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| | aspS | aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (590 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (274 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (491 aa) |
| | ilvY | HTH-type transcriptional activator IlvY; KEGG: shn:Shewana3_3435 1.2e-15 LysR family transcriptional regulator; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM3908; ilvY; Belongs to the LysR transcriptional regulatory family. (300 aa) |
| | ilvA | Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (514 aa) |
| | ilvD | KEGG: seh:SeHA_C4235 0. ilvD; dihydroxy-acid dehydratase K01687; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM3904; ilvD; Belongs to the IlvD/Edd family. (616 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (309 aa) |
| | ilvM | KEGG: sed:SeD_A4292 8.0e-40 ilvM; acetolactate synthase 2 regulatory subunit K11258; locus tag in AE006468 is STM3902; ilvM. (87 aa) |
| | EHY68204.1 | KEGG: ses:SARI_03751 1.0e-284 acetolactate synthase 2 catalytic subunit; K01652 acetolactate synthase I/II/III large subunit; Psort location: Cytoplasmic, score: 9.26; locus tag in AE006468 is STM3901; ilvG. (548 aa) |
| | asnA | Aspartate--ammonia ligase; KEGG: spq:SPAB_04821 5.4e-176 asparagine synthetase AsnA; K01914 aspartate--ammonia ligase; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM3877; asnA. (330 aa) |
| | glmS | Glutamine-fructose-6-phosphate transaminase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (609 aa) |
| | ilvB | KEGG: sei:SPC_3877 5.4e-295 ilvB; acetolactate synthase large subunit; K01652 acetolactate synthase I/II/III large subunit; Psort location: Cytoplasmic, score: 9.26; locus tag in AE006468 is STM3796; ilvB. (562 aa) |
| | ilvN | KEGG: ses:SARI_03854 2.7e-46 acetolactate synthase 1 regulatory subunit; K01653 acetolactate synthase I/III small subunit; locus tag in AE006468 is STM3795; ilvN. (96 aa) |
| | kbl | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (398 aa) |
| | tdh | L-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (341 aa) |
| | EHY68003.1 | KEGG: sec:SC3622 1.1e-143 cysE; serine acetyltransferase K00640; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM3699; cysE; Belongs to the transferase hexapeptide repeat family. (273 aa) |
| | dlgD | malate/L-lactate dehydrogenase; Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate. (332 aa) |
| | glyQ | KEGG: set:SEN3478 1.9e-166 glyQ; glycyl-tRNA synthetase subunit alpha K01878; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM3656; glyQ. (303 aa) |
| | glyS | KEGG: stm:STM3655 0. glyS; glycyl-tRNA synthetase subunit beta K01879; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM3655; glyS. (689 aa) |
| | EHY67940.1 | KEGG: cko:CKO_04984 4.2e-13 hypothetical protein; K01761 methionine-gamma-lyase; locus tag in AE006468 is STM3624A. (46 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (368 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (161 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (342 aa) |
| | trpS | tryptophan--tRNA ligase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (334 aa) |
| | EHY67805.1 | KEGG: seh:SeHA_C3774 2.9e-97 pabA; para-aminobenzoate synthase component II; K01664 para-aminobenzoate synthetase component II; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM3469; pabA. (187 aa) |
| | argD | N-succinyldiaminopimelate- aminotransferase/acetylornithine transaminase protein; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (390 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (272 aa) |
| | argR | Arginine repressor; Regulates arginine biosynthesis genes. (156 aa) |
| | EHY68919.1 | KEGG: spq:SPAB_04154 4.9e-253 gltD; glutamate synthase subunit beta; K00266 glutamate synthase (NADPH/NADH) small chain; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM3331; gltD. (472 aa) |
| | EHY68918.1 | Class II glutamine amidotransferase; KEGG: stt:t3247 0. gltB; glutamate synthase subunit alpha K00265; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM3330; gltB. (1486 aa) |
