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bioF bioF EHY69015.1 EHY69015.1 pdxA pdxA panD panD panC panC panB panB folK folK EHY69347.1 EHY69347.1 ribH ribH thiL thiL EHY69352.1 EHY69352.1 dxs dxs thiI thiI apbA apbA cof cof ywpJ ywpJ bioA bioA bioB bioB bioC bioC bioD bioD supH supH EHY69768.1 EHY69768.1 serC serC pabC pabC thiK thiK EHY70286.1 EHY70286.1 pdxH pdxH pdxY pdxY bioD-2 bioD-2 EHY70577.1 EHY70577.1 EHY70589.1 EHY70589.1 fabI fabI ribA ribA cobO cobO ntpA ntpA EHY71076.1 EHY71076.1 EHY71077.1 EHY71077.1 thiD thiD thiM thiM EHY71433.1 EHY71433.1 pdxB pdxB pdxK pdxK EHY71544.1 EHY71544.1 purC purC pdxJ pdxJ EHY68302.1 EHY68302.1 gapA gapA dkgA dkgA ribB ribB folB folB EHY68884.1 EHY68884.1 cobA cobA bioH bioH panM panM coaBC coaBC yigB yigB yigL yigL EHY67132.1 EHY67132.1 thiG thiG thiS thiS EHY67135.1 EHY67135.1 thiE thiE thiC thiC yjdN yjdN EHY67355.1 EHY67355.1 ulaD ulaD ulaE_2 ulaE_2 araD-3 araD-3
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a 3D structure is known or predicted
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bioF8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (385 aa)
EHY69015.1KEGG: sei:SPC_0047 2.9e-152 ribF; hypothetical protein; K11753 riboflavin kinase / FMN adenylyltransferase; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0045; ribF. (295 aa)
pdxA4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (329 aa)
panDAspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (126 aa)
panCPantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (283 aa)
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (263 aa)
folKKEGG: ses:SARI_02814 2.6e-73 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase; K00950 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; locus tag in AE006468 is STM0183; folK. (159 aa)
EHY69347.1Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (367 aa)
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. (156 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (325 aa)
EHY69352.1Oxidoreductase, aldo/keto reductase family protein; KEGG: ecc:c0530 7.9e-159 yajO; oxidoreductase YajO; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM0421; yajO. (324 aa)
dxs1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (620 aa)
thiIThiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (482 aa)
apbA2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (272 aa)
cofCof-like hydrolase; Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5- hydroxymethylpyrimidine phosphate (HMP-P). (276 aa)
ywpJCof-like hydrolase; KEGG: sew:SeSA_A0934 1.7e-147 phosphotransferase K07024; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0784; ybhA. (286 aa)
bioAAdenosylmethionine-8-amino-7-oxononanoate transaminase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (429 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (346 aa)
bioCBiotin biosynthesis protein BioC; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (251 aa)
bioDDethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. (228 aa)
supHCof-like hydrolase; KEGG: stm:STM0842 1.1e-138 ybiV(1); putative hydrolase; K07757 sugar-phosphatase; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0842; ybiV(1). (269 aa)
EHY69768.1Cof-like hydrolase; KEGG: sed:SeD_A0971 2.8e-140 phosphatase YbjI K07024; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0867. (271 aa)
serCPhosphoserine transaminase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (362 aa)
pabCAminodeoxychorismate lyase; KEGG: sew:SeSA_A1274 1.0e-110 pabC; 4-amino-4-deoxychorismate lyase K02619; locus tag in AE006468 is STM1198; pabC. (269 aa)
thiKThiamine kinase; Catalyzes the phosphorylation of thiamine to thiamine phosphate. (273 aa)
EHY70286.1KEGG: spq:SPAB_01898 6.5e-109 riboflavin synthase subunit alpha; K00793 riboflavin synthase alpha chain; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM1426; ribE. (213 aa)
pdxHPyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (218 aa)
pdxYPyridoxal kinase; Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP. (286 aa)
bioD-2Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. (248 aa)
EHY70577.1Putative organophosphate reductase; KEGG: eci:UTI89_C0323 1.7e-133 2,5-diketo-D-gluconic acid reductase A; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM1676. (289 aa)
EHY70589.1Hypothetical protein; KEGG: eum:ECUMN_0336 8.9e-25 putative aldo-keto reductase. (70 aa)
fabIOxidoreductase, short chain dehydrogenase/reductase family protein; KEGG: ses:SARI_01263 1.9e-134 enoyl-(acyl carrier protein) reductase; K00208 enoyl-[acyl-carrier protein] reductase I; Psort location: CytoplasmicMembrane, score: 10.00; locus tag in AE006468 is STM1700; fabI. (262 aa)
ribAGTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate. (225 aa)
cobOcob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (196 aa)
ntpAHydrolase, NUDIX family; Locus tag in AE006468 is STM1900; ntpA. (127 aa)
EHY71076.1Hypothetical protein; KEGG: sek:SSPA0797 1.4e-15 cobyric acid synthase; K02232 adenosylcobyric acid synthase. (53 aa)
EHY71077.1Hypothetical protein; KEGG: stm:STM2019 3.8e-49 cbiP; cobyric acid synthase; K02232 adenosylcobyric acid synthase. (108 aa)
thiDKEGG: sec:SC2161 9.7e-138 thiD; phosphomethylpyrimidine kinase; K00877 hydroxymethylpyrimidine kinase K00941; locus tag in AE006468 is STM2146; thiD. (266 aa)
thiMHydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (262 aa)
EHY71433.1Protein FolC; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. (422 aa)
pdxBPutative erythronate-4-phosphate dehydrogenase; Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate. (378 aa)
pdxKPyridoxal kinase; B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i.e. PNP, PLP and PMP. (287 aa)
EHY71544.1cob(I)yrinic acid a,c-diamide adenosyltransferase; KEGG: sea:SeAg_B2612 6.3e-134 eutT; ethanolamine utilization cobalamin adenosyltransferase K04032; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2467; eutT. (267 aa)
purCKEGG: seg:SG2517 2.5e-123 purC; phosphoribosylaminoimidazole-succinocarboxamide synthase K01923; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2487; purC; Belongs to the SAICAR synthetase family. (237 aa)
pdxJPyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (243 aa)
EHY68302.1SMP-30/Gluconolaconase/LRE-like region; KEGG: ent:Ent638_3078 7.1e-135 gluconolactonase K01053; locus tag in AE006468 is STM2668. (302 aa)
gapAD-erythrose-4-phosphate dehydrogenase; Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate. (342 aa)
dkgAOxidoreductase, aldo/keto reductase family protein; KEGG: stm:STM3165 9.5e-147 dkgA; 2,5-diketo-D-gluconate reductase A K06221; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM3165; yqhE. (275 aa)
ribB3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (217 aa)
folBDihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (119 aa)
EHY68884.1Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (282 aa)
cobAuroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. (457 aa)
bioHPutative pimeloyl-BioC--CoA transferase BioH; The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters. (256 aa)
panMAcetyltransferase, GNAT family; Controls both the activation and catalytic activity of PanD in a coenzyme A (CoA)-dependent fashion; Belongs to the PanZ/PanM family. (127 aa)
coaBCPhosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (407 aa)
yigBHAD-superfamily hydrolase, subfamily IA, variant 1; KEGG: vcj:VCD_001589 1.2e-50 2-haloalkanoic acid dehalogenase K07025; locus tag in AE006468 is STM3950; yigB. (238 aa)
yigLCof-like hydrolase; KEGG: bau:BUAPTUC7_028 1.7e-55 yigL; sugar phosphatase K07024; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM3962; yigL. (266 aa)
EHY67132.1Thiazole biosynthesis protein ThiH; Locus tag in AE006468 is STM4159; thiH. (377 aa)
thiGThiazole biosynthesis protein ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (256 aa)
thiSThiamine biosynthesis protein ThiS; Locus tag in AE006468 is STM4161. (66 aa)
EHY67135.1Putative thiazole biosynthesis adenylyltransferase ThiF; Locus tag in AE006468 is STM4162; thiF. (252 aa)
thiEThiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (211 aa)
thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (631 aa)
yjdNProtein PhnB; Locus tag in AE006468 is STM4288; phnB. (147 aa)
EHY67355.1Hypothetical protein; Locus tag in AE006468 is STM4382; yjfR. (354 aa)
ulaDOrotidine 5'-phosphate decarboxylase / HUMPS family protein; Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. Is involved in the anaerobic L-ascorbate utilization. Belongs to the HPS/KGPDC family. KGPDC subfamily. (216 aa)
ulaE_2Putative hexulose-6-phosphate isomerase; Catalyzes the isomerization of L-xylulose-5-phosphate to L- ribulose-5-phosphate. Is involved in the anaerobic L-ascorbate utilization; Belongs to the L-ribulose-5-phosphate 3-epimerase family. (284 aa)
araD-3L-ribulose-5-phosphate 4-epimerase; Catalyzes the isomerization of L-ribulose 5-phosphate to D- xylulose 5-phosphate. Is involved in the anaerobic L-ascorbate utilization. (228 aa)
Your Current Organism:
Salmonella enterica houtenae
NCBI taxonomy Id: 523831
Other names: S. enterica subsp. houtenae str. ATCC BAA-1581, Salmonella enterica subsp. houtenae str. ATCC BAA-1581
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