase. (452 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (337 aa)
Your Current Organism:
Caldicellulosiruptor bescii
NCBI taxonomy Id: 521460
Other names: Anaerocellum thermophilum DSM 6725, C. bescii DSM 6725, Caldicellulosiruptor becscii str. DSM 6725, Caldicellulosiruptor bescii DSM 6725, Caldicellulosiruptor bescii strain DSM 6725
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