| | argG | KEGG: ses:SARI_04334 4.0e-235 argininosuccinate synthase; K01940 argininosuccinate synthase; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM3290; argG; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (447 aa) |
| | yhbO | Intracellular protease, PfpI family; KEGG: spq:SPAB_04080 3.9e-86 hypothetical protein; K05520 protease I; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM3269; yhbO. (172 aa) |
| | EHY68849.1 | Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (329 aa) |
| | tdcD | Acetate kinase; Catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. (402 aa) |
| | yhaM | Hypothetical protein; KEGG: hiq:CGSHiGG_07795 0.00068 hypothetical protein; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM3238; yhaN; Belongs to the UPF0597 family. (436 aa) |
| | ygjG | Putrescine aminotransferase; Catalyzes the aminotransferase reaction from putrescine to 2- oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. This is the first step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate (gamma-aminobutyrate or GABA) via 4- aminobutanal. Also functions as a cadaverine transaminase in a a L- lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. (459 aa) |
| | metC | Cystathionine beta-lyase; KEGG: sea:SeAg_B3335 3.0e-207 metC; cystathionine beta-lyase K01760; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM3161; metC. (395 aa) |
| | feaB | Aldehyde dehydrogenase family protein; KEGG: ses:SARI_04502 2.3e-248 hypothetical protein; K00146 phenylacetaldehyde dehydrogenase; Psort location: Cytoplasmic, score: 9.26; locus tag in AE006468 is STM3129. (494 aa) |
| | EHY68676.1 | Orn/Lys/Arg decarboxylase, major domain protein; KEGG: sew:SeSA_A3289 0. speC; ornithine decarboxylase K01581; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM3114; speC. (711 aa) |
| | EHY68668.1 | L-asparaginase, type II; KEGG: stm:STM3106 1.7e-181 ansB; L-asparaginase II K01424; Psort location: Periplasmic, score: 10.00; locus tag in AE006468 is STM3106; ansB; Belongs to the asparaginase 1 family. (348 aa) |
| | speA | Arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. (632 aa) |
| | speB | Agmatinase; Catalyzes the formation of putrescine from agmatine. Belongs to the arginase family. Agmatinase subfamily. (306 aa) |
| | serA | KEGG: spq:SPAB_03816 2.1e-213 D-3-phosphoglycerate dehydrogenase; K00058 D-3-phosphoglycerate dehydrogenase; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM3062; serA; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (410 aa) |
| | gcvT | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (364 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa) |
| | gcvP | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (957 aa) |
| | lysS | lysyl-tRNA synthetase; KEGG: stm:STM3040 5.5e-270 lysS; lysyl-tRNA synthetase K04567; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM3040; lysS; Belongs to the class-II aminoacyl-tRNA synthetase family. (505 aa) |
| | lysA_1 | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (420 aa) |
| | argA | Amino-acid N-acetyltransferase; KEGG: stt:t2900 2.1e-229 argA; N-acetylglutamate synthase K00619; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2992; argA; Belongs to the acetyltransferase family. ArgA subfamily. (443 aa) |
| | csdE | KEGG: see:SNSL254_A3211 1.9e-70 csdE; cysteine desulfurase, sulfur acceptor subunit CsdE K02426; Psort location: Cytoplasmic, score: 9.26; locus tag in AE006468 is STM2985; ygdK. (147 aa) |
| | csdA | KEGG: see:SNSL254_A3210 1.4e-209 csdA; cysteine desulfurase, catalytic subunit CsdA K01766; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2984; csdA. (401 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa) |
| | cysJ | Sulfite reductase [NADPH] flavoprotein, alpha-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. Belongs to the NADPH-dependent sulphite reductase flavoprotein subunit CysJ family. In the N-terminal section; belongs to the flavodoxin family. (599 aa) |
