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thrB thrB EHY68979.1 EHY68979.1 dapB dapB dapD dapD aroL aroL aroG aroG EHY69716.1 EHY69716.1 aroA aroA pabC pabC aroQ aroQ aroH aroH aroD aroD ydiB ydiB EHY70645.1 EHY70645.1 trpD trpD trpF trpF trpB trpB trpA trpA pabB pabB hisG hisG hisD hisD hisC hisC hisB hisB hisH hisH hisA hisA hisF hisF hisI hisI EHY71106.1 EHY71106.1 EHY71107.1 EHY71107.1 aroC aroC dapA dapA pheA pheA tyrA tyrA EHY68304.1 EHY68304.1 lysA_1 lysA_1 aroE aroE EHY67805.1 EHY67805.1 aroB aroB aroK aroK asd asd dapF dapF metL metL lysC lysC
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (309 aa)
EHY68979.1Threonine synthase; KEGG: sed:SeD_A0004 1.2e-224 thrC; threonine synthase K01733; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0004; thrC. (428 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (273 aa)
dapDKEGG: sed:SeD_A0234 5.6e-142 dapD; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase K00674; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM0213; dapD; Belongs to the transferase hexapeptide repeat family. (274 aa)
aroLShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. (181 aa)
aroG3-deoxy-7-phosphoheptulonate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (393 aa)
EHY69716.1Glycosyl transferase family, helical bundle domain protein; KEGG: mms:mma_0486 6.3e-63 trpD2; glycosyl transferase family protein; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0822; ybiB. (324 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (399 aa)
pabCAminodeoxychorismate lyase; KEGG: sew:SeSA_A1274 1.0e-110 pabC; 4-amino-4-deoxychorismate lyase K02619; locus tag in AE006468 is STM1198; pabC. (269 aa)
aroQPutative chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. (181 aa)
aroH3-deoxy-7-phosphoheptulonate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (348 aa)
aroD3-dehydroquinate dehydratase, type I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (233 aa)
ydiBQuinate/shikimate dehydrogenase; The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate. Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively. It can use both NAD or NADP for catalysis, however it has higher catalytic efficiency with NAD. (288 aa)
EHY70645.1KEGG: set:SEN1311 7.3e-275 trpE; anthranilate synthase component I; K01657 anthranilate synthase component I; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM1723; trpE. (520 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (531 aa)
trpFKEGG: spq:SPAB_01520 6.2e-230 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; K01609 indole-3-glycerol phosphate synthase K01817; locus tag in AE006468 is STM1725; trpC; Belongs to the TrpC family. (452 aa)
trpBTryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (397 aa)
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (268 aa)
pabBKEGG: sea:SeAg_B1307 1.6e-240 pabB; aminodeoxychorismate synthase, component I; K01665 para-aminobenzoate synthetase component I; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM1824; pabB. (454 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. (289 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (434 aa)
hisCKEGG: spq:SPAB_00960 1.2e-187 histidinol-phosphate aminotransferase; K00817 histidinol-phosphate aminotransferase; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2073; hisC; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (359 aa)
hisBHistidinol-phosphatase; KEGG: sea:SeAg_B2199 2.4e-189 hisB; imidazole glycerol-phosphate dehydratase/histidinol phosphatase K01089; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2074; hisB; In the N-terminal section; belongs to the histidinol- phosphatase family. (355 aa)
hisHImidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (196 aa)
hisAKEGG: see:SNSL254_A2255 7.9e-120 hisA; phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase K01814; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2076; hisA. (245 aa)
hisFImidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (258 aa)
hisIphosphoribosyl-ATP diphosphatase; KEGG: sew:SeSA_A2306 7.9e-104 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein K11755; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2078; hisI; In the N-terminal section; belongs to the PRA-CH family. (203 aa)
EHY71106.1KEGG: gur:Gura_1692 2.6e-82 imidazole glycerol phosphate synthase subunit HisF; K02500 cyclase HisF; Psort location: Cytoplasmic, score: 9.26. (262 aa)
EHY71107.1KEGG: vvy:VV0355 1.5e-61 hisH; imidazole glycerol phosphate synthase subunit HisH; K02501 glutamine amidotransferase; Psort location: Cytoplasmic, score: 9.26. (204 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (361 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa)
pheAChorismate mutase; KEGG: seg:SG2645 1.3e-199 pheA; bifunctional chorismate mutase/prephenate dehydratase; K04093 chorismate mutase K04518; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2667; pheA. (386 aa)
tyrAChorismate mutase; KEGG: spq:SPAB_03380 6.0e-193 tyrA; bifunctional chorismate mutase/prephenate dehydrogenase; K04092 chorismate mutase K04517; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2669; tyrA. (373 aa)
EHY68304.13-deoxy-7-phosphoheptulonate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (356 aa)
lysA_1Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (420 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (272 aa)
EHY67805.1KEGG: seh:SeHA_C3774 2.9e-97 pabA; para-aminobenzoate synthase component II; K01664 para-aminobenzoate synthetase component II; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM3469; pabA. (187 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (342 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (161 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (368 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (274 aa)
metLHomoserine dehydrogenase; KEGG: sty:STY3768 0. metL, metM; bifunctional aspartate kinase II/homoserine dehydrogenase II K12525; Psort location: CytoplasmicMembrane, score: 9.82; locus tag in AE006468 is STM4101; metL; In the C-terminal section; belongs to the homoserine dehydrogenase family. (810 aa)
lysCAspartate kinase, monofunctional class; Locus tag in AE006468 is STM4220; lysC; Belongs to the aspartokinase family. (449 aa)
Your Current Organism:
Salmonella enterica houtenae
NCBI taxonomy Id: 523831
Other names: S. enterica subsp. houtenae str. ATCC BAA-1581, Salmonella enterica subsp. houtenae str. ATCC BAA-1581
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