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pckG pckG Athe_0552 Athe_0552 Athe_0619 Athe_0619 Athe_0621 Athe_0621 Athe_0702 Athe_0702 Athe_0703 Athe_0703 Athe_0874 Athe_0874 Athe_0875 Athe_0875 Athe_0876 Athe_0876 Athe_0877 Athe_0877 Athe_1096 Athe_1096 Athe_1097 Athe_1097 pfkA pfkA Athe_1266 Athe_1266 eno eno gpmI gpmI pgk pgk Athe_1406 Athe_1406 Athe_1409 Athe_1409 Athe_1708 Athe_1708 Athe_1709 Athe_1709 pfp pfp ldh ldh Athe_1995 Athe_1995 Athe_2244 Athe_2244 Athe_2390 Athe_2390
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
pckGPhosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (588 aa)
Athe_0552TIGRFAM: glucokinase, ROK family; PFAM: ROK family protein; KEGG: csc:Csac_0778 ROK family protein. (316 aa)
Athe_0619Bifunctional phosphoglucose/phosphomannose isomerase; Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency. Belongs to the PGI/PMI family. (354 aa)
Athe_0621KEGG: csc:Csac_1189 fructose-1,6-bisphosphate aldolase, class II; TIGRFAM: fructose-1,6-bisphosphate aldolase, class II; ketose-bisphosphate aldolase; PFAM: ketose-bisphosphate aldolase class-II. (323 aa)
Athe_0702PFAM: catalytic domain of components of various dehydrogenase complexes; biotin/lipoyl attachment domain-containing protein; E3 binding domain protein; KEGG: csc:Csac_0872 dehydrogenase catalytic domain-containing protein. (453 aa)
Athe_0703TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; HI0933 family protein; KEGG: csc:Csac_0873 dihydrolipoamide dehydrogenase. (454 aa)
Athe_0874KEGG: csc:Csac_1458 pyruvate/ketoisovalerate oxidoreductase, gamma subunit; TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase. (191 aa)
Athe_0875TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: csc:Csac_1459 pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit. (99 aa)
Athe_0876PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: csc:Csac_1460 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein. (393 aa)
Athe_0877PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: csc:Csac_1461 thiamine pyrophosphate binding domain-containing protein. (312 aa)
Athe_1096PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: csc:Csac_1549 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein. (350 aa)
Athe_1097PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: csc:Csac_1550 thiamine pyrophosphate binding domain-containing protein. (246 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (322 aa)
Athe_1266TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase barrel; PEP-utilising protein mobile region; Pyruvate kinase alpha/beta; KEGG: csc:Csac_1831 pyruvate kinase; Belongs to the pyruvate kinase family. (585 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (434 aa)
gpmIPhosphoglycerate mutase, 2,3-bisphosphoglycerate-independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (512 aa)
pgkTriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (650 aa)
Athe_1406KEGG: csc:Csac_1953 glyceraldehyde-3-phosphate dehydrogenase, type I; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (337 aa)
Athe_1409KEGG: csc:Csac_1955 pyruvate phosphate dikinase; TIGRFAM: pyruvate, phosphate dikinase; PFAM: pyruvate phosphate dikinase PEP/pyruvate-binding; PEP-utilising protein mobile region; PEP-utilizing protein; Belongs to the PEP-utilizing enzyme family. (883 aa)
Athe_1708PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; thiamine pyrophosphate protein domain protein TPP-binding; KEGG: csc:Csac_2248 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein. (735 aa)
Athe_1709TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: csc:Csac_2249 pyruvate/ketoisovalerate oxidoreductase, gamma subunit. (339 aa)
pfpPhosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (415 aa)
ldhL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (314 aa)
Athe_1995KEGG: csc:Csac_0349 ketose-bisphosphate aldolase; TIGRFAM: ketose-bisphosphate aldolase; PFAM: ketose-bisphosphate aldolase class-II. (281 aa)
Athe_2244PFAM: iron-containing alcohol dehydrogenase; KEGG: csc:Csac_0711 iron-containing alcohol dehydrogenase. (395 aa)
Athe_2390KEGG: csc:Csac_0349 ketose-bisphosphate aldolase; TIGRFAM: ketose-bisphosphate aldolase; PFAM: ketose-bisphosphate aldolase class-II. (278 aa)
Your Current Organism:
Caldicellulosiruptor bescii
NCBI taxonomy Id: 521460
Other names: Anaerocellum thermophilum DSM 6725, C. bescii DSM 6725, Caldicellulosiruptor becscii str. DSM 6725, Caldicellulosiruptor bescii DSM 6725, Caldicellulosiruptor bescii strain DSM 6725
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