| | cysI | Sulfite reductase hemoprotein, beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (570 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain; Belongs to the class-II aminoacyl-tRNA synthetase family. (876 aa) |
| | EHY68353.1 | KEGG: spq:SPAB_03468 1.6e-224 4-aminobutyrate aminotransferase; K00823 4-aminobutyrate aminotransferase K07250; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2792; gabT; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (427 aa) |
| | EHY68352.1 | KEGG: see:SNSL254_A2988 2.8e-250 succinate-semialdehyde dehydrogenase (NADP+) K00135; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2791; gabD. (482 aa) |
| | lhgD | FAD dependent oxidoreductase; Catalyzes the dehydrogenation of L-2-hydroxyglutarate (L2HG) to alpha-ketoglutarate and couples to the respiratory chain by feeding electrons from the reaction into the membrane quinone pool. Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. Reaction=(S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol; Xref=Rhea:RHEA:58664, ChEBI:CHEBI:16782, ChEBI:CHEBI:16810, ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58665; Belongs to the L2HGDH family. (422 aa) |
| | glaH | CsiD protein; Acts as an alpha-ketoglutarate-dependent dioxygenase catalyzing hydroxylation of glutarate (GA) to L-2-hydroxyglutarate (L2HG). Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. (328 aa) |
| | EHY68304.1 | 3-deoxy-7-phosphoheptulonate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (356 aa) |
| | tyrA | Chorismate mutase; KEGG: spq:SPAB_03380 6.0e-193 tyrA; bifunctional chorismate mutase/prephenate dehydrogenase; K04092 chorismate mutase K04517; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2669; tyrA. (373 aa) |
| | pheA | Chorismate mutase; KEGG: seg:SG2645 1.3e-199 pheA; bifunctional chorismate mutase/prephenate dehydratase; K04093 chorismate mutase K04518; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2667; pheA. (386 aa) |
| | grcA | Glycine radical; Acts as a radical domain for damaged PFL and possibly other radical proteins. (127 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1295 aa) |
| | cadA | Orn/Lys/Arg decarboxylase, major domain protein; KEGG: ses:SARI_00317 0. hypothetical protein; K01582 lysine decarboxylase; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2559; cadA. (714 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa) |
| | sseA | KEGG: spq:SPAB_00405 5.7e-149 sseA; 3-mercaptopyruvate sulfurtransferase; K01011 3-mercaptopyruvate sulfurtransferase; locus tag in AE006468 is STM2533; sseA. (280 aa) |
| | hisS | KEGG: stm:STM2522 7.6e-225 hisS; histidyl-tRNA synthetase K01892; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2522; hisS. (424 aa) |
| | guaA | GMP synthase protein; Catalyzes the synthesis of GMP from XMP. (525 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa) |
| | dapE | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (375 aa) |
| | eutB | KEGG: sec:SC2455 2.9e-241 eutB; ethanolamine ammonia-lyase, heavy chain; K03735 ethanolamine ammonia-lyase large subunit; locus tag in AE006468 is STM2458; eutB. (453 aa) |
| | eutC | KEGG: set:SEN2437 2.9e-152 eutC; ethanolamine ammonia-lyase small subunit K03736; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2457; eutC; Belongs to the EutC family. (298 aa) |
| | cysM | Cysteine synthase B; KEGG: sea:SeAg_B2585 1.3e-151 cysM; cysteine synthase B K12339; locus tag in AE006468 is STM2440; cysM; Belongs to the cysteine synthase/cystathionine beta- synthase family. (303 aa) |
| | cysK | Cysteine synthase A; KEGG: see:SNSL254_A2623 1.7e-165 cysK; cysteine synthase A K01738; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2430; cysK; Belongs to the cysteine synthase/cystathionine beta- synthase family. (323 aa) |
| | cysZ | Putative sulfate transport protein CysZ; High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway; Belongs to the CysZ family. (253 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (471 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (361 aa) |
