STRINGSTRING
Athe_0277 Athe_0277 comB comB Athe_0621 Athe_0621 Athe_0820 Athe_0820 Athe_0874 Athe_0874 Athe_0875 Athe_0875 Athe_0876 Athe_0876 Athe_0877 Athe_0877 glyA glyA pfkA pfkA Athe_1322 Athe_1322 eno eno gpmI gpmI ackA ackA Athe_1494 Athe_1494 Athe_1708 Athe_1708 Athe_1709 Athe_1709 pfp pfp Athe_1994 Athe_1994 Athe_1995 Athe_1995 Athe_2125 Athe_2125 Athe_2359 Athe_2359 Athe_2390 Athe_2390
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
Athe_0277PFAM: formylmethanofuran dehydrogenase subunit E region; KEGG: csc:Csac_0177 formylmethanofuran dehydrogenase, subunit E region. (179 aa)
comBPFAM: 2-phosphosulfolactate phosphatase; KEGG: csc:Csac_0183 2-phosphosulfolactate phosphatase; Belongs to the ComB family. (242 aa)
Athe_0621KEGG: csc:Csac_1189 fructose-1,6-bisphosphate aldolase, class II; TIGRFAM: fructose-1,6-bisphosphate aldolase, class II; ketose-bisphosphate aldolase; PFAM: ketose-bisphosphate aldolase class-II. (323 aa)
Athe_0820PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: csc:Csac_0968 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein. (136 aa)
Athe_0874KEGG: csc:Csac_1458 pyruvate/ketoisovalerate oxidoreductase, gamma subunit; TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase. (191 aa)
Athe_0875TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: csc:Csac_1459 pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit. (99 aa)
Athe_0876PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: csc:Csac_1460 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein. (393 aa)
Athe_0877PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: csc:Csac_1461 thiamine pyrophosphate binding domain-containing protein. (312 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (415 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (322 aa)
Athe_1322PFAM: Phosphoglycerate mutase; KEGG: csc:Csac_1886 phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. (209 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (434 aa)
gpmIPhosphoglycerate mutase, 2,3-bisphosphoglycerate-independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (512 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (399 aa)
Athe_1494TIGRFAM: phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; KEGG: csc:Csac_2041 phosphate acetyltransferase. (332 aa)
Athe_1708PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; thiamine pyrophosphate protein domain protein TPP-binding; KEGG: csc:Csac_2248 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein. (735 aa)
Athe_1709TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: csc:Csac_2249 pyruvate/ketoisovalerate oxidoreductase, gamma subunit. (339 aa)
pfpPhosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (415 aa)
Athe_1994PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: lwe:lwe0350 phosphoglycerate dehydrogenase family protein. (365 aa)
Athe_1995KEGG: csc:Csac_0349 ketose-bisphosphate aldolase; TIGRFAM: ketose-bisphosphate aldolase; PFAM: ketose-bisphosphate aldolase class-II. (281 aa)
Athe_2125TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein; KEGG: csc:Csac_1304 D-3-phosphoglycerate dehydrogenase. (531 aa)
Athe_2359PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: csc:Csac_0545 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein. (155 aa)
Athe_2390KEGG: csc:Csac_0349 ketose-bisphosphate aldolase; TIGRFAM: ketose-bisphosphate aldolase; PFAM: ketose-bisphosphate aldolase class-II. (278 aa)
Your Current Organism:
Caldicellulosiruptor bescii
NCBI taxonomy Id: 521460
Other names: Anaerocellum thermophilum DSM 6725, C. bescii DSM 6725, Caldicellulosiruptor becscii str. DSM 6725, Caldicellulosiruptor bescii DSM 6725, Caldicellulosiruptor bescii strain DSM 6725
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