| | EHY71437.1 | Semialdehyde dehydrogenase, dimerization domain protein; KEGG: see:SNSL254_A2557 2.7e-174 aspartate-semialdehyde dehydrogenase family protein; K00133 aspartate-semialdehyde dehydrogenase; Psort location: Cytoplasmic, score: 9.26; locus tag in AE006468 is STM2369; usg. (337 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (505 aa) |
| | EHY71427.1 | KEGG: sty:STY2590 5.5e-254 putative amino acid decarboxylase; K01586 diaminopimelate decarboxylase; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2360. (465 aa) |
| | gtdA | KEGG: sew:SeSA_A2417 4.4e-190 gtdA; gentisate 1,2-dioxygenase K00450; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2178. (345 aa) |
| | maiA | KEGG: sea:SeAg_B2322 4.3e-112 maiA; maleylacetoacetate isomerase; locus tag in AE006468 is STM2176. (214 aa) |
| | metG | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (704 aa) |
| | wcaB | Bacterial transferase hexapeptide repeat protein; KEGG: spq:SPAB_00916 4.0e-84 putative colanic acid biosynthesis acetyltransferase WcaB; K03819 putative colanic acid biosynthesis acetyltransferase WcaB; Psort location: Cytoplasmic, score: 9.26; locus tag in AE006468 is STM2114; wcaB; Belongs to the transferase hexapeptide repeat family. (162 aa) |
| | EHY71107.1 | KEGG: vvy:VV0355 1.5e-61 hisH; imidazole glycerol phosphate synthase subunit HisH; K02501 glutamine amidotransferase; Psort location: Cytoplasmic, score: 9.26. (204 aa) |
| | EHY71106.1 | KEGG: gur:Gura_1692 2.6e-82 imidazole glycerol phosphate synthase subunit HisF; K02500 cyclase HisF; Psort location: Cytoplasmic, score: 9.26. (262 aa) |
| | hisI | phosphoribosyl-ATP diphosphatase; KEGG: sew:SeSA_A2306 7.9e-104 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein K11755; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2078; hisI; In the N-terminal section; belongs to the PRA-CH family. (203 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (258 aa) |
| | hisA | KEGG: see:SNSL254_A2255 7.9e-120 hisA; phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase K01814; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2076; hisA. (245 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (196 aa) |
| | hisB | Histidinol-phosphatase; KEGG: sea:SeAg_B2199 2.4e-189 hisB; imidazole glycerol-phosphate dehydratase/histidinol phosphatase K01089; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2074; hisB; In the N-terminal section; belongs to the histidinol- phosphatase family. (355 aa) |
| | hisC | KEGG: spq:SPAB_00960 1.2e-187 histidinol-phosphate aminotransferase; K00817 histidinol-phosphate aminotransferase; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2073; hisC; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (359 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (434 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. (289 aa) |
| | EHY71077.1 | Hypothetical protein; KEGG: stm:STM2019 3.8e-49 cbiP; cobyric acid synthase; K02232 adenosylcobyric acid synthase. (108 aa) |
| | EHY71076.1 | Hypothetical protein; KEGG: sek:SSPA0797 1.4e-15 cobyric acid synthase; K02232 adenosylcobyric acid synthase. (53 aa) |
| | dcyD | D-cysteine desulfhydrase; Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine; Belongs to the ACC deaminase/D-cysteine desulfhydrase family. (328 aa) |
| | argS | arginyl-tRNA synthetase; Locus tag in AE006468 is STM1909; argS. (577 aa) |
| | metR | KEGG: spl:Spea_0904 1.7e-15 LysR family transcriptional regulator; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM3964; metR; Belongs to the LysR transcriptional regulatory family. (317 aa) |
| | dadA | D-amino acid dehydrogenase small subunit; Oxidative deamination of D-amino acids. (432 aa) |
| | alr | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (356 aa) |
| | gdhA_1 | KEGG: see:SNSL254_A1932 2.8e-227 glutamate dehydrogenase K00261; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM1795; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (424 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (268 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (397 aa) |
| | trpF | KEGG: spq:SPAB_01520 6.2e-230 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; K01609 indole-3-glycerol phosphate synthase K01817; locus tag in AE006468 is STM1725; trpC; Belongs to the TrpC family. (452 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (531 aa) |
| | EHY70645.1 | KEGG: set:SEN1311 7.3e-275 trpE; anthranilate synthase component I; K01657 anthranilate synthase component I; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM1723; trpE. (520 aa) |
| | ycjG | Mandelate racemase / muconate lactonizing enzyme protein; KEGG: sdy:SDY_1403 1.7e-142 ycjG; putative muconate cycloisomerase I K01861; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM1681; ycjG. (321 aa) |
| | EHY70559.1 | B3/4 domain protein; KEGG: mse:Msed_2004 5.6e-07 phosphoenolpyruvate synthase; locus tag in AE006468 is STM1665. (228 aa) |
| | patD | Putative 1-pyrroline dehydrogenase; Catalyzes the oxidation 4-aminobutanal (gamma- aminobutyraldehyde) to 4-aminobutanoate (gamma-aminobutyrate or GABA). This is the second step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate via 4- aminobutanal. Also functions as a 5-aminopentanal dehydrogenase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. (322 aa) |
| | EHY70467.1 | KEGG: stm:STM1597 1.5e-84 ydcW; gamma-aminobutyraldehyde dehydrogenase K00137; locus tag in AE006468 is STM1597; ydcW. (166 aa) |
| | gutB | Oxidoreductase, zinc-binding dehydrogenase family protein; KEGG: efe:EFER_2666 1.4e-152 putative L-threonine 3-dehydrogenase; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM1542. (341 aa) |
| | glsA-2 | Glutaminase; KEGG: spq:SPAB_01779 3.7e-161 glutaminase; K01425 glutaminase; Psort location: CytoplasmicMembrane, score: 9.82; locus tag in AE006468 is STM1525; yneH; Belongs to the glutaminase family. (308 aa) |
| | EHY70392.1 | Putative succinic semialdehyde dehydrogenase; KEGG: see:SNSL254_A1637 1.5e-237 aldehyde dehydrogenase (NAD) family protein K08324; Psort location: Cytoplasmic, score: 9.26; locus tag in AE006468 is STM1524; yneI. (462 aa) |
| | rspA | Mandelate racemase / muconate lactonizing enzyme protein; KEGG: eci:UTI89_C1768 2.1e-215 rspA; starvation sensing protein RspA K08323; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM1505; rspA. (404 aa) |
| | tyrS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (424 aa) |
| | sufS | Cysteine desulfurase/selenocysteine lyase; Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L- selenocysteine. Selenocysteine lyase activity is however unsure in vivo. (406 aa) |
| | ydiB | Quinate/shikimate dehydrogenase; The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate. Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively. It can use both NAD or NADP for catalysis, however it has higher catalytic efficiency with NAD. (288 aa) |
| | aroD | 3-dehydroquinate dehydratase, type I; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (233 aa) |
| | aroH | 3-deoxy-7-phosphoheptulonate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (348 aa) |
| | pheT | KEGG: set:SEN1706 0. pheT; phenylalanyl-tRNA synthetase subunit beta K01890; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM1338; pheT. (795 aa) |
| | pheS | KEGG: sek:SSPA1398 3.4e-174 phenylalanyl-tRNA synthetase alpha chain; K01889 phenylalanyl-tRNA synthetase alpha chain; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM1337; pheS; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (327 aa) |
| | thrS | threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). (642 aa) |
| | astE | Succinylglutamate desuccinylase; Transforms N(2)-succinylglutamate into succinate and glutamate; Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily. (322 aa) |
| | astB | Succinylarginine dihydrolase; Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)- succinylornithine, ammonia and CO(2). (447 aa) |
| | astD | Succinylglutamic semialdehyde dehydrogenase; Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate. (492 aa) |
| | astA | Arginine N-succinyltransferase; Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine. (344 aa) |
| | astC | N-succinyldiaminopimelate- aminotransferase/acetylornithine transaminase protein; Catalyzes the transamination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate. Can also act as an acetylornithine aminotransferase. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. AstC subfamily. (392 aa) |
| | gdhA_2 | Glu/Leu/Phe/Val dehydrogenase, dimerization domain protein; KEGG: seh:SeHA_C1426 6.8e-240 gdhA; glutamate dehydrogenase; K00262 glutamate dehydrogenase (NADP+); Psort location: OuterMembrane, score: 9.92; locus tag in AE006468 is STM1299; gdhA; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (447 aa) |
| | selD | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. (347 aa) |
| | ansA | L-asparaginase, type I; KEGG: ses:SARI_01685 8.5e-178 ansA; cytoplasmic asparaginase I; K01424 L-asparaginase; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM1294; ansA. (338 aa) |
| | EHY70046.1 | Histidine triad domain protein; KEGG: seh:SeHA_C1319 4.1e-59 purine nucleoside phosphoramidase K12150; locus tag in AE006468 is STM1205; ycfF. (119 aa) |
| | putA | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. (1320 aa) |
| | EHY69914.1 | KEGG: bxe:Bxe_A3826 7.1e-135 glutamate decarboxylase K01580; Psort location: Cytoplasmic, score: 9.26; Belongs to the group II decarboxylase family. (447 aa) |
| | EHY69913.1 | KEGG: pmu:PM1115 2.5e-132 gltX; glutamyl-tRNA synthetase K01885; Psort location: Cytoplasmic, score: 9.97. (465 aa) |
| | glsA | Glutaminase; KEGG: cps:CPS_4729 8.3e-77 glsA; glutaminase K01425; Belongs to the glutaminase family. (332 aa) |
| | asnS | KEGG: sea:SeAg_B1008 2.1e-236 asnC; asparaginyl-tRNA synthetase K01893; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM1000; asnS. (441 aa) |
| | aspC | Aminotransferase, class I/II; KEGG: spq:SPAB_02515 1.6e-208 aromatic amino acid aminotransferase; K00813 aspartate aminotransferase; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM0998; aspC. (396 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (399 aa) |
| | serC | Phosphoserine transaminase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (362 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (430 aa) |
| | EHY69810.1 | Glycine hydroxymethyltransferase; KEGG: see:SNSL254_A0969 3.9e-173 ltaE; low-specificity L-threonine aldolase K01620; locus tag in AE006468 is STM0934; ltaA. (333 aa) |
| | EHY69716.1 | Glycosyl transferase family, helical bundle domain protein; KEGG: mms:mma_0486 6.3e-63 trpD2; glycosyl transferase family protein; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0822; ybiB. (324 aa) |
| | hutH | KEGG: stm:STM0791 3.2e-258 hutH; histidine ammonia-lyase K01745; locus tag in AE006468 is STM0791; hutH. (506 aa) |
| | hutU | Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (561 aa) |
| | hutC | KEGG: reh:H16_A3019 3.4e-55 hutC; histidine utilization repressor K05836; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0789; hutC. (241 aa) |
| | hutG | Formimidoylglutamase; Catalyzes the conversion of N-formimidoyl-L-glutamate to L- glutamate and formamide; Belongs to the arginase family. (313 aa) |
| | hutI | Imidazolonepropionase; KEGG: sew:SeSA_A0937 7.2e-213 hutI; imidazolonepropionase K01468; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0787; hutI. (407 aa) |
| | aroG | 3-deoxy-7-phosphoheptulonate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (393 aa) |
| | sucB | Dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (402 aa) |
| | speF | Orn/Lys/Arg decarboxylase, major domain protein; KEGG: stm:STM0701 0. speF; ornithine decarboxylase K01581; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM0701; speF. (732 aa) |
| | glnS | KEGG: sew:SeSA_A0841 0. glnS; glutaminyl-tRNA synthetase K01886; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM0686; glnS. (555 aa) |
| | asnB | Asparagine synthase; KEGG: spq:SPAB_02863 1.1e-301 asnB; asparagine synthetase B; K01953 asparagine synthase (glutamine-hydrolysing); Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0680; asnB. (554 aa) |
| | leuS | KEGG: ses:SARI_02284 0. leuS; leucyl-tRNA synthetase; K01869 leucyl-tRNA synthetase; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM0648; leuS; Belongs to the class-I aminoacyl-tRNA synthetase family. (860 aa) |
| | folD | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (288 aa) |
| | cysS | cysteinyl-tRNA synthetase; KEGG: see:SNSL254_A0590 1.1e-250 cysS; cysteinyl tRNA synthetase K01883; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM0537; cysS; Belongs to the class-I aminoacyl-tRNA synthetase family. (461 aa) |
| | EHY69381.1 | Pyridoxal-phosphate dependent enzyme; KEGG: set:SEN0440 3.4e-190 putative lyase; K01738 cysteine synthase A; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0458. (351 aa) |
| | aroM | AroM protein; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0390; aroM. (225 aa) |
| | aroL | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. (181 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (269 aa) |
| | proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (416 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (367 aa) |
| | EHY69266.1 | KEGG: vfm:VFMJ11_2065 1.3e-101 putative glutamine amidotransferase K07008; locus tag in AE006468 is STM0311; yafJ. (255 aa) |
| | proS | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (572 aa) |
| | ldcC | Orn/Lys/Arg decarboxylase, major domain protein; KEGG: sea:SeAg_B0275 0. lysine decarboxylase, constitutive K01582; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM0234; ldcC. (713 aa) |
| | dapD | KEGG: sed:SeD_A0234 5.6e-142 dapD; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase K00674; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM0213; dapD; Belongs to the transferase hexapeptide repeat family. (274 aa) |
| | mtnN | MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation. Belongs to the PNP/UDP phosphorylas [...] (232 aa) |
| | gluQ | glutamyl-Q tRNA(Asp) synthetase; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily. (313 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (126 aa) |
| | EHY69079.1 | KEGG: see:SNSL254_A0129 7.2e-78 ilvH; acetolactate synthase, small subunit, isozyme III K01653; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0117; ilvH. (164 aa) |
| | EHY69078.1 | KEGG: spq:SPAB_00147 1.0e-300 acetolactate synthase 3 catalytic subunit; K01652 acetolactate synthase I/II/III large subunit; Psort location: CytoplasmicMembrane, score: 8.46; locus tag in AE006468 is STM0116; ilvI. (566 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (523 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (363 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (466 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa) |
| | EHY69046.1 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (159 aa) |
| | carB | KEGG: ses:SARI_02937 0. carB; carbamoyl phosphate synthase large subunit; K01955 carbamoyl-phosphate synthase large subunit; locus tag in AE006468 is STM0067; carB; Belongs to the CarB family. (1074 aa) |
| | carA | KEGG: see:SNSL254_A0070 5.5e-199 carA; carbamoyl-phosphate synthase, small subunit K01956; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0066; carA; Belongs to the CarA family. (382 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (273 aa) |
| | ileS | isoleucine--tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (956 aa) |
| | EHY68979.1 | Threonine synthase; KEGG: sed:SeD_A0004 1.2e-224 thrC; threonine synthase K01733; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0004; thrC. (428 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (309 aa) |
| | thrA | Homoserine dehydrogenase; KEGG: set:SEN0001 0. thrA; bifunctional aspartokinase I/homeserine dehydrogenase I; K12524 bifunctional aspartokinase/homoserine dehydrogenase 1; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0002; thrA; In the C-terminal section; belongs to the homoserine dehydrogenase family. (820 aa) |
| | serB | Phosphoserine phosphatase SerB; Locus tag in AE006468 is STM4578; serB. (294 aa) |
| | trpS-2 | tryptophan--tRNA ligase; Locus tag in AE006468 is STM4508; trpS2; Belongs to the class-I aminoacyl-tRNA synthetase family. (337 aa) |
| | EHY67443.1 | Hypothetical protein; Locus tag in AE006468 is STM4484; idnD. (41 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (951 aa) |
| | EHY67434.1 | Hypothetical protein. (44 aa) |
| | EHY67433.1 | Hypothetical protein. (51 aa) |
| | EHY67430.1 | Acetyltransferase, GNAT family; Locus tag in AE006468 is STM4473; yjgM. (158 aa) |
| | argF-2 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (334 aa) |
| | arcA | Arginine deiminase; Locus tag in AE006468 is STM4467. (406 aa) |
| | arcC | Carbamate kinase; Locus tag in AE006468 is STM4466; Belongs to the carbamate kinase family. (310 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (334 aa) |
| | argR_2 | Arginine repressor protein; Regulates arginine biosynthesis genes. (162 aa) |
| | pyrB | Aspartate carbamoyltransferase; Locus tag in AE006468 is STM4460; pyrB; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (311 aa) |
| | ridA | Putative endoribonuclease L-PSP; Locus tag in AE006468 is STM4458; yjgF. (128 aa) |
| | epmA | lysyl-tRNA synthetase-like protein GenX; With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF- P) on 'Lys-34'. Catalyzes the ATP-dependent activation of (R)-beta- lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of EF- P 'Lys-34'; Belongs to the class-II aminoacyl-tRNA synthetase family. EpmA subfamily. (325 aa) |
| | epmB | KamA family protein; Locus tag in AE006468 is STM4333; yjeK. (342 aa) |
| | aspA | Aspartate ammonia-lyase; Locus tag in AE006468 is STM4326; aspA. (478 aa) |
| | adi | Orn/Lys/Arg decarboxylase, major domain protein; Locus tag in AE006468 is STM4296; adi. (756 aa) |
| | tyrB | Aromatic-amino-acid transaminase TyrB; KEGG: ses:SARI_03430 1.5e-203 aromatic amino acid aminotransferase; K00832 aromatic-amino-acid transaminase; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM4248; tyrB. (397 aa) |
| | alr-2 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (359 aa) |
| | lysC | Aspartate kinase, monofunctional class; Locus tag in AE006468 is STM4220; lysC; Belongs to the aspartokinase family. (449 aa) |
| | EHY67160.1 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1227 aa) |
| | metAS | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. (309 aa) |
| | argH | Argininosuccinate lyase; KEGG: spq:SPAB_05108 3.8e-239 argininosuccinate lyase; K01755 argininosuccinate lyase; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM4123; argH. (457 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate. (257 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (334 aa) |
| | argE | KEGG: set:SEN3915 1.6e-208 argE; acetylornithine deacetylase; K01438 acetylornithine deacetylase; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM4120; argE. (383 aa) |
| | metF | KEGG: stt:t3511 5.8e-156 metF; 5,10-methylenetetrahydrofolate reductase K00297; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM4105; metF. (296 aa) |
| | metL | Homoserine dehydrogenase; KEGG: sty:STY3768 0. metL, metM; bifunctional aspartate kinase II/homoserine dehydrogenase II K12525; Psort location: CytoplasmicMembrane, score: 9.82; locus tag in AE006468 is STM4101; metL; In the C-terminal section; belongs to the homoserine dehydrogenase family. (810 aa) |
| | EHY67714.1 | O-succinylhomoserine (thiol)-lyase; KEGG: sew:SeSA_A4317 3.7e-200 metB; cystathionine gamma-synthase K01739; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM4100; metB. (386 aa) |
| | metJ | Met Apo-repressor, MetJ; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. (105 aa) |
| | EHY67655.1 | KEGG: cko:CKO_03091 2.7e-44 hypothetical protein; K01714 dihydrodipicolinate synthase. (133 aa) |
| | dtd | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (145 aa) |
| | glnA | KEGG: sec:SC3899 3.4e-254 glnA; glutamine synthetase K01915; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM4007; glnA. (469 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (754 aa) |
